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Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science)
Published by Universitas Ahmad Dahlan
ISSN : 14127946     EISSN : 25035223     DOI : 10.12928
Core Subject : Health, Science,
Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology
Media Farmasi is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Media Farmasi published two times a year, namely in March and September since 2002 with ISSN 1412-7946 and e-ISSN 2503-5223. The article published in the Journal Media Farmasi selected by editors and reviewed by the reviewer. Articles published in Media Farmasi must not be published in other journals or have been previously published. Media Farmasi publishes a review article, original article, as well as short communication in all scopes of Pharmaceutical Science.
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Articles 22 Documents
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Search results for , issue "Vol 12, No 1: Maret 2015" : 22 Documents clear
Simvastatin sebagai Hepatoprotektor pada Tikus Sprague Dawley yang Diinduksi Aloksan Akrom Akrom; Meilan Meilan
Media Farmasi: Jurnal Ilmu Farmasi Vol 12, No 1: Maret 2015
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (117.53 KB) | DOI: 10.12928/mf.v12i1.3022

Abstract

Secara klinis simvastatin dimanfaatkan tidak hanya sebagai antidislipidemia namun juga diindikasikan sebagai antiinflamasi dan antioksidan. Adanya gugus karbonil pada struktur simvastatin yang dapat berikatan dengan electron bebas dari radikal reaktif diduga kuat berhubungan dengan aktifitas antioksidan ini.Bagaimana pengaruh simvastatin terhadap fungsi hepar pada tikus SD yang diinduksi aloksan belum diketahui. Tujuan penelitian ini adalah untuk mengetahui pengaruh simvastatin terhadap kadar SGPT dan SGOT pada tikus Sprague dawley (SD) yang diinduksi aloksan. Penelitian ini menggunakan metode pre and post test design pada 7 kelompok hewan uji (n=7). Kelompok pertama sebagai kontrol normal. Kelompok kedua, kontrol negatif, hewan uji diberi aloksan (12,5 mg/kgBB). Kelompok ketiga diberi simvastatin (15mg/kgBB) selama 7 hari sebelum dan 2 hari setelah diinduksi aloksan. Kelompok keempat diberi vitamin C (20mg/kgBB) selama 7 hari sebelum dan 2 hari setelah diinduksi aloksan.Induksialoksan dilakukan pada hari ke-7 secara intraperitoneal. Darah tikus diambil melalui sinus orbitalispada hari ke-7 sebelum diinduksi aloksan dan pada hari ke9. Kadar SGPT dan SGOT ditetapkan secara enzimatik. Kadar SGPT/SGOT yang diperoleh dianalisis dengan One Way ANOVA. Hasil penelitian menunjukan bahwa pemberian perlakuan 7 hari dengan simvastatin dan vitamin C tidak mempengaruhi kadar SGPT dan SGOT. Rerata kadar SGPT/SGOT kelompok perlakuan tidak berbeda dengan rerata kadar SGPT/SGOT kelompok normal (p>0,05). Induksi aloksan meningkatkan rerata kadar SGPT/SGOT. Pemberian simvastatin dan vitamin C sebelum dan setelah diinduksi aloksan dapat mengurangi peningkatan rerata kadar SGPT/SGOT pada kelompok perlakuan dankelompok kontrol positif.  Rerata kadar SGPT/SGOT kelompok simvastatin lebih rendah dari pada kelompok vitamin C (p<0,05).  Rerata kadar SGPT/SGOT kelompok simvastatin dan vitamin C lebih rendah dari kelompok aloksan (p<0,05). Berdasarkan hasil penelitiandapat disimpulkan bahwa simvastatin dapat  mencegah kenaikan kadar SGPT/SGOT tikus yang diinduksi aloksan.
The Influence of Polyvinyl Pyrrolidone (PVP) on Piroxicam Absorption with Everted Intestinal SAC Method Fea Prihapsara; Anif Nur Artanti; Mimiek Murrukmihadi
Media Farmasi: Jurnal Ilmu Farmasi Vol 12, No 1: Maret 2015
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (125.006 KB) | DOI: 10.12928/mf.v12i1.3028

Abstract

Oral drug absorption was highly influenced by dissolution rate, especially for poorly and insoluble drugs. Piroxicam is a nonsteroidal anti-inflammatory drug that is practically insoluble in water. The oral absorption rate of piroxicam is dependent on its dissolution rate in the GI tract. Polyvinyl Pyrrolidone (PVP) as surfactant can increase drug solubility by means of a micelle forming mechanism. The aim of the study was to know the influence of addition and variation of Polyvinyl Pyrrolidone (PVP) on Piroxicam absorption with everted intestinal sac method.  The  concentration of piroxicam solution was prepared by PVP in  1.0,2.0 and 3.0 % respectively. Crane and Wilson tube containing 75 ml of themucosal fluid was taken at 37 0 C in waterbath. Than, serosal solution of 1.5 mlwas added to intestinal sac by turned upside down and tied to a cannula, then put into the tube containing the mucosal fluid and constantly flowing oxygen gas.Serosal solution of 1 ml were taken every 15 minutes and then diluted with 2 ml of Ba (OH) 2 and 2 ml of ZnSO4 then centrifuge until 25 minute. The absorbant of supernatant was measured by UV spectrophotometer and data analyse wascalculated by one-way ANAVA.  PVP at 1%,2% and 3% increased piroxicamabsorption from the phosphate buffer pH 7.5 compared with negative control.According to P app , the values were 2.52 ± 0.43 cm/minute (negative control), 3.41 ± 2.17 cm/minute (1% PVP), 2.75± 1.14 cm/minute (2% PVP) and 4.77 ± 4.93 cm/minute (3% PVP) respectively. In conclusion. Lower doses of the surfactant (1%, 2%, and 3% PVP) significantly increased absorption of the drug by altering the membrane permeability.  

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