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Journal of Healthcare and Biomedical Science (JHBS)
Published by Research Synergy Foundation
ISSN : 29863058     EISSN : 29863376     DOI : https://doi.org/10.31098/jhbs
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Nursing Public Health
Journal of Healthcare and Biomedical Science (JHBS) is an open access, peer-reviewed journal that encompasses all publication of novel research in healthcare and biomedical sciences, with an emphasis on the molecular studies of biomedical problems and molecular mechanisms. The scope of this journal is Anatomic, Biochemistry/ Medical Biochemistry, Pathology, Genetics, Immunology, Microbiology, Virology, Molecular, cellular and cancer biology, Neuroscience, Pharmacology, Physiology, Health engineering (Health system, Health regulation, Health issues, Personal health, Public health, Health professional, Health education, Health nutrition, social care, sleep health, international health, Social and behavioral science), Epidemiology, Nursing, Public health, Physical therapy, Medicine, Pharmacy, and Biostatistic.
Arjuna Subject : Kedokteran - Biokimia, Kedokteran
Articles 36 Documents
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Anti-Angiogenic Activity of Sabungai (Gynura procumbens) using a Cancer-induced Chicken Embryo Armie Joyce P. Aterrado
Journal of Healthcare and Biomedical Science Vol. 2 No. 2 (2024): Vol. 2 No. 2 (2024) : Journal of Healthcare and Biomedical Science (JHBS)
Publisher : Research Synergy Foundation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31098/jhbs.v2i2.2659

Abstract

Cancer has been increasing over recent years and is considered the primary cause of mortality following cardiovascular disease. Angiogenesis, the biological process by which new blood vessels are generated, plays a crucial role in the growth and spread of tumors. The objective of this study was to assess the anti-angiogenic activity of different Sabungai (Gynura procumbens) leaf extract concentrations in the Chorioallantoic Membrane (CAM) of cancer-induced chicken embryos. The results of a one-way analysis of variance (25.20 ± 2.70, 27.20 ± 1.08, and 22.80 ± 1.66) indicated a statistically significant difference in CAM vascularization between the various treatments. Post hoc analysis utilizing Tukey's Honest Significant Difference (HSD) test revealed that Treatment 2 (300ppt) significantly affected CAM vascularization, as evidenced by an average vascularization count of 27.20 ± 1.08, followed by Treatment 1 (100ppt) and Treatment 3 (500ppt). The results indicated that the extract from Sabungai leaves effectively hinders the formation of new blood vessels in a dose-dependent manner. The highest concentration of leaf extract (500 ppt) resulted in an average vascularization of 22.80 ± 1.66. However, excessively high doses can cause bleeding and embryo death. The results demonstrated that sabungai leaf extract affected blood vessel development in chicken embryos. The results of this research have various implications that contribute to scientific knowledge and potential applications in cancer treatment.
Performance of Dye-Sensitized Solar Cell Utilizing the Extract of Cassava (Manihot Esculenta) Leaves, Guava (Psidium Guajava) Leaves, and Mango (Mangifera Indica) Leaves Kathleen E. Espina; Alberto D. Yazon; Karen D. Manaig; Sherwin B. Sapin; Lerma P. Buenvinida
Journal of Healthcare and Biomedical Science Vol. 3 No. 1 (2024): December Issue
Publisher : Research Synergy Foundation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31098/jhbs.v3i1.2660

Abstract

Dye- sensitized solar cell (DSSC) is a third-generation solar cells that utilize natural dyes from leaves extract to absorb sunlight and generate electricity. This study aimed to investigate the performance of DSSCs using the leaf extracts of cassava, guava, and mango as natural dyes in terms of UV-Vis absorption and energy output. The experimental method was applied in which the researcher constructed three DSSCs, with each treatment involving the same fabrication and construction. The UV-Vis Spectrum peak value and UV absorption was obtained from UV-Vis Analysis. A multimeter was used to record each voltage to determine the energy output produced by the DSSCs and the commercial solar cell. One-way ANOVA was used to determine the significant difference in the UV absorption of the natural dyes. To determine the significant difference between the three treatments and control in pairwise comparison in terms of energy output, One-Way ANOVA Analysis and Post Hoc Tukey were used. The results showed no significant difference in UV absorption among the three natural dyes. This result signified that the same pigment content gave almost the same UV absorbance at a common UV spectrum peak wavelength. DSSCs with natural dyes produce less electrical energy than commercial solar cells. There was a significant difference in the energy output between the three treatments and the control. DSSCs utilizing natural dyes produced electrical energy in smaller amounts.
Acceptability of Mango Seed Kernel (Mangifera Indica) as Potential Tea Source Reynald P. Alican
Journal of Healthcare and Biomedical Science Vol. 3 No. 1 (2024): December Issue
Publisher : Research Synergy Foundation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31098/jhbs.v3i1.2706

