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INDONESIA
Jurnal Farmasi Klinik Indonesia
Published by Universitas Padjadjaran
ISSN : 23375701     EISSN : 2337 5701     DOI : -
Core Subject :
Indonesian Journal of Clinical Pharmacy (IJCP) is a scientific publication on all aspect of clinical pharmacy. It published 4 times a year by Clinical Pharmacy Master Program Universitas Padjadjaran to provide a forum for clinicians, pharmacists, and other healthcare professionals to share best practice, encouraging networking and a more collaborative approach in patient care. Indonesian Journal of Clinical Pharmacy is intended to feature quality research articles in clinical pharmacy to become scientific guide in fields related to clinical pharmacy. It is a peer-reviewed journal and publishes original research articles, review articles, case reports, commentaries, and brief research communications on all aspects of Clinical Pharmacy. It is also a media for publicizing meetings and news relating to advances in Clinical Pharmacy in the regions.
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Search results for , issue "Vol 5, No 3 (2016)" : 15 Documents clear
Kepatuhan dan Efektivitas Terapi Obat Anti Tuberkulosis (OAT) Kombinasi Dosis Tetap (KDT) dan Tunggal pada Penderita TB Paru Anak di Salah Satu Rumah Sakit di Kota Bandung Angga P. Kautsar; Tina A. Intani
Indonesian Journal of Clinical Pharmacy Vol 5, No 3 (2016)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (7273.231 KB) | DOI: 10.15416/ijcp.2016.5.3.215

Abstract

Pengobatan TB anak menjadi perhatian karena sulitnya menegakkan diagnosis dan kesembuhan serta dengan penggunaan OAT yang tidak efektif dan tidak sesuai aturan mengakibatkan terjadinya resistensi. OAT KDT dan tunggal merupakan pilihan terapi yang dapat diberikan pada pasien anak dimana KDT diklaim memiliki keuntungan dibandingkan OAT tunggal, namun masih sedikit publikasi mengenai efektivitas penggunaan dua jenis obat tersebut. Tujuan penelitian ini adalah untuk mengetahui hubungan penggunaan OAT KDT dan tunggal terhadap kepatuhan dan efektivitas pengobatan pada penderita TB Paru anak di salah satu rumah sakit di kota Bandung periode Januari 2010–Desember 2013. Metode potong lintang digunakan dengan pengambilan data sekunder retrospektif dilakukan pada 213 penderita dengan analisis deskriptif dan Chi-Square. Hasil penelitian menunjukkan bahwa tidak ada hubungan antara jenis OAT (KDT dan tunggal) terhadap kepatuhan (p=0,09) dan efektivitas pengobatan (p=0,32). Sehingga dapat disimpulkan bahwa penyedia pelayanan kesehatan dapat memberikan OAT KDT atau tunggal saja walaupun KDT lebih banyak memiliki keuntungan dibandingkan dengan tunggal.Kata kunci: KDT, OAT, TB, tunggalComplience and Effectiveness of Single Tuberculosis Drugs and Fixed Dose Combination (FDC) on Pediatric Patients in a Hospital in Bandung Treatment of TB in children is a concern because of the difficulty of determining the diagnosis and healing as well as with ineffective consumption and non-adherence result in drug-resistant TB. The FDC and single TB drugs are the option that can be administered in pediatric patients where FDC is claimed to have advantages over single, nevertheless a few publication on the effectiveness of the use of two drugs. The purpose of this study is to determine the relationship FDC and single TB drugs on compliance and effectiveness of treatment TB pulmonary in children in a hospital in Bandung period January 2010 until December 2013. The method used by the cross-sectional retrospective collection of secondary data conducted in 213 patients with descriptive analysis and Chi-Square. The results showed that no difference between the types of TB drugs for compliance and effectiveness of treatment. It can be concluded that health care providers can provide FDC or single although FDC well-known have more advantages over single.Keywords: FDC, TB drugs, TB, single
Analisis Kejadian Leukositosis Pasca Terapi Aminofilin Intravena Dibandingkan dengan Salbutamol Nebulasi pada Pasien Eksaserbasi Asma Amelia Lorensia; Zullies Ikawati; Tri M. Andayani; Daniel Maranatha; Mariana Wahjudi
Indonesian Journal of Clinical Pharmacy Vol 5, No 3 (2016)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (513.611 KB) | DOI: 10.15416/ijcp.2016.5.3.149

