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Current Biochemistry
Published by Institut Pertanian Bogor
ISSN : 23557877     EISSN : 23557931     DOI : -
Core Subject : Science, Education,
Biochemistry, Genetics & Molecular Biology Education
Current Biochemistry (CB) publishes the results of original research that contribute significantly to the understanding of the chemical compound and reaction that occur within living organism. Preference will be accorded to manuscripts that develop new concepts or experimantal approaches, particularly in the advancing areas of biochemistry science. Manuscripts that are primarily theoretical in nature or in the field of bioinformatics must be directed toward explaining important results previously not understood, making important predictions that can be experimentally tested, or developing segnificant advances in theory of general interest to biochemists. Submission of manuscripts in emerging areas in biochemistry, chemical biology, biophysics, proteomics, model studies and structures, cellular and molecular biology, computational biochemistry, biotechnology, and new methods development is encouraged especially if they address basic biochemical mechanisms.
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Articles 5 Documents
 1 
Search results for , issue "Vol. 6 No. 1 (2019)" : 5 Documents clear
Characterization and Bioactivity Test of Pectin from Musa balbisiana Peel Extracted using Various Acid Solvents Husnawati Husnawati; Ika Yuni Astutik; Laksmi Ambarsari
Current Biochemistry Vol. 6 No. 1 (2019)
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/cb.6.1.1

Abstract

Banana (Musaceaea) is one of the highest production fruits in Indonesia, which amounted to 7,162,685 tons in 2017. Banana peel waste produced can reach 40% of the total production of fresh bananas. Kepok banana peel contains a lot of nutrients and pectin. Pectin levels in banana peel ranged from 1.92% to 3.25% of dry weight. This study aims to characterize pectin from kepok banana peel (Musa balbisiana) extracted using nitric acid, citric acid, and HCl and screening potential of pectin bioactivity based on LC50 values. The highest pectin yield was obtained from extraction using pH 4 citrate buffer which was 3.68 ± 1.23%. In general, the characteristics of the best pectin from kepok banana peel are pectin extracted with HNO3 pH 4 with methoxyl degree 3.74 ± 0.34%, galacturonate content 87.64 ± 8.36%, and esterification degree 24.24 ± 0.098%. Based on the LC50 value the pectin extraction results can be classified into two, namely commercial pectin and pectin HCl pH 1.5 which is low bioactivity (LC50 > 100 ppm), and pH 4 HNO3 pectin and pH 4 citrate buffer pectin which has high bioactivity (LC50 ≤ 30 ppm). Keywords: Cytotoxicity, galakturonat, kepok banana pectin, methoxyl
Antioxidant Status of Sprague-Dawley Female Rat with Curcuminoids Nanoparticles of Balittro Curcuma Laksmi Ambarsari; Riska Febrianti; Edy Djauhari Purwakusumah
Current Biochemistry Vol. 6 No. 1 (2019)
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/cb.6.1.2

Abstract

Curcuma (Curcuma xanthorrhiza) is an Indonesian herbs plant with antioxidant activity. This research aimed to measure the increase of curcuminoids bioavailability through the effectivity of nanoparticle curcuminoids as an antioxidant for carbon tetrachloride (CCl4) induced rats. Nanoparticle curcuminoids were produced by homogenization-ultrasonication method showed results particle size of curcuminoids nanoparticle was 141.85±38.82 nm with polydispersity index was 0.233 and entrapment efficiency was 71%. During the treatment, the rat’s body weight was increased. Clinical symptoms of rats (behavior and feces) were normal. Nanoparticle curcuminoids can decrease malondialdehyde concentrations and increase peroxide, glutathione peroxide, and superoxide dismutase activity. Keywords : antioxidant, curcuminoid, solid lipid nanoparticle, Curcuma.
Bioethanol Production from Tapioca-Waste as Potential Additive Fuel for LCGC (Low-Cost Green Car) Danty Oktiana Prastiwi; Novia Anggita; Yudha Putra Arishandy
Current Biochemistry Vol. 6 No. 1 (2019)
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/cb.6.1.6

