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All Journal Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal Farmasi Sains dan Komunitas Jurnal Pengabdian UntukMu NegeRI AKSIOLOGIYA : Jurnal Pengabdian Kepada Masyarakat Jurnal Pengabdian Pada Masyarakat PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Karinov Bubungan Tinggi: Jurnal Pengabdian Masyarakat Madaniya Jurnal Pengabdian Pada Masyarakat

Anif Nur Artanti, Anif Nur

Farmasi Sekolah Vokasi Universitas Sebelas Maret

Author-ID : 526713

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The Influence of Polyvinyl Pyrrolidone (PVP) on Piroxicam Absorption with Everted Intestinal SAC Method Prihapsara, Fea; Artanti, Anif Nur; Murrukmihadi, Mimiek
Media Farmasi: Jurnal Ilmu Farmasi Vol 12, No 1: Maret 2015
Publisher : Universitas Ahmad Dahlan

Oral drug absorption was highly influenced by dissolution rate, especially for poorly and insoluble drugs. Piroxicam is a nonsteroidal anti-inflammatory drug that is practically insoluble in water. The oral absorption rate of piroxicam is dependent on its dissolution rate in the GI tract. Polyvinyl Pyrrolidone (PVP) as surfactant can increase drug solubility by means of a micelle forming mechanism. The aim of the study was to know the influence of addition and variation of Polyvinyl Pyrrolidone (PVP) on Piroxicam absorption with everted intestinal sac method. The concentration of piroxicam solution was prepared by PVP in 1.0,2.0 and 3.0 % respectively. Crane and Wilson tube containing 75 ml of themucosal fluid was taken at 37 0 C in waterbath. Than, serosal solution of 1.5 mlwas added to intestinal sac by turned upside down and tied to a cannula, then put into the tube containing the mucosal fluid and constantly flowing oxygen gas.Serosal solution of 1 ml were taken every 15 minutes and then diluted with 2 ml of Ba (OH) 2 and 2 ml of ZnSO4 then centrifuge until 25 minute. The absorbant of supernatant was measured by UV spectrophotometer and data analyse wascalculated by one-way ANAVA. PVP at 1%,2% and 3% increased piroxicamabsorption from the phosphate buffer pH 7.5 compared with negative control.According to P app , the values were 2.52 ± 0.43 cm/minute (negative control), 3.41 ± 2.17 cm/minute (1% PVP), 2.75 ± 1.14 cm/minute (2% PVP) and 4.77 ± 4.93 cm/minute (3% PVP) respectively. In conclusion. Lower doses of the surfactant (1%, 2%, and 3% PVP) significantly increased absorption of the drug by altering the membrane permeability. Keywords: Piroxicam, absorption, in vitro, PVP

STUDY OF KINETICS MODEL OF FLAVONOID TOTAL RELEASE IN PATCH OF ANTIHYPERTENSIVE HERBS Dian Eka Ermawati; Anif Nur Artanti; Dyah Ayu Ambarwati; Niken Rosyana Dewi Septini; Sholichah Rohmani; Wisnu Kundarto
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 18, No 1 (2021)
Publisher : Sanata Dharma University

The liquid extract of antihypertensive herbs could reduce blood pressure equivalent to Hydrochlorothiazide 25 mg based on research conducted in “Hortus Medicus” clinic, Tawangmangu, Central Java, but parameters of herbal medicine taste, design, and packaging had the lowest scores. Transdermal patch was chosen as an alternative to resolve those problems. Polymers determined the effectiveness of the active substance release from the formula. Patch was formulated from combination of hydrophilic hydroxy methylcellulose (HPMC) and carboxymethylcellulose natrium (CMC-Na) polymer which would produce a fast release profile. The objective of this research was to study the kinetics models of total flavonoid release and to study the total number of flavonoids released from the antihypertensive herbs patch for 5 hours, as well as to determine the optimum formula for observing the weight, pH and loss on drying. Herbs were infused with distilled water at 90 ° C for 15 minutes, filtered then evaporated. Release kinetics model used a modified type-5 dissolution apparatus equipment with a cellophane membrane. The optimum proportion of HPMC and CMC-Na was 220:180 mg. Patch was dark brown, circle shaped, moist and flexible. It had pH value of 7.29 ± 0.09, folding endurance of 350, and thickness of 0.64 ± 0.05 mm. The average percentage of total flavonoids released from the matrix patch was 37.23% for 5 hours. The release kinetics followed the Higuchi kinetics model with a diffusion mechanism.

