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All Journal Majalah Kedokteran Bandung Althea Medical Journal Indonesian Journal of Urology Indonesian Journal of Obstetrics & Gynecology Science Majalah Patologi Indonesia Eduvest - Journal of Universal Studies
Anglita Yantisetiasti
Department of Anatomical Pathology, Faculty of Medicine/Padjadjaran University, Hasan Sadikin Hospital, Bandung.
Aerospace Engineering Computer Science & IT Health Professions Medicine & Pharmacology Neuroscience Public Health Social Sciences

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Distribution of Cartilage Neoplasm based on Histopathological Types at Dr. Hasan Sadikin General Hospital Bandung Period 2008–2012 Anggraini, Desy; Yantisetiasti, Anglita; Ismono, Darmadji
Althea Medical Journal Vol 2, No 4 (2015)
Publisher : Althea Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (675.848 KB)

Abstract

Background: Cartilage neoplasms are less common compared to other neoplasms. Its incidence is 22% among all the musculoskeletal neoplasms. Despite many other studies about patient characteristics of theneoplasm in other regions, descriptive data in Bandung city is still unknown. The objective of this study is to determine the distribution of both benign and malignant neoplasms based on their characteristics of histopathological type, gender, age and anatomical site.Methods: The subjects of this descriptive study were taken from the medical records of the patients who had been examined histopathologically in Anatomical Pathology Department at Dr. Hasan Sadikin General Hospital Bandung, Indonesia within the period of 2008 to2012. The sample was obtained using total sampling technique. Patients diagnosed with cartilage neoplasms were included whereas incomplete medical records were excluded. Histopathological type, gender, age and anatomical site of each patients were collected and analyzed.Results: Seventy cartilage neoplasm cases were found. The distribution of cases comprised of 48 (67%) benign and 23 (33%) malignant. The most common benign neoplasm was osteochondroma and chondroma. Benign neoplasms were more prevalent among men and patients <30 years old, while malignant neoplasm was prevalent among women and patients >60 years old. Femur was the most common site for all neoplasms except for chondroma.Conclusions: PThere are differences in characteristic of benign and malignant cartilage neoplasm patients. Both benign and malignant cartilage neoplasms showed differences on the distribution of patient characteristics. [AMJ.2015;2(4):561–7] DOI: 10.15850/amj.v2n4.641
Epidemiology of Giant Cell Tumor in Dr. Hasan Sadikin General Hospital Bandung from 2010-2013 Gunasegaran, Kirtana; Irawan, M.Naseh Sajadi Budi; Yantisetiasti, Anglita
Althea Medical Journal Vol 3, No 2 (2016)
Publisher : Althea Medical Journal

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Abstract

Background: Giant cell tumor (GCT) of bone is a primary bone tumor. It is commonly seen in South East Asia and found in female around 20–45 years old. The GCT mostly occurs in epiphysis around the knee. The patients normally suffer from pain, swelling, limitation of joint movement, and pathologic fracture. This study aimed to determine the epidemiology of GCT of the bone based on age, sex, location, type, metastases, and recurrence in Dr. Hasan Sadikin General Hospital Bandung.Methods: A descriptive study with retrospective cohort using total sampling method was used to obtain 33 medical records of patients with GCT of bone in Department of Orthopedic & Traumatology and Anatomical Pathology Dr. Hasan Sadikin General Hospital Bandung in the period of January 2010–December 2013.Results: The GCT of bone was mostly found in female of 20 to 29 years old and around 32 years old in male. Distal femur will be the most common site while zygoma, mandibular vertebrae, proximal tibia were rare sites. Twenty nine cases were benign lesion and the rest (4 cases) were malignant. The probability of GCT of bone to metastasize to lungs was very low. Four recurrences occurred within a year.Conclusions: The GCT of bone in male mostly occurs in the third and fourth decade of age. It is found around the knee, mostly benign, rarely metastasize to the lungs and recurrence happens within a year. [AMJ.2016;3(2):244–7] DOI: 10.15850/amj.v3n2.477
DISTRIBUTION OF GLEASON SCO¬RE IN PROSTATE ZONES AMONG PROSTATIC CANCER PATIENTS Jaya, Indra; Sugandi, Suwandi; Yantisetiasti, Anglita; Hernowo, Betthy S. S.
Indonesian Journal of Urology Vol 19 No 1 (2012)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v19i1.50

