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International Journal of Integrated Health Sciences
Published by Universitas Padjadjaran
ISSN : 23021381     EISSN : 23384506     DOI : 10.15850/ijihs
Core Subject : Health,
Health Professions
International Journal of Integrated Health Sciences (IJIHS) is a peer-review journal which publishes original articles, medical research, clinical research and case report. This journal is supported by Faculty of Medicine Universitas Padjadjaran and was launched on September 22nd 2012 and firstly published on July 2013. The first and second publications in 2013 and 2014 were published annually. In 2015 IJIHS published twice in a year, March and September.
Arjuna Subject : -
Articles 187 Documents
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Amyotrophic Lateral Sclerosis: First Case Report in Department of Neurosurgery, Faculty of Medicine, Universitas Padjadjaran, Bandung Ahmad Faried; Priandana Adya Eka Saputra; Alief Dhuha; Muhammad Zafrullah Arifin
International Journal of Integrated Health Sciences Vol 7, No 1 (2019)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (126.846 KB) | DOI: 10.15850/ijihs.v7n1.1237

Abstract

Objective: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that is incurable and results in paralysis of the muscles. Electromyography (EMG) is used to diagnosis amyotrophic lateral sclerosis. Although recently there is no cure for ALS, knowledge has increased significantly in the past several years and is helping those who are newly diagnosed.Methods: This study reported for the first time in Department of Neurosurgery, Faculty of Medicine, Universitas Padjadjaran-Dr. Hasan Sadikin General Hospital, Bandung a 58-year old man who was presented in the institution with a history of weakness of both lower extremities for four months preceded by weakness of both upper extremities since the previous month. There was no history of any medical illness or any chronic medication. The patient then underwent EMG studies, followed by muscle biopsy.Result: Electromyography and histopathological results confirmed a diagnosis of ALS.Conclusion: This case was so exceptional, since ALS occurrence in Neurosurgery Centre is extremely rare, and the diagnosis can only be established through EMG and histopathological of muscle biopsy studies.Keywords: The fist reported of ALS in Neurosurgery Bandung, electromyography studies 
Triple Negative Breast Cancer Characteristics Based on Basal-like and Non-Basal-like Subtypes Fifi Akwarini; Trinugroho Heri Fadjari; Bethy Suryawathy Hernowo
International Journal of Integrated Health Sciences Vol 7, No 1 (2019)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/ijihs.v7n1.1570

Abstract

Objective: To observe triple negative breast cancer (TNBC) characteristics in three hospitals located in Bandung based on basal-like (BL) and non-basal-like (NBL) subtypes.Methods: This was a cross-sectional study which used descriptive categorical data from medical records and paraffin blocks of TNBC patients treated in Dr. Hasan Sadikin General Hospital, Bandung; Borromeus Hospital; and Santosa Hospital Bandung Central in the period of January 1, 2012–December 31, 2016. The subjects of the study were 57 TNBC patients. The data collected in the study based on medical records were age, tumor size, histopathological images, severity, and immunohistochemical data. The paraffin blocks of the patients based on the completed medicals records were investigated through examinations of immunohistochemichal cytokeratin (CK) 5/6 expressions and epidermal growth factor receptor (EGFR).Results: Prevalence of TNBC were 82.5% of basal-like subjects and 17.5% of non-basal-like subjects. Among the TNBC subjects, median age of each subtype was 50 years of basal-like subtype and 45 years of non-basal-like subtype. Both subtypes were mostly found in the subjects who aged >40 years. Higher histopathological grade was discovered in both subtypes. The therapy mostly carried out to the subjects was adjuvant chemotherapy. Majority of basal-like subtype subjects were still alive and had longer survival rate and lower incidences of deaths when compared to the non-basal-like subtype.Conclusion: In TNBC, the basal-like subjects showed greater median age, lower severity stage, and longer survival rate than the non-basal-like subjects. There was no histopathology grade between both subtypes. Keywords: Basal-like and non-basal-like subtypes, breast cancer, characteristics, triple negative 
Social Determinant Factors of Elderly as an Input in Enhancing Primary Health Care in Indonesia Sharon Gondodiputro; Henni Djuhaeni
International Journal of Integrated Health Sciences Vol 7, No 1 (2019)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (269.947 KB) | DOI: 10.15850/ijihs.v7n1.1495