Pendampingan Pembuatan Hand Sanitizer Aroma Minyak Atsiri Sebagai Penunjang Pembelajaran Luring Di SMP Muhammadiyah 1 Prambanan Wisnu Kundarto; Dian Eka Ermawati; Muhammad Fiqri Zulpadly; Heru Sasongko; Sholichah Rohmani; Anif Nur Artanti; Daswati Rofiatun Sahifah
Jurnal Pengabdian UntukMu NegeRI Vol 5 No 2 (2021): Pengabdian Untuk Mu negeRI
Publisher : LPPM UMRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37859/jpumri.v5i2.3085

The schools have been allowed for doing face-to-face learning process with many requirements.Making own hand sanitizer will help schools to keep applying health protocol beside washing hands. Essential oils have been trusted for a long time give a calm effect and reduce stres. This activity have purpose to assistance hand sanitizer production with essential oils fragrance at SMP Muhammadiyah 1 Prambanan Yogyakarta. Knowledge have been transfered by team followed with demo and training to produce hand sanitizer with lemongrass fragrance at first activity. Knowledge score was determined from pre-test and post test answer score from multiple choice questions about hand sanitizer. Follow up became the next activity to ensure school can make their own hand sanitizer independently. The result showed knowledge score was increased from 52,11 to 92,11. School also have been made hand sanitizer independently with another essential oil varians. This products were limited used for school. Communication between team and school still continues.

Optimalisasi Pembuatan Rajangan Empon-Empon di Kelompok Tani Suroloyo I, Kecamatan Bandar, Pacitan Fea Prihapsara; Okid Parama Astirin; Endang Siti Rahayu; Anif Nur Artanti
Jurnal KARINOV Vol 4, No 1 (2021): Januari
Publisher : Institute for Research and Community Service (LP2M), Universitas Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17977/um045v4i1p%p

Sebagian besar masyarakat di Desa Bandar menanam empon-empon seperti kunyit, jahe dan temu-temuan sebagai komoditas utama. Namun penjualannya selama ini langsung ke tengkulak tanpa pengolahan pasca panen. Program Pengabdian kepada Masyarakat dari Tim Pusat Penelitian Lingkungan Hidup Universitas Sebelas Maret (PPLH UNS) dengan Mitra Kelompok Petani Suroloyo I ini bertujuan untuk meningkatkan nilai jual produk empon-empon dengan optimalisasi pengolahan pasca panen. Mitra Kelompok Tani Suroloyo I memiliki permasalahan diantaranya: 1) ketergantungan tengkulak untuk penjualan produk curahnya; 2) belum memiliki teknologi pasca panen; dan 3) tidak ada manajemen usaha yang benar. Solusi yang ditawarkan dalam kegiatan ini adalah pengolahan pasca panen yaitu optimalisasi pembuatan rajangan empon-empon dengan menggunakan alat perajang dan pengering. Kegiatan yang telah dilaksanakan adalah sosialisasi kegiatan pengabdian, pelatihan dan penerapan penggunaan mesin perajang dan pengering, serta evaluasi kegiatan. Terdapat peningkatan pendapatan petani sebesar yang cukup signifikan melalui pengolahan produk menjadi rajangan kering dari pada langsung dijual dalam kondisi basah.Kata Kunci: empon-empon, kelompok tani, rajangan, teknologi pasca panenAbstract Most of the people in Bandar Village grow empon-empon such as turmeric, ginger and temu-finds as their main commodities. However, sales so far have been direct to middlemen without post-harvest processing. The Community Service Program of Universtas Sebelas Maret Environmental Research Center Team (PPLH UNS) with Suroloyo I Farmer Group Partners aims to increase the sale value of empon-empon products by optimizing post-harvest processing. Suroloyo I Farmers Group Partners have problems including: 1) dependence of middlemen for the sale of their bulk products; 2) do not have post harvest technology; and 3) there is no proper business management. The solution offered in this activity is post-harvest processing, namely optimizing the making of empon-empon slices using a chopper and dryer. Activities that have been carried out are socialization of community service activities, training and application of the use of chopper and dryer machines, and evaluation of activities. There is a significant increase in farmers' income through processing the product into dry chunks instead of selling it directly in wet conditions.Keywords: empon-empon, farmer groups, chopped, post harvest technology

