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INDONESIA
Indonesian Journal of Urology
Published by Universitas Airlangga
ISSN : 0853442X     EISSN : 23551402     DOI : 10.32421
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
The aim of Indonesian Journal of Urology is to encompass the whole spectrum of urology. The journal publishes papers on a wide range of urological issues such as oncology, functional urology, reconstructive urology, laparoscopy, robotic surgery, endourology, female urology, andrology, pediatric urology, and sexual medicine. We welcome authors for original article (research), review article, interesting case reports, special article, clinical practices, and medical illustrations that focus on the clinical area of urology.
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Articles 5 Documents
 1 
Search results for , issue "Vol 17 No 1 (2010)" : 5 Documents clear
INTRATESTICULAR INJECTION OF 20% HYPERTONIC SODIUM CHLORIDE AS A NOVEL CASTRATION METHOD: A PRECLINICAL STUDY Hendry, Marta; Hardjowijoto, Sunaryo; Purnomo, Basuki B; Joewarini, Endang; Meles, Dewa Ketut; P, Widodo J
Indonesian Journal of Urology Vol 17 No 1 (2010)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v17i1.339

Abstract

Objectives: To demonstrate that intratesticular injection of 20% hypertonic sodium chloride can result in permanent castration and to evaluate serum changes in sodium chloride levels. Materials and Methods: A total of 40 Wistar rats were divided into 4 groups, consisting of bilateral orchidectomy (n=10), control (n=10) and 2 groups receiving intratesticular injections of 20% sodium chloride (n=10 in each group). Serum testosterone was measured on day 0, day 1, day 15 and day 30. Serum sodium chloride was assessed before injection, at 1 hour and 24 hours after injection. All testicles were harvested for histological examination. One way ANOVA and student t-test were used for statistical analysis. Results: Serum testosterone decreased to castrate levels in the orchidectomy and injected groups with no significant difference (p>0,05). Significant rise in serum sodium chloride was found 1 hour post injection (p<0,05) but after 1 day it decreased significantly (p<0,05). There was no significant difference in histopathological findings between the 2 injected groups after day 15 and 30 (p>0,05). Conclusion: Twenty percent hypertonic chloride injection has the same permanent castration effect with bilateral orchidectomy in rats. The serum sodium chloride changes did not reach the lethal level for rats. Therefore this treatment has a promising potential as a novel and cost-effective castration method with the additional benefit of retaining both testes.
APOPTOSIS IN IPSILATERAL KIDNEY. COMPARISON BETWEEN GROUP RECEIVING VERAPAMIL AND CONTROL GROUP POST-ARTIFICAL TOTAL UNILATERAL URETERAL OBSTRUCTION Syahrir, Syakri; Soetojo, Soetojo; Santoso, Adi; Joewarini, Endang; P, Widodo J
Indonesian Journal of Urology Vol 17 No 1 (2010)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v17i1.340

Abstract

Objective: Obstruction of the urinary tract has marked effects on renal blood flow, glomerular filtration rate (GFR), and tubular function. Ureteral obstruction results in an injury response that can progress to irreversible renal fibrosis and tubular damage by apoptosis. Materials and Methods: Forty five rabbits aged 13-17 weeks with body weights of 1250-1750 grams were divided into 4 groups. Group 1 underwent a sham operation and group 2 had unilateral ureteral ligation to cause total obstruction. Groups 3 and 4 also underwent unilateral ureteral ligation but with verapamil given on day 0 and day 7 respectively. Apoptosis to the renal tubules were assessed after nephrectomy on day 14 using immunohistochemistry by counting the number cell deaths/high power field (hpf). Results: The groups that received verapamil showed significantly less apoptosis compared to those without verapamil (2,73 vs 12,46 cell deaths/hpf; p<0,05). However, there was no significant difference between groups 3 and 4 (2,73 vs 2,89 cell deaths/hpf; p>0,05), although both groups still showed more cell deaths compared to group 1 (0,38 cell deaths/hpf). Conclusion: Verapamil appears to significantly decrease apoptosis during total unilateral ureteral obstruction. However, it cannot replace the benefit of relieving total obstruction
EVALUATION OF PROSTATE BASAL CELL BY CYTOKERATIN 903 STAINING IN PROSTATIC ADENOCARCINOMA GLEASON SCORE 6 Nasution, Ramlan; Sugandi, Suwandi; Sihombing, Aaron Tigor; Yantisetiasti, Anglita; Hernowo, Betthy S
Indonesian Journal of Urology Vol 17 No 1 (2010)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v17i1.341

