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Journal of the Medical Sciences (Berkala Ilmu Kedokteran)
Published by Universitas Gadjah Mada
ISSN : 01261312     EISSN : 23563931     DOI : http://dx.doi.org/10.19106/JMedSci005303202101
Core Subject : Science,
Immunology & microbiology Neuroscience
Journal of the Medical Sciences (JMedSci) or Berkala Ilmu Kedokteran (BIK) is an international, open-access, and double-blind peer-reviewed journal, published by Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada Yogyakarta Indonesia. JMedSci aiming to communicate high-quality articles in the areas of biomedical science from basic to clinical sciences.The journal welcomes papers from original articles, case reports, reviews, and book reviews. All papers published in JMedSci are freely available as downloadable pdf files. The journal began its publication on March 1973 and published quarterly (January, April, July, and October). JMedSci is abstracted and indexed in DOAJ, Crossref, Google Scholar, Sinta, Indonesia One Search. JMedSci is accredited by Directorate of General Higher Education, the Ministry of Research, Technology, and Higher Education, Indonesia
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 15 Documents
 1   2 
Search results for , issue "Vol 50, No 2 (2018)" : 15 Documents clear
Prognostic factors affecting the mortality of 2nd and 3rd degree burn injuries at a tertiary care center in Indonesia Ishandono Dachlan; Khoirul Anam
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 2 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (352.771 KB) | DOI: 10.19106/JMedSci005002201809

Abstract

About two million people suffer from burn injuries in the United States eachyear, with 100,000 hospitalized in the burn unit. Around 1000 patients sufferfrom severe burn injuries, with each year average of 300 deaths. Improvementsin the understanding of the prognostic factors affecting burn injuries over thepast decades have led to advances in medical and surgical treatment. However,comprehensive data on the factors affecting burn injuries in Indonesia havenot been available, yet. The aim of the study was to investigate the prognosticfactors affecting the mortality of 2nd and 3rd burn injuries patients in Dr. SardjitoGeneral Hospital, Yogyakarta. This was a cross-sectional study conducted withinthe period of 2007-2011 using secondary data from the Department of MedicalRecords. Chi-square and logistic regression analysis were used to evaluate thecorrelation between the prognostic factors and the mortality. A p value < 0.05(95% confidence interval) was considered to be significant. A significantlycorrelation between age, burn injuries percentage, arrival time, inhalation trauma,hemoglobin level, albumin level, creatinine level, hematocrit level and the patient’smortality was observed in this study (p<0.05). However, the cause of burn injuriesand leukocyte count had no correlation with the patient’s mortality (p>0.05).Furthermore, patients with albumin level < 3.5 mg/dL, burn injuries percentage>50%, inhalation trauma and hospitalized in 24 hours after the incident were at22.98, 7.65, 3.0 and 4.59 times higher risk of mortality, respectively (p<0.05).In conclusion, albumin level, burn injury percentage, inhalation trauma and time ofarrival are prognostic factors affecting the mortality of the burn injuries patients.
Chronic wound mitomycin-c-induced animal models Andreas Ariawan; Aditya Wicaksana; Aditya Rifqi Fauzi; Rosadi Seswandhana*
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 2 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (818.646 KB) | DOI: 10.19106/JMedSci005002201803

Abstract

ABSTRACTChronic wound is a problem often encountered, especially in areas that do not have adequate health facilities. Some of the factors that caused the injury are mechanical, chemical, electrical, or heat. Chronic inflammation and bacterial infections are the two major factors that affect the process of wound chronicity. Mitomycin-C (MMC) is widely used as an intravenous, oral, and topical anti-cancer drug. MMC that is applied topically to a wound can cause cross-linking and decrease or stop the process of DNA transcription so that the wound will not develop the healing phase because MMC works as an inhibitor of fibroblast and proliferation that can inhibit wound healing. This study aimed to create animal models of chronic wound using topical MMC compared to those who given exposure of NaCl without topical MMC. This study used eight female Wistar rats aged 70 to 90 days, weighed between 300 to 350 grams. Wounds were made in the hip area with a diameter of approximately two centimeters. The subjects were divided into two groups. The first group, we compressed the wounds using sterile gauze moistened with MMC 0.5 mg/ml for 5 minutes and rinsed with a saline solution as much as 10 ml6. The second group was compressed using sterile gauze moistened with saline for 5 minutes. On day 3, 5, and 15 we observed the wound profile that was consist of diameter (as an indicator of wound healing), necrosis, and the consistency. The wounds that were compressed using MMC showed brownish-black, dry, thick chronic wounds and took longer to heal compared to those with NaCl. Application of MMC topically on the wound after day 15 showed an inhibition of wound healing process. The animal models showed a slower decrease of wound diameter, fewer scar tissue formation, and development of necrotic tissue.
Effect of rich resistant starch snack on MCP- 1 promoter methylation and triglycerides levels in type 2 diabetes mellitus patients Synta Haqqul Fadlilah; . Sunarti; Arta Farmawati
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 2 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (427.427 KB) | DOI: 10.19106/JMedSci005002201813

