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Systematic Literature Review: Could Plasma Convalescent Prevent Death on COVID-19? Widjaja, Jordan Steven; Utami, Prawesty Diah; Putri, Jeanaya Hedya Alfara; Kusbijantoro, Yemima Billyana
JURNAL PENDIDIKAN KEPERAWATAN INDONESIA Vol 7, No 2 (2021): Volume 7, Nomor 2 (2021)
Publisher : Universitas Pendidikan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17509/jpki.v7i2.38945

Abstract Introduction: The COVID-19 pandemic is still a global health problem, and the lack of effective and efficient treatment standards is one of the causes of the high morbidity and mortality rates. One approach that is often used in various cases of COVID-19 is convalescent plasma therapy. The administration of convalescent plasma is one of the treatment options that are often used in cases of COVID-19 with mild, moderate, severe, chronic, and critical symptoms. Objectives: The article reviewâ€™s objective isÂ to analyze of convalescent plasma transfusion in various cases of COVID-19 can prevent death and improve clinical outcomes. Methods: The PRISMA flowchart is applied to filter the literature that meets the inclusion criteria: published articles with experimental or observational research discussing the use of convalescent plasma in COVID-19 patients; published January 2020 - March 2021.Â We conducted article searches through PubMed, Google Scholar, and Science Direct. Assessment of the quality of the articles using the EPHPP form, and we chose ten articles. Result: The results of the qualitative analysis prove that convalescent plasma administration in various COVID-19 cases significantly reduces viral load, clinical improvement and prevents death in mild, moderate, and severe COVID-19s, but for terminal or critical cases, it does not show significant results. Discussion: The success rate of convalescent plasma therapy is determined by the high antibody titer in plasma donors, the distance between its administration and the onset of symptoms, and the patient's baseline condition before plasma administration. Based on these results, further research is needed to determine the standard dose and method of administration of convalescent plasma referring to the varied baseline conditions of patients.Â Abstrak Pendahuluan : Pandemik COVID-19 masih menjadi masalah kesehatan global, dan belum ditemukannya standar pengobatan yang efektif dan efisien menjadi salah satu penyebab tingginya angka morbiditas serta mortalitasnya. Salah satu pendekatan yang sering digunakan pada berbagai kasus COVID-19 adalah terapi plasma konvalesen. Pemberian plasma konvalesenÂ menjadi salah satu pilihan terapi yang sering digunakan pada kasus COVID-19 dengan gejala ringan, sedang, berat, kronis serta fase kritis. Tujuan : Tujuan penulisan artikel ini untuk menganalisis hasil penelitian lain yang mengulas tentang pemberian plasma konvalesen di berbagai kasus COVID-19. Metode : Metode penyusunan sistematik literatur review ini menggunakan diagram alir PRISMA untuk menyaring literatur yang memenuhi kriteria inklusi: artikel publikasi berupa penelitian eksperimental atau observasional yang membahas penggunaan plasma konvalesen pada pasien COVID-19; terbit bulan Januari 2020 â€“ Maret 2021. Pencarian artikel dilakukan melalui tiga sumber: Pub Med, Google Scholar dan Science Direct. Penilaian kualitas artikel menggunakan formulir EPHPP, sehingga terdapat 10 artikel yang terpilih. Hasil : Hasil analisis kualitatif membuktikan bahwa pemberian plasma konvalesen pada berbagai kasus COVID-19 secara signifikan menurunkan viral load, perbaikan klinis, serta mencegah kematian pada pasien COVID-19 yang ringan, sedang dan berat, namun untuk kasus terminal atau kristis tidak menunjukkan hasil yang signifikan. Diskusi : Tingkat keberhasilan terapi plasma konvalesen ditentukan oleh tingginya titer antibodi dalam donor plasma, jarak pemberiannya dengan awal gejala serta kondisi awal pasien sebelum pemberian plasma. Berdasarkan hasil tersebut diperlukan penelitian lebih lanjut mengenai dosis dan cara pemberian plasma konvalesen mengacu pada kondisi awal pasien yang bervariasi.