Abstract

Salbutamol adalah terapi lini pertama untuk mengatasi gejala eksaserbasi asma. Aminofilin sudah tidak digunakan karena merupakan obat rentang terapi sempit yang sering menimbulkan adverse drug reaction (ADR). Kedua terapi tersebut dapat menimbulkan peningkatan kadar leukosit terkait ADR yang dapat memengaruhi terapi lain. Penelitian ini bertujuan membandingkan kejadian leukositosis antara terapi salbutamol nebulasi yang merupakan terapi lini pertama dengan aminofilin intravena yang sering digunakan di beberapa tempat untuk terapi eksaserbasi asma. Metode yang digunakan adalah kuasi eksperimental dengan pengukuran profil leukosit darah sebelum dan sesudah intervensi. Penelitian ini dilaksanakan pada bulan Januari 2014–Juni 2015 di beberapa rumah sakit di Surabaya, Indonesia. Kejadian leukositosis terkait ADR pada kelompok aminofilin (n=2) dengan nilai skala naranjo sebesar 6 poin yang kemungkinan besar merupakan ADR. Perubahan profil darah yang terjadi pada kedua pasien hanya pada kadar leukosit saja sedangkan data darah lainnya normal. Oleh karena itu, profil darah pada penggunaan kedua terapi dalam eksaserbasi asma perlu dipantau secara berkesinambungan agar tidak memengaruhi rekomendasi penambahan terapi lainnya.Kata kunci: Aminofilin, eksaserbasi asma, leukositosis, salbutamolPost-Therapy Leukocytosis Events After Intravenous Aminophylline Compared to the Nebulized Salbutamol in Asthma Exacerbations Patients Salbutamol known as the first-line therapy for asthma exacerbations symptoms relieving. Aminophylline are now no longer used because of its narrow therapeutic range of drugs and frequently provoking adverse drug reaction (ADR). Both of these therapies can lead to ADR-related leukocytes level increasing that interfere the concurrent therapies. This study was aimed to compare the state of leukocytosis after therapy with salbutamol nebulizer therapy as the first-line therapy with intravenous aminophylline for the treatment of asthma exacerbations. Quasi experimental method was used in this study, with blood leukocytes profile measure before and after the intervention body temperature measurement as data supplement. This research was conducted in January 2014–June 2015 at several hospitals in Surabaya, Indonesia. The incidence of ADRs associated leukocytes in aminophylline group (n=2) with a value scale naranjo by 6 points, most likely ADR. Significant difference found only in leukocyte level in two patient. More biomarkers profiles should be monitored assording to concurrent therapies for asthma exacerbation.Keywords: Aminophyiline, asthma exacerbation, leukocytosis, salbutamol
Ekspresi Negatif Melanoma Cell Adhesion Molecule (MCAM) Berkorelasi dengan Metastasis Kelenjar Getah Bening Aksila pada Triple Negative Breast Cancer Sartika Nurwenda; Birgitta M. Dewayani; Afiati Afiati; Bethy S. Hernowo
Indonesian Journal of Clinical Pharmacy Vol 5, No 3 (2016)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2448.054 KB)

