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Dian Andriani RD
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Fakultas Kedokteran Militer, Universitas Pertahanan Republik Indonesia In collaboration with Perdokmil (Perkumpulan Kedokteran Militer)
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The ASEAN Journal of Military and Preventive Medicine
Published by Universitas Pertahanan Republik Indonesia
ISSN : 30319447     EISSN : 3031870X     DOI : https://doi.org/10.47353/ajmpm
Core Subject :
The ASEAN Journal of Military and Preventive Medicine is an open-access, peer-reviewed scientific journal dedicated to advancing knowledge and innovation in the fields of military medicine, preventive medicine, biodefense, emergency medicine, disaster response, humanitarian health, and global public health. As one of the leading scholarly platforms in Indonesia and the ASEAN region, the journal provides an essential forum for researchers, military health professionals, clinicians, academics, and policymakers to disseminate high-quality research findings, emerging technologies, and interdisciplinary perspectives relevant to military and civilian healthcare systems. While military medicine remains the journal’s primary focus, contributions from allied disciplines with translational and practical impact are highly encouraged, particularly studies related to medical preparedness, humanitarian assistance, operational medicine, epidemiology, tropical diseases, public health resilience, and preventive healthcare strategies.
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Articles 12 Documents
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Human PPARG Gene Mutation as Risk Factor for Type 2 Diabetes Melitus: In Silico Analysis Naufal Yafi Rais Wiguna; Taufik Hidayat B; Putrya Hawa; Jonny Jonny
The ASEAN Journal of Military and Preventive Medicine Vol. 1 No. 1 (2024): January
Publisher : Perkumpulan Kedokteran Militer

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/ajmpm.v1i1.1

Abstract

Introduction: Type 2 diabetes (T2DM) involves genetic and environmental factors. PPARG, encoding peroxisome proliferator-activated receptor gamma, is one of the key gene in T2DM development. Our study investigates PPARG variants' role as risk factor for T2DM by in silico analysis. Methods: We identified Single Nucleotide Polymorphisms (SNPs) within the PPARG gene via UniProt and analyzed their effects using Ensembl Variant Effect Predictor (VEP). The VEP analysis provided us four important indicators: impact assessment, Sorting Intolerant from Tolerant (SIFT) score, PolyPhen score, and clinical significance. We also investigated PPARG's interactions with other T2DM-related genes using StringDB. Results: In our analysis of 35 UniProt-sourced SNPs, 32 underwent successful VEP analysis.The SIFT indicators identified 23 of SNPs as deleterious, The PolyPhen identified 18 of SNPs as probably damaging . Impact assessments revealed that 27 had a moderate impact on gene function. Clinically, 8 of the SNPs were considered pathogenic and rs1805192 emerged as a notable risk factor for T2DM. Additionally, StringDB analysis confirmed PPARG's role in the T2DM-associated gene network, from the 25 proteins involved in T2DM, 21 of them exhibit correlations with PPARG. Discussion: PPARG SNPs variant has a significant impact on T2DM as a risk factor. However, SNPs associated with T2DM vary across different populations. Conclusion: Analysis of PPARG genetic variations highlights their significant association with T2DM susceptibility in specific populations. Bioinformatics tools are useful for investigating genetic mutations but require additional research, such as functional studies, to improve reliability as their outcomes are primarily predictions.
Introducing the Camry Electronic Hand Dynamometer EH101 as a Functional Strength Measurement Tool among Healthy Teenagers in Jakarta, Indonesia Nury Nusdwinuringtyas; Ni Luh Made Murniasih Jayanthi; Endang Ernandini; Peggy Sunaryo; Jonathan Alvin Wiryaputra
The ASEAN Journal of Military and Preventive Medicine Vol. 1 No. 1 (2024): January
Publisher : Perkumpulan Kedokteran Militer