Abstract

This study determined the acceptability and phytochemical properties of mango seed kernel (Mangifera Indica) as a tea source. Kernels from Carabao, Apple, and Indian Mango seeds were used in the study, which involved four drying processes: 7, 14, 21, and 28 days. The hedonic scale method was used to determine the mean level of acceptability of the tea, which was evaluated by the panelists. The presence of DPPH scavenging activity, total flavonoids, phenols, tannins, and anthocyanins was analyzed for phytochemical analysis. Statistical analysis, including mean and standard deviation, was used to evaluate acceptability levels, and ANOVA was used to determine significant differences. The results revealed that tea derived from Carabao mango kernels dried for 7 days had the highest acceptability. The phytochemical analyses of Carabao mango powder showed DPPH scavenging activity, flavonoids, phenols, and tannins; however, anthocyanins were not detected. The findings indicate that there were no significant differences in the mean sensory evaluation of the Carabao Mango kernel tea samples in terms of color, odor, taste, and general acceptability. In contrast, significant differences were observed among Apple Mango kernel tea samples for color and odor, while no significant differences were found for taste and general acceptability. Similarly, significant differences were noted among the samples of Indian Mango kernel tea for color but not for odor, taste, and general acceptability. The study highlights the potential of using mango seed kernels for tea production, thereby contributing to waste reduction and promoting health-conscious food production and consumption practices.
Hypolipidemic and Adipose-reducing Effects of Ethanolic Extract of Ziziphus Talanai (Blanco) Merr. in Monosodium Glutamate-Induced Obese Female Albino Rats Maria Anabelle A. Samson; Lourdes Fatima S. David; Glen S. Nolasco; John Dave Dicuangco; Marilyn S. Arcilla
Journal of Healthcare and Biomedical Science Vol. 3 No. 1 (2024): December Issue
Publisher : Research Synergy Foundation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31098/jhbs.v3i1.2738

Abstract

Obesity is a global health-related risk factor associated with metabolic disorders characterized by excessive fat accumulation and high lipid serum profile. One major factor contributing to obesity is the chronic consumption of monosodium glutamate (MSG). Generally, this study aimed to evaluate the hypolipidemic and anti-adipogenic effects of Ziziphus talanai ethanolic leaf extract (ZTELE) in MSG-induced obesity in female albino rats. A total of twelve (12) female albino rats were used in the study and divided into four treatment groups: T (distilled water), T+ (simvastatin), T1 (400 mg/kg ZTELE), and T2 (800 mg/kg ZTELE). Before treatment, rats were fed a high-fat diet and MSG for 1 month to induce obesity. Significant reductions in body weight, intrascapular and visceral fats, and selected lipid serum profiles (total cholesterol, high-density lipoproteins, low-density lipoproteins) were observed in the ZTELE-treated groups (T1 and T2), with comparable results to those of simvastatin-treated (T+). Phytochemicals, such as flavonoids, saponins, and tannins, influence metabolic pathways by their antioxidative potential, inhibition of lipid synthesis, and regulation of fat cell differentiation. In conclusion, ZTELE is a promising natural therapeutic agent for managing obesity by regulating fat accumulation and lipid metabolism.
Protective Effects of Premna serratifolia L. Leaf Extract Against Gentamicin-Induced Nephrotoxicity in ICR Mice Josel D. Cruz; Glen S. Nolasco; John Dave A. Dicuangco; Lourdes Fatima S. David
Journal of Healthcare and Biomedical Science Vol. 3 No. 1 (2024): December Issue
Publisher : Research Synergy Foundation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31098/jhbs.v3i1.2752

Abstract

Many therapeutic drugs, including aminoglycosides, are known to cause nephrotoxicity and impair kidney function. Gentamicin is a type of aminoglycoside commonly used to treat infection caused by gram-negative bacteria, but it can induce nephrotoxicity by accumulation in the proximal convoluted tubules, resulting in stress, degeneration, and injury to the kidney. Although traditional treatments are limited, natural products, such as in Premna serratifolia, have potential for ameliorative bioactivities. This study examined the nephroprotective effects of P. serratifolia ethanolic leaf extract (PSELE) against gentamicin-induced nephrotoxicity in male ICR mice. Twelve male ICR mice were divided into four groups: normal (T0), negative (T-), 0.3 ml/20 g b.w. PSELE-treated (T1), and 0.5 ml/20 g b.w. PSELE-treated (T2). The kidneys were then extracted, weighed, and subjected to histopathological examination. Results showed that PSELE counteracts gentamicin-induced nephrotoxicity by mitigating its effect on weight and kidney tissue alterations in PSELE-treated mice (T1 and T2), with comparable results to normal (T0). The protective effects of the extract were attributed to the phytochemicals that mitigated the oxidative stress of gentamicin. In conclusion, PSELE is a potential therapeutic agent for nephrotoxicity mitigation.
Evaluating the Impact of Immunotherapy on Long-term Survival Rates in Lung Cancer Patients in Sub-urban Areas in Bangladesh Md Khorshed Alam; S M Nazmul Hasan; Sharif Ahmed; Soumittra Kumar
Journal of Healthcare and Biomedical Science Vol. 3 No. 1 (2024): December Issue
Publisher : Research Synergy Foundation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31098/jhbs.v3i1.2778

