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<![CDATA[Analisis Kejadian Leukositosis Pasca Terapi Aminofilin Intravena Dibandingkan dengan Salbutamol Nebulasi pada Pasien Eksaserbasi Asma ]]>
<![CDATA[Lorensia, Amelia]]>;
<![CDATA[Ikawati, Zullies]]>;
<![CDATA[Andayani, Tri M.]]>;
<![CDATA[Maranatha, Daniel]]>;
<![CDATA[Wahjudi, Mariana]]>
<![CDATA[ Indonesian Journal of Clinical Pharmacy Vol 5, No 3 (2016) ]]>
Publisher : <![CDATA[Indonesian Journal of Clinical Pharmacy ]]>
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DOI: 10.15416/ijcp.2016.5.3.149
<![CDATA[Salbutamol adalah terapi lini pertama untuk mengatasi gejala eksaserbasi asma. Aminofilin sudah tidak digunakan karena merupakan obat rentang terapi sempit yang sering menimbulkan adverse drug reaction (ADR). Kedua terapi tersebut dapat menimbulkan peningkatan kadar leukosit terkait ADR yang dapat memengaruhi terapi lain. Penelitian ini bertujuan membandingkan kejadian leukositosis antara terapi salbutamol nebulasi yang merupakan terapi lini pertama dengan aminofilin intravena yang sering digunakan di beberapa tempat untuk terapi eksaserbasi asma. Metode yang digunakan adalah kuasi eksperimental dengan pengukuran profil leukosit darah sebelum dan sesudah intervensi. Penelitian ini dilaksanakan pada bulan Januari 2014âJuni 2015 di beberapa rumah sakit di Surabaya, Indonesia. Kejadian leukositosis terkait ADR pada kelompok aminofilin (n=2) dengan nilai skala naranjo sebesar 6 poin yang kemungkinan besar merupakan ADR. Perubahan profil darah yang terjadi pada kedua pasien hanya pada kadar leukosit saja sedangkan data darah lainnya normal. Oleh karena itu, profil darah pada penggunaan kedua terapi dalam eksaserbasi asma perlu dipantau secara berkesinambungan agar tidak memengaruhi rekomendasi penambahan terapi lainnya.Kata kunci: Aminofilin, eksaserbasi asma, leukositosis, salbutamolPost-Therapy Leukocytosis Events After Intravenous Aminophylline Compared to the Nebulized Salbutamol in Asthma Exacerbations Patients Salbutamol known as the first-line therapy for asthma exacerbations symptoms relieving. Aminophylline are now no longer used because of its narrow therapeutic range of drugs and frequently provoking adverse drug reaction (ADR). Both of these therapies can lead to ADR-related leukocytes level increasing that interfere the concurrent therapies. This study was aimed to compare the state of leukocytosis after therapy with salbutamol nebulizer therapy as the first-line therapy with intravenous aminophylline for the treatment of asthma exacerbations. Quasi experimental method was used in this study, with blood leukocytes profile measure before and after the intervention body temperature measurement as data supplement. This research was conducted in January 2014âJune 2015 at several hospitals in Surabaya, Indonesia. The incidence of ADRs associated leukocytes in aminophylline group (n=2) with a value scale naranjo by 6 points, most likely ADR. Significant difference found only in leukocyte level in two patient. More biomarkers profiles should be monitored assording to concurrent therapies for asthma exacerbation.Keywords: Aminophyiline, asthma exacerbation, leukocytosis, salbutamol]]>
<![CDATA[PENGARUH SUPLEMENTASI VITAMIN D TERHADAP NILAI PENGUKURAN FEV1/ FVC PADA PENDERITA ASMA TERKONTROL SEBAGIAN ]]>
<![CDATA[Donastin, Adyan]]>;
<![CDATA[Bakhtiar, Arief]]>;
<![CDATA[Maranatha, Daniel]]>
<![CDATA[ Jurnal Ilmu Kesehatan dan Kesehatan Vol 1 No 1 (2017): FEBRUARY ]]>
Publisher : <![CDATA[UNUSA Press ]]>
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DOI: 10.33086/mhsj.v1i1.617