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/ajmpm.v1i1.2

Abstract

Hand grip strength (HGS) is correlated with activities of daily living (ADL) and is intricately related to lung function. The American College of Sports Medicine recommends incorporating hand grip strength tests as a component of musculoskeletal fitness assessment for children. The hydraulic Jamar dynamometer, developed by Bechtol in 1954, is the most widely used tool among clinicians for measuring HGS. Currently, the widely available HGS measurement tool in Indonesia is the Camry electronic hand dynamometer EH101. This study aimed to introduce a new tool, known for its easy accessibility and affordability. An analytical observational design with a cross-sectional method. 19 males and 19 females, aged between 12–18 years, in one junior high school and one senior high school in Central Jakarta, who find inclucion criterias. There were differences of the results between both tools for all parameters. However, we detected consistency in term of the values of measurements. When the Jamar® measured a lower result than the other parameter, the Camry® would measure the same. A significant correlation between both values, as measured by Camry® and Jamar® (>0.7) that might be interpreted as a strong correlation of statistical significance. Camry EH101 had a significant correlation with Jamar, indicating consistency in measurements despite observed value gaps. While the Camry holds promise for use in Indonesia due to its affordability and accessibility, further investigation is warranted. It is recommended to calculate sensitivity and specificity of the Camry, considering its unique cut-off points for clinical application.
Heat Therapy Intervention and Pulse Dose Itraconazole as Combination Treatment for Chromoblastomycosis: An Unusual Case Report Sissy Sissy; Clara Virginia Allun; Daniel Ahmad Romero; Mahfudz Shidiq
The ASEAN Journal of Military and Preventive Medicine Vol. 1 No. 1 (2024): January
Publisher : Perkumpulan Kedokteran Militer

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/ajmpm.v1i1.3

Abstract

Chromoblastomycosis (CBM) is a rare chronic fungal infection caused by dematiaceous fungi, presenting a significant challenge in Indonesia. This case involves a 54-year-old man who reported a lump on his right leg persisting for 10 years. Examination revealed multiple erythematous nodules with well-defined borders and a verrucous surface, forming a linear pattern around the ankle, some covered by brownish crusts. The patient denied itching and pain in the lesions. The initial diagnosis of chromoblastomycosis was confirmed through culture and histopathology. Treatment involved pulsed doses of intraconazole and heat therapy. Remarkably, lesions significantly improved after one month, underscoring the efficacy of combination therapy for chromoblastomycosis. Pulsed dose itraconazole enhances treatment compliance with its cost-effectiveness, while heat therapy, as a physical intervention, proves to be an easily administered option with promising efficacy. Considering the prolonged management required for CBM, it is imperative to factor in the patient's socioeconomic condition during treatment planning.
The Significance of Entrepreneurial Leadership in Armed Forces Hospitals Dian Andriani Ratna Dewi; Lila Irawati Tjahjo Widuri; Ni Made Wiliantari; Sherryn Sherryn
The ASEAN Journal of Military and Preventive Medicine Vol. 1 No. 1 (2024): January
Publisher : Perkumpulan Kedokteran Militer

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/ajmpm.v1i1.4

Abstract

Background: Currently, merely possessing leadership or entrepreneurial qualities is insufficient for assuming the role of a hospital head in the armed forces. Successful hospital leadership necessitates the embodiment of Entrepreneurial Leadership (EL), a contemporary model combining leadership excellence with an entrepreneurial spirit. The capacity of a hospital to advance is profoundly shaped by its economic acumen, and to thrive, leaders surpassing EL standards are imperative. Methods: A scoping review was conducted utilizing the Google Scholar database and PubMed, adhering to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement guidelines. A total of 136 articles from various studies conducted between 2018 and 2023, spanning diverse countries, were reviewed. Extraction focused on 5 studies from 4 countries that implemented leadership interventions among doctors, dentists, and hospitals. Discussion: In light of the global impact of the COVID-19 pandemic, the landscape of hospital management is undergoing rapid transformation. Internet-based technologies are becoming essential for hospitals to address service requirements and enhance efficiency, thereby increasing overall effectiveness. Only leaders possessing EL can ensure the survival, development, and competitiveness of hospitals amidst these evolving challenges. Conclusion: The characteristics of EL exhibited by hospital leaders significantly influence the performance, continuity, effectiveness, and productivity of competitive hospital enterprises. The application of EL enables hospitals to attain superiority, professionalism, resilience, innovation, and adaptability to various changing conditions.
Temperature and Cardiovascular Morbidity Harikrishna Halaharvi; Paul J. Schramm, MS, MPH; Ambarish Vaidyanathan, PhD
The ASEAN Journal of Military and Preventive Medicine Vol. 1 No. 1 (2024): January
Publisher : Perkumpulan Kedokteran Militer

