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International Journal of Biomedical Science and Travel Medicine
Published by Universitas Warmadewa
ISSN : 30477441     EISSN : 30477433     DOI : https://doi.org/10.22225/ijbstm
Core Subject : Health,
Medicine & Pharmacology Public Health
International Journal of Biomedical Science and Travel Medicine is published twice (March and September) a year. The objective is to promote articles on biology and medicine. International Journal of Biomedical Science and Travel Medicine publishes original research work related to biological and medicine. The journal publishes Original articles, Short Reports, Case Reports, and Review articles. All articles published in International Journal of Biomedical Science and Travel Medicine (IJBSTM) are peer-reviewed and published online for immediate access and citation. International Journal of Biomedical Science and Travel Medicine (IJBSTM) publishes the Original clinical and experimental research studies, Review articles, Case reports on topics but not limited to: Biocemistry, Genetics and molecular biology, Medicine, Environmental health, Tropical diseases, Diseases in tropics, Global health, Pharmacological sciences, Biomedical sciences, Public health, Infection, Epidemiology and clinical epidemiology, Molecular biology, Microbiology, Travel Medicine
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 5 Documents
 1 
Search results for , issue "vol. 2 no. 1 (2025)" : 5 Documents clear
Management of Diabetes on Long Trips and High Temperatures Ida Bagus Aditya Nugraha; Ketut Suastika; Wira Gotera; Made Ratna Saraswati; I Made Pande Dwipayana; I Made Siswadi Semadi
International Journal of Biomedical Science and Travel Medicine Vol. 2 No. 1 (2025)
Publisher : Publication Department, Universitas Warmadewa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/ijbstm.2.1.2025.1-6

Abstract

Although safe and fast, air travel can cause problems in diabetic passengers and pilots. In fact, most diabetes-related emergencies can be prevented during the flight. Diabetic passengers and pilots can fly safely with proper control and planning. During air travel, diabetes sufferers are faced with unhealthy diet choices, limited access to medicines and health services, disrupted drug dosing intervals, and exposure to hypobaric aircraft cabin environments. Disruptions to routine dosing intervals are most severe when travelers cross multiple time zones. Traveling east or west will shorten or lengthen the interval between scheduled doses. This increases the possibility of inadvertent, premature, or delayed administration of antihyperglycemic therapy. In this review, we have discussed in detail about flights in diabetic passengers and some issues to be considered during and after the flight especially in high temperature.
A Systematic Review: The Effectiveness of Triple Drug versus Dual Drug Approach Against Lymphatic Filariasis Devina Hanalily Maharani Ferguszon; Putri Cahya Purwaningrum; Raihanah labibah; Prawesty Diah Utami
International Journal of Biomedical Science and Travel Medicine Vol. 2 No. 1 (2025)
Publisher : Publication Department, Universitas Warmadewa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/ijbstm.2.1.2025.7-13

Abstract

Background: Lymphatic Filariasis (LF) is a neglected tropical disease caused by filarial nematode parasites (Wuchereria bancrofti, Brugia malayi, and B. timori), which is transmitted via mosquitoes in the form of microfilariae (Mf). The transmission cycle for each species is the same parasites or worms transmitted through the bite of all types of mosquitoes. The most severe clinical manifestations of LF are lymphedema and elephantiasis. The treatment of filariasis receives mass drug administration with a single dose of the triple-drug oral regimen. Therefore, the World Health Organization (WHO) reported that the triple-drug oral regimen was an LF treatment.Methods: The research is in the form of systematic review research using the PRISMA (Preferred Reporting Items for Systematic Review and Meta-analysis) method, which is carried out systematically. The research was conducted in December-February with a review of articles published in the last 5 years (2018-2023). Researchers searched for literature independently through PubMed and Science Direct.Results:Triple drug therapy or a combination of Ivermectin-Diethylcarbamazine -Albendazole (IDA) is safer and more tolerable for filariasis than dual drug (combination of Diethylcarbamazine -Albendazole/DA), according to various articles. In addition, IDA reduces microfilaria formation more than DA. Most filariasis treatment side effects are modest, such as fever and soreness.Conclusion: In comparison to dual drug therapy, triple drug therapy exhibits a substantial advantage; however, the level of endemicity and the species of the causative agents must be considered when applying this approach.
Neuroprotective Mechanism of Icariin against Cerebral Ischemic-Reperfusion Injury: A Systematic Review Diana Yuswanti Putri; Yuyun Yueniwati; Sri Utami; Nirmala Halid; Husnul Khotimah
International Journal of Biomedical Science and Travel Medicine Vol. 2 No. 1 (2025)
Publisher : Publication Department, Universitas Warmadewa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/ijbstm.2.1.2025.14-18