Abstract

Objective: To analyze the differences of social determinant factors among elderly according to gender, in urban and rural areas in Indonesia. Indonesia is one of the most populated countries in the world,  faces an increased number of elderly. This situation leads to the increase of degenerative diseases and demands of caregivers as well. The identification of social determinant factors of elderly has an important role in enhancing primary health care.Methods: A comparative study was carried out in 33 provinces in Indonesia using secondary data from Statistics Indonesia 2013. The variables included in this study were percentage of elderly according to  education, marital status, occupation, income and living arrangements, divided in gender, urban and rural areas.  The normally distributed data were analyzed using unpaired T test and not normally distributed data were analyzed using Mann-Whitney test. Results: This study showed that there were differences in education, occupation and income between urban and rural areas. In urban area, most of the elderly worked in industry and trade and in rural area they worked in agricultural, indicated huge risks of occupational haxards.  Most of them were poor, still married, lived with spouses and family of three generations.Conclusions: It can be concluded that there were differences of social determinant factors (education, occupation and income) in elderly who live in urban and rural areas that can contribute to the risks of disease in elderly and these situations must be considered as an input  to enhance the primary health care.Keywords: Elderly, gender, rural, social determinants, urban
Prevalence of Trichomonas vaginalis Based on Clinical Manifestation and Polymerase Chain Reaction among Reproductive Women Huriyah Hafizhotul 'Ummah; Gita Widya Pradini; Reiva Farah Dwiyana; Muhammad Ersyad Hamda
International Journal of Integrated Health Sciences Vol 7, No 1 (2019)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/ijihs.v7n1.1490

Abstract

Objective: To measure the prevalence of Trichomonas vaginalis (T. vaginalis) based on clinical manifestations and polymerase chain reaction (PCR) among reproductive women.Methods: Subjects of the study were the vaginal swab obtained from reproductive women who attended the gynecology examination at Kandanghaur and Sindang primary health care of Indramayu District, West Java in 2016. This study was a descriptive study with cross-sectional method. Sampling was performed with total sampling method and 76 of vaginal swabs were included in this study. The prevalence of T. vaginalis was measured using PCR. The vaginal specimens were collected and then processed for PCR analysis using TVK3/TVK7.Results: Prevalence of T. vaginalis among reproductive women in Indramayu District, West Java that analyzed using PCR was 0%. This result could be affected by the study setting in community, presence or absence of symptoms, and population studied.Conclusion: There were no positive results of T. vaginalis, suggested by the samples that obtained from community-based of a low-risked population.Keywords: Trichomonas vaginalis, polymerase chain reaction, prevalence, reproductive women 
Prevalence of Hematotoxic Effect of Intravenous Chemotherapy among Retinoblastoma Population in Tertiary Hospital in Bandung, Indonesia Jennifer Hadiman; Susi Susanah; Adhi Kristianto Sugianli
International Journal of Integrated Health Sciences Vol 7, No 1 (2019)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (484.591 KB) | DOI: 10.15850/ijihs.v7n1.1520

Abstract

Objective: To observe the prevalence of hematotoxic effect in retinoblastoma patients who were given intravenous chemotherapy with vincristine, etoposide, and carboplatin (VEC) regimen. Retinoblastoma is the second most common cancer in children in Indonesia. Standard chemotherapy agents used in retinoblastoma treatment is VEC given in 7 cycles intravenously. The most common side effect of VEC regimen is hematotoxic effect which might lead to chemotherapy failure.Methods: This study used descriptive method with cross sectional study design. Data were collected from medical records of retinoblastoma patients in Dr. Hasan Sadikin General Hospital Bandung, Indonesia, from 2014 until 2016 using total sampling technique.Results: Forty-six patients were included in this study. Of those subjects, 36 (78.3%) patients experienced hematotoxic effect. The most common hematotoxic effect occurred were anemia and neutropenia, that occurred in 32 (69.6%) and 18 (39.1%) patients, respectively. The most common hematotoxic effect severity occurred were grade 1 anemia, grade 1 leukopenia, grade 1 neutropenia, and grade 3 thrombocytopenia. Percentage of patients experienced anemia tended to increase until the 7th cycle. Seven (15.2%) patients had anemia prior to chemotherapy administration.Conclusion: The majority (78.3%) of the patients experienced hematotoxic effect on intravenous chemotherapy administration with VEC regimen. Anemia was the most common hematotoxic effect occurred.Keywords: Hematotoxic effect, intravenous chemotherapy, retinoblastoma 
Acute and Sub-chronic Toxicity Studies of Combination of Physalis angulata L. (Cecendet) Extract and Methylprednisolone on Animals Elin Yulinah Sukandar; Shiane Hanako Sheba
International Journal of Integrated Health Sciences Vol 7, No 1 (2019)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/ijihs.v7n1.1619

