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All Journal Majalah Kedokteran Bandung Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Althea Medical Journal Jurnal Farmasi Klinik Indonesia Global Medical and Health Communication Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Jurnal MedScientiae Indonesian Journal of Endocrinology Metabolism and Diabetes (InaJEMD)
Hikmat Permana
Department Of Internal Medicine, Faculty Of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital Bandung,
Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Anti-hyperglycemic Effect of Psidium guajava Leaf Infusion Zartiana, Rizda Nurul; Surialaga, Samsudin; Permana, Hikmat
Althea Medical Journal Vol 2, No 4 (2015)
Publisher : Althea Medical Journal

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Abstract

Background: Prevalence of diabetes mellitus is estimated to increase annually. Numerous people use traditional medicine, such as the Poidium guajava leaf to prevent this disease. This study aimed to analyse the effect of Psidium guajava leaf to inhibit glucose absorption in intestine epithelial membrane of wistar rats.Methods: This laboratory experimental study used 5 wistar rats as subjects in the Laboratory of Biochemistry at Padjadjaran University from 10−26 October 2012. All rats were given three solutions by in situ perfusionmethod. The first was 25 ml 3.0 X 10-3 M glucose solution, the second was 25 ml 3.0 X 10-3 M glucose solution with 1 ml Psidium guajava infusion added, and the third was 25 ml 3.0 X 10-3 M glucose solution.The sample from each solution was taken five times at 0, 15, 30, 45, and 60 minutes after the solutions were given. The spectrophotometer was to quantify the concentration of glucose from the samples. Data were analyzed using Friedman and Wilcoxon test.Results:The means of glucose concentration for each solution from the first solution to the third were 6.126 mg/dl, 2.447 mg/dl, and 5.345 mg/dl. The probability value showed significant difference between the first and second solutions (p ≤ 0.05).Conclusions: Psidium guajava leaf infusion can inhibit glucose absorption in wistar rat intestine and the effect is reversible. [AMJ.2015;2(4):546–9] DOI: 10.15850/amj.v2n4.508
Metabolic Syndrome Components and Nutritional Status among Hypertensive Outpatiens at Dr. Hasan Sadikin General Hospital Bandung Mirandus, Lira; Permana, Hikmat; Fatimah, Siti Nur
Althea Medical Journal Vol 3, No 3 (2016)
Publisher : Althea Medical Journal

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Background: Metabolic syndrome and overnutritional status (overweight and obesity) are examples of determinants that can give rise to hypertension, so the three diseases are correlated with each other. This study aimed to reveal metabolic syndrome components and nutritional status among hypertensive outpatients.Methods: This study involved 44 hypertensive outpatients who visited the Nephrology and Hypertension Clinic of Dr. Hasan Sadikin Hospital, Bandung in September to October 2013. Anthropometric and blood pressure measurements, anamnesis, and medical record data collection were carried out to describe the patient’s metabolic syndrome components by using International Diabetes Federation criteria on South Asian people and nutritional status by WHO classification in Asian people.Results: Among respondents, 25 (57%) had abdominal obesity, 14 (32%) had hypertrygliceridemias, 14 (32%) had low HDL cholestrol, 19 (43%) were taking lipid-lowering medications, 20 (45 %) had high level of fasting blood glucose, 21 (48%) had been diagnosed as mellitus type 2, 15 (34%) had high blood pressure, 40 (91%) were taking antihypertensive medications, 19 (43%) had metabolic syndrome, and 31 (70%) were overweight or obese.Conclusions: Less than a half of the respondents meet the metabolic syndrome criteria and over two third of them are at overnutrition state (overweight or obesity). [AMJ.2016;3(3):476–80]DOI: 10.15850/amj.v3n3.862 
Kadar Hypoxia Inducible Factor-1α pada Penderita Diabetes Melitus Tipe 2 Disertai Mikroalbuminuria dan Retinopati Hoo, Yumilia; Permana, Hikmat; Soetedjo, Nanny Natalia M; Arifin, Augusta Y. L.
