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Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Published by Universitas Gadjah Mada

ISSN : 01261312 EISSN : 23563931 DOI : http://dx.doi.org/10.19106/JMedSci005303202101

Core Subject : Science,

Immunology & microbiology Neuroscience

Journal of the Medical Sciences (JMedSci) or Berkala Ilmu Kedokteran (BIK) is an international, open-access, and double-blind peer-reviewed journal, published by Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada Yogyakarta Indonesia. JMedSci aiming to communicate high-quality articles in the areas of biomedical science from basic to clinical sciences.The journal welcomes papers from original articles, case reports, reviews, and book reviews. All papers published in JMedSci are freely available as downloadable pdf files. The journal began its publication on March 1973 and published quarterly (January, April, July, and October). JMedSci is abstracted and indexed in DOAJ, Crossref, Google Scholar, Sinta, Indonesia One Search. JMedSci is accredited by Directorate of General Higher Education, the Ministry of Research, Technology, and Higher Education, Indonesia

Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)

Articles 10 Documents

Search results for , issue "Vol 53, No 1 (2021)" : 10 Documents clear

Dynamic myelin regulation as a novel form of neural plasticity . Yuliana
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 53, No 1 (2021)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Dynamic changes in myelin could optimize information transmission in neuralcircuits and enhance conduction velocity. This review aimed to provide anunderstanding of how dynamic myelin plasticity is important in neuronalactivity and how astrocytes have an important role that is not equal in theperipheral nervous system. Myelin is dynamically regulated by neuronalactivity. It takes part continuously in nervous system plasticity duringdevelopment. Newly differentiating oligodendrocytes can create a new myelinsheath. Mature myelin sheaths can grow again in adults. Oligodendrocytesinteract with astrocytes in the central nervous system through gap junctions.Astrocytes have an important role as synaptic network integrators; therefore,decreasing astrocyte numbers will cause a loss of presynaptic plasticity. Theconcept considers plasticity as a mechanism that depends on myelination.Higher brain functions and myelination interplay in the hippocampus andprefrontal cortex. The mechanism and function of these changes remainpoorly understood. Genetic, neural activity, environment, and axonal activitymight play important roles. Dynamic myelin regulation reveals a new form ofneural plasticity. Myelination is similar to synapse formation and plasticity. Itenables plasticity in the central nervous system and helps improve the learningprocess.

Potential role of fenugreek (Trigonella foenumgraecum) in the prevention of skin aging Shannaz Nadia Yusharyahya
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 53, No 1 (2021)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Skin aging is a process influenced by several factors, including estrogen.Estrogen modulates the physiology of the skin, and its deficiency inpostmenopausal women accelerates skin aging. Administration of estrogencan delay the skin aging process. Phytoestrogens are estrogen-like compoundsderived from plants that administered via oral as well astopical routes.Trigonella foenum-graecum, commonly known as fenugreek, is one plantscontaining phytoestrogens. Several studies have been conducted on thephytoestregonic activity of fenugreek. Fenugreek extract exhibits estrogenicactivity, as observed in the study of mouse and rat reproductive organs.Fenugreek exhibits estrogenic activity in the reproductive organs of a rat, aswell as demonstrates positive effects on the skin by topical administration.This review explored the fenugreek as the source of phytoestrogens and itsrole in delaying skin aging.

Adjustment of sperm cryopreservation laboratory management during the COVID-19 pandemic Dicky Moch Rizal
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 53, No 1 (2021)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

The COVID-19 pandemic has changed the order of life in all fields, particularlyin medical services. Laboratory services in sperm cryopreservation that partof andrology or in vitro fertilization (IVF) laboratory cannot be separated withhandling sperm from patients. Although the presence of viruses in semenhas been known through various studies, there is scarce evidence regardingwhether sperm fluid can be a medium of COVID-19 transmission. This raisedthe question of whether some adjustments to manage patient sperm shouldbe made. This review described an overview of the various efforts that can bemade to reduce the risk of disease transmission to health workers who handlepatient sperm fluid.

