Articles
<![CDATA[Distribution of Cartilage Neoplasm based on Histopathological Types at Dr. Hasan Sadikin General Hospital Bandung Period 2008â2012 ]]>
<![CDATA[Anggraini, Desy]]>;
<![CDATA[Yantisetiasti, Anglita]]>;
<![CDATA[Ismono, Darmadji]]>
<![CDATA[ Althea Medical Journal Vol 2, No 4 (2015) ]]>
Publisher : <![CDATA[Althea Medical Journal ]]>
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<![CDATA[Background: Cartilage neoplasms are less common compared to other neoplasms. Its incidence is 22% among all the musculoskeletal neoplasms. Despite many other studies about patient characteristics of theneoplasm in other regions, descriptive data in Bandung city is still unknown. The objective of this study is to determine the distribution of both benign and malignant neoplasms based on their characteristics of histopathological type, gender, age and anatomical site.Methods: The subjects of this descriptive study were taken from the medical records of the patients who had been examined histopathologically in Anatomical Pathology Department at Dr. Hasan Sadikin General Hospital Bandung, Indonesia within the period of 2008 to2012. The sample was obtained using total sampling technique. Patients diagnosed with cartilage neoplasms were included whereas incomplete medical records were excluded. Histopathological type, gender, age and anatomical site of each patients were collected and analyzed.Results: Seventy cartilage neoplasm cases were found. The distribution of cases comprised of 48 (67%) benign and 23 (33%) malignant. The most common benign neoplasm was osteochondroma and chondroma. Benign neoplasms were more prevalent among men and patients <30 years old, while malignant neoplasm was prevalent among women and patients >60 years old. Femur was the most common site for all neoplasms except for chondroma.Conclusions: PThere are differences in characteristic of benign and malignant cartilage neoplasm patients. Both benign and malignant cartilage neoplasms showed differences on the distribution of patient characteristics. [AMJ.2015;2(4):561â7] DOI: 10.15850/amj.v2n4.641]]>
<![CDATA[Epidemiology of Giant Cell Tumor in Dr. Hasan Sadikin General Hospital Bandung from 2010-2013 ]]>
<![CDATA[Gunasegaran, Kirtana]]>;
<![CDATA[Irawan, M.Naseh Sajadi Budi]]>;
<![CDATA[Yantisetiasti, Anglita]]>
<![CDATA[ Althea Medical Journal Vol 3, No 2 (2016) ]]>
Publisher : <![CDATA[Althea Medical Journal ]]>
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<![CDATA[Background: Giant cell tumor (GCT) of bone is a primary bone tumor. It is commonly seen in South East Asia and found in female around 20â45 years old. The GCT mostly occurs in epiphysis around the knee. The patients normally suffer from pain, swelling, limitation of joint movement, and pathologic fracture. This study aimed to determine the epidemiology of GCT of the bone based on age, sex, location, type, metastases, and recurrence in Dr. Hasan Sadikin General Hospital Bandung.Methods: A descriptive study with retrospective cohort using total sampling method was used to obtain 33 medical records of patients with GCT of bone in Department of Orthopedic & Traumatology and Anatomical Pathology Dr. Hasan Sadikin General Hospital Bandung in the period of January 2010âDecember 2013.Results: The GCT of bone was mostly found in female of 20 to 29 years old and around 32 years old in male. Distal femur will be the most common site while zygoma, mandibular vertebrae, proximal tibia were rare sites. Twenty nine cases were benign lesion and the rest (4 cases) were malignant. The probability of GCT of bone to metastasize to lungs was very low. Four recurrences occurred within a year.Conclusions: The GCT of bone in male mostly occurs in the third and fourth decade of age. It is found around the knee, mostly benign, rarely metastasize to the lungs and recurrence happens within a year. [AMJ.2016;3(2):244â7]Â DOI:Â 10.15850/amj.v3n2.477]]>