Majalah Kedokteran Bandung Vol 46, No 2 (2014)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Diabetes melitus tipe 2 (DMT2) sampai saat ini masih menjadi masalah kesehatan karena bersifat progresif dan menimbulkan komplikasi. Menurut data epidemiologi dari International Diabetes Federation (IDF) tahun 2011, dinyatakan bahwa retinopati diabetik sering kali mendahului mikroalbuminuria. Komplikasi tersebut diawali oleh disfungsi endotel yang akan meningkatkan sekresi sitokin yang menginduksi angiogenesis dan limpangiogenesis. Pada keadaan hipoksia akibat perubahan mikrovaskular, hypoxia inducible factor-1 alpha (HIF-1α) disekresikan dan akan merangsang produksi vascular endothelial growth factor (VEGF) yang menginduksi angiogenesis. Penelitian ini bertujuan untuk mengetahui hubungan kadar HIF-1α plasma penderita DMT2 dengan mikroalbuminuria dan retinopati diabetik. Penelitian menggunakan rancangan studi potong lintang terhadap 158 penderita DMT2 yang berobat di poliklinik endokrinologi Rumah Sakit Dr. Hasan Sadikin Bandung periode Juli─Desember 2012. Data dianalisis menggunakan uji-t, Mann Whitney, dan multivariate analysis of variance (MANOVA). Subjek penelitian terdiri atas 82 orang pria (51,9%) dan 76 orang wanita (48,1%). Delapan puluh orang (50,6%) normoalbuminuria dan 78 orang (49,4%) mikroalbuminuria. Pada penelitian ini didapatkan 38 orang dengan retinopati diabetik (24,1%). Median kadar HIF-1α kelompok mikroalbuminuria adalah 0,103 (0,041–0,735) ng/mL dan pada normoalbuminuria 0,144 (0,041–0,481) ng/mL (p=0,257). Median kadar HIF-1α kelompok retinopati positif 0,041 (0,041–0,33) ng/mL, sedangkan kelompok tanpa retinopati 0,167 (0,041–0,735) ng/mL dengan p<0,01. Simpulan, kadar HIF-1α plasma yang rendah atau normal bergantung pada derajat retinopati diabetik. Kadar HIF-1α plasma yang tinggi pada penderita tanpa retinopati diabetik, menunjukkan akan terjadi retinopati diabetik di masa mendatang. [MKB. 2014;46(2):100–5]Kata kunci: Hypoxia inducible factor-1α, mikroalbuminuria, retinopati diabetikHypoxia Inducible Factor-1α in Type 2 Diabetes Mellitus with Microalbuminuria and RetinopathyType 2 diabetes mellitus (T2DM) is still considered a major problem in healthcare, mainly for its progressivity and complications. According to the epidemiological data from the International Diabetes Federation (IDF) in 2011, it is stated that microalbuminuria often precedes the onset of diabetic retinopathy. Complications are preceded by endothelial dysfunction that will increase the secretion of cytokines inducing angiogenesis and limpangiogenesis. In hypoxic conditions induced by microvascular changes, hypoxia inducible factor-1 alpha (HIF-1α) is secreted, stimulating the production of vascular endothelial growth factor (VEGF) which induce angiogenesis. The aim of this study was to know the correlation between plasma HIF-1α concentration with microalbuminuria pattern and diabetic retinopathy in T2DM patients. This cross-sectional study was conducted on 158 T2DM patients in Endocrinology Outpatient Departement of Dr. Hasan Sadikin Hospital during July to December 2012. Data were analyzed using t-test, Mann Whitney, and multivariate analysis of variance (MANOVA) methods. Eighty two males (51.9%) and 76 females (48.1%) participated in the study, making up 158 subjects. Eighty patients (50.6%) had normoalbuminuria and 78 patients (49.4%) had microalbuminuria. Thirty eight patients were found with diabetic retinopathy (24.1%). The median of HIF-1α plasma concentrations was 0.103 (0.041–0.735) ng/mL in the microalbuminuria group and 0.144 (0.041–0.481) ng/mL (p=0.257).in the normoalbuminuria group. The median of HIF-1α plasma concentration in the group with diabetic retinopathy was 0.041 (0.041–0.33) ng/mL, while in the group without diabetic retinopathy the median was 0.167 (0.041–0.735) ng/mL (p<0.01). In conclusion, low or normal HIF-1α plasma levels in patients without diabetic retinopathy predict the grading of diabetic retinopathy, while high levels of plasma HIF-1α suggests the likehood of retinopathy event in the future. [MKB. 2014;46(2):100–5]Key words: Diabetic retinopathy, hypoxia inducible factor-1α, microalbuminuria DOI: 10.15395/mkb.v46n2.281
Polimorfisme Gly972Arg Gen IRS-1 dan Cys981Tyr Gen PTPN1 sebagai Faktor Risiko pada Sindrom Metabolik dengan Riwayat Berat Bayi Lahir Rendah Permana, Hikmat; Nugraha, Gaga Irawan; Kariadi, Sri Hartini K. S.