<![CDATA[Background:Airflow resistance in asthma caused by changes in the airways that is bronchoconstriction,airway edema, airway hyperresponsiveness and airway remodeling. Vitamin D supplementation is expectedto raise the value of the measurement of FEV1/ FVC in patients with asthma controlled in part through therole of vitamin D in terms of antiviral effects, atopic response, response improvement steroid and preventairway remodeling process.Objective:Comparing the measurement values of FEV1/ FVC in patients withasthma controlled most of which do not get supplemental vitamin D than getting supplemental vitaminD.Methods:This study is a randomized experimental simple study. This research was conducted in drSoetomo Hospital from June to July 2015. The sampling technique using consecutive sampling. Sampleswere divided into two groups each consisting of 14 samples which have earned a combined therapy ofinhaled corticosteroids and LABA. The control group that was not given additional vitamin Dsupplementation and the treatment group were given supplements of vitamin D for 1 month. Measurementand main result:Testing of data distribution using the ShapiroWilk method because the sample size is lessthan 50. The result of the difference in FEV1 / FVC with a paired sample t - test is known that in the controlgroup (not given additional vitamin D supplements) did not occur significant difference (p = 0.219> 0.05),while the treatment group (given additional vitamin supplements D) proved significant difference (p = 0.020<0.05) where the value of FEV1 / FVC after being given additional vitamin D supplements increased to96.071% of the initial conditions is 84.786%.Conclusions:The measurement values of FEV1/ FVC in patientswith asthma controlled most of which get vitamin D supplementation are the most significant increasecompared to the control group who did not receive supplementation ofvitamin D.]]>
<![CDATA[Severe Pneumonia: Etiology and Outcome in a Tertiary Hospital in Indonesia ]]>
<![CDATA[Daniel Maranatha, Mawardi]]>;
<![CDATA[Hamzah]]>
<![CDATA[ Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology ]]>
Publisher : <![CDATA[Institute of Medico-legal Publications Pvt Ltd ]]>
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DOI: 10.37506/ijfmt.v15i2.14698
<![CDATA[Background: Severe pneumonia represents a subset of life-threatening pneumonia. The mortality rate ofpatients with severe pneumonia is considerably high. This study aims to determine the etiology and outcomeof severe pneumonia.Methods: An observational prospective study was conducted from September 2017 to September 2018 onpneumonia patients in a tertiary hospital. Clinical and diagnostic evaluations were carried out to assess theseverity of the disease, etiology, comorbidities, and several other factors associated with outcomes.Results: 140 pneumonia patients were evaluated and 41 patients met the severe pneumonia criteria. Apathogen was found in 20 community-acquired pneumonia (CAP) and 13 hospital-acquired pneumonia(HAP). The most frequently isolated pathogen from the sputum culture of patients with either severe CAPor HAP was Acinetobacter baumannii. The mortality rate of severe HAP patients was higher than thatof severe CAP patients (84% vs. 65%), but the difference was nonsignificant. Most of the subjects hadcomorbidities (CAP 75%, HAP 61.6%). Procalcitonin (PCT) and C-reactive protein (CRP) levels in severeCAP were higher than those in severe HAP (PCT 7.7 vs 6.0, p=0.658; CRP 163.1 vs 93.6, p=0.580), but thedifferences were also nonsignificant.Conclusion: The most frequently isolated pathogens from the sputum culture of patients with severepneumonia were Acinetobacter baumanii, which should be considered at the time of diagnosis and empiricalantibiotic therapy. Severe pneumonia was often accompanied by comorbidities, inflammation responsesincrease in both severe CAP and HAP with a high mortality rate.]]>
<![CDATA[PENGARUH SUPLEMENTASI VITAMIN D TERHADAP NILAI PENGUKURAN FEV1/ FVC PADA PENDERITA ASMA TERKONTROL SEBAGIAN ]]>
<![CDATA[Adyan Donastin]]>;
<![CDATA[Arief Bakhtiar]]>;
<![CDATA[Daniel Maranatha]]>
<![CDATA[ Jurnal Ilmu Kesehatan dan Kesehatan Vol 1 No 1 (2017): FEBRUARY ]]>
Publisher : <![CDATA[UNUSA Press ]]>
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DOI: 10.33086/mhsj.v1i1.617
