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All Journal Majalah Kedokteran Bandung ARSHI Veterinary Letters Jurnal Kedokteran Hewan Current Biomedicine
Putra, Hamdika Yendri
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health Veterinary

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Toksisitas akut infusa daun pepaya Calina jantan (Carica papaya L.) pada mencit betina Sari, Nurma; Safika, Safika; Putra, Hamdika Yendri; Andriyanto, Andriyanto
Current Biomedicine Vol. 1 No. 1 (2023): January
Publisher : School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/currbiomed.1.1.46-53

Abstract

Latar belakang: Pepaya (Carica papaya L) merupakan salah satu tanaman yang berpotensi sebagai obat untuk beragam penyakit. Tujuan: Penelitian bertujuan menguji toksisitas akut ekstrak daun pepaya Calina (IPB 9) jantan pada mencit betina dengan menentukan nilai lethal dose 50 (LD50), mengamati pengaruhnya pada organ tubuh mencit, dan menghitung konsentrasi ekstrak yang paling efektif. Metode: Penelitian menggunakan 20 ekor mencit galur DDY yang dibagi secara acak ke dalam 4 kelompok perlakuan, yaitu kelompok kontrol (pemberian akuades) dan kelompok perlakuan pemberian infusa daun pepaya Calina jantan masing-masing dengan dosis 5, 10, dan 15 g/kg BB secara per oral. Pengamatan dilakukan pada mortalitas, gejala klinis, respons fisiologis, bobot badan, dan bobot relatif organ. Hasil: Nilai LD50 menunjukkan pemberian infusa daun pepaya Calina jantan pada mencit betina bersifat tidak toksik. Pemberian infusa daun pepaya Calina jantan sampai dengan dosis 15 g/kg BB tidak menimbulkan gejala klinis yang bersifat patologis, perubahan makroanatomi organ, atau kematian. Pemberian infusa tidak menunjukkan efek yang signifikan pada peningkatan atau penurunan bobot badan. Pemberian infusa daun pepaya Calina jantan dengan dosis 10 g/kg BB terbukti paling efektif dalam mempertahankan pertambahan bobot badan secara normal dan tidak bersifat toksik. Simpulan: Berdasarkan penelitian, pemberian infusa daun pepaya Calina jantan sampai dengan dosis 15 g/kg BB bersifat tidak toksik dan tidak memengaruhi organ tubuh mencit, dengan dosis efektif sebesar 10 g/kg BB.
Efektivitas Nutrichick Gel® dalam mempertahankan bobot badan day-old chick selama masa transportasi dengan jarak tempuh yang berbeda Putra, Hamdika Yendri; Sampurno, Nugroho; Alfiansyah, Fiqhi; Nugraha, Pratama Gusti; Idayanto, Sugeng
Current Biomedicine Vol. 2 No. 1 (2024): January
Publisher : School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/currbiomed.2.1.13-20

Abstract

Background: Stress during the transportation period can cause a decrease in day-old chicken (DOC) body weight, which will increase maintenance costs to achieve harvest weight targets. Objective: The research aimed to examine the effect of Nutrichick Gel® product on maintaining body weight of DOC during transportation with different distances. Method: A total of 816 DOC from a hatchery in Sukabumi, West Java, were divided into 4 groups: S+Nutrichick, S-Nutrichick, P+Nutrichick, and P-Nutrichick, with 204 heads in each group. The S+Nutrichick and P+Nutrichick groups received 0.5 mL of Nutrichick Gel® per head, while the S-Nutrichick and P-Nutrichick groups were not given any supplements. The S+Nutrichick and S-Nutrichick groups were transported to Sukoharjo (518 km, ±8 hours; short distance) and the P+Nutrichick and P-Nutrichick groups were transported to Padang (1350 km, ±36 hours; long distance). The difference in weight gain and uniformity was observed before and after transportation. Results: Nutrichick Gel® supplemented groups showed the increased body weight and uniformity percentages, with 0.78% and 4.88% for the S+Nutrichick group, and 4.14% and 2.81% for the P+Nutrichick groups, respectively. The control group without supplementation displayed the decreased body weight and uniformity percentages, with -1.66% and -2.77% for the S-Nutrichick groups and -7.34% and -9.21% for the P-Nutrichick groups, respectively. No DOC’s mortality was observed in all groups. Conclusion: Nutrichick Gel® supplementation could maintain the DOC's body weight during transportation. The longer the distance traveled, the higher the benefits obtained from the difference in body weight using Nutrichick Gel® supplementation.
Effectivity of Carrot (Daucus carota) Seed Oil as Hair Growth Promoter on Rats (Rattus novergicus) Andriyanto, Andriyanto; Aurelia, Sharon; Zylviana, Tengku; Natalie, Gabriela; Putra, Hamdika Yendri
Majalah Kedokteran Bandung Vol 56, No 4 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3634