Majalah Kedokteran Bandung Vol 44, No 3 (2012)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Abstract

Peningkatan prevalensi obesitas terjadi di seluruh dunia dan dapat mengenai semua tingkatan usia. Faktor risiko peningkatan sindrom metabolik berhubungan dengan perubahan gaya hidup, obesitas, dan berat lahir rendah. Penelitian ini dilakukan bertujuan menganalisis genotipe IRS-1, genotipe PTPN1, dan berat bayi lahir rendah (BBLR) sebagai risiko terhadap sindrom metabolik. Pada tahun 2009 terkumpul sebanyak 97 BBLR dan 100 bayi berat lahir normal (BBLN) berusia 20–21 tahun. Penelitian kohort retrospektif ini merupakan bagian penelitian kohort sebelumnya di kecamatan Tanjung Sari pada tahun 1989. Peran genotipe IRS-1, genotipe PTPN1, dan BBLR terhadap sindrom metabolik diuji dengan regresi logistik multipel. Hasil penelitian menunjukkan tidak terdapat hubungan bermakna genotipe IRS-1 dan PTPN1 dengan faktor-faktor sindrom metabolik, tetapi hanya genotipe IRS-1 berhubungan signifikan dengan trigliserida (p=0,006). Polimorfisme Gly972Arg gen IRS-1 pada BBLR mempunyai nilai prediksi terhadap peningkatan tekanan darah diastol, lingkaran perut, dan trigliserida. Polimorfisme Cys981Tyr gen PTPN1 menunjukkan faktor risiko terhadap tekanan darah sistol dan kolesterol high density lipoprotein (HDL). Polimorfisme Gly972Arg gen IRS-1 merupakan faktor dominan sebagai penyebab peningkatan tekanan darah diastol, lingkaran perut, dan trigliserida. Simpulan, polimorfisme Cys981Tyr gen PTPN1 merupakan faktor risiko peningkatan tekanan darah sistol dan kolesterol HDL. Bayi berat lahir rendah merupakan faktor risiko peningkatan gula darah puasa. [MKB. 2012;44(3):170–8].Role of Polymorphism Gly972Arg Gene IRS-1 and Cys981Tyr Gene PTPN1 as Risk Factors in Metabolic Syndrome with History of Low Birth WeightIncreasing prevalence of obesity occurs worldwide and can affect all ages levels. Risk factors of increasing metabolic syndrome were associated with changes in lifestyle, obesity and low birth weight (LBW). This study was aimed to analyze the genotype IRS-1, genotype PTPN1 and LBW in metabolic syndrome risk factors. In 2009, this restrospective cohort study was comprised of 97 LBW and 100 normal birth weight (NBW), aged 20–21 years old, from the previous cohort study in District Tanjung Sari since 1989. The role of IRS-1 gene, PTPN1 gene and LBW in the metabolic syndrome factors were analyzed using multiple logistic regressions. The result showed there were no significant relationship between IRS-1 and PTPN1 genotype with metabolic syndrome factors but only IRS-1 genotype was significantly associated with trygliceride (p=0.006). Gly972Arg IRS-1 gene polymorphism in LBW has predictive value of increasing diastolic blood pressure, waist circumference and trygliceride. Cys981 Tyr PTPN1 gene polymorphism showed a risk factor for systolic blood pressure and high density lipoprotein (HDL) cholesterol. Gly972Arg IRS-1 gene polymorphism was a dominant factor to increase diastolic blood pressure, waist circumference and trygliceride. In conclusions, Cys981 Tyr PTPN1 gene polymorphism is a risk factor of increased systolic blood pressure and HDL cholesterol, and LBW is the risk factor increasing fasting glucose level. [MKB. 2012;44(3):170–8]. DOI: http://dx.doi.org/10.15395/mkb.v44n3.137
Perbedaan Kadar Liver Fatty Acid Binding Protein (L-FABP) Urine Penderita Diabetes Melitus Tipe 2 dengan Normoalbuminuria dan Mikroalbuminuria Wiharjo, Kristina; Permana, Hikmat; Noormartany, -; Rachmayati, Sylvia
