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Majalah Kedokteran Bandung
Published by Universitas Padjadjaran
ISSN : 0126074X     EISSN : 23386223     DOI : 10.15395/mkb
Core Subject : Health,
Medicine & Pharmacology
Majalah Kedokteran Bandung (MKB)/Bandung Medical Journal publishes peer-reviewed original articles and case reports in basic medical research, clinical research, and applied medical science. This journal is published quarterly (March, June, September, and December) by Faculty of Medicine Universitas Padjadjaran. Articles are original research that needs to be disseminated and written in English. All submitted manuscripts will go through the double-blind peer review and editorial review before being granted with acceptance for publication.
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Articles 12 Documents
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Search results for , issue "Vol 57, No 1 (2025)" : 12 Documents clear
Neutrophil Lymphocyte Ratio and Mortality in Patients with Acute Limb Ischemia Hapsari, Putie; Djajakusumah, Teguh Marfen; Nugroho, Hendri Bayu
Majalah Kedokteran Bandung Vol 57, No 1 (2025)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v57.3848

Abstract

Acute Limb Ischemia (ALI) is a sudden decrease in limb perfusion with a potential of limb loss and is an indication for immediate vascular intervention. Apart from reducing the quality of life, the mortality rate in ALI is reported to be high, i.e., around 40%. Neutrophil Lymphocyte Ratio (NLR) can be used to reflect the inflammatory process in this condition. This study aimed to assess the correlation of NLR to mortality rate in ALI Rutherford Category III patients treated in Dr. Hasan Sadikin General Hospital Bandung, Indonesia. This was a cross-sectional analytical observative retrospective study on data collected from medical records of ALI Rutherford Category III patients treated in the hospital from 2019 to 2022. Sampling was performed consecutively and data were processed using the SPSS with univariate analysis and bivariate analysis using Kendall's tau b analysis test. Results demonstrated that of a total of 46 patients, the majority were female patients (n=31) and 28 patients died. The mean NLR levels in patients who survived was 5.8, in contrast with 9.7 observed among those who died. The statistical test results showed a significant correlation between the NLR and mortality rate of ALI Rutherford category III patients (p
Evaluation of Kidney Proximal Tubule Following Immunization with Plasmodium falciparum CIDR1α-PfEMP1 Recombinant Protein in Rats Dewi, Rosita; Sulistyaningsih, Erma; Kusuma, Irawan Fajar; Rachmania, Sheilla; Rahma, Nafisah Hani Asyifah
Majalah Kedokteran Bandung Vol 57, No 1 (2025)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v57.3801

Abstract

Malaria vaccines are continuously explored as an approach to eradicate malaria. The cysteine-rich interdomain region 1α-Plasmodium falciparum erythrocyte membrane protein 1 (CIDR1α-PfEMP1) is an antigenic protein that can bind to the endothelial protein C receptor (EPCR) and CD36, resulting in microvascular obstruction. The PfEMP1-induced antibody can induce antibodies, reducing the severity of malaria risk by impeding cytoadherence and destructing rosette formation. Preclinical safety testing is an important step of vaccine development, including safety testing of the kidney as the main excretory organ. The proximal tubule has the most mitochondria to support its main role in reabsorption and excretion, making it prone to oxidative stress caused by foreign substances. This study aimed to evaluate kidney proximal tubule cells after CIDR1α-PfEMP1 immunization in rats. This study was conducted at the Laboratory of Biology Molecular and Biotechnology, Faculty of Medicine, University of Jember. Eight rats were injected subcutaneously with 150 µg of the protein and four rats were injected with 0.9%  NaCl on days 0, 21, and 42. The rats were euthanized on day 56. The kidney histopathological slides were stained using Hematoxylin-Eosin (HE) and the necrotic proximal tubule cells were counted at five (5) visual fields (100 cells/visual fields). The average number of necrotic cells of the control and the treatment groups were 0.125±0.25 and 2.438±2.5972 while the Mann-Whitney test showed a significance value of p=0.12,  indicating no significant difference between the control and treatment groups. In conclusion, there is no change in the kidney histopathology based on the proximal tubule necrotic cell count after CIDR1α-PfEMP1 immunization in rats.

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