Abstract

Objective: To analyze the distribution features of Gleason score in the different prostate zones. Material & Method: Twenty paraffin block specimens of radical prostatectomy were analyzed looking for Gleason score distribution in each zone. Specimens were stained with Hematoxilin Eosin. Results: Among the 20 cancers, 16 (80%) specimens had more than one focus. Most foci were found in peripheral zone (95%), only one specimen contained foci solely found in transitional zone. More than half (55%) prostate specimens contain three different Gleason grades. Only one specimen contained a single grade. Conclusion: Our results confirm the heterogeneous, multifocal, and multizonal nature of prostate carcinomas. Most specimens had more than one tumor focus, with predominant location in the peripheral zone. Almost all transition zone foci were found concomitantly with peripheral zone foci. Keywords: Prostate cancer, prostate zones, Gleason score.
THE EFFECT OF PREDNISONE ON SERTOLI CELL OF CONTRALATERAL TESTICULAR TORSION Tanuwidjaja, Dandy; Sugandi, Suwandi; Sihombing, Aaron Tigor Tigor; Yantisetiasti, Anglita; Hernowo, Betthy S.
Indonesian Journal of Urology Vol 19 No 2 (2012)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v19i2.58

Abstract

Objective: To evaluate the effect of prednisone in unilateral testicular torsion on Sertoli cell quality of contralateral testis. Material & Method: Thirty Wistar rats were divided into three groups i.e. group A (sham procedure), group B (unilateral torsion + orchiectomy after 6 hours), and group C (unilateral torsion + orchiectomy after 24 hours). Group B and C were further divided into subgroup with and without Prednisone administration. Prednisone was given orally once a day an hour after torsion, continued till one month later. Orchiectomy of contralateral testis was performed one month later. Those testes were examined by a pathologist. Results: In group A, no abnormality on Sertoli cell quality was found. There is significant difference among groups in Sertoli cell quality (p = 0,01). Ischemic time is associated with Sertoli cell quality (2 rats with severe damage in group C and none in group B). In group B and C, prednisone administration inhibited Sertoli cell damage. Prednisone administration in 6 hours group gave better results than 24 hours group (3 rats vs 1 rat with good Sertoli cell quality). Conclusion: Sertoli cell in contralateral testis is significantly affected by unilateral testicular torsion. Prednisone inhibit Sertoli cells damage. Ischemic time affected Sertoli cell quality of contralateral testis and respond to prednisone.Keywords: Prednisone, unilateral testicular torsion, sertoli cell.
EVALUATION OF PROSTATE BASAL CELL BY CYTOKERATIN 903 STAINING IN PROSTATIC ADENOCARCINOMA GLEASON SCORE 6 Nasution, Ramlan; Sugandi, Suwandi; Sihombing, Aaron Tigor; Yantisetiasti, Anglita; Hernowo, Betthy S
Indonesian Journal of Urology Vol 17 No 1 (2010)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v17i1.341

Abstract

Objective: To evaluate the role of prostate basal cell staining in diagnosing Gleason score 6 prostate cancer. Materials & Methods: During research period, we collected 20 medical records and paraffin block specimens of Gleason score 6 prostatic adenocarcinoma patients. Specimens were taken from prostate needle biopsy. Demographic data and PSA level were extracted from medical records. Basal cells were detected by immunohistochemical staining for antikeratin 34β-E12 on paraffin block specimens analyzed by an experienced pathologist. Positive results suggest a benign lesion. Results: Mean age is 70 ± 6,5 years. Mean prostate volume and PSA level was 52±17cc and 25±21 ng/ml. Three specimens (15%) showed presence of basal cells on antikeratin 34β-E12 staining, which indicated benign lesions. Leucocyturia was found in all patients of this group. There was a significant association between PSA level and antikeratin 34β-E12 staining (p=0,03). In multivariate analysis, there is no significant association between antikeratin 34β-E12 staining with age, prostate volume, and leucocyturia. Conclusions: 15 % cases of prostatic cancer Gleason score 6 still showed basal cell existence. Immunohistochemical staining of basal cell should be considered in suspicious cases of prostatic cancer. 
CLINICOHISTOPATHOLOGICAL STUDY OF TESTICULAR TUMOURS IN DR. HASAN SADIKIN GENERAL HOSPITAL BANDUNG Rindra Rizqyahya Retossa; Yantisetiasti, Anglita; Gita Tiara Dewi Nasution; Ahmad Agil; Muhammad Hasan Bashari
Indonesian Journal of Urology Vol 31 No 3 (2024)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v31i3.888