Abstract

The majority style of people in transportation is 24% contribute to increasing premium demand as energy. Unfortunately, fossil fuel is not renewable and limited quantity. Its means, potential biomass of tapioca waste should be an alternative energy source to solve that problem. Today, the biosystem of bioethanol production needs to be optimized to maximize filtration and minimize the production cost. First, composition and time incubation needs to be optimized. The research found that to fermented 50 g waste on 200 mL water, we need 2 g of yeast, and the time of harvesting optimum is fourth days with 17% ethanol. Without acid hydrolyze, tapioca waste in yeast fermentation serves 2600 ppm glucose on the first day and increases significantly on the second day with 2964.77 ppm glucose. This concentration found by DNS (Dinitrosalicylic acid) method. Yeast is the subject that converts glucose on medium to be ethanol. Secondly, that medium distillate gets pure ethanol. Thirdly, this ethanol mix with premium in some concentration, include 0%, 10%, 20%, 30%, 40%, 50%. This variant would do test emission to understand the advantages of tapioca bioethanol compare to fossil fuel. The result of this research should be support government to enhance LCGC (Low-cost green car) program to achieve lower air pollutants, green energy resolution, and cleaner production in tapioca industry. Key Word: bioethanol, emission, formulation, LCGC, tapioca,
Inhibition of α-glucosidase Activity Seed Extract from Mahogany (Swietenia macrophylla King.) Waras Nurcholis; Rini Muthoharoh; Antonius Padua Ratu
Current Biochemistry Vol. 6 No. 1 (2019)
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/cb.6.1.7

Abstract

Diabetes mellitus is a chronic disorder that affects the metabolism of blood glucose inside the body. One of the alternative treatments is by using traditional medicinal plants, which have hypoglycemia effects. A mahogany seed is one of the traditional medicinal plants that has been proven to treat diabetes and has been used for generations. In the aqueous extract, ethanol 96 %, ethyl acetate, and hexane from mahogany seeds (Swietenia macrophylla King.) the inhibition of α-glucosidase activity are checked by measuring p-nitrophenol from p-nitrophenyl-α-D-glucopyranose (pNPG) on 400 nm. The percentage value of the inhibition for α-glucosidase ranged from 6,36-56,77 %, with 96 % ethanol extract that has the highest value and the hexane extract with the lowest value. Phytochemical screening revealed the presence of alkaloids, flavonoids, saponins, and triterpenoids, which could be responsible for the bioactivities shown by the 96 % ethanol extract and aqueous extract of S. macrophylla. Keywords : α-glucosidase activity, diabetes mellitus, mahogany seeds (Swietenia macrophylla King.), phytochemical screening.
The Potency of Nanocurcuminoid of Temulawak as A Preventive Agent for Lipid Peroxidation on Inflammation in Rats Waras Nurcholis; Chelsea; Laksmi Ambarsari
Current Biochemistry Vol. 6 No. 1 (2019)
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/cb.6.1.5

Abstract

The formation of prostaglandins and free radicals in the body occurs in response to inflammation. The use of non-steroidal synthetic drugs to overcome the effects of free radicals often causes harmful side effects to the body. Natural ingredients that have high antioxidant potential, such as curcumin, ginger are expected to overcome this problem. This study aims to measure the antioxidant potential of ginger nanocurcuminoid preparations coated with palmitic acid, by observing the lipid peroxide profile in the liver of inflammatory Spague-Dawley rats. SpagueDawley mice were induced with 1% carrageenan to trigger inflammation, then the lipid peroxide levels were measured after 24 hours. Measurement of lipid peroxide levels was carried out using a spectrophotometer with a wavelength of 532 nm. The size of the nanocurcuminoid preparation coated with palmitic acid was 561.53 nm with an IP value of 0.309. Lipid peroxide levels in the curcuminoid extract group at a dose of 100 mg / kg BW and the nanocurcuminoid group at a dose of 250 mg / kg BW were 0.27x10-4 nmol / g and 1.22 x10-4 nmol / g respectively. These showed that the antioxidant potential of temulawak nanocurcuminoids at a dose of 250 mg / kg BW was 114 times higher than that of curcuminoid extract at a dose of 100 mg / kg BW.

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