<![CDATA[Background:Airflow resistance in asthma caused by changes in the airways that is bronchoconstriction,airway edema, airway hyperresponsiveness and airway remodeling. Vitamin D supplementation is expectedto raise the value of the measurement of FEV1/ FVC in patients with asthma controlled in part through therole of vitamin D in terms of antiviral effects, atopic response, response improvement steroid and preventairway remodeling process.Objective:Comparing the measurement values of FEV1/ FVC in patients withasthma controlled most of which do not get supplemental vitamin D than getting supplemental vitaminD.Methods:This study is a randomized experimental simple study. This research was conducted in drSoetomo Hospital from June to July 2015. The sampling technique using consecutive sampling. Sampleswere divided into two groups each consisting of 14 samples which have earned a combined therapy ofinhaled corticosteroids and LABA. The control group that was not given additional vitamin Dsupplementation and the treatment group were given supplements of vitamin D for 1 month. Measurementand main result:Testing of data distribution using the ShapiroWilk method because the sample size is lessthan 50. The result of the difference in FEV1 / FVC with a paired sample t - test is known that in the controlgroup (not given additional vitamin D supplements) did not occur significant difference (p = 0.219> 0.05),while the treatment group (given additional vitamin supplements D) proved significant difference (p = 0.020<0.05) where the value of FEV1 / FVC after being given additional vitamin D supplements increased to96.071% of the initial conditions is 84.786%.Conclusions:The measurement values of FEV1/ FVC in patientswith asthma controlled most of which get vitamin D supplementation are the most significant increasecompared to the control group who did not receive supplementation ofvitamin D.]]>
<![CDATA[Differences of Respiratory Rate Between Salbutamol and Aminofilin in Exacerbation Asthma ]]>
<![CDATA[Amelia Lorensia]]>;
<![CDATA[Zullies Ikawati]]>;
<![CDATA[Tri Murti Andayani]]>;
<![CDATA[Daniel Maranatha]]>
<![CDATA[ Indonesian Journal of Pharmaceutical Science and Technology Vol 7, No 1 (2020) ]]>
Publisher : <![CDATA[Indonesian Journal of Pharmaceutical Science and Technology ]]>
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DOI: 10.24198/ijpst.v6i3.17034
<![CDATA[Exacerbation of asthma is a progressive step in progressive breathing, coughing, wheezing, breathing. In Indonesia salbutamol nebulation is used for the therapy of the first exacerbation attack. In addition, intravenous aminophylline is also recommended as a therapy, even if the use of aminophylline abroad is reduced due to its smaller effectiveness and often leads to greater unwanted reaction events. The effectiveness of asthma exacerbation therapy needs to be monitored and one of the monitoring parameters that is easily seen is the rate of breath.The aim of this study was to investigate the difference in respiratory rate values using salbutamol nebulisation and intravenous aminophylline in patients with asthma exacerbations in hospitals in Surabaya. The research was conducted by using quasi experimental method and data collection by purposive sampling. Analysis of the data to be used is a independent t-test. The results showed that the salbutamol group decreased respiratory rate by 50.00%, there were also patients who experienced an increase of breath rate of 13.64%. In the aminophylline group experienced a decrease in respiratory rate of 43.75% with an increase of breath rate of 18.75%. From the results of the study, it is necessary to monitor the effectiveness and the need to monitor the unwanted reactions of both treatments so that the therapies produced in the treatment of asthma exacerbations are more effective.Key words: Aminophylline, exacerbation asthma, respiratory rate, salbutamol ]]>
