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Jurnal Farmasi Klinik Indonesia

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Published by Universitas Padjadjaran

ISSN : 23375701 EISSN : 2337 5701 DOI : -

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Indonesian Journal of Clinical Pharmacy (IJCP) is a scientific publication on all aspect of clinical pharmacy. It published 4 times a year by Clinical Pharmacy Master Program Universitas Padjadjaran to provide a forum for clinicians, pharmacists, and other healthcare professionals to share best practice, encouraging networking and a more collaborative approach in patient care. Indonesian Journal of Clinical Pharmacy is intended to feature quality research articles in clinical pharmacy to become scientific guide in fields related to clinical pharmacy. It is a peer-reviewed journal and publishes original research articles, review articles, case reports, commentaries, and brief research communications on all aspects of Clinical Pharmacy. It is also a media for publicizing meetings and news relating to advances in Clinical Pharmacy in the regions.

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Search results for , issue "Vol 5, No 4 (2016)" : 16 Documents clear

Perbedaan Fungsi Ginjal, Hati dan Darah pada Pasien Kanker Serviks dengan Kemoterapi Bleomisin, Oncovin®, Mitomisin dan Karboplatin (Studi Kasus di RSUP Sanglah Denpasar Tahun 2015) Rini Noviyani; I Nyoman G. Budiana; Putu A. Indrayathi; Rasmaya Niruri; I Ketut Tunas
Indonesian Journal of Clinical Pharmacy Vol 5, No 4 (2016)
Publisher : Universitas Padjadjaran

Regimen Bleomisin Oncovin® Mitomisin-Karboplatin (BOM-Karboplatin) sebagai kemoterapi tidak terlepas dari efek samping yang ditimbulkan yaitu toksisitas pada organ tubuh diantaranya adalah ginjal, hati, dan darah, dimana terjadinya toksikitas pada organ ginjal dapat diindikatorkan dengan parameter Serum Kreatinin dan Blood Urea Nitrogen (BUN). Terjadinya toksisitas pada organ hati dapat diukur dengan parameter SGOT dan SGPT serta toksisitas pada fungsi darah diindikatorkan dengan nilai hemoglobin, trombosit, leukosit. Belum terdapat data mengenai efek toksik dari kemoterapi BOM-Karboplatin pada pasien kanker serviks sel skuamosa stadium IIB–IIIB di RSUP Sanglah Denpasar, sehingga penelitian ini dilakukan melalui pemantauan terhadap fungsi ginjal, hati dan darah. Penelitian ini merupakan studi kasus observasional terhadap sembilan pasien yang diikuti selama tiga seri kemoterapi dari bulan Februari hingga Agustus 2015. Data serum kreatinin, BUN, SGOT, SGPT, hemoglobin, trombosit, dan leukosit yang diperoleh dianalisis menggunakan uji t berpasangan untuk data yang terdistribusi normal dan uji Wilcoxon untuk data yang tidak terdistribusi normal dengan tingkat kepercayaan 95% dan dikatakan berbeda bermakna bila p<0,05. Hasil studi kasus ini menunjukkan nilai serum kreatinin (p=0,530), BUN (p=0,553), SGOT (p=0,162), SGPT (p=0,054), Hemoglobin (p=0,034), Trombosit (p=0,028), dan Leukosit (p=0,011), sehingga dapat disimpulkan bahwa terdapat penurunan fungsi darah yang signifikan ditandai dengan adanya penurunan signifikan pada parameter hemoglobin, trombosit dan leukosit sebelum kemoterapi I dan sesudah kemoterapi III BOM-Karboplatin, sehingga diperlukan monitoring ketat terhadap fungsi darah pasien yang menerima kemoterapi BOM-Karboplatin di RSUP Sanglah Denpasar.Kata kunci: BOM-Karboplatin, fungsi darah, kanker serviks, kemoterapi, RSUP Sanglah, toksisitasThe Difference of Kidney, Heart and Blood Function on Cervical Cancer Patients with Chemotherapy, Bleomycin, Oncovin®, Mitomycin and Carboplatin (Case Study in Sanglah General Hospital, Denpasar in 2015) Oncovin® bleomycin mitomycin-carboplatin (BOM-carboplatin) regimen as chemotherapy is inseparable from the side effects it can caused which is toxicity to organs including the kidneys, liver, and blood where the toxicity in the kidneys can be indicated by the parameter of Serum Creatinine and Blood Urea Nitrogen (BUN), the occurrence of toxicity in the liver can be measured by the parameters of SGOT and SGPT, and toxicity to blood function can be indicated by the value of hemoglobin, platelets, leukocytes. The absence of data on the toxic effects of chemotherapy BOM-carboplatin in patients with squamous cell cervical cancer stage IIB–IIIB in Sanglah General Hospital in Denpasar, had made this research conducted through monitoring of kidney, liver and blood function. This study is an observational case study of nine patients who were followed for three rounds of chemotherapy from February to August 2015. Data of creatinine serum, BUN, SGOT, SGPT, hemoglobin, platelets, and leukocytes were analyzed using paired t-test for the data that were normally distributed and Wilcoxon test for the data that were not normally distributed with a confidence level of 95% and was said to be significantly different when p<0.05. The results of this case study demonstrated the value of serum creatinine (p=0.530), BUN (p=0.553), SGOT (p=0.162), SGPT (p=0.054), hemoglobin (p=0.034), platelets (p=0.028), and leukocytes (p=0.011) so it could be concluded that there was a significant decrease of blood function which could be characterized by a significant decrease in the parameters of hemoglobin, platelets and leucocytes before chemotherapy I and after chemotherapy III BOM-carboplatin, so it required strict monitoring of the blood function of the patients who received chemotherapy BOM-carboplatin in Sanglah General Hospital in Denpasar.Keywords: BOM-carboplatin, blood function, cervical cancer, chemotherapy, Sanglah General Hospital, toxicity