Formulation optimization and antioxidant test for Self-nano emulsifying drug delivery system of soursop leaves (Annona muricata L.) chloroform extract using candlenut oil as oil phase Anif Nur Artanti; Anggraini Febriyanty; Fea Prihapsara; Dian Eka Ermawati
Pharmaciana Vol 11, No 1 (2021): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Soursop leaves (Annona muricata L.) chloroform extract has an anticancer agent that can be developed for traditional medicine preparation, even though the extract's solubility is low in the water. This study aims to generate new soursop leaves chloroform extract in the Self-Nano Emulsifying Drug Delivery System (SNEDDS). The expected result is that the solubility increases so that the drug delivery system is more effective. The extraction process of soursop leaves uses the percolation method with chloroform as a solvent. It used tween 80 and cremophore E.L. as surfactant, propylene glycol as a cosurfactant, and candlenut oil as a carrier, to make the SNEDDS formulation. Then performed a comparison between the optimal parameters for the physical properties of the SNEDDS formulation with the predictive Simplex Lattice Design (SLD) formulation with the students' t-test statistical analysis [p> 0.05]. Then carried out several tests such as loading dosage extractability, accelerated stability test, particle size, and zeta potential. Furthermore, the antioxidant test was carried out using the DPPH reagent. The optimum composition of candlenut oil, propylene glycol, a mixture of tween 80, and cremophor E.L. based on SLD is 12%: 22%: 66%, respectively. The SNEDDS optimum formulation for chloroform extract of soursop leaves produces a stable nanoemulsion, homogenous. It has a transmittance value of 90.58% Â± 0.151, emulsification time of 59.44 Â± 1.763 seconds, and a value of separation phase 1. The physical formulation test results showed no significant difference between observations with predictive design expert software. SNEDDS can produce 25.0 mg of soursop chloroform extract with particle size 411.4 nm, polydispersion index 0.482, and zeta potential 34.2 mV. IC50 value in 36.28 ppm indicated the antioxidant potential of the SNEDDS formulation for chloroform extract of soursop leaves is high.

The Influence of Polyvinyl Pyrrolidone (PVP) on Piroxicam Absorption with Everted Intestinal SAC Method Fea Prihapsara; Anif Nur Artanti; Mimiek Murrukmihadi
Media Farmasi: Jurnal Ilmu Farmasi Vol 12, No 1: Maret 2015
Publisher : Universitas Ahmad Dahlan