<![CDATA[Analisis Kejadian Leukositosis Pasca Terapi Aminofilin Intravena Dibandingkan dengan Salbutamol Nebulasi pada Pasien Eksaserbasi Asma ]]>
<![CDATA[Amelia Lorensia]]>;
<![CDATA[Zullies Ikawati]]>;
<![CDATA[Tri M. Andayani]]>;
<![CDATA[Daniel Maranatha]]>;
<![CDATA[Mariana Wahjudi]]>
<![CDATA[ Indonesian Journal of Clinical Pharmacy Vol 5, No 3 (2016) ]]>
Publisher : <![CDATA[Universitas Padjadjaran ]]>
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DOI: 10.15416/ijcp.2016.5.3.149
<![CDATA[Salbutamol adalah terapi lini pertama untuk mengatasi gejala eksaserbasi asma. Aminofilin sudah tidak digunakan karena merupakan obat rentang terapi sempit yang sering menimbulkan adverse drug reaction (ADR). Kedua terapi tersebut dapat menimbulkan peningkatan kadar leukosit terkait ADR yang dapat memengaruhi terapi lain. Penelitian ini bertujuan membandingkan kejadian leukositosis antara terapi salbutamol nebulasi yang merupakan terapi lini pertama dengan aminofilin intravena yang sering digunakan di beberapa tempat untuk terapi eksaserbasi asma. Metode yang digunakan adalah kuasi eksperimental dengan pengukuran profil leukosit darah sebelum dan sesudah intervensi. Penelitian ini dilaksanakan pada bulan Januari 2014–Juni 2015 di beberapa rumah sakit di Surabaya, Indonesia. Kejadian leukositosis terkait ADR pada kelompok aminofilin (n=2) dengan nilai skala naranjo sebesar 6 poin yang kemungkinan besar merupakan ADR. Perubahan profil darah yang terjadi pada kedua pasien hanya pada kadar leukosit saja sedangkan data darah lainnya normal. Oleh karena itu, profil darah pada penggunaan kedua terapi dalam eksaserbasi asma perlu dipantau secara berkesinambungan agar tidak memengaruhi rekomendasi penambahan terapi lainnya.Kata kunci: Aminofilin, eksaserbasi asma, leukositosis, salbutamolPost-Therapy Leukocytosis Events After Intravenous Aminophylline Compared to the Nebulized Salbutamol in Asthma Exacerbations Patients Salbutamol known as the first-line therapy for asthma exacerbations symptoms relieving. Aminophylline are now no longer used because of its narrow therapeutic range of drugs and frequently provoking adverse drug reaction (ADR). Both of these therapies can lead to ADR-related leukocytes level increasing that interfere the concurrent therapies. This study was aimed to compare the state of leukocytosis after therapy with salbutamol nebulizer therapy as the first-line therapy with intravenous aminophylline for the treatment of asthma exacerbations. Quasi experimental method was used in this study, with blood leukocytes profile measure before and after the intervention body temperature measurement as data supplement. This research was conducted in January 2014–June 2015 at several hospitals in Surabaya, Indonesia. The incidence of ADRs associated leukocytes in aminophylline group (n=2) with a value scale naranjo by 6 points, most likely ADR. Significant difference found only in leukocyte level in two patient. More biomarkers profiles should be monitored assording to concurrent therapies for asthma exacerbation.Keywords: Aminophyiline, asthma exacerbation, leukocytosis, salbutamol]]>
<![CDATA[CYP1A2 Gene Polymorphism and Theophylline Level in Asthma ]]>
<![CDATA[Amelia Lorensia]]>;
<![CDATA[Zullies Ikawati]]>;
<![CDATA[Tri Murti Andayani]]>;
<![CDATA[Daniel Maranatha]]>;
<![CDATA[Mariana Wahyudi]]>
<![CDATA[ The Indonesian Biomedical Journal Vol 11, No 1 (2019) ]]>
Publisher : <![CDATA[The Prodia Education and Research Institute (PERI) ]]>
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DOI: 10.18585/inabj.v11i1.475