Majalah Kedokteran Bandung Vol 46, No 2 (2014)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Abstract

Diabetes melitus (DM) merupakan salah satu penyebab end stage renal disease (ESRD), 20−40% akan mengalami nefropati diabetik yang berkembang menjadi ESRD. Prevalensi nefropati diabetik meningkat pada DM tipe 2. Akumulasi stres oksidatif dapat menyebabkan peningkatan permeabilitas glomerulus sehingga menyebabkan peningkatan ekskresi albumin pada urine yang terbagi menjadi normoalbuminuria, mikroalbuminuria, dan makroalbuminuria. Kerusakan glomerulus terjadi setelah kerusakan tubulointerstisial ginjal yang menyebabkan penurunan aliran kapiler peritubular dan menyebabkan hipoksia. Liver fatty acid binding protein (L-FABP) berfungsi mengurangi hipoksia dengan mengikat stres oksidatif dan mengeluarkannya ke dalam urine. Penelitian ini bertujuan untuk menganalisis apakah terdapat perbedaan kadar L-FABP antara penderita DM tipe 2 normoalbuminuria dan mikroalbuminuria. Metode penelitian adalah observasional analitik dengan rancangan potong lintang. Subjek penelitian sebanyak 70 orang penderita DM tipe 2 dengan normoalbuminuria (38 orang) dan mikroalbuminuria (32 orang) yang diambil secara acak pada pasien yang datang ke Laboratorium Rawat Jalan Rumah Sakit Dr. Hasan Sadikin pada periode Juli−September 2012. Uji statistik menggunakan Uji Mann-Whitney. Hasil penelitian menunjukkan perbedaan bermakna kadar L-FABP urine pada normoalbuminuria dengan mikroalbuminuria dengan nilai ZM-W=3.513; p<0,001, median pada normoalbuminuria adalah 5, dan mikroalbuminuria adalah 7. Dari penelitian ini didapatkan kadar L-FABP urine meningkat karena kompensasi pembentukan stres oksidatif dan hipoksia yang terjadi sebelum kerusakan glomerulus. Simpulan, kadar L-FABP urine pada pasien DM tipe 2 dengan mikroalbuminuria lebih tinggi daripada pasien DM tipe 2 dengan normoalbuminuria. [MKB. 2014;46(2):83–7]Kata kunci: Diabetes melitus tipe 2, kadar L-FABP urine, mikroalbuminuria, nefropati diabetik, normoalbuminuria Comparison of Urinary Liver-Fatty Acid Binding Protein (L-FABP) in Normoalbuminuria and Microalbuminuria in Type 2 Diabetes Mellitus PatientsDiabetes mellitus (DM) is the leading cause of the end stage renal disease (ESRD). Around 20−40% patients with DM develop diabetic nephropathy and eventually progress into ESRD. Type 2 DM has a greater prevalence to develop diabetic nephropathy. Oxidative stress accumulation can increase permeability of the glomerulus which results in increased urine albumin excretion, which is divided into three groups: normoalbuminuria, microalbuminuria and macroalbuminuria. Glomerulus dysfunction occurs after tubulointerstisial renal dysfunction which decreases peritubular capillary flow that leads to tubulointerstisial hypoxia. Liver fatty acid binding protein function is to reduce hypoxia by binding oxidative stress and excretes it into urine. The aim of this study was to analyze the differences in the urine L-FABP level between normoalbuminuria and microalbuminuria type 2 DM patients. The study design was observational analytic using cross-sectional method. Subjects were 70 DM type 2 patients with normoalbuminuria (38 patients) and microalbuminuria (32 patients). Statistical analysis was performed using the Mann Whitney test The results found that there were significant differences in levels of urine L-FABP between normoalbuminuria and microalbuminuria type 2 DM patients (ZM-W=3.513, p<0.001) with medians of 5 and 7 in normoalbuminuria and microalbuminuria, respectively. The urine L-FABP level increased because of the oxidative stress and hypoxia that happened before the glomerulus dysfunction. In conclusion, urine L-FABP level in patients DM type 2 with microalbuminuria is higher than that of the normoalbuminuria. [MKB. 2014;46(2):83–7]Key words: diabetic nephropathy, L-FABP urine level, microalbuminuria, normoalbuminuria, type 2 DM DOI: 10.15395/mkb.v46n2.278