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/ajmpm.v1i1.5

Abstract

The negative influence of extreme heat on cardiovascular health has been observed across various geographical locations across the world. In the state of New York, discovered a significant increase in cardiovascular disease (CVD) related emergency department, following an extremely hot day. Increase in 3-day delayed CVD hospital admissions with every 1°C above the temperature-health effect curve (29°C–36°C). Another study conducted in China, estimated that the cumulative relative risk of having an out-of-hospital cardiac arrest (OHCA) following a day with extreme heat. Analogous impacts of extreme heat on cardiovascular morbidity have also been observed in Australia and Korea. Data from Thai Nguyen province in Vietnam with the daily weather, observed no statistically significant association between hot temperatures and CVD-related hospital admission over the course of lag days 0–30. Contradictory evidence was also found in epidemiological studies conducted across Europe. A systematic review and meta-analysis of twenty-one studies also failed to detect a significant association between cardiovascular morbidity and ambient temperature.
Biological Threats as Emerging Challenges in Modern Military Biodefense Nizamuddin Ubaidillah
The ASEAN Journal of Military and Preventive Medicine Vol. 1 No. 1 (2024): January
Publisher : Perkumpulan Kedokteran Militer

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/ajmpm.v1i1.6

Abstract

A biological threat refers to an infectious disease with the potential to spread and cause an outbreak. The challenges posed by rapidly changing and increasingly complex biological threats became apparent after the global COVID-19 pandemic, leading to a decline in the preparedness of nations and sluggish responses. Despite the potential severity of casualties, military readiness should be the first line of defense, emphasizing deep prevention. The role of the military in overcoming threats becomes an urgency that cannot be avoided and must be an integral part of the handling of biological threats nationally.
Gene & Cell Therapy for Cancers: The Promise of Chimeric Antigen Receptor (CAR)-T Cells Taruna Ikrar
The ASEAN Journal of Military and Preventive Medicine Vol. 1 No. 2 (2024): July
Publisher : Perkumpulan Kedokteran Militer

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/ajmpm.v1i2.7

Abstract

The pharmacology of cell and genetic therapy represents a highly advanced and contemporary treatment technology, capable of addressing the root causes of numerous diseases with remarkable accuracy and precision at the DNA and molecular levels. Genetic technology aims to develop treatments for genetic disorders caused by inherited genetic mutations, which affect millions of people worldwide and are often life-threatening terminal illnesses. Moreover, pharmacologists and genetic biologists are striving to treat hereditary disorders. By integrating cell and genetic molecular biology, scientists have developed Chimeric Antigen Receptor T-Cell (CAR-T) technology, which has been approved for the treatment of blood cancer. Cell-based and genetic therapy is a groundbreaking therapeutic approach poised to become a cornerstone in the future treatment of degenerative and malignant diseases, particularly cancer, congenital or genetic disorders.
Recessive Dystrophic Bullous Epidermolysis with Squamous Cell Carcinoma: A Rare Case Report Sissy Sissy; Mahfudz Shidiq; Clara Virginia Allun; Daniel Ahmad Romero
The ASEAN Journal of Military and Preventive Medicine Vol. 1 No. 2 (2024): July
Publisher : Perkumpulan Kedokteran Militer