Abstract

Objective: To evaluate the safety of combination of Physalis angulata L. (Cecendet) extract and methylprednisolone through a single dose in mice (acute toxicity) and repeated doses within 90 days in rats (subchronic toxicity).Methods: Acute toxicity test was conducted to 2 groups of female mice by monitoring their behavior and death at 4 hours and 24 hours after cecendet adminstration. While subchronic toxicity test was conducted to 6 groups of rats as normal group, control group, and receive varoius cecendet dose. Each group was combined with methylprednisolone 5 mg/kg b.w. at first month and gradually taperred to 3.2 mg/kg b.w. at third month. Subchronic toxicity was evaluated by monitoring rats’ behavior, mortality, blood biochemistry, blood cell count, urinalysis, and organ macroscopic and histologic.Results: The study showed cecendet extracts did not affect mice behavior in single dose therapy up to 5 g/kg b.w. and had LD50 of more than 5 g/kg b.w., which was categorized as practically non-toxic. The sub-chronic toxicity study showed that up to 1 g/kg b.w. of cecendet extracts that was administered for 90 days did not cause death, was not organ toxic, did not affect blood biochemistries, blood cell count, and urinalysis.Conclusions: Cecendet extract and methylprednisolone combination was safe based on acute and sub-chronic toxicity data.Keywords: Acute toxicity, LD50, Lupus, Physalis angulata L, subchronic toxicity 
Pattern of Bacteria, Antibiotic Uses and Sensitivity among Ear, Nose, and Throat Infectious Disease in Otolaryngology Ward in Tertiary Hospital Yolla Sri Agustina; Imam Megantara; Arif Dermawan
International Journal of Integrated Health Sciences Vol 7, No 1 (2019)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/ijihs.v7n1.1545

Abstract

Objective: To provide an overview of antibiotic use, bacterial patterns and sensitivity to antibiotics in the otolaryngology ward.Methods: This was a cross-sectional study, with total sampling method from medical record data of otolaryngology inpatients that use antibiotics for the period of January 1, 2016–June 30, 2016. Exclusion criteria are incomplete patient medical records and chemotherapy or radiotherapy patients. The variables studied were antibiotic use, bacterial pattern and susceptibility.Results: Among 276 subjects included in the inclusion criteria, the most widely used are single antibiotics (98.9%), generally used for 2–3 days (73.9%), via intravenous lines (92%), and with indications as empirical+prophylaxis (77.5%). Commonly used antibiotics are cefazolin (42.51%), ceftriaxone (29.54%), and cefotaxime (20.76%). The most common bacteria were E. coli (36.36%) and the most sensitive types of antibiotics were meropenem, amikacin, and tigecyclin, while the most resistant antibiotics were ampicillin, ciprofloxacin, and ceftriaxone.Conclusions: The majority of antibiotics used in the otolaryngology treatment room are cefazolin as prophylaxis. E. coli were the most found culture results and the most sensitive types of antibiotics, namely meropenem, amikacin, and tigecyclin, while the most resistant antibiotics were ampicillin, ciprofloxacin, and ceftriaxone.Keywords: Antibiotics, antibiotic sensitivity, bacterial pattern, ears, nose, throat
Correlation between Learning Comfort and the Risk of Musculoskeletal Disorder in Anatomy Laboratorium Activity Based on RULA Method Lubis, Leonardo; Putri, Jesslyn Christianningrum; Ardisasmita, Mulya Nurmansyah
International Journal of Integrated Health Sciences Vol 7, No 1 (2019)
Publisher : International Journal of Integrated Health Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/ijihs.v7n1.1566