Induced pluripotent stem cells and genome editing technology as therapeutic strategies for Duchenne muscular dystrophy Irwan Saputra Batubara
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 53, No 1 (2021)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Duchenne muscular dystrophy (DMD) is a rare genetic, progressiveand devastating skeletal and cardiac muscle disorder due to mutationof the dystrophin gene that affects 1 in 3500 young males. Currently,there is no curative management for this pathology. The development ofinducedpluripotent stem cells (iPSCs) offers a promising cell-based strategyfor the treatment of muscular dystrophy. Several techniques have beenestablished to generate functional myogenic progenitor cells derived fromiPSCs. In addition, technologies in genetic modification using ZFN, TALENs, orCRISPR/Cas9 demonstrate potent methods to restore dystrophin expression.However, current evidence shows that either iPSCs or gene editing carrya risk of oncogenesis caused by the integration of exogenous DNA into therecipient gene. Thus, the safety issue is a major challenge for translatingthis method into human clinical applications. This review briefly discussedrecent developments and progressions of iPSCs as well as genome engineeringtechnologies relevant to regenerative medicine, especially for the treatmentof DMD.

The impact of glucose control index on erectile hardness score among type 2 diabetes mellitus patients Sakti Brodjonegoro; Andy Zulfiqqar; Franky Renato Anthonius; Amanda Cyko; Pandu Ishaq Nandana
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 53, No 1 (2021)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

The prevalence of erectile dysfunction (ED) was reported to vary from 37.5 to52% in men above 40. Type 2 diabetes mellitus (T2DM) maycause the nervesand blood vessels damages that worsened the ED. This study aimed to evaluatethe correlation between the glucose control index and the erection hardnessscore (EHS) among T2DM patients. The cross-sectional observational studywas conducted in two district hospitals i.e. Manambai Abdulkadir DistrictHospital, Sumbawa, and Dompu District Hospital, Dompu, West Nusa Tenggara,Indonesia. Forty-five patients with T2DM were involved in this study. Data werecollected using structural questioners during the period from June 1st to August1st, 2017 and were analyzed using SPSS 24.0. Pearson correlation and logisticregression analysis were used to determine the odds ratio (OR). Among 45patients having age 57.38± 7.22 years involved in this study, 38 (84.4%) patientshad ED, 26 (57.8%) uncontrolled DM, 5 (11.1%) congestive heart failure (CHF),4 (8.9%) chronic kidney diseases (CKD), and 7 (15.6%) neuropathy diabetic.A strong correlation between random glucose level and IIEF-5 score (r=0.91;p=0.01) was observed. The overall odds ratio of ED in this study was 4.3 (95%CI: 0.73 to 25.1) for uncontrolled DM, 2.5 (95% CI: 0.1 to 51.1) for CHF, 2 (95%CI: 0.01 to 41.6) for CKD, and 1.2 (95% CI: 0.1 to 11.5) for neuropathy diabetics.In conclusion, there is a strong correlation between random glucose level,duration of diagnosed DM and EHS. Active screening is recommended for thispopulation.

Comparison between plasma lactate and lactate clearance with the impact of acute phase complication in burn injury patient Hamilton Lowis; Sachraswaty R. Laidding; Fonny Josh; Yudhy Arius; Fritz Nasuhuly; Joko Hendarto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 53, No 1 (2021)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Severe burn can cause rapid loss of intravascular volume with resultant adecrease in peripheral blood flow which reduces tissue oxygen transport and inturn, increases plasma lactate. Plasma lactate and lactate clearance are usefulparameters to compare complicated and uncomplicated burn patients in theacute phase. The study aimed to evaluate the initial and 24-h plasma lactatelevels as well as lactate clearance as useful parameters to assess acute phasecomplications of burn patients. This was a cross-sectional study involving35 burn patients who admitted at Abdul Wahab Sjahranie District Hospital,Samarinda during the period of September 2018 to September 2019. Thestudy was immediately begun after admission of the patients. Plasma lactatelevels were measured at admission and24-h after the first measurement. Theacute phase complication was assessed 72 h after burns from the laboratoryparameter. Fisher’s exact test and t test using SPSS software version 24wereapplied for statistical analysis. The 24-h plasma lactate level (p= 0.001) andplasma lactate clearance (p = 0.002) were significantly correlated with theoccurrence of acute phase complications of burns. However, the initial plasmalactate level was not significantly correlated (p = 0.609). In conclusion, there isa significantly correlation between 24-h plasma lactate level and plasma lactateclearance are with the occurrence of acute phase complications of burns.