<![CDATA[BACKGROUND: Aminophylline (theophylline) is one of the most frequent asthma therapies in Indonesia, although it remains as a narrow therapy. The effects of drugs are individualized and strongly influenced by genetic, one of which is CYP1A2 gene polymorphisms. This study aimed to determine the profile of CYP1A2 polymorphism and theophylline level in asthma exacerbation patients receiving intravenous aminophylline therapy.METHODS: This cross sectional study was conducted in the emergency room (ER), to adults asthma exacerbation patients without complication (n=27), visiting the ER. The gene polymorphism data were compared with theophylline levels in the blood using chi-square test.RESULTS: In the CYP1A2 gene polymorphism profile, the most common heterozygous alleles are T/G genotype of CYP1A2*1E and C/A genotype of CYP1A2*1F. Most homozygote alleles exist in CYP1A2*1D and CYP1A2*1F. There was significant difference between CYP1A2*1D (p<0.005), CYP1A2*1E (p<0.023) and CYP1A2*1F (p<0.000) polymorphisms and theophylline level.CONCLUSION: CYP1A2*1D, CYP1A2*1E and CYP1A2*1F gene polymorphisms had an effect on theophylline levels. However, no one experienced an overdose theophylline, and no correlation between theophylline levels with CYP1A2 gene polymorphism.KEYWORDS: exacerbation asthma, intravenous aminophylline, CYP1A2 polymorphism gene, theophylline]]>
<![CDATA[METODE INTERPRETATIVE PHENOMENOLOGICAL ANALYSIS (IPA): PERSEPSI TENAGA KESEHATAN DAN PASIEN TERHADAP PENGOBATAN ASMA ]]>
<![CDATA[Marthy Meliana Ariyanti Jalmav]]>;
<![CDATA[Amelia Lorensia]]>;
<![CDATA[Ananta Yudiarso]]>;
<![CDATA[Daniel Maranatha]]>
<![CDATA[ Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 6 No 2 (2021): JIIS ]]>
Publisher : <![CDATA[Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin ]]>
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DOI: 10.36387/jiis.v6i2.691
<![CDATA[Pharmaceutical care by pharmacists in the management have an important role of treatment monitoring. Optimal asthma treatment for patients requires cooperation between patients, healthcares, involving doctors, nurses, and pharmacists. Therefore the purpose of this study is to know the perception of healthcares and patients about asthma treatment and pharmaceutical cares on asthma mangement. The method of this study is based on phenomenological perspective with interpretative phenomenological analysis (IPA) on pulmonologist, outpatient asthma, pharmacist and nurse who directly correlated with asthma treatment at a hospital in Surabaya conducted for two years using purposive sampling. The results of this study indicate that asthma patients know how to manage asthma and use asthma drugs well. In addition it is known that asthma patients feel the role of doctors in the treatment of asthma is very dominating; pulmonologists and nurses perceive that the role of pharmacists is limited to drug delivery; and pharmacists assume that their role has been well done although not all patients get the same asthma treatment education. It is therefore necessary to evaluate the role of pharmacist in performing its role in the treatment of this asthma in order for a more harmonious collaboration.]]>
<![CDATA[THE CORRELATION OF NAIVE CD4+T LYMPHOCYTE CELL PERCENTAGE, INTERLEUKIN-4 LEVELS AND TOTAL IMMUNOGLOBULIN E IN PATIENTS WITH ALLERGIC ASTHMA (Kenasaban antara Persentase Sel Limfosit T-CD4+ Naive dengan Kadar Interleukin-4 dan Jumlah Imunoglobulin E Total di Pasien Asma Alergi) ]]>
<![CDATA[Si Ngr. Oka Putrawan]]>;
<![CDATA[Endang Retnowati]]>;
<![CDATA[Daniel Maranatha]]>
<![CDATA[ INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 23, No 1 (2016) ]]>
Publisher : <![CDATA[Indonesian Association of Clinical Pathologist and Medical laboratory ]]>
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DOI: 10.24293/ijcpml.v23i1.1190
