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All Journal Jurnal Veteriner Jurnal Kedokteran Syiah Kuala Indonesian Journal of Urology Bioscientia Medicina : Journal of Biomedicine and Translational Research Biomolecular and Health Science Journal Indian Journal of Forensic Medicine & Toxicology Narra J Bioscientia Medicina : Journal of Biomedicine and Translational Research
Bambang Soeprijanto
Department Of Radiology, Faculty Of Medicine Universitas Airlangga, Surabaya, Indonesia - Dr. Soetomo General Hospital Surabaya
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Veterinary

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EFFECTS OF X-RAY RADIATION EXPOSURE ON SPERM MOTILITY AND MORPHOLOGY CHANGES OF WISTAR STRAIN RATS Hariyoto, Bangun Oktavian; Soebadi, Doddy M; Soetojo, Soetojo; Soeprijanto, Bambang
Indonesian Journal of Urology Vol 27 No 1 (2020)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v27i1.599

Abstract

Objective: To analyze the differences of sperm motility and viability changes in Wistar Rats that exposed to X-ray radiation compared to Wistar Rats that were not exposed to X-ray radiation. Material and Methods: Experimental laboratory research within vivo design using Wistar strain rats as subjects. There are three treatment groups in this study: rats exposed to 50 mGy X-ray radiation, 100 mGy, and 200 mGy and one untreated control group. Radiation exposure was calibrated using the RTI Piranha dosimetry. After radiation exposure, at week 4, orchidectomy was performed in rats. Sperm analysis was carried out to determine sperm motility by direct observation and sperm viability by Hematoxylin Eosin (HE) staining observations using a light microscope. One Way ANOVA was used to compare motility and viability of rats spermatozoa in the treatment group compared to control group with a significant value of p<0.05. The analysis was continued with a Post Hoc test to determine the differences in each group. Results: The percentage of motile sperm decreased in all treatment groups compared to control group (p<0.05). There was no significant difference in mean sperm motility on rats exposed to 200 mGy X-ray radiation compared to 100 mGy X-ray radiation (p>0.05). Viability counts decreased in all treatment groups compared to control group (p<0.05) and the spermatozoa viability in 200 mGy radiation group was not significantly different from 100 mGy group (p>0.05). Conclusion: X-ray radiation exposure decreases sperm motility and viability in Wistar rats with the optimum doses 100 mGy.
COMPARISON OF S.T.O.N.E. SCORE AND GUY SCORE IN PREDICTING STONE FREE RATES OF PERCUTANEOUS NEPHROLITHOTOMY PROCEDURES IN THE SOETOMO GENERAL HOSPITAL I Dewa Gede Reza Sanjaya; Doddy M. Soebadi; Djojodimedjo, Tarmono; Bambang Soeprijanto
Indonesian Journal of Urology Vol 28 No 1 (2021)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v28i1.703

Abstract

Objective: To determine the effectiveness of Modified Guy's Stone Score (GSS) and S.T.O.N.E score (SS) as predictors of stone free rates in patients undergoing PCNL. Material & Methods: The design of this study was a prospective observational analytic. Samples were patients with kidney stones who came to the Urology Polyclinic of Soetomo0 General Hospital Surabaya, which was planned to undergo PCNL surgery, patients who met the inclusion criteria will have a CT stonographic examination then counted for the S.T.O.N.E score and Modified Guy's Stone Score before the PCNL procedure. Postoperative stone size evaluation used KUB X-ray (BOF) to assess Stone Free Rate (SFR). Results: In the ETA statistical test there was a strong relationship between GSS and SFR with a relationship strength value of 0.609, the direction of the relationship between these two variables was positive. This means that the greater the GSS, the less likely the SFR could be achieved. The relationship between these two variables was significant with p= 0.05. While between SS and SFR with a relationship strength value of 0.55, the strength of the relationship in these two variables was positive which indicated the higher the SS, the less likely the occurrence of SFR. But both of them were not statistically significant with p= 0.228. Conclusion: Guy Stone Score (GSS) gives a better predictive value than the STONE score (SS) on the stone free rates in patients undergoing PCNL procedures.
Hippocampal Volume and Entorhinal Cortex Thickness in Alzheimer’s Disease Leon Agung Manurung; Widiana Ferriastuti; Bambang Soeprijanto; Hartono Yudi Sarastika
Indian Journal of Forensic Medicine & Toxicology Vol. 16 No. 1 (2022): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v16i1.17577