Abstract

Objective: The purpose of this research was to describe the clinical and histopathological characteristics of testicular tumours at Hasan Sadikin General Hospital (RSHS) between 2017-2021. Material & Methods: This research was a cross-sectional descriptive study examining the clinical and histopathological profiles of testicular tumours. The secondary data sources included medical records from the Department of Urology, Anatomic Pathology, Medical Records, and Hospital Information System (SIRS). The collected data covered age, ethnicity, clinical symptoms, site, stage, annual prevalence rate, and analyzed using Microsoft Excel. Results: There were 42 patients who had primary testicular tumour. The highest prevalence of testicular tumours at RSHS was in 2019 consist of 12(29%) patients and the lowest in 2020 were 6(14%) patients. Most patients were >35 years old amounting 19(45%) patients, Sundanese ethnicity were 29(69%) patients, and testicular enlargement revealed in 27(64%) patients. Majority patients were in stage 0/IB 36(86%) patients and occurred in unilateral testis which 34(80%) patients, with 3(7%) patients metastasized. The most common histopathological type was seminoma 18(43%) cases followed by prepubertal-type yolk sac tumour 9(21%) patients. Seminomas, and the fibroma-thecoma group were mostly in patients over 35 years old, while prepubertal-type yolk sac tumour was more commonly in children under 15 years old. Conclusion: Prevalence of testicular tumours increased from 2017 to 2019, then started to decrease in 2020. Histopathologically, seminoma was the most common type. These tumours were most commonly found in older individuals (>35 YO) and unilateral, diagnosed in stage 0/IB, and were mostly presented with enlargement of testis. Keywords: Testicular tumours, clinical features, histopathology
Clinicopathological Characteristics of Cervical Carcinoma with Pelvic Lymph Node Metastases in Dr. Hasan Sadikin General Hospital, Bandung 2013-2021 Sri Rejeki, Henny; Suryanti, Sri; Yantisetiasti, Anglita; Mantilidewi, Kemala I.; Winarno, Gatot Nyarumenteng Adhipurnawan
Althea Medical Journal Vol 10, No 2 (2023)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v10n2.2776

Abstract

Background: Carcinoma of the cervix is the most common gynecological malignancy, which ranks first among carcinomas in Indonesia. Lymph node metastasis is a risk of recurrence, affecting survival and therapy. The purpose of this study was to determine the clinicopathological characteristics of cervical carcinoma with pelvic lymph node metastasis that had undergone radical hysterectomy and lymphadenectomy at Dr. Hasan Sadikin General Hospital, Bandung.Methods: This study used a cross-sectional retrospective descriptive study. Data on the clinical stage I-II cervical cancer patients with pelvic lymph node metastasis were collected  from the archives of the pathological anatomy  laboratory during period from 2013 to 2021. Data were presented in percentage.Results: There were 64 data patients, and the most common age of cervical carcinoma ranged from 40 to 50 years old (52%), the most common stage was stage II (66%), and the most frequent histopathological type was squamous cell carcinoma (70%). The highest degree of differentiation was moderate differentiation (50%). There was no difference in tumor size between sizes <4 cm and ≥4 cm.Conclusion: The cases of cervical carcinoma at Dr. Hasan Sadikin General Hospital Bandung are treated with radical hysterectomy and lymphadenectomy. The patients generally aged between 41–50 years old, stage II, and squamous cell carcinoma with a moderate degree of differentiation.
Effectiveness of Short-Term Use Denosumab and Risedronate Using β-Crosslaps and Histopathology as a Parameter in Osteoporotic Rat Model Siwendro, Afrisya Bimo; Ramdan, Ahmad; Ismiarto, Yoyos Dias; Yantisetiasti, Anglita; fachri, Dliyauddin
Majalah Kedokteran Bandung Vol 56, No 3 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3016