Abstract

Objective: To describe learning comfort in the anatomy class of the Faculty of Medicine, Universitas Padjadjaran as one of the learning facilities, to assess the risk of musculoskeletal disorders in students, and to observe correlation between learning comfort and the risk of musculoskeletal disorders in students. Method: A cross sectional research design conducted to the participants that were students from batch 2017 (second year), faculty of Medicine, Universitas Padjadjaran as the population sample. Data were taken using a Likert scale questionnaire (very uncomfortable–very comfortable) about the comfort aspects in the class, meanwhile the risk of musculoskeletal disorders were assessed by using Rapid Upper Limb Assessment (RULA). After data collection, there were 106 respondents with complete data, then the data were processed by using descriptive statistical analyses. The correlation between the two variables was analyzed using the Gamma correlation test.Results: Majority of the students were very comfortable with the aspects of learning comfort (majority scale 5), except in aspects of furniture, work area, room aroma, personal storage area, maintenance and repair. A moderate risk level of musculoskeletal disorders (58.5%) was found in the majority of the students. There was a relative significant relationship  between learning comfort and the risk of musculoskeletal disorders in the aspect of colors (γ=0.445, p<0.01).Conclusion: There is a significant relationship between learning comfort in the aspect of colors and the risk of musculoskeletal disorders. Other aspects do not indicate a significant relationship.Keywords: Learning comfort, risk of musculoskeletal disorders, RULA 
Chronic Rhinosinusitis Patient with Nasal Polyp Characteristics at Otorhinolaryngology-Head and Neck Surgery Outpatient Clinic, Dr. Hasan Sadikin General Hospital, Bandung Dina Riana; Arif Dermawan; Wijana Wijana; Ongka Muhammad Saifuddin
International Journal of Integrated Health Sciences Vol 4, No 2 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (627.53 KB)

Abstract

Objective: To evaluate chronic rhinosinusitis (CRS) with nasal polyp (NP) characteristics in patients with routine visits to the Otolaryngology-Head and Neck Surgery outpatient clinic of Dr. Hasan Sadikin General Hospital, Bandung.Methods: This descriptive retrospective cross-sectional study was conducted at the Rhinology-Allergy Outpatient Clinic, Departement of Otolaryngology-Head and Neck Surgery, Dr. Hasan Sadikin General Hospital, Bandung, in the period of January 2014 to December 2014. Data were obtained from medical records and the sampling method used was total sampling. A total of 100 CRS with NP patients were evaluated. Nasal endoscopy examinations were performed. Patients were classified based on age into 10–20 years, 21–31 years, 32–42 years, 43–53 years, and >54 years groups. Results: Chronic rhinosinusitis with NP incidences were mostly found in male patients compared to females. There were several CRS cases with NP risk factors, including smoking and allergy. Conclusions: In the study, CRS with NP patients may possibly have one or more risk factors. Smoking is the major risk factor from CRS with NP after allergy. Keywords: Nasal polyp, nasal endoscopy, rhinosinusitis, risk factor DOI: 10.15850/ijihs.v4n2.834
Association of Ki-67 Expression and Response of Neoadjuvant Chemotherapy in Invasive Breast Cancer Patients in Bandung Andri Rezano; Chen En Pan; Afrida Aizzatun Istiqomah; Almira Zada
International Journal of Integrated Health Sciences Vol 6, No 2 (2018)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1663.038 KB) | DOI: 10.15850/1374

Abstract

Objective: To analyze the association of Ki-67 expression and response of neoadjuvant chemotherapy in patients with invasive breast cancer.   Methods: A retrospective observational study on the association of Ki-67 expression and response of neoadjuvant chemotherapy in patients with invasive breast cancer was conducted. This study included twenty-five female patients with invasive breast cancer who met the inclusion criteria. Parameters analyzed were age, tumor size, and immunohistochemical expression of Ki-67. Size of the tumor at pre- and post-neoadjuvant chemotherapy were obtained in cm3 and compared between 3 groups of Ki-67 expression levels. One way ANOVA was used to perform the statistical analysis. Results: A significant difference in changes of tumor size for Ki-67 level >20% compared to <14% and 14–20% was seen. Based on the result, neoadjuvant chemotherapy was proven to have similar effects in patients with Ki-67 expression of <14% and 14–20% but less effective in patients with Ki-67 expression of >20%. Conclusions: Low to modest expression of Ki-67 was a better biomarker to predict the response of neoadjuvant chemotherapy in patients with invasive breast cancer compared to high expression of Ki-67. However, the cut-off value of 20% could be ideal to predict the outcome of neoadjuvant chemotherapy in patients with invasive breast cancer. DOI: 10.15850/ijihs.v6n2.1374

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