Abstract

Magnetic Resonance Imaging (MRI) is the standard imaging evaluations in Alzheimer’s Disease (AD).Information regarding hippocampus and entorhinal cortex sizes plays an important role in Alzheimer’sdisease. This study aims to determine hippocampal volume and entorhinal cortex thickness inAlzheimer’s disease obtained from a group of patients who underwent head MRI.This study was an observational study with retrospective approach in patients who were diagnosedwith AD and had available head MRI examination results. A total of 14 patients were diagnosed by aneurologist with AD using MMSE, Hachinsky, and NIA-AA criteria.From head MRI measurement in AD patients, we found that the mean volume of right, left, andtotal hippocampal was 1700±0.395 cm3; 1.670±0.349 cm3; and 3.370±0.725 cm3, respectively. Themean thickness of right, left, and total entorhinal cortex was 1.821±0.459 mm; 1.463±0.369 mm; and3.285±0.791 mm, respectively. There is a possible difference between the early and late stages of AD inthe same patient. Further studies with larger cohorts are needed to examine these correlations.
Images of Ultrasonography or Abdominal Computed Tomography Scanning in Cases of Malignant Kidney Tumors Muhammad Hidayat Surya Atmaja; Bambang Soeprijanto
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14819

Abstract

Background: The malignant kidney tumor is a urinary tract tumor with the highest mortality and morbiditycompared to other urinary tract tumors. The role of USG radiology and CT scan is essential for diagnosingmalignant kidney tumors.Objective: To examine the diagnostic value of USG radiology and CT scan in diagnosing malignancy ofkidney tumor and its accuracy in assessing renal tumor operability.Methods: This study was a retrospective observational study using secondary data of radiologicalexamination including ultrasonography, CT scan and other postoperative results derived from medicalrecords. Data analysis was conducted descriptively.Results: The sensitivity score of USG, CT scan, and USG and CT scan was 60%, 82%, and 83% respectively.Sensitivity value of ultrasound examination was 60% and CT Scan was 82%. The incompatibility ofultrasound with pathology results was found in the case of hydronephrosis with the stone of 64%, stone of18%, cyst of 18 %, on CT Scan hydronephrosis with stone (83%) Pyelonephritis (17%). The incompatibilityof USG and CT Scan with operating results was 8%.Conclusion: Incompatibility of USG results with anatomic pathology results was found in cases ofhydronephrosis accompanied by stones, kidney stones, and benign lesions (cysts). Incompatibility of CTScan results with anatomic pathology results was found in cases of hydronephrosis accompanied by stoneand pyelonephritis.
Evaluation of Radiographers Experience and Knowledge Related to Estimation, Radiation Dose Comparation, and CT Parameters in Kota Medan, Indonesia Wahyudi Ifani; Bambang Soeprijanto; J. Moekono; Nur Ainy Fardana4
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.16015