Prognostic factor for prolonged ventilator usage and ICU occupancy time after mitral valve replacement surgery: a retrospective cohort study . Supomo; Herpringga Lara Sakti; Galih Asa Andrianto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 53, No 1 (2021)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

This study was conducted to identify the prognostic factors for prolongedventilator usage time and ICU occupancy time after mitral valve replacement(MVR) surgery. It was a retrospective cohort study involving 70 MVR surgerypatients at Dr. Sardjito General Hospital, Yogyakarta, Indonesia during theperiod of January 2013 to December 2018. Prognostic factors as independentvariables including age, gender, heart failure, ejection fraction, pulmonaryhypertension, chronic pulmonary disease, active endocarditis, renalinsufficiency, duration of aortic cross clamp (AOX) time and cardiopulmonarybypass (CPB) time were evaluated. Where as the dependent variables werethe prolongation of ventilator usage time (>24 h) and the intensive care unit(ICU) occupancy time (>96 h). Of the total 70 studied patients, 25 patients(35.7%) used ventilator >24 h, meanwhile 15 patients (21.4%) occupied the ICU>96 h. Patients who used ventilator >24 h had CPB time ≥126.5 min (OR=10;95%CI=2.581-41.252), renal insufficiency (OR= 14; 95%CI = 1.487-150.970), andactive endocarditis (OR=7; 95%CI = 1.257-45.213). Meanwhile, patients whooccupied the ICU >96 h had age ≥40 years old (OR=6.4; 95% CI = 1.26-15.3),CPB time ≥126.5 min (OR=5.7; 95% CI = 1.8-38.1), and heart failure with NYHAfunctional classification 3 (OR=9.8; (95% CI = 1.4-67.2). In conclusion, theprognostic factors for prolonged ventilator usage time after MVR surgery areCPB time ≥126.5 min, renal insufficiency and active endocarditis. Furthermore,the prognostic factors for prolonged ICU occupancy time are age ≥40 years old,heart failure with NYHA functional classification 3 and CPB time ≥126.5 min.

The rotavirus causing acute gastroenteritis in children of under 5-year of age in Indonesia 1972-2018: a review Abu Tholib Aman
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 53, No 1 (2021)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

The reason of this review is the absence of thorough information of rotavirusinfection that had been the major cause of severe diarrhea in children of under5-years of age in Indonesia, despite numerous publications elaborating rotavirusinfection in some geographic areas of Indonesia. A review was conductedtowards 52 published articles covering rotavirus research in Indonesia duringperiod of 1972-2018.A thirty three selected articles were match with reviewcriteria which comprises rotavirus positive rate, clinical features, and severityof rotavirus infection, as well as genotypes of the rotavirus. Rotavirus has beenknown as the major cause of severe diarrhea among children under 5 years ofage world wide including in Indonesia. The rotavirus positive rates were rangefrom 31.1 to 90.9%, which variably to different subject’s population, studycriteria and methods, and time. Rotavirus can cause severe diarrhea withmajority of infected children suffered from dehydration, vomiting, and fever.The first genotyping conducted in Indonesia in the early 1980s revealed thepredominant genotypes were G3 and G4, followed by G2, and small proportionof G1 and mixed genotypes. However the following decades G1 and G2 were onthe raise with G3 predominantly re-appeared on 2015. G9 was first identified in2004, and occasionally detected until 2015. The P genotyping revealed P[4], P[6],and P[8] were the common genotypes detected. Mixed and untyped genotypeswere also detected in various proportion. Rotavirus diarrhea is a vaccinationpreventable disease, after natural infection, the immune system will produceprotective antibodies that will protect from infection of both homotypic andheterotypic, however homotypic infection will protect stronger. Therefore thisreview recommends continuous rotavirus genotypes surveillance in Indonesia.