Abstract

Hair quality and health are important not only for the esthetical reasons but also to maintained the hair’s function in protecting the head. Carrot seed oil (CSO) is rich in vitamin A and beta-carotene, which influence hair quality. CSO also contains carotol, which has anti-fungal properties that treat dandruff. This research aimed to observe the potential of CSO as a hair growth promoter. Twenty male rats were used in the study, with their backs shaved and divided into two areas, each with different frequencies of CSO application. The backs of the rats were given CSO every day for 14 consecutive days with different concentrations, i.e., 25%, 50%, and 75%. Hair growth  was assessed based on its length, root, shaft, and tip thickness on days 9,12, and 14 and the results were recorded. On day 15, the rats were euthanized and their skin was collected to observe the number of follicles. Results showed that the application of CSO with different concentrations had no effect on hair length growth but it did affect the thickness of the root, shaft, and tip of the hair, with the best concentration being 75%. The frequency of application did not seem to affect the growth in terms of the length or thickness of the root, shaft, and tip of the hair; however, the application of CSO with 75% concentration and an application frequency of once a day produced the best amount of follicle regeneration.
Acute Toxicity (LD50 value) of Peppermint (Mentha piperita) Suspension in Female Mice Andriyanto, Andriyanto; Aurelia, Sharon; Zilviana, Tengku; Hibban, Muhammad Farhan Ibnu; Putra, Hamdika Yendri
Majalah Kedokteran Bandung Vol 57, No 2 (2025)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v57.3919

Abstract

Peppermint has several benefits, such as antibacterial, anti-inflammatory, and antifungal properties, that leads to its use in various products, especially in herbal medicine. This study aimed to evaluate the LD50 value of peppermint suspension through an acute toxicity test. This study was conducted at the Animal Laboratory Management Unit of the School of Veterinary Medicine and Biomedical Sciences, IPB University, from October 9 to 30, 2024. A total of 25 female mice were divided into 5 groups, and given different doses of peppermint suspension of 0, 0.5, 1, 1.5, and 2.0 g/kgBW. Observations were then carried out for 14 days on the parameters of body weight, physiological responses, clinical symptoms, absolute and relative organ weight, body weight, and number of mortalities per day. Results showed that the highest mortality was found in the groups administered with a 1.5 and 2.0 g/kgBW of peppermint suspension. Clinical symptoms, such as hair standing, lethargies, and decreased locomotor activity were also observed in these groups. In addition, the administration of peppermint suspension in mice had no significant effect on body weight, as well as on absolute and relative organ weight, It was also demonstrated that organs collected did not present any significant lesion. Thus, the acute toxicity test of peppermint suspension  showed no macroscopic lesion or changes in organs and body weight. The LD50 value suggested that the is in the moderate toxicity category, with an LD50 value of 1.92 g/kgBW.
Evaluasi terapi doxycicline kasus infeksi Haemobartonella felis pada kucing Putra, Hamdika Yendri; Maulana, Naufal Hadam; Bahtiar, Noor Ihsan Anzhary; Pratiwi, Puteri; Vadya, Dieniza; Mayori, Geovany
ARSHI Veterinary Letters Vol. 7 No. 2 (2023): ARSHI Veterinary Letters - Mei 2023
Publisher : School of Veterinary Medicine and Biomedical Sciences, Bogor Agricultural University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avl.7.2.31-32

