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International Journal of Integrated Health Sciences
Published by Universitas Padjadjaran
ISSN : 23021381     EISSN : 23384506     DOI : 10.15850/ijihs
Core Subject : Health,
Health Professions
International Journal of Integrated Health Sciences (IJIHS) is a peer-review journal which publishes original articles, medical research, clinical research and case report. This journal is supported by Faculty of Medicine Universitas Padjadjaran and was launched on September 22nd 2012 and firstly published on July 2013. The first and second publications in 2013 and 2014 were published annually. In 2015 IJIHS published twice in a year, March and September.
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Articles 12 Documents
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Search results for , issue "Vol 13, No 2 (2025)" : 12 Documents clear
Relationship Between Blood Pressure and Intraocular Pressure in Patients at the Ophthalmology Clinic of Hospital X Jakarta, Indonesia Purwakusuma, Anindya Emiraryanti; Batubara, Lilian; Poerwanto, Eko
International Journal of Integrated Health Sciences Vol 13, No 2 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/ijihs.v13n2.4319

Abstract

Background: Hypertension, a prevalent and often asymptomatic condition, has been associated with various ocular disorders. Ocular hypertension, in particular, is a notable risk factor for glaucoma. Understanding the relationship between systemic blood pressure and intraocular pressure is important for early detection of ocular hypertension and prevention of vision-threatening complications.Objective: To analyze the relationship between blood pressure and intraocular pressure, as well as the association between hypertension and ocular hypertension. Methods: This observational analytical study used secondary data from the medical records of 74 patients at the ophthalmology clinic of Hospital X Jakarta, collected between January and March 2023. The sample was selected using purposive sampling. Results: Hypertension was observed in 30 individuals (41%), including 19 females (26%) and 11 individuals aged 70–79 years (15%). Ocular hypertension was reported in 17 individuals (23%), with ten (10) females (14%) and nine (9) individuals aged 60–69 years (12%). Chi-Square analysis showed a significant relationship between blood pressure and intraocular pressure, with a p-value of 0.004 (p<α=0.05). In addition, Spearman's test showed correlations between systolic blood pressure and intraocular pressure in both the right eye (r=0.395; p=0.001) and the left eye (r=0.290; p=0.012). Additionally, there were correlations between diastolic blood pressure and intraocular pressure in the right eye (r=0.234; p=0.045) and the left eye (r=0.230; p=0.049).Conclusion: The relationship between blood pressure and intraocular pressure is found to be significant in this study, suggesting that higher blood pressure levels are associated with an increased risk of elevated intraocular pressure.
Diagnostic Utility of Claudin-4 Immunohistochemistry in Distinguishing Adenocarcinoma Cells from Reactive Mesothelial Cells in Effusion Cytology Ginnavaram, Mihira; Pamu, Pramod Kumar; Kesarapu, Swetha; Ramakrishna, Narayanan
International Journal of Integrated Health Sciences Vol 13, No 2 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/ijihs.v13n2.4561

Abstract

Background: Differentiating adenocarcinoma cells from reactive mesothelial cells in cases of effusion remains a diagnostic challenge due to overlapping morphological features. Claudin-4, a tight junction protein expressed in epithelial but absent in mesothelial cells, has emerged as a potential immunohistochemical (IHC) marker for this distinguishing between these cell types.Objective: to evaluate the diagnostic utility of Claudin-4 immunohistochemistry in differentiating adenocarcinoma cells from reactive mesothelial cells in effusion cytology.Methods: This prospective study was conducted at the Department of Pathology, Nizam’s Institute of Medical Sciences, Hyderabad, India, between June 2023 and December 2024. A total of 77 formalin-fixed paraffin-embedded cell block samples from effusion fluids (pleural, ascitic, and peritoneal) were analyzed. Inclusion criteria comprised cases diagnosed as malignant or reactive on cytology. Claudin-4 immunostaining was performed by using  EP417 clone. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of Claudine for differentiating malignant versus non-malignant effusion was calculated.Results: Out of the 77 studied cases, 57 were malignant and 20 were non-malignant. Claudin-4 showed positive membranous staining in 50/57 malignant cases (87.72%) and in none of the non-malignant cases (100% specificity). The PPV was 100%, and NPV was 74.10%. Pulmonary adenocarcinoma was the most common malignancy showing Claudin-4 positivity. Claudin demonstrated excellent specificity for diagnosis of malignant effusions. Conclusion: Claudin-4 immunohistochemistry is highly specific as a reliable marker for differentiating malignant cells from reactive mesothelial cells. Its high specificity and positive predictive value make it a valuable diagnostic tool. However, a negative Claudin-4 immunohistochemistry results should be interpreted cautiously, particularly in clinically suspicious cases.

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