Abstract

Osteoporosis is a condition of decreased bone mass density. Pharmacological management uses drugs that decrease bone resorption or increase bone formation. The most commonly used drugs are bisphosphonates. Risedronate is one of these bisphosphonates. It inhibits osteoclasts, resulting in osteoclast apoptosis. Denosumab is a human monoclonal antibody that inhibits receptor activator kappa-B ligand, inhibiting osteoclast activation. Both drugs are widely used. Research on the efficacy of these two mechanisms has yet to obtain conclusive results. β-cross-laps is a parameter that can be used to evaluate the effectiveness of therapy through monitoring the bone resorption process. This experimental study used female rats >9 weeks old and was conducted at the Pharmacology and Therapeutic Laboratory, Universitas Padjadjaran Bandung, Indonesia, from  June to September 2021. This study utilized a simple random sampling to allocate 24 experimental animals into three groups: control, risedronate, and denosumab. β-Crosslaps expression values before ovariectomy, post ovariectomy before receiving medication, and post ovariectomy and receiving medication was recorded and statistically analyzed using the SPSS version 24.0. The analysis of 24 samples revealed a statistically significant decrease in the median value of β-Crosslaps after ovariectomy in the denosumab group (p=0.036) when compared to the control group, whereas the decrease in the risedronate group was not significant (p=0.687). Administration of denosumab in rat models is more effective in reducing bone resorption compared to risedronate.
Karakteristik klinikopatologikal Mucoepidermoid Carcinoma kelenjar liur di Rumah Sakit Umum Pusat dr Hasan Sadikin (RSHS) Bandung tahun 2013-2022: A 10 Year review Noor Fitriana, Maya; Usman, Hermin Aminah; Yantisetiasti, Anglita
Majalah Patologi Indonesia Vol. 33 No. 3 (2024): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v33i2.596

Abstract

Background Primary salivary gland malignancy is rare and has limited reports. Mucoepidermoid Carcinoma (MEC) is the most common malignant tumor of the salivary glands. However, epidemiological reports on salivary gland MEC are still limited, particularly in Indonesia. This study aimed to report the clinicopathological characteristics of Salivary gland MEC in dr Hasan Sadikin Central Hospital (RSHS) from January 2013 to December 2022. Method: This study is a descriptive study with a cross-sectional method. Total cases of salivary glands MEC that were histopathologically diagnosed and recorded in the RSHS Hospital Information System (SIRS) medical records from 2013 to 2022 were collected. It is included demographic, clinical, and histopathological data. Result A total of 86 MEC cases were diagnosed histopathologically between 2013 and 2022. The cases involved 44 (51,2%) females and 42 (48,8%) males. The mean age is 46,4 years old. The most common site affected is a parotid gland (37,2%). According histopathological grade, 51,2% were high grade, 25,6% were intermediate grade, and 23,3% were low grade. The result of clinical stage is Stage III has the highest percentage (n=32, 37,2%). The majority of patients receive surgical combined with radiotherapy treatment (n=53; 61,6%). Conclusion There are 86 cases of Salivary MEC in RSHS period 2013-2022. MEC is common in females, mean age 46,4 years old. Parotid gland is the most common site. The most frequent histopathological grading and clinical staging are high grade and stage III. Keyword Mucoepidermoid carcinoma, salivary gland, clinicopathological, RSHS
Comparison of Chondroitin Sulfate-E Expression in Benign and Malignant Epithelial Type Ovarian Tumors Mantilidewi, Kemala Isnainiasih; A.W., Gatot Nyarumenteng; Kurniadi, Andi; Suardi, Dodi; Harsono, Ali Budi; Salima, Siti; A, Aditiyono; Hapsari, Kartika; Yantisetiasti, Anglita
Indonesian Journal of Obstetrics & Gynecology Science Volume 8 Nomor 2 July 2025
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v8i2.861

