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Fakultas Kedokteran Militer, Universitas Pertahanan Republik Indonesia In collaboration with Perdokmil (Perkumpulan Kedokteran Militer)
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The ASEAN Journal of Military and Preventive Medicine
Published by Universitas Pertahanan Republik Indonesia
ISSN : 30319447     EISSN : 3031870X     DOI : https://doi.org/10.47353/ajmpm
Core Subject :
The ASEAN Journal of Military and Preventive Medicine is an open-access, peer-reviewed scientific journal dedicated to advancing knowledge and innovation in the fields of military medicine, preventive medicine, biodefense, emergency medicine, disaster response, humanitarian health, and global public health. As one of the leading scholarly platforms in Indonesia and the ASEAN region, the journal provides an essential forum for researchers, military health professionals, clinicians, academics, and policymakers to disseminate high-quality research findings, emerging technologies, and interdisciplinary perspectives relevant to military and civilian healthcare systems. While military medicine remains the journal’s primary focus, contributions from allied disciplines with translational and practical impact are highly encouraged, particularly studies related to medical preparedness, humanitarian assistance, operational medicine, epidemiology, tropical diseases, public health resilience, and preventive healthcare strategies.
Arjuna Subject : -
Articles 32 Documents
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The Role of HIF-1α in Gingival Hypoxia Induced by Smoking: A Scoping Review Mutiara Yulina Putri; Siti Sopiatin; Amaliya Amaliya
The ASEAN Journal of Military and Preventive Medicine Vol. 3 No. 1 (2026): January
Publisher : Perkumpulan Kedokteran Militer

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/ajmpm.v3i1.40

Abstract

Background: Smoking is a well-established risk factor for periodontal disease, primarily due to its role in inducing hypoxia within gingival tissues. Hypoxia, defined as reduced oxygen supply, disrupts normal tissue homeostasis, exacerbates inflammation, and impairs healing. Chronic exposure to smoking-related toxins leads to microvascular dysfunction, reduced oxygen delivery, and an upregulation of hypoxia-inducible factor-1 alpha (HIF-1α). This molecular adaptation is associated with increased apoptosis, impaired angiogenesis, and delayed periodontal tissue regeneration, all of which contribute to disease progression. Understanding the role of hypoxia in smoking-related periodontal destruction is crucial for developing targeted therapeutic interventions. Methods: This scoping review followed the Joanna Briggs Institute (JBI) protocol and PRISMA-ScR guidelines. A comprehensive search was performed in PubMed, EBSCOhost, Scopus, ScienceDirect, Google Scholar, and Web of Science using Boolean operators related to hypoxia, gingival health, and smoking. The Population-Concept-Context (PCC) framework guided the eligibility criteria, including observational and experimental studies that compared smokers and non-smokers. Extracted data included study design, sample size, periodontal parameters, and molecular findings. Results: Out of 265 screened articles, 11 met the inclusion criteria. These included experimental, cross-sectional, cohort, and randomized controlled trial (RCT) studies involving 473 participants. Results demonstrated that smokers exhibited significantly higher levels of HIF-1α, VEGF, and inflammatory markers in periodontal tissues compared to non-smokers. Smoking-induced hypoxia disrupted angiogenesis, increased osteoclastogenesis, and altered vascularization, contributing to delayed healing and periodontal tissue degradation. Some studies reported no synergistic effect between smoking and periodontitis on HIF-1α expression; however, smoking independently impacted hypoxia-related pathways. Conclusion and Implications: Smoking significantly contributes to periodontal disease by inducing hypoxia, disrupting angiogenic and inflammatory pathways, and impairing tissue regeneration. The upregulation of HIF-1α plays a central role in these mechanisms. Given these findings, integrating smoking cessation into periodontal management is essential. Future research should explore targeted interventions modulating HIF-1α activity to mitigate smoking-induced periodontal damage and improve treatment outcomes.
Sutureless Electrocautery-Assisted Excision of a Recurrent Giant Earlobe Keloid Following Piercing: A Case Report Dian Andriani Ratna Dewi; Juliandra Firdaus; Khufitha Tasya
The ASEAN Journal of Military and Preventive Medicine Vol. 3 No. 1 (2026): January
Publisher : Perkumpulan Kedokteran Militer

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/ajmpm.v3i1.45

Abstract

Background: Auricular keloids represent challenging fibroproliferative scars frequently induced by ear piercing and are characterized by a high recurrence rate, especially following repeated surgical interventions. In cases of recurrent earlobe keloids, minimizing further trauma and wound tension is critical to reducing the likelihood of subsequent recurrence. Case illustration: A 22-year-old woman presented with a recurrent, giant keloid on the right earlobe subsequent to ear piercing. The lesion had progressively enlarged over a 10-year period, despite four prior surgical interventions and corticosteroid injections. Clinical examination identified a firm, raised, pinkish keloidal mass measuring 7 × 5 × 3 cm. Electrocautery-assisted excision and debulking were performed under local and tumescent anesthesia. The wound was deliberately left unsutured to prevent additional puncture trauma, foreign-body reaction, and wound-edge tension. Postoperative care included local wound management, topical antibiotic and tulle dressings, and pressure therapy, facilitating healing by secondary intention. Discussion: Electrocautery enabled controlled tissue removal with simultaneous hemostasis and minimal manipulation of surrounding skin. Avoiding primary suturing was considered important because suture-related dermal trauma and tension may reactivate abnormal fibroblast activity in keloid-prone tissue. Combined with pressure therapy, this sutureless approach supported gradual wound remodeling. Conclusion: Electrocautery-assisted sutureless excision, followed by secondary intention healing and pressure therapy, may serve as an alternative strategy for selected cases of recurrent giant earlobe keloids. No clinical recurrence was observed at 12-month follow-up.

Page 4 of 4 | Total Record : 32

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