Abstract

Background: Ischemic stroke has become one of the most life-threatening diseases with high disability and mortality rates. New treatment strategies with neuroprotective functions are urgently needed to treat it. Icariin is a flavonol glycoside that has antioxidant capacity, promote neurite outgrowth and modulate the immune system. This systematic review was conducted to assess and evaluate the efficacy, safety and feasibility of icariin in the treatment of ischemic stroke.Methods: This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020. We included predefined inclusion criteria, including: original articles published in the last 10 years and in English. Abstracts, preprints, reviews, articles not published in English and inaccessible full-text articles are excluded. Data extracted from PubMed and ScienceDirect databases using keywords "ischemic stroke“ or ‘”cerebral ischemic-reperfusion injury“ and '"icariin". The JBI critical appraisal tool was used to assess the quality of the data.Results: From the data obtained, a total of 7 research data were found eligible to review. The results showed that icariin had positive effects in reducing the levels of pro-inflammatory cytokines such as interleukin-1beta (IL-1beta), IL-6, and tumour necrosis factor-alfa (TNF-alfa) as well as maintaining brain cell viability. In addition, icariin either given alone or in combination improves post-ischemic neurological function and reduces infarct volume.Conclusion: Icariin has demonstrated neuroprotective effects necessary for neuroprotection and neurovascular recovery. In vitro and in vivo studies using Icariin alone or in combination with other modalities have also shown enhanced protection.
The The Impact of COVID-19 Pandemic on Cognitive Function in Older Adults with Dementia: A Systematic Review Rensa Rensa; Stefania Rosalyn; Alius Cahyadi
International Journal of Biomedical Science and Travel Medicine Vol. 2 No. 1 (2025)
Publisher : Publication Department, Universitas Warmadewa

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: The prevalence of dementia rises with the increasing life expectancy and elderly population. Due to the COVID-19 pandemic, it is challenging for caregivers to help carry out their daily activities and provide cognitive stimulants to slow down the deterioration. Therefore, this research aims to determine the impact of the COVID-19 pandemic on cognitive function in older people with dementia. Methods: This systematic review sought and reviewed observational studies data taken from various databases such as PubMed, EBSCOHost, Google Scholar, and ScienceDirect starting from January to November 2022—using COVID-19, dementia, cognitive function, and elderly along with their synonyms as keywords. Results: As many as 11 literatures with a total of 3132 participants were obtained to be reviewed. Ten out of 11 pieces of literature showed a deterioration in the cognitive function of older people with dementia due to the COVID-19 pandemic. In comparison, one piece of literature showed an improvement in cognitive function that was not significant. Conclusion: The cognitive function of older people with dementia appears to deteriorate when compared between before and after the COVID-19 pandemic. This can be seen as a decrease in MMSE, MoCA, or both scoring results. However, due to confounding variables not being accounted for in the pieces of literature reviewed, it is impossible to pinpoint the Covid-19 pandemic as the exact reason for this deterioration.
Phenotypical analysis of Chloramphenicol toxicity in Drosophila Aditya Satya Pratama; Aizia Risty Rizal; Nurhidayah Ramly; Gimas Fatir Bijaksana; Jihan Atiqah Permatasari; Muhammad Akbar Bahar; Nadila Pratiwi Latada; Mukarram Mudjahid; Risfah Yulianty; Nur Inda Yanti; Firzan Nainu
International Journal of Biomedical Science and Travel Medicine Vol. 2 No. 1 (2025)
Publisher : Publication Department, Universitas Warmadewa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/ijbstm.2.1.2025.19-26

Abstract

Background: Chloramphenicol is a broad-spectrum antibiotic with serious side effects, including aplastic anemia and gray baby syndrome. While Drosophila melanogaster is a cost-effective and genetically relevant model for toxicological studies, its response to chloramphenicol remains unexamined. This study explores the toxic effects of chloramphenicol in Drosophila to provide insights into its broader biological impact. Methods: This study aims to analyze the toxicity of chloramphenicol in terms of developmental toxicity, locomotor activity, morphology and gene expression status (sod1, sod2, tom40, and indy) in Drosophila melanogaster. The study was conducted on Oregon-R strain D. melanogaster larvae fed with chloramphenicol at concentrations of 625; 1,875; 3,125; and 4,375 ppm. Results: Developmental toxicity assay revealed that chloramphenicol exposure significantly delayed developmental progression, as evidenced by a prolonged transition from larval to pupal stages at concentrations of 3,125 and 4,375 ppm. However, no significant alterations were observed in locomotor activity or morphological characteristics. Moreover, chloramphenicol exposure in D. melanogaster appeared to exert toxic effects by significantly altering the expression of sod1, sod2, and tom40, while having no detectable impact on indy gene expression. Conclusion: High concentrations of chloramphenicol significantly impair larval development in D. melanogaster and alter gene expression profiles. However, adult flies exhibit no observable morphological or locomotor abnormalities compared to controls. These findings highlight that Drosophila larvae are susceptible to chloramphenicol toxicity, making it an ideal phase for assessing the detrimental effects of chloramphenicol.

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