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INDONESIA
Indonesian Journal of Urology
Published by Universitas Airlangga
ISSN : 0853442X     EISSN : 23551402     DOI : 10.32421
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
The aim of Indonesian Journal of Urology is to encompass the whole spectrum of urology. The journal publishes papers on a wide range of urological issues such as oncology, functional urology, reconstructive urology, laparoscopy, robotic surgery, endourology, female urology, andrology, pediatric urology, and sexual medicine. We welcome authors for original article (research), review article, interesting case reports, special article, clinical practices, and medical illustrations that focus on the clinical area of urology.
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Articles 18 Documents
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Search results for , issue "Vol 27 No 1 (2020)" : 18 Documents clear
THE ROLE OF CYP17A1 IN ADENOCARCINOMA OF THE PROSTATE AT SARDJITO GENERAL HOSPITAL Prayogo, Dwi; Soeroharjo, Indrawarman
Indonesian Journal of Urology Vol 27 No 1 (2020)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v27i1.550

Abstract

Objective: The purpose of this study is to determine the relationship and role of CYP17A1 gene expression to androgen biosynthesis activity in prostate cancer patients. Material & Methods: The samples of this study are patients diagnosed with prostate adenocarcinoma based on histopathology examination who underwent TURP surgery at Sardjito General Hospital. A total of 30 samples were examined for PCR to determine the presence and absence of CYP17A1 gene expression. CYP17A1 gene expression was analyzed with the patient’s age, stage, organ metastasis, Gleason score, and PSA value. Results: Analysed using Chi-Square Tests, p=0.784 was obtained on expression of CYP17A1 gene with patient’s age, p=0.469 on expression of CYP17A1 gene with staging tumor, p=0.855 on expression of CYP17A1 gene with presence or absence of organ metastasis, p=0.059 on expression of CYP17A1 gene expression with total Gleason score, p=0.895 on expression of CYP17A1 gene with PSA value. Conclusion: There was no association between CYP17A1 gene expression and intratumoral androgen biosynthesis activity based on the patient’s age, patient’s clinical stage, organ metastasis, Gleason score, and PSA value.
PARTIAL VERSUS TOTAL UROGENITAL MOBILIZATION IN UROGENITAL RECONSTRUCTION: A META-ANALYSIS Putra, Prima Ciko Ade; Widia, Fina; Alam, Gampo; Wahyudi, Irfan; Rodjani, Arry
Indonesian Journal of Urology Vol 27 No 1 (2020)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v27i1.577

Abstract

Objective: Urogenital sinus, cloacal malformation and congenital adrenal hyperplasia are some of the congenital anomalies which comprehensive management should be done to achieve better outcomes. Total Urogenital Mobilization (TUM) and Partial Urogenital Mobilization (PUM) are the most widely used in term of surgical management. However, many researches showed different outcomes of those procedures. This meta-analysis aims to compare the outcome of TUM and PUM in urogenital reconstruction. Material & Methods: Studies were collected from five different search engines (PubMed, EBSCO, ProQuest, Science Direct, Google Scholar) with keyword as mentioned in the methods section of this paper. All full text articles were included. Critical appraisal for each study was done using the Oxford Center of Evidence Based Medicine Worksheet for therapy. Data were analyzed by Cochrane's Review Manager 5.3 for charts and plots builder. Results: Three studies were found with 81 participants divided into PUM or TUM group. All studies were analyzed by using the Mantel-Haenszel test to produce Forest plot. Overall, urinary incontinence event was more common found in patient who underwent TUM compare with PUM (OR 8.21; 95%CI: 1.1-61.11; p=0.04). Conclusion: PUM has a better urinary outcome in comparison with TUM. Further study with a better study design, follow-up and standardized evaluation is needed to achieve a better understanding on urogenital reconstruction and management.
OUTCOME COMPARISON OF TRANSURETHRAL RESECTION PROSTATE IN BENIGN PROSTATIC HYPERPLASIA PATIENT IN KARAWANG GENERAL REFERRAL HOSPITAL Halimi, Ramlan; Pratama, Achmad Rizky Herda
Indonesian Journal of Urology Vol 27 No 1 (2020)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v27i1.578