Studi Epidemiologis dan Laboratoris: Peran Metformin pada Kanker Kolorektal Ratih D. Yudhani
Indonesian Journal of Clinical Pharmacy Vol 5, No 4 (2016)
Publisher : Universitas Padjadjaran

Data GLOBOCAN tahun 2012 menunjukkan kanker kolorektal merupakan keganasan urutan ketiga terbanyak di dunia. Di Indonesia, berdasarkan data WHO tahun 2014, kanker ini menempati urutan kedua terbanyak pada laki-laki dan ketiga pada perempuan. Studi epidemiologis menunjukkan diabetes melitus terkait erat dengan insidensi kanker secara umum dan meningkatkan risiko kanker kolorektal sebesar 30%. Beberapa studi epidemiologis melaporkan terapi metformin pada penderita diabetes menurunkan risiko insidensi kanker dan didukung studi laboratorik yang menunjukkan metformin mampu menghambat pertumbuhan dan proliferasi sel kanker melalui mekanisme utama mempengaruhi jalur AMPK/mTOR. Metode dalam review ini adalah penelusuran data berbasis Pubmed, Scopus dan Google Scholar dan tanpa pembatasan Index Factor dengan kata kunci metformin, colorectal cancer dan colon cancer, pada jurnal gratis maupun jurnal berbayar. Review ilmiah ini bertujuan memberikan pemahaman baru terkait aktivitas antikanker metformin dan potensinya untuk digunakan sebagai terapi preventif maupun adjuvan terapi pada kanker, khususnya kanker kolorektal.Kata kunci: Diabetes, kanker, kolorektal, metforminEpidemiological and Experimental Studies: The Role of Metformin on Colorectal CancerGLOBOCAN data in 2012 showed colorectal cancer was the third leading cancer worldwide. In Indonesia, based on WHO data in 2014, colorectal cancer was the second common cancer ini men and third cancer in women. Epidemiological studies showed that diabetes mellitus have a correlation with the incidence of cancer and increase colorectal cancer risk by 30%. Some of epidemiological study showed that metformin therapy in diabetes patient reduce the risk of cancer incidence. It supported by experimental study which showed that metformin inhibit the growth and proliferation of cancer cells by influence the AMPK/mTOR pathway as a main role. The method was literature review based on publication at Pubmed, Scopus, and Google Scholar with keywords “metformin, colorectal cancer”, “metformin, colon cancer”, without index factor limitation in free journal and paid journal. The aim of this review is to give a new insight of metformin activity as anti-cancer and its potential for both preventif and adjuvant cancer therapy, especially for colorectal cancer.Keywords: Cancer, colorectal, diabetes, metformin

