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All Journal Majalah Kedokteran Bandung Althea Medical Journal Jurnal Riset Kedokteran
Wasilah, Fajar
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Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health

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Correlation of Platelet to Lymphocyte Ratio and C-Reactive Protein to Albumin Ratio with MEX-SLEDAI Scores in Patients with Systemic Lupus Erythematosus Amelia, Rachel; Wasilah, Fajar; Suraya, Nida Suraya
Althea Medical Journal Vol 11, No 3 (2024)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v11n3.3255

Abstract

Background: One of the methods used to assess systemic lupus erythematosus (SLE) disease activity is the Mexican systemic lupus erythematosus disease activity index (MEX-SLEDAI) score. Markers of SLE  disease activity such as anti-dsDNA antibodies, complement, and anti C1q  have limitations in terms of sensitivity and specificity.  In rural areas where these markers are not available, simpler alternative markers are valuable. This study aimed to explore markers related to SLE disease activity based on the platelet to lymphocyte ratio (PLR) and C-reactive protein albumin ratio (CAR) using the MEX-SLEDAI score.Methods: This was a cross-sectional study using a correlational analytical design. Data collection was carried out retrospectively using secondary data taken from medical records of patients with SLE treated at Dr. Hasan Sadikin General Hospital Bandung, Indonesia in 2019–2021 and the Laboratory Information System (LIS). The data was analyzed using the Spearman rank correlation test.Results: Of the 51 participants, 92% were female with median MEX-SLEDAI scores of 9. The median value of PLR and CAR were 247.07 and 2.01, respectively. The CAR showed a moderate positive correlation (r=0.563, p<0.001), whereas the PLR showed no correlation (r=0.023, p>0.05) with the MEX-SLEDAI score.Conclusions: MEX-SLEDAI scores has a moderate positive correlation with CAR, suggesting that CAR may be used as a marker in assessing disease activity in adult patients with SLE.
Validity Test For C-Reactive Protein and Ferritin Level in Moderate and Severe Covid-19 Patients Kurnia, Chyntia Putriasni; Wasilah, Fajar; Lismayanti, Leni
Majalah Kedokteran Bandung Vol 55, No 4 (2023)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v55n4.3025

Abstract

Mild, moderate, severe, and critical COVID-19 are associated with hyperinflammation. The CRP and ferritin are acute phase proteins that marks incidence of inflammation and used as the paramaters of hyperinflammation. This study aimed to determine the validity of CRP and ferritin level examination in moderate and severe COVID-19 since the time of admission. This was a cross-sectional analytical retrospective study with on moderate and severe COVID-19 patients admitted to Dr. Hasan Sadikin General Hospital Bandung, Indonesia, during the period of March 2020 to December 2020. The CRP and ferritin levels were obtained since the beginning of admission to the fourth day since admission on patients without any history of anemia. Subjects in this study were divided into moderate and severe COVID-19 groups based on the 3rd edition of COVID-19 Prevention and Control Guideline issued by the Ministry of Health Republic of Indonesia. Each group consisted of 30 subjects. The cut-off value was 7.65 mg/dL (AUC 0.698) for CRP and 963.1 mcg/L (AUC 0.938) for ferritin. The validity of ferritin vs CRP were reflected respectively as follows:  93.3% vs 76.7% sensitivity; 80.0% vs 63.3% specificity; 82.4% vs 67.6% PPV; and 92.3% vs 73.1% NPV. The validity of ferritin was proven to be superior as it  significantly increases since day one, persisted longer and reaches its peak on  the16th day. Meanwhile, CRP increases within 6-8 hours and reaches its peak within 48 hours after inflammation, then declines soon afterwards.
Comparison of ABO Blood Group Antibody Titers in Elderly and Young Adult Patients Dianawati, Dina Asri; Lismayanti, Leni; Wasilah, Fajar
Majalah Kedokteran Bandung Vol 57, No 2 (2025)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v57.4066