Abstract

Objective: Benign Prostatic Hyperplasia (BPH) is the most common pathological condition in man and causes Lower Urinary Tract Syndrome (LUTS). The most popular therapeutic modality for BPH is the Transurethral Resection of Prostate (TURP). This study describes the TURP outcome in BPH patients with prostate volume >75 grams compared to <75 grams Karawang General Referral Hospital. Material & Methods: We performed a retrospective review of clinical outcome from BPH patient with LUTS who underwent TURP procedure between January 2017–April 2018. Data is taken through patient medical records and processed descriptively to describe complications, quality of life, laboratory. Qualitative data compared with Chi-Square test. Results: During this study, we evaluate 40 patients, 20 patients with prostate volume >75 grams (Group 1) and 20 patients prostate volume <75 grams. Mean age in group 1 65,60 ± 9.960 and in group 2 65,35 ± 10,297. IPSS after TURP between group 1 and group 2 show a significant difference, where the Incomplete Emptying found most in group 2 (P<0,05). There is no significant difference Quality of Life Score between group 1 and group 2 (P>0,05). From laboratory result obtain decrease of mean Haemoglobin percentage in both groups with P value <0,05 in group 1 and P value <0,05 in group 2. Conclusion: TURP procedure for patient with prostate volume >75 grams is safety and effective with lower complications and there is no significant difference compared to patient with prostate volume <75 grams.
DIFFERENCES OF TESTOSTERONE LEVELS TO THE DURATION OF INHALED NICOTINE EXPOSURE IN SPRAGUE-DAWLEY MALE WHITE RATS Ramadhan, Ido Putra; Djojodimedjo, Tarmono; Soebadi, Doddy M
Indonesian Journal of Urology Vol 27 No 1 (2020)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v27i1.593

Abstract

Objective: To analyze the differences in testosterone level in young Sprague-Dawley white rats after exposure of inhaled nicotine and the recovery effect that occurs when nicotine exposure is stopped. Material & Methods: This is an experimental study, which variable measurements were taken after the experimental animals were treated. The experimental grouping process was carried out randomly, with repetitions of 12 experimental animals in each group and the control group as a comparison (negative control). This study using male Sprague-Dawley white rats as samples. Nicotine administration was carried out by inhalation using pure nicotine (C10H14N2), which was diluted using distilled water. Treatment group 1 (P1) was given nicotine exposure for 30 days, treatment group 2 (P2) for 15 days, and treatment group 3 (P3) for 15 days and then stopped for 15 days compared to the control group. Testosterone levels are measured using the ELISA (Enzyme-Linked Immunosorbent Assay) method in the morning. Results: The lowest testosterone levels were found in the P1 and significantly different from the P2 (p=0.029) and P3 (p=0.001). The results of the analysis show that a decrease in testosterone levels in mice is related to the duration of nicotine exposure. Conclusion: Testosterone levels in the control group were significantly higher compared to the treatment group that exposed by nicotine inhalation with a dose of 4 mg/kgBW/day for 15 days, and also there is a significant recovery effect on testosterone levels after the treatment was halted for 15 days.
THE EFFECT OF THE DURATION OF INHALED NICOTINE EXPOSURE TO THE NUMBER OF LEYDIG, SPERMATOGONIUM, AND SERTOLI CELLS ON THE SPRAGUE-DAWLEY STRAIN WHITE RATS Hoesain, Fadil Pramudhya; Soebadi, Doddy M.; Djatisoesanto, Wahjoe
Indonesian Journal of Urology Vol 27 No 1 (2020)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v27i1.596

Abstract

Objective: To analyze the differences of the number of Leydig, spermatogonium, and Sertoli cells in mice, after being given nicotine inhalation, and the effect of recovery when nicotine stopped. Materials & Methods: This is experimental studies with a post-test only control group design. The sample used was 36 adult male mice (10-12 weeks) (Rattus Norvegicus) Sprague-Dawley strain, which were divided into three groups. P1 group was given nicotine inhalation at a dose of 4 mg/kg/day for 15 days, P2 group was given nicotine inhalation at a dose of 4 mg/kg/day for 15 days and was free of treatment for 15 days. The control group (NC) has no treatment at all. Histological examination and calculation of Sertoli cells, Leydig cell, and spermatogonium were processed within 1 hour after terticular sample collection. Then carried out to statistical analysis. 100x and 400x magnification is used to obtain the histopathological. Results: Post-hoc LSD test for each variable (Leydig cells, Sertoli cells, and spermatogonium), showed that the NC group had a significantly higher number compared to group P1. P2 group has a significantly higher number compared to group P1. There is no significant difference between the NC group and the P2 group. There was a structural difference in the sample testicles which exposed to nicotine. Conclusion: Nicotine exposure with a dose of 4 mg/kg/day for 15 days has a significant effect on decreasing the number of Leydig cells, spermatogonium cells, and Sertoli cells in rats and giving a free-treatment period for 15 days, giving the testis time to do recovery and regeneration (the reversible damage of testicular structure).
THE EFFECT OF VITAMIN E (α-TOCOPHEROL) ADMINISTRATION ON GLOMERULUS AND PROXIMAL KIDNEY TUBULES DAMAGE WHICH RECEIVED CISPLATIN EXPOSURE ON SPRAGUE DAWLEY MICE Rakhmatiar, Fadhilla; Soebadi, Doddy M.; Soetojo, Soetojo
Indonesian Journal of Urology Vol 27 No 1 (2020)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v27i1.597