Oral drug absorption was highly influenced by dissolution rate, especially for poorly and insoluble drugs. Piroxicam is a nonsteroidal anti-inflammatory drug that is practically insoluble in water. The oral absorption rate of piroxicam is dependent on its dissolution rate in the GI tract. Polyvinyl Pyrrolidone (PVP) as surfactant can increase drug solubility by means of a micelle forming mechanism. The aim of the study was to know the influence of addition and variation of Polyvinyl Pyrrolidone (PVP) on Piroxicam absorption with everted intestinal sac method. The concentration of piroxicam solution was prepared by PVP in 1.0,2.0 and 3.0 % respectively. Crane and Wilson tube containing 75 ml of themucosal fluid was taken at 37 0 C in waterbath. Than, serosal solution of 1.5 mlwas added to intestinal sac by turned upside down and tied to a cannula, then put into the tube containing the mucosal fluid and constantly flowing oxygen gas.Serosal solution of 1 ml were taken every 15 minutes and then diluted with 2 ml of Ba (OH) 2 and 2 ml of ZnSO4 then centrifuge until 25 minute. The absorbant of supernatant was measured by UV spectrophotometer and data analyse wascalculated by one-way ANAVA. PVP at 1%,2% and 3% increased piroxicamabsorption from the phosphate buffer pH 7.5 compared with negative control.According to P app , the values were 2.52 ± 0.43 cm/minute (negative control), 3.41 ± 2.17 cm/minute (1% PVP), 2.75± 1.14 cm/minute (2% PVP) and 4.77 ± 4.93 cm/minute (3% PVP) respectively. In conclusion. Lower doses of the surfactant (1%, 2%, and 3% PVP) significantly increased absorption of the drug by altering the membrane permeability.

Menjaga Kualitas Jamu Kunyit Asam Segar Industri Rumah Tangga X Yogyakarta dengan Penyimpanan Suhu yang Tepat Berdasarkan Kadar Kurkuminoid Dian Eka Ermawati; Villian Septiana; Wisnu Kundarto; Anif Nur Artanti; Sholichah Rohmani; Heru Sasongko
Jurnal Pengabdian Pada Masyarakat Vol 6 No 2 (2021)
Publisher : Universitas Mathla'ul Anwar Banten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30653/002.202162.617

IMPROVING THE QUALITY OF FRESH ACID TURMERIC JAMU OF HOME INDUSTRY X AT THE RIGHT TEMPERATURE STORAGE BASED ON CURCUMINOID CONCENTRATION. Tamarind turmeric herbal medicine contains about 10% curcuminoids, consisting of: 1-5% curcumin, demectosicurcumin and bisdemethoxy-curcumin. Curcuminoids are a group of phenolic compounds as antibacterial, anticholesterol and antioxidants. Home Industry (IRT) X in Yogyakarta produces fresh turmeric and sour herbal medicine and is sold via delivery via an online application. Handling and storage at inappropriate temperatures can affect curcuminoid levels in herbal medicine, so it is necessary to do research on curcuminoid levels at various temperatures to provide information on IRT X in particular and herbal medicine manufacturers in general. Samples of herbal turmeric acid IRT X Yogyakarta stored at room temperature (25±2°C), refrigerator temperature (4±2°C), and freezer temperature (-10±2°C), analyzed the levels of curcuminoids on variations in storage temperature manually. quantitative method with UV-Vis Spectrophotometry. The analysis begins with the manufacture of standard curves and assays which are replicated three times. The results showed that curcuminoid levels were affected by storage temperature. Samples of herbal turmeric acid IRT X Yogyakarta which were analyzed by UV-Vis spectrophotometry method obtained a standard curve of y = 0.009x + 0.025 with a value of r = 0.997. The results of curcuminoid levels at room temperature were 4.74±0.13; refrigerator temperature 4.85±0.22; and freezer temperature 5.18±0.22. The optimum temperature in the handling and storage of the tamarind turmeric herbal medicine is at low temperatures, namely the refrigerator temperature and freezer temperature to maintain the curcuminoid content in the herbal medicine.