<![CDATA[Asma alergi merupakan fenotip asma paling sering didapatkan di anak dan dewasa. Alergen masuk ke saluran napas yang akanmemicu respons imun sehingga menimbulkan gejala asma.Tujuan penelitian ini adalah membuktikan adanya kenasaban antarapersentase sel limfosit T-CD4+ naive dengan kadar IL-4 dan jumlah IgE total di pasien asma alergi. Penelitian bersifat analitikobservasional dengan rancangan potong lintang. Sampel terdiri dari 25 pasien asma alergi yang diperiksa di Ruang Poliklinik Asmadan Poliklinik Paru RSUD Dr. Soetomo. Pemeriksaan persentase sel limfosit T-CD4+ naive dengan flowcytometri, kadar IL-4 denganEnzyme Linked Immunosorbent Assay (ELISA), dan jumlah IgE Total dengan chemiluminescence. Persentase sel limfosit T-CD4+ naivecenderung meningkat yang berkisar antara 25,74–47,68% dengan rerata 36,72% dan Simpang Baku (SB) 6,0%. Kadar IL4 meningkatberkisar antara 43,4–97,2 pg/mL dengan rerata 70,8 pg/mL dan SD 14,95 pg/mL. Jumlah IgE total juga meningkat berkisar antara231,8–684,8 IU/mL dengan rerata 410,9 IU/mL dan SD 114,65 IU/mL. Terdapat kenasaban antara persentase sel limfosit T-CD4+ naivedengan kadar IL-4 dan jumlah IgE total di pasien asma alergi.]]>
<![CDATA[Membandingkan Kejadian Gangguan Gastrointestinal Penggunaan Aminofilin dan Salbutamol pada Pasien Eksaserbasi Asma di Surabaya ]]>
<![CDATA[Amelia Lorensia]]>;
<![CDATA[Zullies Ikawati]]>;
<![CDATA[Tri Murti Andayani]]>;
<![CDATA[Daniel Maranatha]]>;
<![CDATA[Rizki Amalia]]>
<![CDATA[ Keluwih: Jurnal Kesehatan dan Kedokteran Vol. 1 No. 1 (2019): Keluwih: Jurnal Kesehatan dan Kedokteran (December) ]]>
Publisher : <![CDATA[Direktorat Penerbitan dan Publikasi Ilmiah, Universitas Surabaya ]]>
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DOI: 10.24123/kesdok.V1i1.2487
<![CDATA[Abstract—Asthma is a heterogeneous disease, which is characterized by inflammation of the respiratory tract with respiratory classification such as wheezing, shortness of breath, distress in the chest and coughing over time and intensity with variations in expiratory air flow. In Indonesia the prevalence of asthma is uncertain, it is not estimated that 2-5% of Indonesia's population has asthma. The main objective of this study is to study gastrointestinal-related cases of the use of aminophylline and salbutamol in asthma exacerbation patients in hospitals in Surabaya and also to discuss gastrointestinal problems related to ADRs (Bad Drug Reactions) using the use of aminophylline and salbutamol on Naranjo scale. In this study using the Quasi Experimental method. This research was conducted in October 2014 to February 2015. The results of the study of 7 samples obtained 14.29% using ADR from the use of aminophylline and from 13 patients in the use of salbutamol was not found ADR can be used in accordance with the existing salbutamol in patients with asthma exacerbations at hospitals in Surabaya. The general benefits of this study are useful in monitoring the treatment of acute asthma patients who need salbutamol and theophylline therapy so as to reduce the incidence of ADR. Abstrak—Asma merupakan penyakit heterogen, yang ditandai dengan peradangan saluran napas kronis dengan disertai riwayat gejala pernapasan seperti mengi, sesak napas, rasa tertekan di dada dan batuk dari waktu ke waktu dan intensitas dengan variasi keterbatasan aliran udara ekspirasi. Di Indonesia prevalensi asma belum diketahui secara pasti, namun diperkirakan 2-5 % penduduk Indonesia menderita asma. Tujuan utama penelitian ini adalah untuk mengetahui perbedaan kejadian gangguan gastrointestinal pada penggunaan aminofilin dan salbutamol pada pasien eksaserbasi asma di Rumah Sakit di Surabaya serta mengetahui kejadian gangguan gastrointestinal terkait ADRs (Adverse Drug Reaction) akibat penggunaan aminofilin dan salbutamol berdasarkan penilaian Naranjo scale. Pada penelitian ini menggunakan metode Quasi Eksperimental. Penelitian ini dilakukan pada bulan Oktober 2014 sampai Februari 2015. Hasil penelitian dari 7 sampel diperoleh 14,29% mengalami ADR dari penggunaan aminofilin dan dari 13 pasien pada pengguanaan salbutamol tidak ditemukan ADR sehingga dapat disimpulkan bahwa tidak ada perbedaan kejadian gangguan gastrointestinal pada penggunaan aminofilin dan salbutamol pada pasien eksaserbasi asma di Rumah Sakit di Surabaya. Manfaat umum dari penelitian ini adalah berguna dalam monitoring pengobatan pasien asma akut terutama yang mendapat terapi salbutamol dan teofilin sehingga dapat mengurangi angka kejadian ADR.]]>