Efek Antidiabetes Kombinasi Ekstrak Bawang Putih (Allium sativum Linn.) dan Rimpang Kunyit (Curcumma domestica Val.) dengan Pembanding Glibenklamid pada Penderita Diabetes Melitus Tipe 2 Setiawan, Ame Suciati; Yulinah, Elin; Adnyana, I Ketut; Permana, Hikmat; Sudjana, Primal
Majalah Kedokteran Bandung Vol 43, No 1
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Kombinasi ekstrak bulbus bawang putih (Allium sativum Linn.) dan rimpang kunyit (Curcumma domestica Val.) dapat digunakan sebagai obat antidiabetes oral pada penderita diabetes melitus (DM) tipe 2, dan secara klinis telah terbukti dapat menurunkan kadar glukosa darah dengan dosis 2,4 g/hari. Penelitian klinis dilakukan untuk melihat efek antidiabetes kombinasi ekstrak dibandingkan dengan antidiabetik oral, glibenklamid. Subjek adalah usia >35 tahun dengan DM tipe 2 yang berobat ke poliklinik Penyakit Dalam dan Endokrin Rumah Sakit Hasan Sadikin Bandung periode November 2007–Agustus 2008 dan telah mendapat terapi gizi medis selama 2 minggu. Penelitian dilakukan secara paralel, acak, dan tersamar ganda. Penggunaan kombinasi ekstrak menunjukkan penurunan kadar glukosa darah puasa rata-rata 9,25 mg/dL, glukosa darah 2 jam postprandial (PP) 22,25 mg/dL, HbA1c 1,30%, serta insulin 12,57 mg/dL bila dibandingkan dengan baseline glibenklamid rata-rata kadar glukosa darah puasa 72,37 mg/dL, glukosa darah 2 jam PP 114,25 mg/dL, dan HbA1c 4,12%, tetapi meningkatkan insulin 3,34 mg/ dL. Kombinasi ekstrak tidak mempengaruhi fungsi hati, ginjal, dan profil hematologi. Kesimpulannya kombinasi ekstrak memiliki efek antidiabetes tetapi efek yang ditimbulkan tidak sebaik glibenklamid. [MKB. 2011;43(1):26–34].Kata kunci: Bawang putih, kunyit, diabetes melitus tipe 2, glibenklamid, glukosa darah Antidiabetic Effect of Garlic Extract (Allium sativum Linn.) and Curcumin Extract (Curcumma domestica Val.) Combination Compared to Glibenclamide in Type 2 Diabetes MellitusThe combination of garlic (Allium sativum Linn.) and curcumin extract (Curcumma domestica Val.) can be used as an oral antidiabetic in type 2 diabetes mellitus (DM) patients. The clinical trial has shown that the extract can decrease blood glucose at a dose of 2.4 g/day. This clinical trial  was conducted to explore the antidiabetic effect of garlic and curcumin extract combination compared to oral antidiabetics, glibenclamide. The subjects were >35 years old patients with type 2 DM who visited the internal and endocrine clinic of Dr. Hasan Sadikin Hospital Bandung and has been treated with medical nutrition therapy for 2 weeks during the period of November 2007–December 2008. This study was a parallel, randomized and double blind study. The garlic and curcumin extract combination decreased the mean value of fasting blood glucose 9.25 mg/dL, 2h PP blood glucose 22.25 mg/dL, HbA1c 1,30% and insulin 12.57 mg/dL  compared to baseline whereas glibenclamide decreased the mean value of fasting blood glucose to 72.37 mg/dL, 2h PP 114,25 mg/dL, HbA1c 4.12% and increased the insulin to 3.34 mg/dL. In conclusion, the extract combination has antidiabetic effect even though it is lower than the glibenclamide. [MKB. 2011;43(1):26–34].Key words: Blood glucose, curcumin, garlic, glibenclamide, type 2 diabetes mellitus DOI: http://dx.doi.org/10.15395/mkb.v43n1.41