Sosialisasi Swamedikasi Tanaman Obat Keluarga (TOGA) dan Potensi Lingkungan Masyarakat di Desa Borongan Nindita Clourisa Amaris Susanto; Anif Nur Artanti; Dian Eka Ermawati
Madaniya Vol. 3 No. 3 (2022)
Publisher : Pusat Studi Bahasa dan Publikasi Ilmiah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53696/27214834.244

Desa Borongan merupakan salah satu desa yang terdapat di Kabupaten Boyolali. Desa tersebut mempunyai penduduk dengan perkarangan yang luas, daerah subur dan belum dimanfaatkan. Oleh karena itu, Desa Borongan ini mempunyai potensi dari segi lingkungan dan masyarakatnya untuk menjadi desa TOGA yang dapat dimanfaatkan sebagai obat mandiri keluarga atau dikembangkan menjadi produk yang bernilai ekonomis. Masyarakat masih belum menyadari khasiat TOGA terutama sebagai salah satu upaya swamedikasi dan menjaga imun tubuh terlebih di masa pandemi. Tujuan dari kegiatan ini adalah untuk memberikan pengetahuan kepada masyarakat agar tergerak untuk memanfaatkan lahan di rumah menjadi apotek hidup melalui penanaman TOGA dan pemanfaatanTOGA sebagai swamedikasi. Metode yang digunakan dalam kegiatan ini dimulai dengan sosialisasi pemberian materi, evaluasi dan pendampingan. Hasi dari kegiatan ini masyarakat lebih mengetahui manfaat TOGA sebagai swamedikasi dan dapat tergerak untuk menjadi desa TOGA yang dapat memberikan nilai ekonomis seperti menghasilkan produk dari TOGA.

Pelatihan Pemanfaatan Minyak Atsiri sebagai Bahan Aktif Balsam Aromaterapi kepada Warga Kelurahan Mojosongo M Fiqri Zulpadly; Dian Eka Ermawati; Heru Sasongko; Anif Nur Artanti; Sholichah Rohmani; Wisnu Kundarto; Diyah Tri Utami
Bubungan Tinggi: Jurnal Pengabdian Masyarakat Vol 4, No 4 (2022)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/btjpm.v4i4.6684

Pandemi Covid-19 yang melanda hampir seluruh negara di dunia khususnya di Indonesia membuat banyak masyarakat cemas, stres, dan frustasi akibat ketidakpastian dari berbagai aspek kehidupan. Stres pada umumnya merupakan kondisi normal dan tidak menimbulkan masalah pada kesehatan. Balsam aromaterapi dengan bahan utama dari minyak atsiri dapat digunakan sebagai alternatif untuk dapat merelaksasikan tubuh serta berperan dalam pengaturan emosional. Pengabdian kepada masyarakat ini adalah transfer pengetahuan dan pendampingan pelatihan pembuatan balsam aromaterapi. Kegiatan yang dilakukan mencakup pemberian informasi terkait pembuatan balsam yang dilanjutkan dengan demo pelatihan pembuatan balsam aromaterapi. Kegiatan pengabdian yang dilaksanakan pada tanggal 25 Oktober 2022 menghasilkan sebuah produk balsam aromaterapi hasil karya tangan para warga yang turut hadir yang didampingi oleh tim dari D3 Farmasi UNS. Kegiatan ini telah mencapai sasaran yang diinginkan yaitu kemampuan warga Kelurahan Mojosongo dalam membuat suatu produk skala kecil menengah namun memiliki nilai yang tinggi baik dari aspek guna maupun finansial. Kegiatan pendampingan ini merupakan langkah awal dalam membentuk kemandirian masyarakat setempat untuk memproduksi balsam aromaterapi secara mandiri ataupun kelompok yang berada dalam lingkup UMKM.The Covid-19 pandemic that hit almost all countries, especially in Indonesia, made many people anxious, stressed, and frustrated due to the uncertainty of various aspects of life. Stress is generally a normal condition and does not cause health problems. Aromatherapy balms with the main ingredients of essential oils can be used as an alternative to relax the body and play a role in emotional regulation. This community service is the transfer of knowledge and assistance in training on making aromatherapy balm. The activities included providing information on making balm, followed by a training demonstration on aromatherapy balm. The service activity, carried out on October 25, 2022, resulted in an aromatherapy balm product that was handmade by the present residents, accompanied by a team from UNS Pharmacy D3. This activity has achieved the desired target, namely the ability of the residents of Mojosongo Village to make a small-medium-scale product that has a high value both in terms of use and finances. This mentoring activity is the first step in establishing the independence of the local community to produce aromatherapy balm independently or in groups within the scope of Micro Small and Medium Enterprises (MSME).