Abstract

Introduction: In patient examination, the role of a radiographer is very important especially in applying appropriate techniques and procedures to minimize exposure received by patients as needed or optimization. Given this, radiographer knowledge of CT parameters is very important, especially the impact on radiation and the quality of the image produced. Perception of the risk and estimation of CT radiation doses also need to be radiographer’s knowledge because in the service, radiographers are the most frequently interacted with patients.Purpose: To assess the opinion, experience and knowledge of radiographers regarding radiation risk and CT parameters in Kota Medan , Indonesia. Materials and Methods: a survey study was conducted on 33 radiographers from three hospitals in Kota Medan using a 60-question questionnaire consisting of three parts: characteristics, experience, and knowledge. Data were analyzed using Excell and SPSS version 25. Results: the calculation of 48 knowledge problem questions answered, the total value of each respondent is then calculated. Average knowledge value of respondents 56.3% (poor category) with correct value range 14 - 32 with an average value of 26.1 + 4.2. None of the respondents answered all the questions correctlyConclusion: the score of the radiographer’s knowledge of estimation, dose comparison and CT parameters is still low. Review of knowledge, training or further courses related to CT optimization techniques need to be attempted again in the hospital for radiographers.
Kanker Paru dan Penatalaksanaannya Arief Bakhtiar; Bambang Soeprijanto
Jurnal Kedokteran Syiah Kuala Vol 6, No 1 (2006): Volume 6 Nomor 1 April 2006
Publisher : Universitas Syiah Kuala

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Abstract

Abstr  ak.  Keluhan    kanker  paru   terjadi   akibat   kelainan   :  intra  pulmonal,    intra  torasik    ekstra  pulmonal, ekstra   torasik    metastatik,     ekstra  torasik   non  meiastatik.     Prosedur   diagnosa    meliputi    deteksi   dini   dan tindakan   diagnostik    lebih   Ianjut    yang secara  garis  besar dapat dibagi  dua :  Tindakan  Non  lnvasif  ( CT­ Scan   Toraks,   Positron Emission Tomography (PET)   Magnetic Resonance Imaging);  dan  tindakan invasif    (Transthoracic   Needle  Aspiration,   Fiber  Optik  Bronkoscopi,      Endoscopic      Ultrasound, Mediastinoskopi).      Klasifikasi    kanker  paru jenis   karsinorna    bukan   sel  kecil  berdasarkan   TNM  staging, sedangkan   small cell lung carsinoma berdasarkan   Veterans  Administrasion      Lung  Cancer  Study  grup. Penatalaksanaan     kanker  paru  bersifat   multimodalitas      terapi   yang   terdiri   dari:    pernbedahan,     radiasi, kernoterapi,    irnunoterapi,   terapi  hormonal   dan tempi  gen.  (JKS 2006;1:23-38) Kata   kunci   :  karsinorna  bron.kogenik,    diagnose,    penatalaksanaan. Abstract.  Lung  cancer  is  caused  by  intra­pulmonary,      intra­thoracic     extra­pulmonary,     extra­thoracic metastatic,     and  extra  thoracic   non­metastatic     abnormalities.     The  diagnosis    procedure   includes    early detection   and  further  diagnostic   action   which are divided  into  two: Non­Invasive     Action  (Thoracic   CT­ Scan,     Positron     Emission       Tomography     (PET),      Magnetic      Resonance     Imaging)     and    invasive (Transthoracic        Needle       Aspiration,         Fiber     Optical       Bronchoscopy,       Endoscopic       Ultrasound, Mediastinoscopy).     The  classification   of carcinoma  lung  caricer of non­small  cell  carcinoma    is  based  on TNM  staging,   whereas  small  cell  lung  Veterans  Administrasion     carcinoma    is  based  on Lung  Cancer Study  Group.  The  treatment   of lung  cancer  is identi   lied as multi modality  therapy  consisting   of surgery,radiation,    chemotherapy,   irnrnunotherapy,     hormonal   therapy and gene  therapy.  (JKS 2006;1:23-38) Keywords: carcinoma bronchogenic, diagnosis, treatment.
Mekanisme Peningkatan Heat Shock Protein-70 pada Kanker Payudara Tikus yang Diradiasi, Pascapemberian Ekstrak Meniran (Phyllanthus niruri) (MECHANISM OF INCREASING OF HSP-70 ON IRRADIATED RAT BREAST CANCER, DUE TO APPLICATION OF EXTRACT OF PHYLLANTHUS NIR Bambang Soeprijanto; Juliati Hood Assegaf
Jurnal Veteriner Vol 15 No 3 (2014)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (208.277 KB)

