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Majalah Kedokteran Bandung
Published by Universitas Padjadjaran
ISSN : 0126074X     EISSN : 23386223     DOI : 10.15395/mkb
Core Subject : Health,
Medicine & Pharmacology
Majalah Kedokteran Bandung (MKB)/Bandung Medical Journal publishes peer-reviewed original articles and case reports in basic medical research, clinical research, and applied medical science. This journal is published quarterly (March, June, September, and December) by Faculty of Medicine Universitas Padjadjaran. Articles are original research that needs to be disseminated and written in English. All submitted manuscripts will go through the double-blind peer review and editorial review before being granted with acceptance for publication.
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Articles 12 Documents
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Search results for , issue "Vol 57, No 2 (2025)" : 12 Documents clear
Comparison of ABO Blood Group Antibody Titers in Elderly and Young Adult Patients Dianawati, Dina Asri; Lismayanti, Leni; Wasilah, Fajar
Majalah Kedokteran Bandung Vol 57, No 2 (2025)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v57.4066

Abstract

Immunosenescence in the elderly decreases their antibodies, which may lead to weaker degree of agglutination formation that potentially causes ABO discrepancies. This may lead to misinterpretation of blood group in this group. This study aimed to determine whether there are differences in antibody titer levels and degree of agglutination formed when examining ABO blood groups in the elderly as compared to young adults. This was a cross-sectional study employing analytical observational methods. Data were collected prospectively from the Blood Services Unit of Dr. Hasan Sadikin General Hospital Bandung, Indonesia, between May 2022 and July 2022. The subjects included were 42 elderly participants and 42 young adults, grouped accordingly. The ABO blood typing was performed using the slide method, while anti-A and anti-B titers were measured by serial two-fold dilution using the tube method. A significant difference in ABO blood group antibody titer levels was observed between elderly and young adult groups (median: 6 vs 64, p<0.001). Antibody titers were lower in the elderly across blood groups A (median: 8 vs 64, p<0.001), B (median: 8 vs 64, p<0.001), and O (median: 4 vs 64, p<0.001). The degree of agglutination was lower in the elderly (2+) compared to young adults (4+). On average, antibody titers in elderly individuals were approximately tenfold lower than those in young adults across all three blood groups. The reduced degree of agglutination further supports the diminished antibody response in the elderly group.
Acute Toxicity (LD50 value) of Peppermint (Mentha piperita) Suspension in Female Mice Andriyanto, Andriyanto; Aurelia, Sharon; Zilviana, Tengku; Hibban, Muhammad Farhan Ibnu; Putra, Hamdika Yendri
Majalah Kedokteran Bandung Vol 57, No 2 (2025)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v57.3919

Abstract

Peppermint has several benefits, such as antibacterial, anti-inflammatory, and antifungal properties, that leads to its use in various products, especially in herbal medicine. This study aimed to evaluate the LD50 value of peppermint suspension through an acute toxicity test. This study was conducted at the Animal Laboratory Management Unit of the School of Veterinary Medicine and Biomedical Sciences, IPB University, from October 9 to 30, 2024. A total of 25 female mice were divided into 5 groups, and given different doses of peppermint suspension of 0, 0.5, 1, 1.5, and 2.0 g/kgBW. Observations were then carried out for 14 days on the parameters of body weight, physiological responses, clinical symptoms, absolute and relative organ weight, body weight, and number of mortalities per day. Results showed that the highest mortality was found in the groups administered with a 1.5 and 2.0 g/kgBW of peppermint suspension. Clinical symptoms, such as hair standing, lethargies, and decreased locomotor activity were also observed in these groups. In addition, the administration of peppermint suspension in mice had no significant effect on body weight, as well as on absolute and relative organ weight, It was also demonstrated that organs collected did not present any significant lesion. Thus, the acute toxicity test of peppermint suspension  showed no macroscopic lesion or changes in organs and body weight. The LD50 value suggested that the is in the moderate toxicity category, with an LD50 value of 1.92 g/kgBW.

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