Transformasi Penjualan Digital Produk Jamu dan Obat Tradisional pada UKM Jamu di Kabupaten Sukoharjo Anif Nur Artanti; Fea Prihapsara; Esti Suryani; Muhammad Hatta Rahmatul Kholiq; Okid Parama Astirin; Endang Siti Rahayu
Aksiologiya: Jurnal Pengabdian Kepada Masyarakat Vol 7 No 1 (2023): Februari
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/aks.v7i1.9033

Dampak pandemi COVID-19 telah menurunkan pendapatan beberapa industri jamu di Kabupaten Sukoharjo. Industri jamu terkendala dalam proses produksi dan penjualan produknya. Cara pemasaran berubah, terutama saat diberlakukan pembatasan kegiatan masyarakat darurat (PPKM Darurat). Salah satu cara alternatif untuk meningkatkan kapasitas penjualan adalah melalui pemasaran digital online yang berfokus pada pemasaran digital melalui website yang digunakan sebagai e-commerce, media sosial, mesin pencari, dan membentuk tim reseller untuk menjual produknya. Di masa pandemi, industri jamu harus cepat beradaptasi seiring dengan PPKM Darurat, karena hal ini akan mengubah tren perilaku konsumen dalam membeli produk jamu. Salah satu industri jamu yang menjadi mitra proyek ini adalah Usaha Kecil Menengah (UKM) Ching Lung. Melalui transformasi digital ini dapat menjadi solusi atas permasalahan yang dihadapi oleh UKM Ching Lung saat ini. Selain itu, dengan meningkatkan kreativitas model penjualan produk, UKM dapat bertahan dengan melakukan diversifikasi produk yang sesuai dengan kebutuhan di masa pandemi COVID-19. Bekerjasama dengan UKM Jamu Ching Lung, dibuatlah website online yang dirancang dengan konsep toko online untuk meningkatkan penjualan jamu dan obat tradisional di Kabupaten Sukoharjo. Melalui kegiatan ini diharapkan dapat membantu UKM untuk memasarkan produknya agar dapat dikenal oleh masyarakat luas.

Co-Authors Anggraini Febriyanty Darojati, Ulfa Afrinurfadhilah Daswati Rofiatun Sahifah Diyah Tri Utami Dyah Ayu Ambarwati Endang Siti Rahayu Endang Siti Rahayu ERMAWATI, DIAN EKA Esti Suryani Esti Suryani Fea Prihapsara Fea Prihapsara Fea Prihapsara Fea Prihapsara, Fea Heru Sasongko Heru Sasongko Heru Sasongko M Fiqri Zulpadly Meitasari, Annisa Diyan Mimiek Murrukmihadi Muhammad Fiqri Zulpadly Muhammad Hatta Rahmatul Kholiq Niken Rosyana Dewi Septini Nindita Clourisa Amaris Susanto Okid Parama Astirin Okid Parama Astirin Okid Parama Astirin Prihapsara, Fea Rahmatul Kholiq, Muhammad Hatta Sholichah Rohmani Sholichah Rohmani, Sholichah Susanto, Nindita Clourisa Amaris untari, meta kartika Utami, Diyah Tri Villian Septiana Wisnu Kundarto Wisnu Kundarto Wisnu Kundarto Zulpadly, M. Fiqri

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