Anti-hyperglycemic Effect of Psidium guajava Leaf Infusion Rizda Nurul Zartiana; Samsudin Surialaga; Hikmat Permana
Althea Medical Journal Vol 2, No 4 (2015)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Background: Prevalence of diabetes mellitus is estimated to increase annually. Numerous people use traditional medicine, such as the Poidium guajava leaf to prevent this disease. This study aimed to analyse the effect of Psidium guajava leaf to inhibit glucose absorption in intestine epithelial membrane of wistar rats.Methods: This laboratory experimental study used 5 wistar rats as subjects in the Laboratory of Biochemistry at Padjadjaran University from 10−26 October 2012. All rats were given three solutions by in situ perfusionmethod. The first was 25 ml 3.0 X 10-3 M glucose solution, the second was 25 ml 3.0 X 10-3 M glucose solution with 1 ml Psidium guajava infusion added, and the third was 25 ml 3.0 X 10-3 M glucose solution.The sample from each solution was taken five times at 0, 15, 30, 45, and 60 minutes after the solutions were given. The spectrophotometer was to quantify the concentration of glucose from the samples. Data were analyzed using Friedman and Wilcoxon test.Results:The means of glucose concentration for each solution from the first solution to the third were 6.126 mg/dl, 2.447 mg/dl, and 5.345 mg/dl. The probability value showed significant difference between the first and second solutions (p ≤ 0.05).Conclusions: Psidium guajava leaf infusion can inhibit glucose absorption in wistar rat intestine and the effect is reversible. [AMJ.2015;2(4):546–9] DOI: 10.15850/amj.v2n4.508
Metabolic Syndrome Components and Nutritional Status among Hypertensive Outpatiens at Dr. Hasan Sadikin General Hospital Bandung Lira Mirandus; Hikmat Permana; Siti Nur Fatimah
Althea Medical Journal Vol 3, No 3 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Background: Metabolic syndrome and overnutritional status (overweight and obesity) are examples of determinants that can give rise to hypertension, so the three diseases are correlated with each other. This study aimed to reveal metabolic syndrome components and nutritional status among hypertensive outpatients.Methods: This study involved 44 hypertensive outpatients who visited the Nephrology and Hypertension Clinic of Dr. Hasan Sadikin Hospital, Bandung in September to October 2013. Anthropometric and blood pressure measurements, anamnesis, and medical record data collection were carried out to describe the patient’s metabolic syndrome components by using International Diabetes Federation criteria on South Asian people and nutritional status by WHO classification in Asian people.Results: Among respondents, 25 (57%) had abdominal obesity, 14 (32%) had hypertrygliceridemias, 14 (32%) had low HDL cholestrol, 19 (43%) were taking lipid-lowering medications, 20 (45 %) had high level of fasting blood glucose, 21 (48%) had been diagnosed as mellitus type 2, 15 (34%) had high blood pressure, 40 (91%) were taking antihypertensive medications, 19 (43%) had metabolic syndrome, and 31 (70%) were overweight or obese.Conclusions: Less than a half of the respondents meet the metabolic syndrome criteria and over two third of them are at overnutrition state (overweight or obesity). [AMJ.2016;3(3):476–80]DOI: 10.15850/amj.v3n3.862 