Abstract

The used of radiation as a cancer treatment is also proven giving the side effect of damaging thenormal tissue. The extract of Phyllanthus niruri L plant has already been known have an ability to modulatethe immune system. Heat Shock Protein 70 (HSP70) is a protein which can protect other proteins from anydamages. The transcription factor, such as Nuclear factor kappa-light-chain-enhancer of activated B cells(NfkB),is required for protein synthesis. This research was intended to analyze the mechanism, of the immunecompetent cells in expressing the HSP70,through the increase of Nf-kB, at the rat breast cancer tissueunder radiation, due to the application of the extract of P.niruri L plant. An experimental study wasperformed by using the randomized separate pre-test post test controlled group design. The female whiterat (Rattus norvegicus) strain Sprague Dawleystrain, undergoing breast cancer due to the application ofcarcinogen materials 7,12-dimethylbenz(a)antrasen(DMBA) at 20 mg/kg.b.wt, and then the externalradiation at 6Gy given. The treatment group was given the aqueous extract of P.niruri L plant per oral at250 mg/kg b.wt.By immunohistochemistry and t-test study we observe a significant increases in thenumber of cells expressing Nf-kB (p<0.05) and a significant increases in the number of cells expressingHSP70 (p<0.05) at the treatment group. At the regression test, there found to be a stronger influence of NfkBto HSP70 at the treatment group. It is concluded that the mechanism of cell increase expressing theHSP70 at the rat breast cancer tissue under radiation due to the application of the aqueous extract ofP.niruri L plant per oral, is through the increase of cells expressing the Nf-kB.
Diagnostic Value of CT Angiography (CTA) in Carotid Cavernous Fistula (CCF) Patients Using the Digital Subtraction Angiography (DSA) as The Gold Standard: Observation in Dr. Soetomo General Hospital Surabaya from January 2016 to July 2020 Laila Amalia; Hartono Yudi Sarastika; Bambang Soeprijanto
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 6 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i6.318

Abstract

Background: CT angiography (CTA) is the initial modality for diagnosing the Carotid Cavernous Fistula (CCF), identifying the type of CCF, measuring the diameter of the fistula and the diameter of the internal carotid artery (ICA) pre and post fistula, and then confirmed by Digital Subtraction Angiography (DSA) as the gold standard. CTA is expected to provide more information to improve the accuracy of CCF diagnosis to benefit therapy and prevent complications. This study aimed to determine the diagnostic value of CTA in CCF patients in Dr. Soetomo General Hospital Surabaya, using the DSA as a gold standard. Methods: An observational retrospective study of CCF patients met the inclusion and exclusion criteria and underwent CTA and DSA examinations at the Radiology Installation of Dr. Soetomo General Hospital, Surabaya, from January 2016 to July 2020. Results: In the comparison of types of CCF CTA to DSA, the direct group was 53.8% and 57.7%, respectively, while the indirect group was 46.1% and 42.3% with a very strong correlation (κ = 0.922; p = 0.000), sensitivity was 93.3%, specificity was 100 %, PPV of 100%, NPV of 91.7% and accuracy of 96.15%. Direct type evaluation on the DSA showed a large picture of the fistula diameter; the ICA pre fistula's size was enlarged; therefore, the ICA post fistula diameter was reduced or absent. There was a strong correlation of fistula diameter measurement results between CTA and DSA (r = 0.695, p = 0.006). Conclusion: CTA has a similarity rate of 92.2% with DSA in identifying the type of CCF. The accuracy value of CTA is close to DSA in fistula diameter measurements.
Head Computed Tomography Images of HIV/AIDS Patients with Suspected Cerebral Toxoplasmosis in Dr. Soetomo General Hospital Surabaya Ria Wibawani; Bambang Soeprijanto; Widiana Ferriastuti; Erwin A Triyono
Biomolecular and Health Science Journal Vol. 2 No. 1 (2019): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (257.739 KB) | DOI: 10.20473/bhsj.v2i1.13343