Abstract

Haemobartonella felis merupakan endoparasit yang menyebabkan kerusakan sel darah merah dan dapat menurunkan status kesehatan hewan peliharaan khususnya kucing. Tulisan ini melapporkan hasil pengamatan pada kucing yang didiagnosa mengidap infeksi parasit darah Haemobartonella felis dengan terapi antibiotik doxycicline dosis 5 mg/kg BB 2 kali sehari selama 21 hari. Hasil pengobatan menunjukkan penurunan tampilan parasit darah pada pemeriksaan ulas darah pada hari ke-0 dibandingkan dengan hari ke-22. Hasil evaluasi menunjukkan bahwa doxycicline menjadi salah satu pilihan pengobatan pada pasien dengan diagnosa Haemobartonella felis.
Diagnosa ultrasonografi hepatocellular carcinoma pada anjing Putra, Hamdika Yendri
ARSHI Veterinary Letters Vol. 6 No. 2 (2022): ARSHI Veterinary Letters - Mei 2022
Publisher : School of Veterinary Medicine and Biomedical Sciences, Bogor Agricultural University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avl.6.2.27-28

Abstract

Molly seekor anjing Rottweiler berwarna hitam, berusia 9 tahun dengan jenis kelamin betina dibawa pemilik ke Rumah Sakit Hewan Pendidikan Sekolah Kedokteran Hewan dan Biomedis IPB University (RSHP SKHB IPB). Pemilik menyampaikan keluhan nafsu makan Molly menurun, muntah, lemas, abdomen membesar, dan tidak mampu berdiri. Pemeriksaan kondisi fisik pada Molly menunjukkan suhu tubuh 39,0 °C, frekuensi napas 64 kali/menit, dan frekuensi jantung 100 kali/menit, tampak lemah dan tidak mampu berdiri. Hasil pemeriksaan ultrasonografi menunjukkan adanya multi nodular yang ditemukan pada organ hati yang mengarah kepada Hepatocecullar Cell Carcinoma.
Diagnosis Haemobartonella felis subklinis pada kucing Putra, Hamdika Yendri; Maulana, Naufal Hadam; Bahtiar, Noor Ihsan Anzary; Pratiwi, Puteri; Aziz, Hakim; Vadya, Dieniza; Mayori, Geovany
ARSHI Veterinary Letters Vol. 6 No. 4 (2022): ARSHI Veterinary Letters - November 2022
Publisher : School of Veterinary Medicine and Biomedical Sciences, Bogor Agricultural University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avl.6.4.69-70

Abstract

Ektoparasit yang teridentifikasi pada satu hewan kesayangan berkorelasi pada infestasi endoparasit, salah satu contoh endoparasit yang menyerang hewan peliharaan adalah Haemobartonella felis. Kucing sebanyak 7 ekor dari pemilik yang sama dibawa ke klinik hewan. Pemilik mengeluhkan seekor kucing memiliki suhu tubuh yang selalu tinggi saat diukur. Kucing yang lain tidak memiliki keluhan dan gejala serupa, namun pemilik ingin dilakukan pemeriksaan umum pada semua kucingnya. Hasil pemeriksaan klinis tidak ditemukan infestasi ektoparasit, suhu tubuh kucing berkisar 39,8-40,0 °C dengan bobot badan 2-4 kg dan berusia antara 5-24 bulan. Pemeriksaan lanjutan yang dilakukan adalah pemeriksaan hematologi dengan metode complete blood count (CBC) mengunakan alat hematology analyzer dan blood smear inspection. Pemeriksaan ulas darah 4 dari 7 kucing menunjukkan hasil positif adanya parasit pada badan sel darah merah. Pemilik diberikan resep berupa antibiotik doxycicline dengan dosis 5 mg/Kg BB untuk diberikan kepada kucingnya 2 kali sehari selama 28 hari.
COMBINATION OF BASIL, TURMERIC AND BEAN SPROUTS TO HEMATOLOGY AND BIOCHEMISTRY OF FEMALE RAT BLOOD BEFORE PREGNANCY Andriyanto, Andriyanto; Mustika, Aulia Andi; Manalu, Wasmen; Subangkit, Mawar; Aurelia, Sharon; Widi, Leliana Nugrahaning; Putra, Hamdika Yendri; Tarigan, Elpita; Irarang, Yusa
Jurnal Kedokteran Hewan Vol 17, No 4 (2023): December
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v17i4.33189