Abstract

  Triple negative breast cancer (TNBC) adalah karsinoma payudara yang memiliki ekspresi negatif untuk estrogen receptor (ER), progesteron receptor (PR), dan Human Epidermal Growth Factor Receptor (HER2). TNBC memiliki sifat agresif, frekwensi metastasis ke Kelenjar Getah Bening (KGB) aksila yang tinggi, prognosis yang buruk, dan rekurensi yang tinggi. Metastasis ke KGB aksila akan mempengaruhi angka kesintasan hidup dan angka rekurensi penderita TNBC. Melanoma cell adhesion molecule (MCAM) adalah membran glikoprotein dari superfamili imunoglobulin, yang terlibat di dalam ikatan antar sel, yang kemudian dikenal sebagai marker untuk progresi dan metastasis melanoma dan karsinoma prostat. Namun, peran MCAM pada karsinoma mammae masih kontroversial. Tujuan penelitian ini untuk menilai korelasi ekspresi MCAM dengan metastasis ke KGB aksila pada TNBC. Penelitian ini dilaksanakan pada periode 1 Januari 2010–31 April 2015 di laboratorium Patologi Anatomi Fakultas Kedokteran, Universitas Padjadjaran. Penelitian ini dilakukan menggunakan desain potong lintang analisis korelasi dengan menggunakan uji korelasi lambda. Pewarnaan imunohistokimia MCAM dilakukan terhadap 56 sampel blok parafin dari kelompok TNBC yang tidak bermetastasis dan telah bemetastasis ke KGB aksila. Sebanyak 22 dari 28 (78,6%) orang TNBC yang telah bermetastasis ke KGB aksila memiliki nilai histoskor MCAM <4 (negatif), sebaliknya 16 dari 28 (57,1%) orang TNBC yang tidak bermetastasis ke KGB aksila memiliki nilai histoskor ≥4 (positif). Ketiadaan ekspresi MCAM berkorelasi dengan metastasis TNBC ke KGB aksila, namun bukan satu-satunya faktor penentu metastasis.Kata kunci: KGB, metastasis, MCAM, triple negative breast cancer Negative Expression of Melanoma Cell Adhesion Molecule (MCAM) Correlated with Axillary Lymph Node Metastasis in Triple Negative Breast Cancer Triple negative breast cancer (TNBC) is breast cancers that demonstrate the absence of oestrogen receptor, progesterone receptor and human epidermal growth factor receptor 2. TNBC has an aggressive behaviour, high frequency of metastases to the axillary lymph nodes and recurrence, and poor prognosis. Metastasis to the axillary lymph nodes will affect the rate of survival and recurrence in TNBC. Melanoma cell adhession molecule (MCAM) is a membrane glycoprotein of the immunoglobulin superfamily, which is involved in the cells binding, which later became known as the marker for the progression and metastasis of melanoma and carcinoma of the prostate. However, MCAM role in mammary carcinoma still kontroversial. The aim of this study was to assess correlation between MCAM expression with incidence of metastatic to axillary lymph nodes in TNBC. This research was conducted during January 1st 2010–April 31st 2015 at Pathology Anatomy, Faculty of Medicine, Universitas Padjadjaran. This study used a cross-sectional design, using lambda correlation test. MCAM immunohistochemical staining performed on 56 samples of paraffin blocks of TNBC group that did not metastasized and has metastasized to the axillary lymph nodes. A total of 22 of 28 (78.6%) of TNBC metastatic to axillary lymph nodes have histoskor MCAM value <4 (negative), whereas 16 of 28 (57.1%) of TNBC non metastatic have histoskor value ≥ 4 (positive). Negative expression of MCAM correlated with TNBC that had metastasized to axillary lymph nodes, although not the only factor that influenced them.Keywords: Lymph node, metastasis, MCAM, triple negative breast cancer
Analisis Penggunaan Antimikroba Parenteral pada Pasien Infeksi Saluran Kemih di Bangsal Penyakit Dalam RSUP Dr. M. Djamil Padang Putri Ramadheni; Sanubari R. Tobat; Fatimatu Zahro
Indonesian Journal of Clinical Pharmacy Vol 5, No 3 (2016)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2417.932 KB) | DOI: 10.15416/ijcp.2016.5.3.184