Abstract

Introduction: Toxoplasma gondii is an intracellular pathogenic parasite with the majority of co-infections occurring in HIV/AIDS patients. This study assesses the head computed tomography (CT) images of cerebral toxoplasmosis in patients with HIV/AIDS.Methods: This study was a cross-sectional design using head CT images of 35 HIV/AIDS patients with suspected cerebral toxoplasmosis. Variables include lesion type, location, size, CD4 count, and therapeutic result with anti-cerebral toxoplasmosis. All data analysed descriptively.Results: From total 110, 35 patients met the inclusion criteria. 24 patients (68.6%) were male and 11 (31.4%) female, average age, was 36.1. 8 patients (22.3%) had lesions in cortical, 31 patients (88.6%) had < 1 cm lesion. Single lesions mainly calcified and found in the right centrum semiovale while multiple lesions were subcortical. A hypodense lesion with rim or nodular contrast enhancement is found in 75% of patients with CD4 > 200 in contrast to slight rim contrast enhancement and perifocal edema in patients with CD4 < 200. 20 patients (57.4%) had improved condition after anti-toxoplasmosis therapy.Conclusion: Cerebral toxoplasmosis lesions in HIV/AIDS patients have various types of imaging findings, mostly multiple, with most frequent location being cortical and diameter < 1 cm. Total recovery is achieved in the majority of patients with therapy.
The Correlation between Apparent Diffusion Coefficient Value on MRI and the Pathology Consistency of Meningioma Wyka Faulani Hafizah Nur; Widiana Ferriastuti; Bambang Soeprijanto
Biomolecular and Health Science Journal Vol. 3 No. 2 (2020): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v3i2.22171

Abstract

Introduction: Preoperative evaluation of meningioma consistency is important because it will affect surgical procedures, surgical optimization, risk assessment, and patient management. The consistency of meningioma can be predicted by Apparent Diffusion Coefficient (ADC) value on MRI. ADC values are useful in quantitative tumor assessment based on diffusivity in the tumor. The objective of the study is to find out the correlation between ADC value and the pathology consistency of meningioma.Methods: A retrospective study was carried out using medical records at Dr. Soetomo General Hospital, Surabaya by January 2017 - December 2018. The ADC value was obtained by placing three ROI in the tumor and the consistency was obtained from the results of the pathology examination, followed by the Spearman correlation test.Results: There The tumor range value of ADC was 0.58 x 10-3mm2 s to 1.63 x 10-3mm2/s. The mean ADC value in soft, intermediate, and hard consistency was 1.247+ 0.200 x 10-3mm2/s, 0.950 + 0.453 x 10-3mm2/s, and 0.793 + 0.161 x 10-3mm2/s, the cut-off value of ADC was + 0.822 x 10-3mm2/s with specificity 68% and sensitivity 85%, the AUC is 0.740 with a significance value of 0.0043 (p<α, α = 0.05). It was obtained an ADC correlation with the consistency of meningioma, the significance value is p=0.000 (p<α, α = 0.05).Conclusion: There is a correlation between the ADC value and the consistency of meningioma. The ADC value can be considered for an optimal preoperative evaluation in assessing the consistency of meningioma.
Co-Authors Bakhtiar, Arief Doddy M Soebadi Doddy M. Soebadi Erwin A Triyono Faradilla litiloly1, Hartono Yudi Sarastika1 Fardana, Nur Ainy Ferriastuti, Widiana Hariyoto, Bangun Oktavian I Dewa Gede Reza Sanjaya J. Moekono Juliati Hood Assegaf Laila Amalia Leon Agung Manurung Muhammad Hidayat Surya Atmaja Ria Wibawani Sarastika, Hartono Y. Soetojo Soetojo Tarmono Djojodimedjo Wahyudi Ifani Wyka Faulani Hafizah Nur Yus, Teuku M.