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/ajmpm.v1i2.8

Abstract

Epidermolysis bullosa (EB) is a genetic disorder in which the skin layer and other epithelia attached to the underlying connective tissue are disrupted with a tendency to form blisters and vesicles after mild trauma or friction. Other organs, like as the esophagus, can be damaged by some forms of EB, and subsequent problems might require several procedures. While there has been substantial progress in illness classification, specifically identifying the genes and proteins involved, there have been limited advancements in disease therapy. The care of an EB patient focuses on suppressing symptoms, protection of the skin, and minimizing complications. This case report presents the unique case of a 13-year-old girl diagnosed with recessive dystrophic epidermolysis bullosa complicated by squamous cell carcinoma. Multiple erosional efflorescences appear geographically defined boundaries covered with brownish yellow crusts, dystrophic scars, milia. Contractures of both fingers and toes (pseudosyndactyly) were present. The diagnosis was established through a comprehensive evaluation including history, physical examination, and relevant tests. The patient's parents did not have any of these problems and were not linked. There is no family history of the patient suffering from comparable problems. Therapy is therefore focused on the prevention of lesions and complications. The complexity of the therapeutic strategy depends on the severity of the patient's lesions. Optimal management of this disease can only be done through a multidisciplinary team of different disciplines. The management given is Sodium Fusidate cream every 12 hours applied to open erosions, open compresses NaCl 0.9% every 8 hours for 15-20 minutes, on crusts, levertrans on erosion areas. The prognosis for individuals with this condition remains uncertain, highlighting the challenges in addressing the complex nature of this disease.
Case Report: Effective Use of the Orticochea Flap in the Surgical Treatment of Non-Hodgkin Lymphoma Anastasia Dessy Harsono; Metaudina Chandra Pratiwi; Dominic Melino Tjokrovonco
The ASEAN Journal of Military and Preventive Medicine Vol. 1 No. 2 (2024): July
Publisher : Perkumpulan Kedokteran Militer

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/ajmpm.v1i2.9

Abstract

Non-Hodgkin lymphoma is a malignant disease arising from lymphoid tissues, primarily affecting the lymph nodes. The clinical manifestations and histological appearances of non-Hodgkin lymphoma are diverse, typically presenting with swelling, pain, and ulcers in the head and neck region. This case report discusses the management of a 55-year-old immunocompetent female patient presenting with a large, painless mass extending from the neck to the occipital region of the scalp, mimicking the features of a sarcoma. Closing scalp defects poses a significant challenge for plastic surgeons due to the limited tissue and variable elasticity of the scalp. Orticochea flap, also known as the "banana peel" flap was performed on the patient after the removal of the tumor mass. The orticochea flap technique allows for greater surface area coverage while maintaining vascularity, resulting in quicker procedures and good aesthetic outcomes.
Modified Keystone Flap: A Versatile Reconstruction for Mastectomy Defects – Our Clinical Experience Anastasia Dessy Harsono; Dominic Melino Tjokrovonco
The ASEAN Journal of Military and Preventive Medicine Vol. 1 No. 2 (2024): July
Publisher : Perkumpulan Kedokteran Militer

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/ajmpm.v1i2.10

Abstract

Introduction: The closure of extensive defects in reconstructive surgery is a common challenge. The keystone flap technique has gained popularity due to its adaptability and reliance on fascia, providing a reliable blood supply and offering a better match for skin color compared to skin grafts. However, keystone flap necrosis can occur due to tension and inadequate tissue perfusion. To address this, a modified keystone flap technique called the "doubled-handle saucepan" was developed, resulting in improved flap vitality and reduced tissue necrosis, particularly in mastectomy defects. Materials and method: We assessed 16 female patients who underwent “doubled-handle saucepan” keystone flaps after modified radical mastectomy (MRM). The average dimensions of wounds in this study were 23.1 ± 3.8 cm × 16.9 ± 2.9 cm, with the largest defect measuring 28.0 cm × 21.5 cm. The average size of the modified keystone flap was 36.3 ± 3.8 cm × 21.2 ± 2.2 cm. Results and Discussion: Modified keystone flap demonstrated effective performance in managing extensive defects without any complication. The average operation time in our study was 124.3 ± 11.2 minutes. Conclusion: The "double-handled saucepan" keystone flap technique is a unique and dependable method derived from the original keystone flap which effectively covers defects and maintains flap vitality without tension by ensuring vascularization at the skin bridge. This modified keystone flap technique proves highly effective for reconstruction after modified radical mastectomy (MRM), offering time efficiency and no need for a secondary donor site makes it an appealing alternative to free flaps or other local flap techniques in many cases.

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