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INDONESIA
EKSAKTA: Journal of Sciences and Data Analysis
Published by Universitas Islam Indonesia
ISSN : 27160459     EISSN : 27209326     DOI : 10.20885
Core Subject : Science, Engineering,
Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Materials Science & Nanotechnology
Ekstakta is an interdisciplinary journal with the scope of mathematics and natural sciences that is published by Fakultas MIPA Universitas Islam Indonesia. All submitted papers should describe original, innovatory research, and modelling research indicating their basic idea for potential applications. The Journal particularly welcomes submissions that focus on the progress in the field of mathematics, statistics, chemistry, physics, biology and pharmaceutical sciences.
Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)
Articles 15 Documents
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Search results for , issue "VOLUME 1, ISSUE 1, February 2020" : 15 Documents clear
Identification and Heme Polymerization Inhibition Activity (HPIA) Assay of Ethanolic Extract and Fraction of Temu Mangga (Curcuma mangga Val.) Rhizome Dhina Fitriastuti; Tatang Shabur Julianto; Annisa Wahyu Nur Iman
EKSAKTA: Journal of Sciences and Data Analysis VOLUME 1, ISSUE 1, February 2020
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/EKSAKTA.vol1.iss1.art10

Abstract

Curcuma mangga Val. is one of Indonesian herbs from Zingiberaceae family that is under explored and could contain potentially active substances to serve as an antimalarial. This research intends not only to examine the antimalarial activity by means of heme polymerization inhibitor mechanism by using the ethanolic extract and fraction of Curcuma mangga Val. but also to identify its compound classification. The extract of temu manga was obtained by Soxhlet extraction method using ethanol solvent followed by fractionation using Vacuum Liquid Chromatography with solvent sequence n-hexane, n-hexane: ethyl acetate (2:1), ethyl acetate and ethanol. The extract and fraction were analyzed by using LC-MS and GC-MS. Activities of hem polymerization inhibition showed by IC50 values which were obtained from analysis of relationship between concentration sample and the percentage of inhibition using the PROBIT on statistical software. The result of HPIA assay shows that the IC50 value of ethanolic extract and ethanolic fraction of Curcuma mangga Val. rhizome are 2.273 and 1.479 mg/mL, respectively. It clearly shows that the heme polymerization inhibition activity of ethanolic fraction relatively better than that of ethanolic extract. Phytochemical screening determines the ethanolic extract contains saponin, terpenoid, and phenol while the ethanolic fraction contains terpenoid. Thus, terpenoid compound is presumed to be the inhibitor of heme polymerization. The results of analysis with LC-MS and GC-MS showed that the active compounds suspected to inhibit heme polymerization in ethanolic extract and fraction were (E) -labda-8 (17), 12-dien-15,16-dial and di-n-octyl phthalate, respectively. Keywords: antimalarial, Curcuma mangga Val., heme polymerization
Adsorption Study of Methylene Blue and Methyl Orange Using Green Shell (Perna Viridis) Febi Indah Fajarwati; Nadya Ika Yandini; Mai Anugrahwati; Amri Setyawati
EKSAKTA: Journal of Sciences and Data Analysis VOLUME 1, ISSUE 1, February 2020
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/EKSAKTA.vol1.iss1.art14

Abstract

Green shell is generally disposed of and become environmental contaminants. In this study, the green shell was used as material to adsorb dyes residue: methylene blue and methyl oranges. Green shell waste from seafood was prepared by removing the dirt then dried at room temperature. It was followed by roughly crushing before being placed in the furnace at temperatures of 300, 500, 700 and 900 °C. The selected adsorbents were sieved at 200 mesh. The adsorbents were characterized by FTIR and SEM-EDX to evaluate their functional groups and morphology. Furthermore, the adsorption process was evaluated by determining the kinetic adsorption models. The results of the FTIR characterization showed the vibration of Ca(OH)2 bone at a wave number of 3400 cm-1 and morphological analysis by SEM showed a homogeneous surface. Adsorption kinetics results obtained from the variation of time with the initial adsorbate concentration showed the kinetic model of both methylene blue and methyl orange adsorption onto the adsorbent followed a pseudo-second order.
In Vitro Tracing of Cytotoxic Compounds in Jarak Cina Stem Bark (Jatropha Multifida Linn.) Sista Werdyani; Annisa Fitria; Sari Rakhmawati
EKSAKTA: Journal of Sciences and Data Analysis VOLUME 1, ISSUE 1, February 2020
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/EKSAKTA.vol1.iss1.art2

Abstract

Cancer remains one of the diseases with increasing number of sufferers, but research on compounds that act as anti-cancer is also ongoing. Terpenoids have been known as a compound that can inhibit the proliferation of cancer cells. One of the medical plants that produce terpenoids is Jarak cina (Jatropha multifida Linn.). Therefore, the possibility of Jarak cina (Jatropha multifida Linn.) to have an cytotoxic activity on cancer cell proliferation is reasonably high. This study was conducted to determine the cytotoxic activity of Jarak cina (Jatropha multifida Linn.) bark extracts against cancer cell MCF-7. Jarak cina bark was extracted using the multilevel soxhlet extraction method with n-hexane, ethyl acetate, and ethanol as the solvents. All the three extracts were then tested against MCF-7 cancer cells using MTT (3-(4,5-dimethylthiazol-2-yl) - 2,5-diphenyltetrazolium bromide) method. Data analysis was performed for IC50 (ppm) parameter. The results showed that the IC50 of n-hexane extract was 313.21 ppm, while the ethyl acetate extract reached 258.38 ppm of IC50, and the IC50 of ethanol extract was 418.51 ppm. The highest potential of cytotoxicity was found in the ethyl acetate extract, so further testing would be required to optimize the proliferation inhibitory activity.
Identification of the Existence and Type of Microplastic in Code River Fish, Special Region of Yogyakarta Elita Nurfitriyani Sulistyo; Suphia Rahmawati; Rizqia Amalia Putri; Nolanda Arya; Yolanda Amertha Eryan
EKSAKTA: Journal of Sciences and Data Analysis VOLUME 1, ISSUE 1, February 2020
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/EKSAKTA.vol1.iss1.art13

Abstract

Microplastics are plastic fragments with size less than 5mm in length, according to the U.S. National Oceanic and Atmospheric Administration (NOAA). Microplastics occur and spread in the environment as a result of plastic pollution. Although further assessment is needed to find the health impact of microplastic exposure to humans, several studies show that microplastic might harm the ocean and aquatic life. Code river is one of the big rivers in Yogyakarta. According to the Regional Environmental Agency of Yogyakarta, Code river was highly polluted by domestic waste and wastewater from the settlement along the river and its tributaries. Therefore, the objectives of this research are to investigate the abundance and characteristic of microplastics in fish from Code River Yogyakarta. Fish samples were collected from the fisherman in the upstream, middle, and downstream areas of Code River from February to May 2019. In the laboratory, the samples were analyzed using Wet Peroxide Oxidation (WPO) method. Fish gills and intestine were oxidized using WPO method followed by density separation for 24 hours. Nikon SMZ445 Stereoscopic Microscope with 35x magnification was used to analyze the shape, color, and total of microplastics. The highest abundance was found in fish samples collected from the upstream area (4.33 particles/gram) compare with the downstream area (3.25 particles/gram). The dominant color is blue, while the dominant type of microplastics is fiber.
Preface and Table of Content Preface and Table of Content EKSAKTA
EKSAKTA: Journal of Sciences and Data Analysis VOLUME 1, ISSUE 1, February 2020
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Preface and Table of Content

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