<![CDATA[DISTRIBUTION OF GLEASON SCO¬RE IN PROSTATE ZONES AMONG PROSTATIC CANCER PATIENTS ]]>
<![CDATA[Jaya, Indra]]>;
<![CDATA[Sugandi, Suwandi]]>;
<![CDATA[Yantisetiasti, Anglita]]>;
<![CDATA[Hernowo, Betthy S. S.]]>
<![CDATA[ Indonesian Journal of Urology Vol 19 No 1 (2012) ]]>
Publisher : <![CDATA[Indonesian Urological Association ]]>
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DOI: 10.32421/juri.v19i1.50
<![CDATA[Objective: To analyze the distribution features of Gleason score in the different prostate zones. Material & Method: Twenty paraffin block specimens of radical prostatectomy were analyzed looking for Gleason score distribution in each zone. Specimens were stained with Hematoxilin Eosin. Results: Among the 20 cancers, 16 (80%) specimens had more than one focus. Most foci were found in peripheral zone (95%), only one specimen contained foci solely found in transitional zone. More than half (55%) prostate specimens contain three different Gleason grades. Only one specimen contained a single grade. Conclusion: Our results confirm the heterogeneous, multifocal, and multizonal nature of prostate carcinomas. Most specimens had more than one tumor focus, with predominant location in the peripheral zone. Almost all transition zone foci were found concomitantly with peripheral zone foci. Keywords: Prostate cancer, prostate zones, Gleason score.]]>
<![CDATA[THE EFFECT OF PREDNISONE ON SERTOLI CELL OF CONTRALATERAL TESTICULAR TORSION ]]>
<![CDATA[Tanuwidjaja, Dandy]]>;
<![CDATA[Sugandi, Suwandi]]>;
<![CDATA[Sihombing, Aaron Tigor Tigor]]>;
<![CDATA[Yantisetiasti, Anglita]]>;
<![CDATA[Hernowo, Betthy S.]]>
<![CDATA[ Indonesian Journal of Urology Vol 19 No 2 (2012) ]]>
Publisher : <![CDATA[Indonesian Urological Association ]]>
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DOI: 10.32421/juri.v19i2.58
<![CDATA[Objective: To evaluate the effect of prednisone in unilateral testicular torsion on Sertoli cell quality of contralateral testis. Material & Method: Thirty Wistar rats were divided into three groups i.e. group A (sham procedure), group B (unilateral torsion + orchiectomy after 6 hours), and group C (unilateral torsion + orchiectomy after 24 hours). Group B and C were further divided into subgroup with and without Prednisone administration. Prednisone was given orally once a day an hour after torsion, continued till one month later. Orchiectomy of contralateral testis was performed one month later. Those testes were examined by a pathologist. Results: In group A, no abnormality on Sertoli cell quality was found. There is significant difference among groups in Sertoli cell quality (p = 0,01). Ischemic time is associated with Sertoli cell quality (2 rats with severe damage in group C and none in group B). In group B and C, prednisone administration inhibited Sertoli cell damage. Prednisone administration in 6 hours group gave better results than 24 hours group (3 rats vs 1 rat with good Sertoli cell quality). Conclusion: Sertoli cell in contralateral testis is significantly affected by unilateral testicular torsion. Prednisone inhibit Sertoli cells damage. Ischemic time affected Sertoli cell quality of contralateral testis and respond to prednisone.Keywords: Prednisone, unilateral testicular torsion, sertoli cell.]]>
<![CDATA[EVALUATION OF PROSTATE BASAL CELL BY CYTOKERATIN 903 STAINING IN PROSTATIC ADENOCARCINOMA GLEASON SCORE 6 ]]>
<![CDATA[Nasution, Ramlan]]>;
<![CDATA[Sugandi, Suwandi]]>;
<![CDATA[Sihombing, Aaron Tigor]]>;
<![CDATA[Yantisetiasti, Anglita]]>;
<![CDATA[Hernowo, Betthy S]]>
<![CDATA[ Indonesian Journal of Urology Vol 17 No 1 (2010) ]]>