Abstract

The purpose of the study was to examine the safety of combination of basil, turmeric and bean sprouts extract solution on the hematological parameters and blood biochemistry profile of rats. The combined ingredients used in the study were obtained from different places. A total of 15 rats were divided into 3 groups based on the treatment dose. Each group consisted of 5 rats. The rats in control group (K) did not given extract combination, while the rats in group KKT 1 % and KKT 5% received combination of basil, turmeric and bean sprouts extract at dose of 1% and 5%, respectively. Effectiveness and safety tests were carried out by evaluating the hematological and blood biochemical profiles of female rats. The data were analyzed using one-way analysis of variance (ANOVA). The results showed that the rats given combination of basil, turmeric and bean sprouts extract at a dose of 1% and, dose of 5% did not had significant different compared to control (P0.05), but tend to have positive effects in increasing several blood components that play an important role in maintaining immunity during pregnancy. It can be concluded that the combination of basil, turmeric and bean sprouts at dose of 1% and 5% do not adversely affect hematology profile and blood biochemistry of rats. This indicates that the extract combination does not cause any toxicity effects on the rats.
Hepatoprotective Potentials of Dates Extract (Phoenix dactylifera) in Acetaminophen-Induced Mice Andriyanto, Andriyanto; Putra, Hamdika Yendri; Aurelia, Sharon; Mustika, Aulia Andi; Manalu, Wasmen; Subangkit, Mawar; Tarigan, Elpita; Irarang, Yusa
Majalah Kedokteran Bandung Vol 55, No 3 (2023)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v55n3.3155

Abstract

Dates (Phoenix dactylifera) are considered as a well-known fruit consumed by many people in various countries. This study aimed to examine potential effects of dates as a hepatoprotective agent in mice. This study was conducted at the Iratco Group’s eLRosa Laboratory Research Facility, Indonesia, starting from June 2022 to July 2022. Mice from ddY strain were randomly divided into 5 groups (n=5 per group) of positive and negative control groups, and treatment groups 1, 2, and 3. The negative control group as the normal baseline did not receive acetaminophen and date extract. In treatment groups, 30 µL/30 gr BW, 60 µL/30 gr BW,  and 100 µL/30 gr BW extract was given per oral to Treatment Group 1, Group 2, and Group 3, respectively for 20 days. On day 21, all  treatment groups were induced with 300mg/KgBW acetaminophen for 3 days via the intraperitoneal route. Blood tests were performed on day 24 to measure the serum transaminase level as the parameter of liver damage. The lowest level of transaminase serum was found in group 3 with the highest volume of dates extract, which was 100 µL, followed by group 2 (60 µL), and group 1 (30 µL). There was a significant difference between the positive control group and treatment groups with  no significant difference was seen between negative and the treatment groups. This study concludes that dates extract has the potential of being a hepatoprotective agent.
Co-Authors Alfiansyah, Fiqhi Andriyanto Andriyanto Aulia Andi Mustika Aurelia, Sharon Aziz, Hakim Bahtiar, Noor Ihsan Anzary Bahtiar, Noor Ihsan Anzhary Elpita Tarigan Hibban, Muhammad Farhan Ibnu Idayanto, Sugeng Irarang, Yusa Maulana, Naufal Hadam Mayori, Geovany Natalie, Gabriela Nugraha, Pratama Gusti Nurma Sari, Nurma Pratiwi, Puteri Safika S, Safika Sampurno, Nugroho Subangkit, Mawar Vadya, Dieniza Wasmen Manalu Widi, Leliana Nugrahaning Zilviana, Tengku Zylviana, Tengku