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Folia Medica Indonesiana The Unit of Journal Consortium and Folia Medica Indonesiana Faculty of Medicine, Universitas Airlangga Jl. Prof. Dr. Moestopo No.47, Pacar Kembang, Kec. Tambaksari, Surabaya, Jawa Timur 60132, Indonesia
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Folia Medica Indonesiana
Published by Universitas Airlangga
ISSN : 23558398     EISSN : 2599056X     DOI : https://doi.org/10.65346/2958-4515.2401
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Folia Medica Indonesiana, as indicated by its name, focuses on publishing good quality articles about research and education on health science and medicine in Indonesia. However, due to the fast growth of science and knowledge in these fields, we also welcome submitted articles from around the world, especially the ones that contain related matters from lower-middle income countries. Folia Medica Indonesiana is an open-access, peer-reviewed journal that is published online at least four times a year. The scope covers various aspects of basic medical sciences includes anatomy, physiology, pathology, microbiology, pharmacology, and molecular medicine) and clinical medicine (covers specialties like internal medicine, surgery, pediatrics, oncology, psychiatry, etc). We highlight the pathology and potential treatment of metabolic syndromes and infectious diseases. Folia Medica Indonesiana also encourages the publication of articles about health education. The scope includes, but is not limited to, articles that emphasize on preventive education on certain diseases in a community, also research report of various materials and/or methods to develop medical education. We recognize the importance of this type of articles to be published alongside the assigned topic in each of our yearly issues, to provide our readers with updated information in medical sciences’ research and education simultaneously.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 13 Documents
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Search results for , issue "Vol. 53, No. 2" : 13 Documents clear
Isolation of streptomyces sp. From lapindo mud soil, sidoarjo, east java province, indonesia as a larvicide candidate against aedes aegypti Yotopranoto, Subagyo; Kurnijasanti, Rochmah; Rohmah, Etik Ainun
Folia Medica Indonesiana Vol. 53, No. 2
Publisher : Folia Medica Indonesiana

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Abstract

Streptomyces sp. is a bacterium that can live in many kind of habitations e.i. marine, sea sponge, coastal area, soil, desert soil, river bank etc. Many antibiotics and secondary metabolites are produced by this bacterium. Several secondary metabolites of the bacterium can be used as an insecticide against insects including mosquito larva.The purpose of this study was to search and isolate until species of Streptomyces sp. from Sidoarjo Lapindo mud soil in East Java province that can be used as a larvicide against Aedes aegypti larva, the dengue haemorrhagic fever vector.The method of study was to collect several mud soil samples from Sidoarjo Lapindo. The collected samples were cultured in ISP-4 media for producing mix-cultures. Then, to isolate the suspected colony of Streptomyces sp. by culturing again in several replications on ISP-4 media in petri-dish. The pure isolates were cultured in ISP-4 slant media. There were could be obtained eight pure isolates of Streptomyces sp.The characterization of 16S rRNA of Streptomyces sp. was done in order to determine the species. DNA isolation was done and followed by DNA sequencing, then compared to Gene Bank with BLAST program. The results showed that the sequence nucleotide bases of Streptomyces Sp-D6 had high similarity to Streptomyces sp. 171524, beside the sequence nucleotide bases of Streptomyces Sp-D7 and Sp-D9 had high similarity to Strepto-myces sp. ACT-01578 and ACT-175695. These three species can be used as larvicide candidate against Ae. aegypti.
Thiamine supplement therapy improves ejection fraction value in stage ii heart failure patients Jikrona, Rafi; Suharjono, Suharjono; Ahmad, Abraham
Folia Medica Indonesiana Vol. 53, No. 2
Publisher : Folia Medica Indonesiana

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Abstract

Thiamine, also called vitamin B1, is a water soluble vitamin that is involved in the formation of ATP in cells. The active metabolite of thiamine is a co-enzyme thiamine pyrophosphate (TPP) that plays an active role in carbohydrate metabolism and the formation of amino acid binding conjugates. Directly, thiamine may increase energy production in heart muscle cells through such mechanism, whereas in conditions of heart failure, a decrease in the contractility of heart muscle may be found. Therefore, thiamine supplementation is needed in stage II heart failure patients due to long-term use of furosemide that triggers the thiamine deficiency condition. Thiamine supplementation here is enabled to increase heart cells contractility which may ultimately increase the ejection fraction value of the heart muscle as a parameter of heart work efficiency measurement. The objective of this study was to evaluate the effect of thiamine administration as a therapeutic supplement in stage II of heart failure patients on the ejection fraction rate changes in pre and post thiamine supplement therapy for 28 days. The study was conducted using Cross Sectional Prospective Observational Analysis method between April and August 2016 in male patients with NYHA II heart failure who received furosemide therapy meeting the inclusion criteria at Heart Clinic Jemursari Islamic Hospital, Surabaya. Patients who fulfilled the inclusion and exclusion criteria in this study were 32 patients, 16 control patients and 16 treatment group patients between the ages of 35-75 years. During this study, after supplementation of thiamine 300 mg/day, 16 patients in the treatment group experienced an increase in ejection fraction rate (13.5%). The result of paired t test p=0.000 (p<α; α=0,05) showed significant difference between ejection fraction rate of pre and post thiamin supplementation. This study concluded that thiamine supplement therapy of 300 mg/day could increase the ejection fraction rate in patients of stage II heart failure.
Plasma lactate versus c-reactive protein as prognositic indicator in urosepsis Prilistiyo, Dwimantoro Iman; Santoso, A; Anniwati, L; Pudjirahardjo, W J
Folia Medica Indonesiana Vol. 53, No. 2
Publisher : Folia Medica Indonesiana

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Abstract

Urosepsis occurs in 20-30 % of septic case. Early diagnosis were undoubtfully important to improve the results of sepsis management. Bacteriological confirmation may be difficult to obtain and negative cultures do not exclude the presence of infection. Increased understanding of inflammatory cascade mechanisms provided several indicator of infection and prognosis. Lactate measurement in patients with infection and possibly severe sepsis to help identify patients at high risk of death in order to apply aggressively therapy. Elevation in serum C-reactive protein (CRP) is also associated with an increasing risk of death in patients with infection. This study was to determine the plasma lactate and CRP levels of patients with urosepsis as a prognostic indicator. This is an analytic observational study to compare the correlation and significance of plasma lactate and CRP with prognosis of urosepsis. Each subject was measured for plasma lactate and serum CRP at time of admission. All subjects were managed according to standard protocol. At the 14th day of treatment, patients were evaluated with a clinical severity score. The outcome was classified as follows: 1=good condition/improved, 2=morbid/worsened and 3=death. The statistical analysis used Spearman's rho test, ρ<0.05 was considerated to indicate significance. We enrolled 25 subjects with urosepsis. 14 patients who were septic, nine patients had severe sepsis and 2 patients had septic shock. Mean plasma lactate level in patients based on outcome (improved/worsened/death) was 2.08 mmol/L; 4.16 mmol/L and 5.27 mmol/L. The mean value of CRP was 13.41 mg/L; 22.28 mg/L and 24.62 mg/L. These were statistically significant (p 0.008 vs 0.016) in determining the outcome of the urosepsis patient. The coefficient correlation is better with plasma lactate than CRP (0.517 vs 0.475). In conclusion, the measurement of plasma lactate and CRP level can be used as a prognostic marker for the outcome of patient with urosepsis. Plasma lactate showed higher correlation with outcome of urosepsis than CRP.

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