Prevalence of Trichomoniasis in Cervical Cancer Patients Luh Putu Diah Ayuning; Risma Risma; Prawesty Diah Utami
Jurnal Ilmu Kesehatan dan Kesehatan Vol 6 No 1 (2022): FEBRUARY
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v6i1.2543

Backgroud: Trichomoniasis is the most frequent non-viral sexually transmitted disease in the world, and it can lead to persistent HPV infection. Trichomonas vaginalis infection causes damage to the vaginal mucosa, activation of oncogenes and inactivation of tumor suppressor proteins, and production of non-specific oxidants that lead to cervical cancer. This study aims to determine the prevalence of trichomoniasis in cervical cancer patients. Methods: This study uses systematic literature review method and uses 10 international journals obtained through machine learning and indexed in Scimago. Journals are screened through PRISMA and have gone through a critical appraisal process.This study took place from April to September 2021. Results: The prevalence of trichomoniasis in cervical cancer patients ranged from 0.022% to 87.7%, according to the findings of this study. The prevalence results vary due to differences in demographics and diagnostic methods used. Statistical analysis of the association between trichomoniasis and cervical cancer varied between significant and insignificant. Differences in the association are influenced by the research design used, diagnostic methods, and sample of the research. Conclusions: The conclusion of this study is that the prevalence of trichomoniasis in cervical cancer patients was discovered to be the highest in the study by Ghosh et al. in Kolkata, India (72.6% women with CIN 1, 71.0% women with CIN 2 or CIN 3, and 87.7% women with invasive cancer) and the lowest in the study by Su et al. in Taiwan (0.022%). The association between trichomoniasis and cervical cancer was found to be varied.

The Effect of Thespesia populnea Against Plasmodium falciparum Enoyl Acyl Carrier Protein Reductase Receptor by Study In Silico I Made Prasetya Kurniawan; Prawesty Diah Utami; Risma Risma
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 5, No 2 (2021)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v5i2.5368

Indonesia is a country that has abundant natural resources; one of them is the Baru laut plant which is the latest breakthrough because it has an active substance that can be used as an anti-malaria medicine. It is very beneficial because there has been a case of resistance of artemisinin derivatives in Indonesia. The purpose of this study was to determine the potential of active compounds in Baru laut plants (Thespesia populnea (L.) Soland ex. Correa) against the Plasmodium falciparum enoyl acyl carrier protein reductase receptor in P. falciparum through in silico studies. This research is purely experimental using the One-Shot Experimental Study research design method. Observations were only made once between the variables studied through three analyzes, namely prediction analysis of active compound content, prediction analysis of the mechanism of action of active compound content, and prediction analysis of ADME active compound. The study results show that there are three active compounds in Baru laut plants that have antimalarial potential. The three compounds include gossypol, linoleic acid, and beta-sitosterol, have their respective potential in becoming a malaria drug. This study concludes that Baru laut plants have potential as anti-malaria drugs.

Inhibitory Effect of Active Substances of Lollyfish (Holothuria atra) Against the Development of Plasmodium falciparum Based on In Silico Study Felly Moelyadi; Prawesty Diah Utami; Irmawati M. Dikman
ILMU KELAUTAN: Indonesian Journal of Marine Sciences Vol 25, No 4 (2020): Ilmu Kelautan
Publisher : Marine Science Department Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/ik.ijms.25.4.135-142

The high level of artemisinin resistance as the antimalarial drug makes the active substances found of lollyfish (Holothuria atra) become a very useful discovery as a new antimalarial drug. The purpose of this research is to find out the inhibitory effect of the active substances of lollyfish against the development of Plasmodium falciparum with in silico method. This is a one-shot experimental study research. Based on the test of potentially active substances of lollyfish through PubChem (https://pubchem.ncbi.nlm.nih.gov/), there are pyrogallol and catechin that have potential as the antimalarial drug. Pyrogallol, chlorogenic acid, catechin dan ascorbic acid have indirect inhibition to P. falciparum Orotidine 5-Monophosphate Decarboxylase (PfOMPDC) through carbon dioxide (CO2) and it is visualized by STITCH DB Version 5.0 (http://stitch.embl.de/). The binding affinity score of catechin, obtained from molecular docking, is higher than other substances and artemisinin. The Physicochemical and pharmacokinetic activity of the substance was predicted through SWISS ADME (http://www.swissadme.ch/index.php), while the toxicity was predicted through Pro-Tox (http://tox.charite.de/protox_II/). Catechin is a substance in lollyfish that is the safest because its lowest toxicity and very effective to be used as the antimalarial drug because of its high lethal dose 50 (LD50). Therefore, active substances in lollyfish have inhibitory effects against the development of P. falciparum based on in silico study.