Abstract

Objective: To analyze the protective effect of Vitamin E on cisplatin toxicity in Sprague Dawley mice nephrons. Material & Methods: This is an experimental study using post-test only control group design, the subject was white male mice (Rattus Norvegicus) adult Sprague Dawley strain (10-12 weeks) of 24 rats divided into four groups. Negative control group (CN) got normal saline 0.9% intraperitoneal 1 cc, Positive control group (CP) got cisplatin 5 mg/kgBB, group P1 got vitamin E 50 mg/kgBB and Cisplatin 5 mg/kgBB, and P2 group got vitamin E 200 mg/kgBB plus cisplatin 5 mg/kgBB intraperitoneal. Cisplatin is conducted in the third week in each treatment group through intraperitoneal injection. Vitamin E is administrated per sonde for the first three weeks resumed on the fourth week to the seventh week. At the end of the seventh week, nephrectomy was performed on the treatment group to analyze the kidney damage. Histopathological observation is performed using a light microscope with a magnification of one hundred and four hundred times magnification. Results: Cisplatin administration resulted in significant tubular and glomerular damage compared to the control group. Increasing the dose of vitamin E in mice that received cisplatin resulted in significant nephron damage compared to the group who received cisplatin alone. Conclusion: Cisplatin administration results in nephrotoxicity in mice. The administration of high dose Vitamin E resulted in increased nephrotoxicity in mice that received cisplatin.
EFFECTS OF X-RAY RADIATION EXPOSURE ON SPERM MOTILITY AND MORPHOLOGY CHANGES OF WISTAR STRAIN RATS Hariyoto, Bangun Oktavian; Soebadi, Doddy M; Soetojo, Soetojo; Soeprijanto, Bambang
Indonesian Journal of Urology Vol 27 No 1 (2020)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v27i1.599

Abstract

Objective: To analyze the differences of sperm motility and viability changes in Wistar Rats that exposed to X-ray radiation compared to Wistar Rats that were not exposed to X-ray radiation. Material and Methods: Experimental laboratory research within vivo design using Wistar strain rats as subjects. There are three treatment groups in this study: rats exposed to 50 mGy X-ray radiation, 100 mGy, and 200 mGy and one untreated control group. Radiation exposure was calibrated using the RTI Piranha dosimetry. After radiation exposure, at week 4, orchidectomy was performed in rats. Sperm analysis was carried out to determine sperm motility by direct observation and sperm viability by Hematoxylin Eosin (HE) staining observations using a light microscope. One Way ANOVA was used to compare motility and viability of rats spermatozoa in the treatment group compared to control group with a significant value of p<0.05. The analysis was continued with a Post Hoc test to determine the differences in each group. Results: The percentage of motile sperm decreased in all treatment groups compared to control group (p<0.05). There was no significant difference in mean sperm motility on rats exposed to 200 mGy X-ray radiation compared to 100 mGy X-ray radiation (p>0.05). Viability counts decreased in all treatment groups compared to control group (p<0.05) and the spermatozoa viability in 200 mGy radiation group was not significantly different from 100 mGy group (p>0.05). Conclusion: X-ray radiation exposure decreases sperm motility and viability in Wistar rats with the optimum doses 100 mGy.
COMPARISON OF BLADDER CANCER CELLS APOPTOSIS INDUCED BY METFORMIN, CISPLATIN, AND COMBINATION OF METFORMIN-CISPLATIN: IN VITRO STUDY Lumbangaol, Arifai; Hakim, Lukman; Soebadi, Doddy M; Djojodimedjo, Tarmono
Indonesian Journal of Urology Vol 27 No 1 (2020)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v27i1.600

Abstract

Objective: To evaluate the effect of metformin, cisplatin, and their combination on apoptosis of bladder cancer cells. Material & Methods: Urothelial cell lines 5637 were cultured until 80% confluence. Cells were exposed to metformin and cisplatin at certain doses for 24 and 48 hours. Cytotoxicity test was carried out by calculating the viability of bladder cancer cells using the MTT assay until IC50 of each drug was obtained. IC50 Metformin and Cisplatin obtained from the cytotoxicity test were used to induce apoptosis in bladder cancer cells using TUNEL assay. Additional combination doses of Metformin and cisplatin used to induce apoptosis were ¼ IC50 (metformin + cisplatin), ½ IC50 (metformin + cisplatin), and IC50 (metformin + cisplatin). Results: IC50 of metformin was 15 uM while cisplatin was 18 uM with a 48-hour exposure. There was a difference in the mean value of the apoptosis index in all treatment groups compared to control except for the group exposed to IC50 metformin and ¼ IC50 (metformin + cisplatin). Conclusion: Metformin administration solely is not able to increase bladder cancer cell apoptosis. Conversely, the administration of Cisplatin can significantly increase bladder cancer cell apoptosis. The combination of Metformin and Cisplatin can significantly increase bladder cancer cell apoptosis. The rate of apoptosis in line with an increase dose of the combination of these two drugs.

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