Abstract

Lung cancer is a leading cause of cancer mortality worldwide, with an exceptionallyhigh incidence and poor outcomes in the suburban areas of Bangladesh due to limited healthcare infrastructure. Immunotherapy is a promising treatment modality for non-small-cell lung cancer (NSCLC), but its impact on resource-limited settings underexplored. This study evaluated the effect of immunotherapy on long-term survival rates among patients with lung cancer in the sub-urban districts of Cumilla and Feni, Bangladesh. A mixed-methods approach was used, involving 22 patients with NSCLC who were divided equally into the immunotherapy group and control group receiving conventional chemotherapy. Quantitative data on survival outcomes were analyzed using Kaplan–Meier estimates and Cox proportional hazard models to adjust for confounders. Qualitative data were collected through semi-structured interviews with patients in the immunotherapy group, focusing on access barriers, perceptions, side effects, and support systems. The immunotherapy group had a median overall survival of 18 months compared with 12 months in the control group (p = 0.03), with an adjusted hazard ratio of 0.55 (95% CI: 0.32–0.95, p = 0.033), indicating a 45% reduction in the risk of death. Qualitative findings revealed significant financial and geographical barriers to receiving immunotherapy. Patients reported a mix of hope and anxiety regarding treatment efficacy and side effects, with support systems playing a crucial role in treatment adherence and coping mechanisms. Immunotherapy significantly improves long-term survival rates among patients with lung cancer in sub-urban Bangladesh. Addressing financial constraints, enhancing healthcare infrastructure, and strengthening support systems are essential to maximize the therapeutic potential of immunotherapy in resource-limited settings.
The Anatomy Study of the Facial Temporal Region, Age 25–50, in Thai Population Based on Ultrasound Investigation Chenda Ly; Chantawat Kasemnet; Thamthiwat Nararatwanchai; Tawee Saiwichai; Sirintip Chaichalotornkul
Journal of Healthcare and Biomedical Science Vol. 3 No. 2 (2025): Journal of Healthcare and Biomedical Science
Publisher : Research Synergy Foundation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31098/jhbs.v3i2.3166

Abstract

Aging affects facial tissues, including skin, fat, muscles, and bones, with the temporal region playing a crucial role in both function and appearance. Temporal depression contributes to an aged look, increasing demand for aesthetic procedures. However, the complex layered structure and vascular pathways present challenges for safe interventions in this region. This study utilized high-frequency ultrasound to map the depth and position of the deep temporal arteries and assess the anatomy of the temporal region in Thai individuals aged 25–50 years. The observational cross-sectional design included 33 participants (15.15% male, 84.85% female) with an average age of 33.42 years. High-frequency ultrasound was used to evaluate the soft tissue and artery positioning. The sample included 10 individuals with and 23 individuals without hyaluronic acid filler injections. Significant differences in skin thickness, subcutaneous layers, SMAS layers, temporalis muscle thickness, and temporal bone characteristics were observed between the two groups. Filler injections notably altered anatomical structures, affecting artery depth and position. Despite limitations in sample size and population specificity, the findings underscore the importance of detailed anatomical knowledge for safer and more effective injectable procedures. Ultrasound imaging serves as a healthcare tool in guiding aesthetic interventions in the temporal region.
Role of Endoscopic Biliary Stenting in the Management of Difficult Common Bile Duct Stones Nimai Das; Chinmoy Saha; Shishir Sikto Sarker; Dr Tasmia Tanjum; Sanghita Ghose; Chanchal Kumar Ghosh
Journal of Healthcare and Biomedical Science Vol. 3 No. 2 (2025): Journal of Healthcare and Biomedical Science
Publisher : Research Synergy Foundation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31098/jhbs.v3i2.3379