Abstract

Immunosenescence in the elderly decreases their antibodies, which may lead to weaker degree of agglutination formation that potentially causes ABO discrepancies. This may lead to misinterpretation of blood group in this group. This study aimed to determine whether there are differences in antibody titer levels and degree of agglutination formed when examining ABO blood groups in the elderly as compared to young adults. This was a cross-sectional study employing analytical observational methods. Data were collected prospectively from the Blood Services Unit of Dr. Hasan Sadikin General Hospital Bandung, Indonesia, between May 2022 and July 2022. The subjects included were 42 elderly participants and 42 young adults, grouped accordingly. The ABO blood typing was performed using the slide method, while anti-A and anti-B titers were measured by serial two-fold dilution using the tube method. A significant difference in ABO blood group antibody titer levels was observed between elderly and young adult groups (median: 6 vs 64, p<0.001). Antibody titers were lower in the elderly across blood groups A (median: 8 vs 64, p<0.001), B (median: 8 vs 64, p<0.001), and O (median: 4 vs 64, p<0.001). The degree of agglutination was lower in the elderly (2+) compared to young adults (4+). On average, antibody titers in elderly individuals were approximately tenfold lower than those in young adults across all three blood groups. The reduced degree of agglutination further supports the diminished antibody response in the elderly group.
Perbandingan Kadar Interleukin-10 pada Pasien Terduga Tuberkulosis Terkonfirmasi dan Tidak Terkonfirmasi Bakteriologis Shibly, Khairunnissa; Parwati, Ida; Suraya, Nida; Wasilah, Fajar
Jurnal Riset Kedokteran Volume 5, No.2, Desember 2025, Jurnal Riset Kedokteran (JRK)
Publisher : UPT Publikasi Ilmiah Unisba

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jrk.v5i2.8742

Abstract

Abstract. Tuberculosis (TB) remains a critical global health crisis, demanding non-sputum biomarkers to overcome the limitations of traditional diagnostics. This study investigated Interleukin-10 (IL-10), a cytokine linked to Mycobacterium tuberculosis survival, as a novel, non-invasive diagnostic marker for active TB. A cross-sectional study (Jan–Mar 2024) at DR. Hasan Sadikin General Hospital in Bandung measured serum IL-10 levels via ELISA in 84 individuals. Levels were compared between patients with bacteriologically confirmed TB and those with unconfirmed or suspected TB. Confirmed TB patients showed significantly higher median IL-10 levels (1.58 pg/mL) than unconfirmed cases (1.10 pg/mL; p=0.0001). Diagnostic utility was strong, with the Receiver Operating Characteristic (ROC) curve analysis yielding an Area Under the Curve (AUC) of 0.787 (P < 0.001), achieving 80.0% sensitivity and 67.3% specificity. The significant difference in IL-10 levels confirms its potential as a non-sputum-based clinical biomarker to enhance the diagnosis and global management of active Tuberculosis. Abstrak. Tuberkulosis (TB) masih menjadi permasalahan kesehatan global, perlunya ditemukan biomarker non-sputum untuk mengatasi keterbatasan diagnostik tradisional. Studi ini meneliti Interleukin-10 (IL-10), sitokin yang terkait dengan kelangsungan hidup Mycobacterium tuberculosis, sebagai penanda diagnostik non-invasif yang baru untuk TB aktif. Studi cross-sectional (Januari–Maret 2024) dilakukan di RSUP Dr. Hasan Sadikin, Bandung. Sebanyak 84 subjek diukur kadar IL-10 serumnya menggunakan metode ELISA. Kadar IL-10 dibandingkan antara pasien TB yang terkonfirmasi secara bakteriologis dan yang tidak terkonfirmasi atau suspek TB. Pasien TB terkonfirmasi menunjukkan kadar IL-10 median yang jauh lebih tinggi (1,58 pg/mL) dibandingkan kasus tidak terkonfirmasi (1,10 pg/mL; p=0,0001). Nilai diagnostik yang kuat didukung analisis kurva ROC dengan Area Under the Curve (AUC) sebesar 0,787 (P < 0,001), mencapai sensitivitas 80,0% dan spesifisitas 67,3%. Perbedaan signifikan pada kadar IL-10 menunjukan potensinya sebagai biomarker klinis non-sputum untuk meningkatkan diagnosis dan penatalaksanaan Tuberkulosis aktif
Co-Authors Amelia, Rachel Dianawati, Dina Asri Ida Parwati Kurnia, Chyntia Putriasni Leni Lismayanti Nida Suraya Shibly, Khairunnissa Suraya, Nida Suraya