Publisher : <![CDATA[Indonesian Urological Association ]]>
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DOI: 10.32421/juri.v17i1.341
<![CDATA[Objective: To evaluate the role of prostate basal cell staining in diagnosing Gleason score 6 prostate cancer. Materials & Methods: During research period, we collected 20 medical records and paraffin block specimens of Gleason score 6 prostatic adenocarcinoma patients. Specimens were taken from prostate needle biopsy. Demographic data and PSA level were extracted from medical records. Basal cells were detected by immunohistochemical staining for antikeratin 34β-E12 on paraffin block specimens analyzed by an experienced pathologist. Positive results suggest a benign lesion. Results: Mean age is 70 ± 6,5 years. Mean prostate volume and PSA level was 52±17cc and 25±21 ng/ml. Three specimens (15%) showed presence of basal cells on antikeratin 34β-E12 staining, which indicated benign lesions. Leucocyturia was found in all patients of this group. There was a significant association between PSA level and antikeratin 34β-E12 staining (p=0,03). In multivariate analysis, there is no significant association between antikeratin 34β-E12 staining with age, prostate volume, and leucocyturia. Conclusions: 15 % cases of prostatic cancer Gleason score 6 still showed basal cell existence. Immunohistochemical staining of basal cell should be considered in suspicious cases of prostatic cancer. ]]>
<![CDATA[Analisis Gambaran Histopatologi Gastritis Kronik dengan dan Tanpa Bakteri Helicobacter pylori Menurut Sistem Sydney ]]>
<![CDATA[Deassy Ariefiany]]>;
<![CDATA[Abdul Hadi Hassan]]>;
<![CDATA[Birgitta M Dewayani]]>;
<![CDATA[Anglita Yantisetiasti]]>
<![CDATA[ Majalah Patologi Indonesia Vol 23 No 2 (2014): MPI ]]>
Publisher : <![CDATA[Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI) ]]>
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<![CDATA[Background Histopathology definition of chronic gastritis is a chronic inflammation of the gastric mucosa that can cause glandular atrophy and intestinal metaplasia of the gastric mucosal epithelium. Chronic gastritis can be caused by many factors. The most common etiology chronic gastritis by the bacterium Helicobacter pylori (Hp). The incidence chronic gastritis causes of Hp is more common in developing country than developed country. Histopathological picture on chronic gastritis causes of Hp similar with chronic gastritis non-Hp. The aims of this study to determine the difference of histopathological picture between chronic gastritis with Hp and chronic gastritis without Hp bacteria in the Hospital Dr Hasan Sadikin Bandung. Methods The sample used in this study were 30 cases of chronic gastritis with Helicobacter pylori (Hp) and 30 cases of chronic gastritis non-Hp bacteria from the Pathology Department of the hospital Dr. Hasan Sadikin Bandung. The research start from May 1st until November 30th 2012. All sample cases histopathology is seen the image of the Sydney sistem classification, after that are staining with immunohistochemical with antibody monoclonal Hp was performed to confirm the presence of the Hp. Results Immunohistochemical staining result obtained from 42 cases of the bacteria Hp positive and 18 negative cases the bacteria Hp. Chronic inflammation in chronic gastritis with Hp with chronic gastritis without Hp bacteria are in category 3 (limfosit cell more than 20/10HPF) as much as 88,1% and 88,9%. Conclusion Histopathological picture of chronic gastritis with Hp bacteria did not differ with chronic gastritis without Hp bacteria. Key words: Chronic gastritis, Helicobacter pylori, Sydney system.]]>
<![CDATA[Hubungan antara HER-2/neu dan Ki-67 dengan Respons Kemo-terapi Neoadjuvan pada Karsinoma Payudara Lanjut Lokal ]]>