Abstract

Objective: To evaluate the role of prostate basal cell staining in diagnosing Gleason score 6 prostate cancer. Materials & Methods: During research period, we collected 20 medical records and paraffin block specimens of Gleason score 6 prostatic adenocarcinoma patients. Specimens were taken from prostate needle biopsy. Demographic data and PSA level were extracted from medical records. Basal cells were detected by immunohistochemical staining for antikeratin 34β-E12 on paraffin block specimens analyzed by an experienced pathologist. Positive results suggest a benign lesion. Results: Mean age is 70 ± 6,5 years. Mean prostate volume and PSA level was 52±17cc and 25±21 ng/ml. Three specimens (15%) showed presence of basal cells on antikeratin 34β-E12 staining, which indicated benign lesions. Leucocyturia was found in all patients of this group. There was a significant association between PSA level and antikeratin 34β-E12 staining (p=0,03). In multivariate analysis, there is no significant association between antikeratin 34β-E12 staining with age, prostate volume, and leucocyturia. Conclusions: 15 % cases of prostatic cancer Gleason score 6 still showed basal cell existence. Immunohistochemical staining of basal cell should be considered in suspicious cases of prostatic cancer. 
COMPARISON OF EPITHELIAL CELL COUNTS BETWEEN MIDDLE AND LATERAL LOBES IN BENIGN PROSTATIC HYPERPLASIA (BPH) PATIENT Rahman, Eka Yudha; Singodimedjo, Prawito
Indonesian Journal of Urology Vol 17 No 1 (2010)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v17i1.342

Abstract

Objective: The aim of this study was to compare the epithelial cell counts in each lobe of prostate glands with benign prostatic hyperplasia (BPH). Material and methods: Twenty-two BPH patients who underwent transurethral resection of the prostate (TURP) in Diponegoro Dua Satu Surgery Hospital Klaten, from May until November 2006 were enrolled in this study. Tissue from each lobe of the prostate gland was separately collected, from the middle (A), left lateral (B), right lateral lobes (C). All samples were fixed in 10% formalin buffer, embedded in paraffin and sectioned in 4 micrometer slices with microtome. After hematoxylin eosin (HE) staining, number of epithelial cells was counted under light microscopy. Difference in epithelial cell counts in each alveolus between the three lobes was statistically analyzed using t-test (p<0,05). Results: Twenty-two patients were included in this study from May to November 2006, mean age was 66,64±7,6 (54-88) years old. The most common occupation was farmer. Almost all patients had symptoms of chronic urinary retention (95,45%). Length of hospital stay was 8,77±2,7 (6-17) days, mean weight of prostate resected was 47,05±23,2 (5-90) grams, mean operative time 77,73±22,24 (45-115) minute, mean volume of irrigation fluid (sterile water) was 24,18±7,87 (5-34) liter. Mean number of cells in groups A, B, and C were 23,67±8,4 (13,6-44,4), 29,22±8,8 (16,4-41,2), and 29,11±8,7 (16,4-41,2) respectively. There was significant difference between groups A and B, and between groups A and C (p<0,05) respectively. Conclusion: There was statistically significant difference in epithelial cell count between the middle lobes compared to lateral lobes of the prostate in BPH surgical samples. These findings are supported by cystoscopic observation of smaller middle lobe compared to the lateral lobes in BPH.
EFFICACY OF DICLOFENAC COMPARED TO PLACEBO IN PAIN RELIEF DURING REMOVAL OF URETHRAL CATHETER Maulana, Akhada; Danarto, H R
Indonesian Journal of Urology Vol 17 No 1 (2010)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v17i1.343

Abstract

Objective: To investigate efficacy of diclofenac compared to placebo in relieving pain on removal of indwelling urethral catheters. Materials and methods: This study was a randomized controlled trial, double blind, comparing diclofenac with placebo in relieving pain on removal of indwelling urethral catheters. Adult male patients with indwelling catheters admitted in surgical ward of RSUP Dr. Sardjito Yogyakarta who met the inclusion criteria were recruited. The independent variables were diclofenac or placebo treatment, while the dependent variables were visual analogue scale (VAS) score, and the external variables were age, education level, and duration of indwelling urethral catheter. We gave patients diclofenac or placebo in capsules 2 hours before urethral catheter removal. Immediately after removal by assistant, the patient filled VAS form. We used Chi-square test, independent T-test, and bivariate analysis with SPSS program version 11.5, with p<0,05 was set as statistically significant level. Results: Thirty patients met inclusion criteria. Mean VAS score of both groups was 33,467 + 20,4577, diclofenac group was 31,567 + 20,0934, and placebo group was 35,367 + 21,3412. There was no statistically significant difference of VAS score between both groups (p=0,844). Conclusion: Efficacy of diclofenac and placebo in relieving pain when performing urethral catheter removal is not significantly different.

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