Abstract

Removing large or multiple common bile duct stones that cannot be cleared at first endoscopic retrograde cholangiopancreatography (ERCP) is difficult in resource-limited settings. This study assessed whether temporary plastic stenting promotes subsequent clearance of these “difficult” stones. In a prospective observational study at Bangabandhu Sheikh Mujib Medical University, Dhaka (November 2019 – March 2021), 35 adults with difficult common bile duct stones underwent endoscopic sphincterotomy followed by placement of a 7–10 Fr plastic stent. Stone size, number, index, and duct diameter were measured before stenting and at repeat ERCP three months later. Clearance rates and stent-related adverse events were recorded. Thirty-one patients completed follow-up. Mean stone size fell from 19.1 ± 2.1 mm to 15.8 ± 3.1 mm; mean stone number from 1.80 ± 0.74 to 1.45 ± 0.67; and mean stone index from 28.9 ± 9.2 mm to 20.9 ± 9.9 mm (all p < 0.001). Complete bile duct clearance at second-session ERCP was achieved in 69.7%, while 6.1% showed spontaneous passage. Complications were limited to stent migration (6%), occlusion (9%), and cholangitis (6%), with no procedure-related mortality. Short-term endoscopic biliary stenting safely reduces stone burden and enables successful second-session extraction in most patients with difficult common bile duct stones. It offers an effective bridge therapy where advanced lithotripsy techniques are unavailable.
Optimizing Protein Extraction from Cowpea (Vigna unguiculata) and Pigeon Pea (Cajanus cajan) via Central Composite Design (CCD) Flores Annabelle C; Aidasani Norli L; Jocson Stanly Adam C
Journal of Healthcare and Biomedical Science Vol. 3 No. 2 (2025): Journal of Healthcare and Biomedical Science
Publisher : Research Synergy Foundation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31098/jhbs.v3i2.3443

Abstract

Plant-based proteins have gained popularity over the last decade due to their sustainability and favorable environmental impact. Proteins from underused legumes can be converted into value-added compounds, helping to sustain protein demand. This study sought to develop a standardized and improved procedure for producing plant protein concentrate from cowpea and pigeon pea. Protein extraction parameters were improved using the Response Surface Methodology with a Central Composite Design (RSM-CCD). The factors optimized were solid-liquid ratio, pH basic, and pH acidic, each varied within ranges defined by the CCD model to evaluate their effect on protein yield and content. The protein extraction processing parameters derived from the optimization trials were used to scale up protein powder production. The upgraded production yield and protein content for cowpea protein powder are 6.77% and 72.6%, respectively, while pigeon pea protein powder yields 6.01% and 63.8%. Statistical analysis confirmed the model adequacy (cowpea: R2=0.9399 for % protein, R2=0.9250 for % yield; pigeon pea: R² = 0.7836 for % protein, R² = 0.7704 for % yield; p < 0.05). Improved yield and protein content can enhance the development of low-cost, sustainable, and culturally inclusive (Halal/vegetarian) protein ingredients, supporting both the food industry and nutrition science by providing alternative protein sources that reduce reliance on imported soy and animal proteins. This study demonstrates that RSM-CCD is a robust and efficient approach for optimizing plant protein extraction parameters, offering valuable insights for functional food formulation and industrial-scale protein production.
Building Communication and Capacity Among Guidance Advocates in Advocating Students’ Mental Health Abegail Panghulan
Journal of Healthcare and Biomedical Science Vol. 3 No. 2 (2025): Journal of Healthcare and Biomedical Science
Publisher : Research Synergy Foundation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31098/jhbs.v3i2.3593

Abstract

The main thrust of this study was to explore the challenges encountered by guidance advocates in addressing students’ mental health in the Division of Calamba City. Qualitative research, specifically the phenomenological approach, was utilized. The data was gathered through interviews with the eight (8) guidance advocates. Based on the guidance advocates' experiences, ten (10) themes emerged from the phenomenological study of guidance advocates. These are: Degrees of Familiarity, Developed Professional Skills, Obligation Focused, Diverse Guidance Advocates Roles, Guide, Immediate Response to Students’ Needs, Visible Changes in Students’ Behavior and Difficulty in Assessing, Communication and Capacity, Divine Intervention and Personal Motivation, Through Seminars and Trainings. Guidance advocates were able to describe a variety of challenges in supporting the mental health of the students, including: Reaching out, Lack of Professional Capacity, Encourage Students to Open up, Students with Separation Anxiety, Handling a Situation, and Emotional and Physical Preparedness. Rooted in the lived experiences of the guidance advocates, communication barriers and a lack of professional capacity to effectively advocate for students' mental health were the two main issues faced by the guidance advocates in the field. Each advocacy role faced unique obstacles, often compounded by a lack of training and institutional support. Despite these obstacles, self-motivation and faith-based coping mechanisms were frequently used by guidance advocates to manage their duties and carry-on providing students with effective support. Considering the results, the study suggests an improvement project called Project I.S.I.P. (Initiated Strategies Inspired by Professionals), a referral and counseling program intended to strengthen school-based mental health support networks and advocacy.

Page 3 of 4 | Total Record : 36

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