<![CDATA[I Made Jatiluhur]]>;
<![CDATA[Anglita Yantisetiasti]]>;
<![CDATA[Abdul Hadi Hassan]]>;
<![CDATA[Bethy S Hernowo]]>
<![CDATA[ Majalah Patologi Indonesia Vol 23 No 3 (2014): MPI ]]>
Publisher : <![CDATA[Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI) ]]>
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<![CDATA[Background Locally advanced breast cancer (LABC) were stage III breast carcinoma based on TNM system, with an incidence >50% of all breast cancers in developing countries , including Indonesia. The first treatment of LABC is neoadjuvant chemotherapy, most often in anthracycline base. The purpose of this study is to analyze the relationship between HER-2/neu and Ki-67 with anthracycline-based neoadjuvant chemotherapy responsse in LABC. Methods The study involved 52 LABC, each of 26 patients responsding and not responsding. Paraffin block from biopsy stained with HER-2/neu and Ki-67 immunohistochemistry. HER-2/neu expression interpreted as positive and negative, while Ki-67 were categorized as]]>
<![CDATA[Epidemiology of Giant Cell Tumor in Dr. Hasan Sadikin General Hospital Bandung from 2010-2013 ]]>
<![CDATA[Kirtana Gunasegaran]]>;
<![CDATA[M.Naseh Sajadi Budi Irawan]]>;
<![CDATA[Anglita Yantisetiasti]]>
<![CDATA[ Althea Medical Journal Vol 3, No 2 (2016) ]]>
Publisher : <![CDATA[Faculty of Medicine Universitas Padjadjaran ]]>
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<![CDATA[Background: Giant cell tumor (GCT) of bone is a primary bone tumor. It is commonly seen in South East Asia and found in female around 20–45 years old. The GCT mostly occurs in epiphysis around the knee. The patients normally suffer from pain, swelling, limitation of joint movement, and pathologic fracture. This study aimed to determine the epidemiology of GCT of the bone based on age, sex, location, type, metastases, and recurrence in Dr. Hasan Sadikin General Hospital Bandung.Methods: A descriptive study with retrospective cohort using total sampling method was used to obtain 33 medical records of patients with GCT of bone in Department of Orthopedic & Traumatology and Anatomical Pathology Dr. Hasan Sadikin General Hospital Bandung in the period of January 2010–December 2013.Results: The GCT of bone was mostly found in female of 20 to 29 years old and around 32 years old in male. Distal femur will be the most common site while zygoma, mandibular vertebrae, proximal tibia were rare sites. Twenty nine cases were benign lesion and the rest (4 cases) were malignant. The probability of GCT of bone to metastasize to lungs was very low. Four recurrences occurred within a year.Conclusions: The GCT of bone in male mostly occurs in the third and fourth decade of age. It is found around the knee, mostly benign, rarely metastasize to the lungs and recurrence happens within a year. [AMJ.2016;3(2):244–7] DOI: 10.15850/amj.v3n2.477]]>
<![CDATA[Distribution of Cartilage Neoplasm based on Histopathological Types at Dr. Hasan Sadikin General Hospital Bandung Period 2008–2012 ]]>
<![CDATA[Desy Anggraini]]>;
<![CDATA[Anglita Yantisetiasti]]>;
<![CDATA[Darmadji Ismono]]>
<![CDATA[ Althea Medical Journal Vol 2, No 4 (2015) ]]>
Publisher : <![CDATA[Faculty of Medicine Universitas Padjadjaran ]]>