Effectivity of alkaline water on the clinical improvement in laryngopharyngeal reflux Muhammad Rizka Yahya; Rery Budiarti; Dwi Antono; . Farokah; . Muyassaroh
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 53, No 1 (2021)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Laryngopharyngeal reflux (LPR) is the reflux of gastric acid through theupper oesophageal sphincter causing mucosal damage of the larynx, thegastrointestinal tract, and the upper airway. Alkaline water has the ability towithstand acidic conditions in the body, the formation of carbonic anhydrase,and reepithelization. This study aimed to investigate the effect of alkaline wateron the clinical improvement in LPR patients. A randomized control trial withpre-test and post-test control group design on LPR patients aged 18 to 60 y.o.was conducted at the ENT-HS outpatient clinic of Dr Kariadi Central Hospital,Semarang, Central Java, Indonesia. Thirty subjects were recruited and dividedinto two group with 15 subjects in each group. In the control group, the subjectswere given standard therapy and mineral water. In the treatment group, thesubjects were given standard therapy and alkaline water. The diagnosis ofLPR was made if the reflux scoring index (RSI) was ≥13, and the reflux findingscore (RFS) was >7. ,After two weeks of intervention, the clinical improvementswere evaluated by reassessing the RSI score. The data were analyzed usingthe Shapiro-Wilk test and independent t-test. The results showed that the mostcommon main complaint was throat clearing [11 subjects (37%)]. Based on theRSI score, there were clinical improvements in both the control (p <0.001) andthe treatment groups (p <0.001). However, there was no significant differencein the RSI score before and after the intervention in the control (p = 0.058)and the treatment groups (p = 0.322). In conclusion,tbe d there is an effect ofalkaline water on the clinical improvement of LPR patients. However, there isno significant difference in the clinical improvement between the control andthe treatment groups.

Excellent response of rituximab and bendamustine in elderly patient with relapsed diffuse large B-cell lymphoma: a case report Wiwiek Probowati; Merari Panti Astuti; Bambang Purwanto Utomo; Mardiah Suci Hardiyanti; Ibnu Purwanto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 53, No 1 (2021)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Rituximab in combination with cyclophosphamide, doxorubicin, vincristine,and prednisone (R-CHOP) is currently the most widely used first-line therapyfor aggressive B-cell lymphomas. However, many patients, including thosewith organ dysfunction, may not tolerate the toxicities associated with thisregimen. Recent data from the phase III study group indolent lymphomas(StiL) non-Hodgkin lymphoma (NHL)-1 trial suggested that bendamustine plusrituximab were superior in effectiveness and tolerability compared to R-CHOPin the treatment of indolent and mantle cell lymphomas. Preliminary studyhas indicated the effective use of bendamustine alone or in combination inthe treatment of aggressive B-cell lymphomas as well. A 70-year-old malewith heavily treated relapsed diffuse large B-cell lymphoma (DLBCL) showedcomplete remission (CR) after receiving 8 cycles of rituximab in combinationwith bendamustine as 3rd line treatment. Bendamustine has demonstratedconsiderable efficacy and well-tolerated therapy in relapsed DLBCL patients.Our case report demonstrated that treating patients with bendamustinebasedregimen, even in the setting of organ impairment and elderly is safeand effective. Given the increasing evidence of its effectiveness, furtherinvestigation of bendamustine’s safety and tolerability aspects in specialgroups is recommended such as those with renal impairment.

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Nurhadiyahya

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Home Page

OAI Link

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Contact

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Contact Name Nurhadiyahya

Contact Email nurhadiyahya@ugm.ac.id

Phone +6289672800034

Journal Mail Official jmedscie@ugm.ac.id

Editorial Address https://jurnal.ugm.ac.id/bik/about/editorialTeam

Location Kab. sleman, Daerah istimewa yogyakarta INDONESIA

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Contact Name
Nurhadiyahya

Contact Email
nurhadiyahya@ugm.ac.id

Phone
+6289672800034

Journal Mail Official
jmedscie@ugm.ac.id

Editorial Address
https://jurnal.ugm.ac.id/bik/about/editorialTeam

Location
Kab. sleman,

Daerah istimewa yogyakarta

INDONESIA