In Vitro Study: Antimalarial Activity of Rivet Sea Cucumber Extract (Holothuria atra) With Ethyl Acetate Solvent Against Plasmodium falciparum : none Prawesty Diah Utami; Zuhro Putri Febrianti Febrianti
WMJ (Warmadewa Medical Journal) Vol 7 No 1 (2022): May 2022
Publisher : Warmadewa University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wmj.7.1.4287.23-32

Abstract Indonesia is experiencing a decreased cure rate of malaria caused by the species Plasmodium falciparum. Alternative medicine, in this case, uses marine biota, namely lollyfish (Holothuria atra), which has a lot of active compound content; the purpose uses the biota because many reports that there is a failure of malaria treatment therapy due to Artemisinin-based Combination Therapy (ACT) resistance. The purpose of this study was to find out the antimalarial activity of Holothuria atra extract with ethyl acetate solvent at dose 0.01; 0.1; 1; 10; and 100 Ug/ml against Plasmodium falciparum in vitro. Extract lollyfish using the maceration method. The lollyfish powder will be dissolved with ethyl acetate solvent for 24 hours. Antimalarial activity testing is measured through 4 parameters, namely the measurement of parasitemia rates, % parasite growth, % inhibitory rate, and IC50. Antimalarial activity with ethyl acetate solvent belongs to a very active category with an IC50 value of 1.52 µg/mL. These results can kill the P. falciparum parasite with a percentage that reaches 0%. A decrease in the percentage of growth occurs when the dose given is too low so that the parasite can grow and survive. The result of higher concentrations of extracts will have a higher percentage of resistance to the growth of parasites. The potential for antimalarial activity in lollyfish extract is influenced by the presence of active content such as alkaloids, flavonoids, catechins, and pyrogallol owned by marine biota animals. This study suggests that lollyfish (H. atra) can be developed as an alternative treatment for malaria. Keywords: Holothuria atra, antimalarial, Plasmodium falciparum, in vitro

Increased Age and Long Working Period Associated with Increased Severi-ty of Pterygium Among Fishermen in Kedung Cowek Sub-District, Surabaya, East Java-Indonesia Irma Andriani Pasaribu; Prawesty Diah Utami
Indonesian Journal of Medical Sciences and Public Health Vol 1 No 2 (2020)
Publisher : Future Science

Pterygium is a degenerative and invasive disorder of the subconjunctival tissue that can reach the cornea area which is become a worldwide health problem. UV exposure is the biggest risk factor for pterygium. A profession as a fisherman is one of the occupations that are often related to the appearance of pterygium, because of long-term exposure to UV rays. This study aimed to determine the correlation between age and duration as a fisherman with the degree of pterygium in Kedung Cowek village, Bulak Surabaya district, East Java - Indonesia. The research design was an analytic observational using consecutive sampling during March - July 2011; with the total number of respondents is 42 fishermen who met the inclusion criteria. The results of the statistical analysis test showed that there was a strong and significant relationship between the age of the fishermen (p = 0.007; coefficient correlation = 502) and the duration of working as a fisherman (p = 0.029; coefficient correlation = 409) with the severity of the pterygium. Based on these results it can be concluded that the age and duration of work as fishermen are related to the severity of the pterygium in fishermen in the Kedung Cowek sub-district, Surabaya, East Java-Indonesia.

Comparison of Cerebral Malaria Mice Models Infected by P. berghei ANKA Prawesty Diah Utami; R. Varidianto Yudo Tjahjono; Indi Jazilah; Ismy Azizah Sisnawati
Denta Journal Kedokteran Gigi Vol 3 No 2 (2020): Oceana Biomedicina Journal Volume 3 Issue (No) 2 July - December 2020
Publisher : Universitas Hang Tuah

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The high morbidity and mortality due to malaria infection makes it a global health problem. The pathogenesis and pathophysiology of cerebral malaria has not been fully understood. The use of cerebral malaria model mice is one alternative to understand its pathogenesis and pathophysiology. The purpose of this study was to compare Swiss mice and C57BL / 6 mice inoculated by P.berghei ANKA as a model of cerebral malaria mice. Methods: The study design was a randomized Post Test Control Only Group Design using 12 Swiss mice and 12 C57BL / 6 mice divided into 2 groups each: the treatment group inoculated by P. berghei ANKA and the control group without inoculation. Observation of clinical manifestations and parasitemia level was carried out from day 1 to day -10. The study results showed that K2 group showed a significant increase in the degree of parasitemia compared to K4. K4 group showed clinical manifestations of cerebral malaria while K2 did not show clinical manifestations of cerebral malaria. Conclusion: C57BL / 6 mice inoculated by PbA can be used as cerebral malaria animal models.