Correlation between haemoglobin concentration and oxygen saturation (SpO2) in elderly professors Della Aprilliana Suherlim*; Hikmat Permana; Leonardo Lubis
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 2 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (253.301 KB) | DOI: 10.19106/JMedSci005002201804

Abstract

The aging process is recognized by the decreases of the body functions which is caused by molecular and cellular damages. The population which is mostly affected by this aging process is elderly. In elderly, it is most likely that tissue oxigenation decreases due to the reduction of haemoglobin level and oxygen saturation (SpO2).This study aimed to evaluate  the correlation between the hemoglobin concentration and SpO2 in the elderly professors in Universitas Padjadjaran (UNPAD), Bandung. This was cross sectional study using secondary data from medical records of the elderly professors. One hundred and eight data of the professors (84 males and 24 females) who met the inclusion and exclusion criteria were used in this study.Spearman’s Rank correlation test was used to analyze the data of total subjects and male professors group, while Pearson correlation test was used to analyze the data of female professors group. Correlation test between hemoglobin concentration and SpO2 resulted in an insignificant results in male professors (r = 0.028; p = 0.801), female professors (r = 0.132; p = 0.538), and total subjects (r = 0.036; p = 0.712).  In conclusion, there is no correlation between hemoglobin concentration and SpO2 in the elderly professors of UNPAD, Bandung.
Profil Massa Lemak dan Lingkar Pinggang Dewasa Obes dan Nonobes di Cirebon Stephanus Kristianto Witono; Gaga Irawan Nugraha; Hikmat Permana; Sudigdo Adi
Global Medical & Health Communication (GMHC) Vol 6, No 1 (2018)
Publisher : Universitas Islam Bandung

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Abstract

Kelebihan berat badan dan kegemukan mulai menjadi masalah terhadap kesehatan pada beberapa dekade terakhir. Hal ini menjadi masalah serius terhadap kesehatan karena dapat menyebabkan sindrom metabolik yang berujung kepada kematian sehingga kegemukan perlu kita cegah sedini-dininya. Deteksi dini khususnya massa lemak dan lingkar pinggang yang menjadikan faktor prediktor sindrom metabolik perlu dilakukan untuk mencegah perjalanan penyakit obesitas. Penelitian deskriptif ini dilakukan terhadap 116 pasien (47 pasien obes dan 69 nonobes) di Klinik Pasar Balong Cirebon, 14–21 April 2016 dengan rentang usia 35–60 tahun. Pengukuran berat badan, massa lemak, dan massa bebas lemak menggunakan professional octapolar body impedance analyzer Beurer BF100, pengukuran tinggi badan menggunakan Stadiometer Seca 213 dan lingkar pinggang menggunakan body tape measure caliper Onemed. Tujuan penelitian ini adalah mengetahui persentase massa lemak dan lingkar pinggang dewasa obes dengan nonobes di Kota Cirebon sehingga dapat dijadikan acuan dalam mengatasi obesitas. Hasil massa lemak rata-rata pria dan wanita obes 30,98±4,24% dan 39,29±3,56%, serta lingkar pinggang 108,20±7,59 cm dan 93,46±8,91 cm yang berarti rata-rata dewasa obes di Cirebon mempunyai massa lemak jauh di atas klasisfikasi buruk dari American College of Sport Medicine dan lingkar pinggang jauh di atas batasan World Health Organization