Abstract

Objective: Ovarian cancer is the fifth leading cause of cancer-related death in women, due to late diagnosis and limited screening methods. Chondroitin Sulfate-E (CS-E) has shown potential as biomarkers. This study aims to evaluate CS-E expression in epithelial-type benign and malignant ovarian tumors and its potential as a biomarker using QuPath software.Methods: This observational analytic study used a cross-sectional design. Samples were selected based on histopathology of patients with epithelial-type benign and malignant ovarian tumors from surgeries in 2023. Immunohistochemistry using the GD3G7 antibody was performed to detect CS-E expression in tumor tissues preserved in paraffin blocks at Dr. Hasan Sadikin General Hospital Bandung. Expression was quantified using QuPath software. Statistical analysis used the Mann-Whitney and t-test. Result: No significant difference in CS-E expression was found between malignant and benign tumors (p = 0.492). Demographic factors (age, BMI, menopausal status, and parity) showed no significant differences between groups. Conclusion: CS-E expression has not yet demonstrated potential as a biomarker to distinguish between benign and malignant ovarian tumors.Perbandingan Ekspresi Chondroitin Sulfate-E pada Tumor Ovarium Jinak dan Ganas Tipe Epitel Abstrak Tujuan: Kanker ovarium merupakan penyebab kematian kelima terbanyak terkait kanker pada wanita yang disebabkan oleh keterlambatan diagnosis dan keterbatasan metode skrining. Chondroitin Sulfate-E (CS-E) menunjukkan potensi sebagai biomarker. Penelitian ini bertujuan mengevaluasi ekspresi CS-E pada tumor ovarium jinak dan ganas tipe epitelial serta menilai potensinya sebagai biomarker menggunakan perangkat lunak QuPath. Metode: Penelitian analitik observasional ini menggunakan desain potong lintang. Sampel dipilih berdasarkan hasil histopatologi pasien dengan tumor ovarium jinak dan ganas tipe epitelial dari operasi tahun 2023. Pemeriksaan imunohistokimia dengan antibodi GD3G7 dilakukan untuk mendeteksi ekspresi CS-E pada jaringan tumor yang diawetkan dalam blok parafin di RSUP Dr. Hasan Sadikin Bandung. Ekspresi dianalisis secara kuantitatif menggunakan perangkat lunak QuPath. Uji statistik yang digunakan adalah Mann-Whitney dan uji t. Hasil: Tidak ditemukan perbedaan bermakna dalam ekspresi CS-E antara tumor ganas dan jinak (p = 0,492). Faktor demografis (usia, indeks massa tubuh, status menopause, dan paritas) juga tidak menunjukkan perbedaan bermakna antar kelompok.Kesimpulan: Ekspresi CS-E belum menunjukkan potensi sebagai biomarker untuk membedakan antara tumor ovarium jinak dan ganas. Kata kunci: Biomarker, GD3G7, Glikosaminoglikan, Kanker Ovarium, Kondroitin sulfat 
Co-Authors A, Aditiyono A.W., Gatot Nyarumenteng Aaron Tigor Sihombing Ahmad Agil Ahmad Ramdan Aminah Usman, Hermin Andi Kurniadi, Andi Bashari, Muhammad Hasan Bethy S Hernowo, Bethy Betthy S Hernowo, Betthy S Betthy S. Hernowo Betthy S. S. Hernowo Dandy Tanuwidjaja Darmadji Ismono, Darmadji Desy Anggraini Dewayani, Birgitta Maria Dodi Suardi fachri, Dliyauddin Gatot Nyarumenteng Adhipurnawan Winarno Gita Tiara Dewi Nasution Gunasegaran, Kirtana Handayani, Astri Harsono, Ali Budi Hermin Aminah Usman Husain, Okky Indra Jaya Irawan, M.Naseh Sajadi Budi Kartika Hapsari Kemala Isnainiasih Mantilidewi Mantilidewi, Kemala I. Misuari Sabirin, Muhammad Syah Muhammad Rivai Noor Fitriana, Maya Rindra Rizqyahya Retossa Salima, Siti Siwendro, Afrisya Bimo Sri Rejeki, Henny Sri Suryanti Sunardi, Mas Adi Suryajaya, Bernard Santoso Suwandi Sugandi Yoyos Dias Ismiarto