Abstract

 Infeksi saluran kemih (ISK) merupakan salah satu penyakit infeksi yang memiliki prevalensi cukup tinggi. Berdasarkan data rekam medis RSUP dr. M. Djamil Padang pada tahun 2013, terdapat pasien ISK sebanyak 273 orang. Tujuan penelitan ini adalah untuk menganalisis rasionalitas terapi antimikroba parenteral serta pengelolaannya di bangsal penyakit dalam RSUP dr. M. Djamil Padang. Penelitian ini merupakan penelitian observasional menggunakan data prospektif pada bulan April sampai Juni 2015 di bangsal penyakit dalam. Kriteria inklusi yaitu pasien ISK dewasa (>18 tahun), dirawat di bangsal penyakit dalam RSUP dr. M. Djamil, serta mendapatkan terapi antimikroba parenteral. Hasil analisis penggunaan antimikroba parenteral menunjukkan bahwa antibiotik sefalosporin generasi III paling banyak digunakan (79,16%) serta dikombinasi dengan quinolon, flukonazol, dan metronidazol. Hasil analisis rasionalitas memperlihatkan bahwa terapi telah tepat indikasi, tepat pasien, tepat obat, dan tepat obat dan penggunaannya (94,7%). Pada proses pengelolaan sediaan antimikroba parenteral ditemukan bahwa penyimpanannya telah tepat, namun proses rekonstitusi belum memenuhi teknik aseptis serta prosedur yang telah ditetapkan oleh Departemen Kesehatan tahun 2009. Penggunaan antimikroba parenteral pada pasien ISK di RSUP dr. M. Djamil Padang telah rasional, namun proses rekonstitusinya belum memenuhi prosedur yang ditetapkan oleh Depkes tahun 2009.Kata kunci: Antimikroba, ISK, parenteral, rasionalitas Analysis of Parenteral Antimicrobial Usage in Patients with Urinary Tract Infection at dr. M. Djamil Padang Hospital Urinary tract infection (UTI) has a high prevalence in dr. M. Djamil Padang hospital in the year of 2013. Based on the Medical Record Data, there were 273 patients with UTI. The purpose of the study was to analyse the rationality of parental antimicrobial preparation use and management. This prospective observasional study used data from April to June 2015 in internal medicine wards. The inclusion criteria include UTI adult patients (>18 years), were treated at the department of internal medicine ward dr. M. Djamil hospital, as well as parenteral antimicrobial therapy. Results of the statistical analysis showed that the use of antimicrobial parenteral used of third generation cephalosporin antibiotik most widely used was (79.16%) and in combination with quinolones, fluconazole, and metronidazole. Results of the analysis showed that the therapy, patient, frequency, dosage and precise method of drug administration was (100%) duration of therapy was (94,7%) appropriate. As for the process management of parenteral antimicrobial preparations was found that the storage was right, but the reconstitution process has not complied with the procedures established by the Ministry of Health in 2009. The use of parenteral antimicrobial in patients with UTIs at dr. M. Djamil Padang hospital has been rational, but the reconstitution process is not appropriate the procedures established by the Ministry of Health in 2009.Keywords: Antimicrobial, parenteral, rationality, UTI
Pola Peresepan Rawat Jalan: Studi Observasional Menggunakan Kriteria Prescribing Indicator WHO di Salah Satu Fasilitas Kesehatan Bandung Dika P. Destiani; Syahrul Naja; Aminah Nurhadiyah; Eli Halimah; Ellin Febrina
Indonesian Journal of Clinical Pharmacy Vol 5, No 3 (2016)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (7961.675 KB) | DOI: 10.15416/ijcp.2016.5.3.225

Abstract

Penelitian ini dilakukan sebagai tahap awal evaluasi peresepan obat di salah satu fasilitas kesehatan yang akan dilakukan berkala untuk meningkatkan kualitas pengobatan pasien dengan menggunakan lima indikator peresepan berdasarkan guideline World Health Organization (WHO) yaitu jumlah obat per lembar resep, penggunaan obat generik, antibiotik, obat injeksi, dan obat esensial. Pengumpulan data resep rawat jalan diambil secara retrospektif pada periode April 2015–Maret 2016 di salah satu fasilitas kesehatan di Bandung. Sebanyak 1.814 lembar resep dengan 3.886 obat yang termasuk kriteria inklusi, diperoleh rata-rata jumlah obat per lembar yaitu 2,13 obat. Penggunaan obat generik sebesar 57,47% dari 3.886 obat. Persentase penggunaan antibiotik sebesar 15,52% dan sediaan injeksi 0,41% dari 1.814 lembar resep, sedangkan penggunaan obat esensial sebesar 39,49% dari 3.886 obat yang diresepkan. Berdasarkan hasil tersebut penggunaan obat generik dan esensial masih sangat jauh dari standar WHO (100%) sedangkan penggunaan antibiotik dan obat injeksi memiliki nilai rendah dibandingkan dengan nilai rujukan World Health Organization. Kata kunci: Indikator peresepan, obat, WHO Prescribing of Outpatient: Observational Study Using WHO Prescribing Indicator in One of Health Care Facilities in Bandung This study was held to evaluate drug pattern in one of the health facilities in Bandung using five World Health Organization guideline for prescribing indicators, which include average number of drugs per encounter, percentage of drugs prescribed by generic name, percentage of encounters with an antibiotic, injection prescribed, and drugs prescribed from essential drugs list or formulary. Outpatient prescriptions were collected retrospectively from April 2015–March 2016. Average number of drugs per encounter 2.13 was gained by dividing 3,886 drugs with 1,814 prescriptions. Percentage of using generic drugs were 57.47%, antibiotics were 15.52 % and 0.41% for injections per encounters, whereas percentage of drugs prescribed from essential drugs list was 39.49%. The result showed that usage of generic and essential drugs were still far from WHO standard (100%) while the usage of antibiotics and injections were lower than World Health Organization recommendation.Keywords: Drug, prescribing indicators, WHO

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