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<![CDATA[Background: Cartilage neoplasms are less common compared to other neoplasms. Its incidence is 22% among all the musculoskeletal neoplasms. Despite many other studies about patient characteristics of theneoplasm in other regions, descriptive data in Bandung city is still unknown. The objective of this study is to determine the distribution of both benign and malignant neoplasms based on their characteristics of histopathological type, gender, age and anatomical site.Methods: The subjects of this descriptive study were taken from the medical records of the patients who had been examined histopathologically in Anatomical Pathology Department at Dr. Hasan Sadikin General Hospital Bandung, Indonesia within the period of 2008 to2012. The sample was obtained using total sampling technique. Patients diagnosed with cartilage neoplasms were included whereas incomplete medical records were excluded. Histopathological type, gender, age and anatomical site of each patients were collected and analyzed.Results: Seventy cartilage neoplasm cases were found. The distribution of cases comprised of 48 (67%) benign and 23 (33%) malignant. The most common benign neoplasm was osteochondroma and chondroma. Benign neoplasms were more prevalent among men and patients <30 years old, while malignant neoplasm was prevalent among women and patients >60 years old. Femur was the most common site for all neoplasms except for chondroma.Conclusions: PThere are differences in characteristic of benign and malignant cartilage neoplasm patients. Both benign and malignant cartilage neoplasms showed differences on the distribution of patient characteristics. [AMJ.2015;2(4):561–7] DOI: 10.15850/amj.v2n4.641]]>
<![CDATA[Hubungan Imunoekspresi Human Telomerase Reserve Transcriptase (hTERT) dan Vascular Endothelial Growth Factor (VEGF) dengan Gradasi Histopatologi Meningioma ]]>
<![CDATA[Betty Marlina]]>;
<![CDATA[Anglita Yantisetiasti]]>;
<![CDATA[Abdul Hadi Hassan]]>;
<![CDATA[Bethy S Hernowo]]>
<![CDATA[ JAMBI MEDICAL JOURNAL "Jurnal Kedokteran dan Kesehatan" Vol. 2 No. 1 (2014): JAMBI MEDICAL JOURNAL Jurnal Kedokteran dan Kesehatan ]]>
Publisher : <![CDATA[FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI ]]>
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DOI: 10.22437/jmj.v2i1.2695
<![CDATA[ABSTRACT Background: Meningioma is a tumor composed of cells of neoplastic meningothelial (arachnoidal) cells that a rise from the arachnoid membrane and the layer of the arachnoid villi associated with intradural venous sinuses and surrounding tissue. Meningiomas tumors is one of the central nervous system (CNS) the most commonly found (the second sequence) and generally grow slowly. Approximately 60-95% activity of telomerase (hTERT ) found on meningiomas and can induces VEGF . The aim of this study is to determine the role of hTERT and VEGF in meningiomas grading . Methods : This study is conducted using analytic observasional cross sectional method and had been analyzed with unpaired categorical analysis of the 60 cases of meningioma (46 cases grade I, 7 cases grade II, and7 cases grade III). The sample were obtained the archive of Anatomical Pathology Department, Faculty of Medicine, Padjadjaran University/Dr. Hasan Sadikin Hospital Result : The result of this study showed: 44 cases (96%) grade I meningiomas showed positive hTERT imunoexpression weak to strong, 2 cases(4%) non-reactive and VEGF imunoexpression showed strong positive 12 cases (26%), 24 cases(52%) were moderate positive and 10 cases (22%) weak positive. 7 cases (100%) grade II showed a strong positive hTERT imunoexpression and 5 cases (71%) showed a strong positive VEGF imunoexpression, 2 cases (29%) were moderate positive. 6 cases (86%) grade III showed strong positive hTERT imunoexpression, 1 case (14%) were moderate positive and 7 cases(100%) showed a strong positive VEGF imunoexpression. Statistical analysis revealed imunoexpression VEGF showed stronger positivity with p- value = 0.02 (< 0.05) compared to the hTERT imunoexpression with p-value = 0.73 (> 0.05). Conclusion : More affecting angiogenesis gradations meningiomas, seen by the presence of VEGF higher imunoexpression on higher gradations. hTERT Imunoexpression cannot determine of the meningiomas histopathological grading.]]>