dan International Diabetes Federation untuk orang Asia. Hasil massa lemak rata-rata pria nonobes dalam klasifikasi rata-rata 17,81±5,21% dan wanita nonobes di bawah rata-rata 25,87±2,48%. Lingkar pinggang pria dan wanita nonobes 79,00±6,93 cm dan 74,72±5,44 cm, masih dalam klasifikasi normal. Simpulan, orang dewasa di Kota Cirebon baik obes maupun nonobes khususnya wanita mempunyai massa lemak masuk ke dalam klasifikasi buruk. Lingkar pinggang dewasa obes baik pria maupun wanita melebihi batasan World Health Organization dan International Diabetes Federation. FAT MASS AND WAIST CIRCUMFERENCE PROFILE OF ADULT OBESE AND NON-OBESE IN CIREBONOverweight and obesity are starting to become a serious health problems in the last few decades because it can cause metabolic syndrome that leads to death, so we need to prevent obesity as early as possible. We need to do early detection especially fat mass percentage and waist circumference that makes predictor factor of the occurrence of metabolic syndrome is needed to prevent or even to cut the course of obesity disease. This descriptive study was conducted on 116 patients (47 obese and 69 non-obese patients) at the Klinik Pasar Balong Cirebon, April 14–21, 2016 with age range of 35–60 years. Measurement of body weight, fat mass, fat free mass using professional octapolar body impedance analyzer Beurer BF100, while height measurement using Seca 213 Stadiometer and waist circumference using body tape measure caliper Onemed. The purpose of this research was to know fat mass and waist circumference of obese and non-obese in Cirebon, so it can be used as a reference in overcoming obesity. The mean value of fat mass men and women obese were 30.98±4.24% and 39.29±3.56%, and waist circumference 108.20±7.59 cm and 93.46±8.91 cm, which means the mean value obese adults in Cirebon have fat mass far above the bad classification of American College of Sport Medicine and waist circumference far above the boundaries of the World Health Organization and International Diabetes Federation for Asians. The mean value of non-obese fat mass percentage gain in the average classification was 17.81±5.21% and non-obese women in the classification below the average 25.87±2.48%. Non-obese male and female waist circumference 79.00±6.93 cm and 74.72±5.44 cm, still in normal classification. In conclusion, adults in Cirebon both obese and non-obese, especially women have fat mass percentage fall into bad classification. While obese adult waist circumference exceeds the limits of World Health Organization and International Diabetes Federation.
Co-Authors Alfaqeeh, Mohammed Ame Suciati Setiawan Annisa Ikhsanawati, Annisa Augusta Y. L. Arifin Bachti Alisjahbana Davin Takaryanto Della Aprilliana Suherlim* Elin Yulinah Gaga Irawan Nugraha Guntur Darmawan Hasrayati Agustina I Ketut Adnyana Khairinisa, Miski Aghnia Kristina Wiharjo Kusumawati, Maya Leonardo Lubis Lira Mirandus Loe, Luse Marshell Tendean Miftahurachman Miftahurachman, Miftahurachman Mirandus, Lira Muhammad Iman Pratama Putra Nanny N. M. Soetedjo Nanny Natalia M Soetedjo Nanny Natalia Mulyani Soetedjo Nanny Natalia Mulyani Soetedjo Nanny Natalia. M Soetedjo Nenny Agustanti Noormartany Primal Sudjana Ritonga, Ervita Rizda Nurul Zartiana Rizda Nurul Zartiana, Rizda Nurul Rudi Supriyadi Samsudin Surialaga Siti Nur Fatimah Siti Nur Fatimah Sri Hartini K. S. Kariadi Stephanus Kristianto Witono Sudigdo Adi Susandi, Evan Sylvia Rachmayati Yohana Azhar Yumilia Hoo