Pengaruh Pemberian Ekstrak Rimpang Temulawak (Curcuma xanthorrhiza Roxb.) Terhadap Jumlah Eritrosit Mencit (Mus musculus L.) Jantan BALB/c yang Diinokulasi Plasmodium Berghei Anka AZARINE NEIRA AVISHA; PRAWESTY DIAH UTAMI
HANG TUAH MEDICAL JOURNAL Vol 15 No 2 (2018): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

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ABSTRACT Malaria is still one of the most important infectious diseases in tropical countries because it can cause severe anemia and death. Nowadays, the choice for treatment of malaria is increasingly limited due to drug resistance. Hence, require the invention of new compounds to overcome them. The objective of this research was to perceive the effect of curcuma (Curcuma xanthorrhiza Roxb.) rhizome extract to the amount of erythrocytes in male BALB/c mice (Mus musculus L.) inoculated by Plasmodium berghei ANKA. This research was conducted experimentally with post-test only control group design using five groups of mice. One group was left normal while the other four groups were inoculated with Plasmodium berghei ANKA. From the groups inoculated with Plasmodium berghei ANKA, one group was given aquades and three other groups treated with curcuma (Curcuma xanthorrhiza Roxb.) extract with dose of 150 mg/KgBB, 100 mg/KgBB and 50 mg/KgBB for four days. On the fifth day, a blood test is performed to determine the amount of erythrocytes. The results of this study indicate that the amount of erythrocytesin male BALB/c mice (Mus musculus L.) inoculated byPlasmodium berghei ANKA and given rhizomesextract (Curcuma xanthorrhizaRoxb.) at doses of 150 mg/KgBB and 50 mg/KgBB wereinsignificantly decreased. Whereas the amount of erythrocytesin male BALB/c mice (Mus musculus L.) inoculated byPlasmodium berghei ANKA and given rhizomesextract (Curcuma xanthorrhiza Roxb.) at doses of 100 mg/KgBB weresignificantly decreased

Pengaruh Pemberian Ekstrak Temulawak (Curcuma Xanthorrizha Roxb.) Terhadap Level Nekrosis Pada Jaringan Lien Mencit Putih (Mus Musculus L.) Jantan Galur Balb/c yang Diinokulasi Plasmodium berghei ANKA Muhammad Reyhan Arsya; Prawesty Diah Utami; Irmawati Dikman
HANG TUAH MEDICAL JOURNAL Vol 16 No 2 (2019): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

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Abstract Background : Malaria is a disease caused by the Plasmodium, transmitted by Anopheles mosquito and is a health problem in Indonesia. Further development to find new innovations in malaria treatment. Purpose : to determine the effect of temulawak rhizome extract on the level of spleen necrosis of male mice inoculated with Plasmodium berghei ANKA. Methods : a post-test only control group design, used five groups. First group a normal mice, 2nd group was inoculated with Plasmodium berghei ANKA and three treatment groups were inoculated with Plasmodium berghei ANKA and treated with temulawak extract with a dose of 150 mg/KgBB (3rd group), 100 mg/KgBB (4rd group ), and 50 mg/KgBB (5rd group) for four day. On the fifth day observation of the level of spleen necrosis was examination by histopathological Result : the administration of ginger rhizome extract has an influence on the level of necrosis of male mice (Mus musculus L.) BALB / c inoculated with Plasmodium berghei ANKA α = 0,002 (ρ<0,05), where the administration of temulawak extract can increase necrosis levels compared to the control group . This is probably due to the lack of temulawak extract dosage and lack of observation in this study. Conclusion : extract Curcuma xanthorriza Roxb. Has an influence on the level of necrosis of male mice inoculated with Plasmodium berghei ANKA Keywords : Malaria, curcuma (Curcuma xanthorrhiza Roxb.), Necrosis level, Plasmodium berghei ANKA

Comparison of Cerebral Malaria Mice Models Infected by P. berghei ANKA Prawesty Diah Utami; R. Varidianto Yudo Tjahjono; Indi Jazilah; Ismy Azizah Sisnawati
Oceana Biomedicina Journal Vol 3 No 2 (2020): Oceana Biomedicina Journal Volume 3 Issue (No) 2 July - December 2020
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v3i2.49

The high morbidity and mortality due to malaria infection makes it a global health problem. The pathogenesis and pathophysiology of cerebral malaria has not been fully understood. The use of cerebral malaria model mice is one alternative to understand its pathogenesis and pathophysiology. The purpose of this study was to compare Swiss mice and C57BL / 6 mice inoculated by P.berghei ANKA as a model of cerebral malaria mice. Methods: The study design was a randomized Post Test Control Only Group Design using 12 Swiss mice and 12 C57BL / 6 mice divided into 2 groups each: the treatment group inoculated by P. berghei ANKA and the control group without inoculation. Observation of clinical manifestations and parasitemia level was carried out from day 1 to day -10. The study results showed that K2 group showed a significant increase in the degree of parasitemia compared to K4. K4 group showed clinical manifestations of cerebral malaria while K2 did not show clinical manifestations of cerebral malaria. Conclusion: C57BL / 6 mice inoculated by PbA can be used as cerebral malaria animal models.

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