Abstract

Type 2 diabetes mellitus (T2DM) is closely related to inflammation. One of inflammation marker in T2DM is monocyte chemoattractant protein-1 (MCP-1). Previous research suggests that MCP-1 promoter methylation correlated significantly with plasma triglycerides levels (TG) in T2DM. Some studies state that TG levels in T2DM can be controlled through consumption of diets containing resistant starch. This study aimed to investigate the effect of high resistant starch snack on MCP-1 promoter methylation and triglycerides levels in type 2 diabetes mellitus. This study was a cross-over trial. A total of 19 T2DM subjects have been selected with the criteria of fasting blood glucose levels (GDP)>126 mg/dL, aged 40-60 years, and duration of DM at least 1 year. Subject consume snack as much as 32 g/day with the resistant starch content are 4.25 g for 4 weeks. Data collection and blood retrieval was doing before and after the intervention. The analysis of MCP-1 promoter methylation was performed by methylated specific-PCR (MS-PCR) using DNA samples extracted from mononuclear cells, whereas TG levels analysis performed by the enzymatic colorimetric method (DiaSys Kit) using blood plasma. Statistic analysis was performed by Fisher Exact test for methylation data, paired t-test and unpaired t test for TG levels, and Spearman correlation test for the correlation between variabels (p<0.05). Methylation result showed that frequency of “methylated” (52.6%) and “unmethylated” (47.4%) status before and after intervention were same, so there was no significant difference (p>0.05). Plasma triglyceride levels after intervention decreased, but not significant statistically. The correlation between MCP-1 promoter methylation and plasma triglyceride levels was significant. This study concludes that the giving of rich resistant starch snacks intervention does not affect MCP-1 promoter methylation changes significantly. This intervention can lead to decrease plasma triglyceride levels subjects, but not statistically significant.  
Correlation between haemoglobin concentration and oxygen saturation (SpO2) in elderly professors Della Aprilliana Suherlim*; Hikmat Permana; Leonardo Lubis
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 2 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (253.301 KB) | DOI: 10.19106/JMedSci005002201804

Abstract

The aging process is recognized by the decreases of the body functions which is caused by molecular and cellular damages. The population which is mostly affected by this aging process is elderly. In elderly, it is most likely that tissue oxigenation decreases due to the reduction of haemoglobin level and oxygen saturation (SpO2).This study aimed to evaluate  the correlation between the hemoglobin concentration and SpO2 in the elderly professors in Universitas Padjadjaran (UNPAD), Bandung. This was cross sectional study using secondary data from medical records of the elderly professors. One hundred and eight data of the professors (84 males and 24 females) who met the inclusion and exclusion criteria were used in this study.Spearman’s Rank correlation test was used to analyze the data of total subjects and male professors group, while Pearson correlation test was used to analyze the data of female professors group. Correlation test between hemoglobin concentration and SpO2 resulted in an insignificant results in male professors (r = 0.028; p = 0.801), female professors (r = 0.132; p = 0.538), and total subjects (r = 0.036; p = 0.712).  In conclusion, there is no correlation between hemoglobin concentration and SpO2 in the elderly professors of UNPAD, Bandung.
Systematic Review: Pre-Stroke Use of Angiotensin Receptor Blockers and Stroke Outcomes Ivana Purnama Dewi; Virandra B. Kusmanto; Kristin Purnama Dewi; Rizaldy Pinzon
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 2 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (635.902 KB) | DOI: 10.19106/JMedSci005002201815

Abstract

Background: Hypertension is the major risk factor and the most important modifiable risk factor for stroke. Angiotensin Receptor Blockers (ARB) are widely used in patient at high risk of cardiocerebrovascular events. The objective of this literature review was to determine the efficacy of pre-stroke use of ARB on stroke outcomes.Methods: Major medical databases (PubMed, MEDLINE, Clinical Key, Cochrane Library, EMBASE) were systematically searched using keyword: “hypertension”, “ARB”, “stroke”, and “outcome”. The search were limited to clinical trials published within the last 10 years, written in English, with full-text availability. We used GRADE Working Group to measure the quality of evidence.Results: Four clinical studies, three retrospective studies and one nationwide population-based cohort study met our inclusion criteria with total of 102.644 patients for analysis. The scientific quality of the studies varied from poor (1 study), moderate (1 study), and high quality (2 studies). Generally, the subjects of the studies were acute ischemic stroke patients. Three studies showed pre-stroke use of ARB were significantly associated with better stroke outcomes. Only one study found different result whereas pre-stroke use of ARB did not appear to affect stroke outcomes. Outcome of the studies was explored according to morbidity (severity and functional status upon discharge) and mortality (30-days mortality or in-hospital mortality). Several limitations were present, including non-random treatment assignment, retrospective study design, and lack of data for longitudinal medication exposure in observational studies.Conclusions: This systematic review shows evidence that there is possible benefit of pre-stroke ARB treatment in relation to better ischemic stroke outcomes. However, further studies with better research method quality are still needed. The efficacy of ARB treatment in relation to other type of stroke outcomes also needs to be furtherly examined.Keywords: ARB, pre-stroke, benefit, prognosis Makalah ini dipresentasikan dalam Poster Session 11th Scientific Meeting of Indonesian Society of Hypertension, 24-26 February 2017

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