Pengaruh Penilaian Prestasi Kerja dan Kompensasi terhadap Kinerja Tenaga Teknis Kefarmasian Non-PNS Instalasi Farmasi RSUP Dr. Hasan Sadikin Rina Winarni; Ahmad Muhtadi; Emma Surahman
Indonesian Journal of Clinical Pharmacy Vol 5, No 4 (2016)
Publisher : Universitas Padjadjaran

Kinerja adalah hasil kerja secara kualitas dan kuantitas yang dicapai oleh seorang pegawai. Penelitian ini bertujuan untuk mengetahui pengaruh penilaian prestasi kerja dan kompensasi terhadap kinerja pegawai Tenaga Teknis Kefarmasian Non-PNS Instalasi Farmasi. Metode yang digunakan adalah metode survei analitik dengan rancangan potong lintang. Sampel yang digunakan 102 karyawan instalasi farmasi kompetensi Tenaga Teknis Kefarmasian dengan status kepegawaian Non-PNS. Pengumpulan data menggunakan kuesioner dan dianalisis menggunakan analisis jalur. Hipotesis pertama penilaian prestasi kerja memengaruhi kinerja (t hitung 4,038 > t tabel 1,984). Hipotesis kedua adalah kompensasi memengaruhi kinerja (t hitung 3,739 > t tabel 1,984). Hipotesis ketiga adalah penilaian prestasi kerja memengaruhi kompensasi (t-hitung 10,208 > t tabel 1,984). Penilaian prestasi kerja dan kompensasi berpengaruh sebesar 51,68% terhadap kinerja pegawai. Penilaian prestasi kerja dan kompensasi masing‑masing berpengaruh sebesar 27% dan 24,68% sedangkan 48,32% merupakan variabel lain yang tidak diteliti. Kinerja Tenaga Teknis Kefarmasian Non-PNS Instalasi Farmasi RSUP Dr. Hasan Sadikin dipengaruhi oleh penilaian prestasi kerja dan kompensasi dengan total pengaruh sebesar 51,68%.Kata kunci: Kinerja, kompensasi, penilaian prestasi kerja, tenaga teknis kefarmasianThe Impact of Performance Appraisal and Compensation to Performance of Pharmacy Technical Personnel Non-Civil Servants at Hasan Sadikin Hospital Abstract Performance is the result of the quality and quantity of work achieved by an employee. This study aimed to determine the effect of performance appraisal and compensation to performance of Pharmacy Technical Personnel Non Civil Servants. This study used analytic survey with cross-sectional study design. The sample are 102 pharmacy employees. Data was collected by using questionnaires and analyzed using path analysis. The first hypothesis is the performance appraisal affect the performance (t value 4,038 > t table 1.984). The second hypothesis is the compensation affects the performance (t value 3.739 > t table 1.984). The third hypothesis is the performance appraisal affects the compensation (t value 10.208 > t table 1.984). Performance appraisal and compensation affected employee performance by51.68%. Performance appraisal and compensation affected employee performance by 27% and 24.68% respectively, while 48.32% is other variable that is not investigated. Performance of Pharmacy Technical Personnel Non Civil Servants in RSUP DR. Hasan Sadikin is influenced among others by the performance appraisal and compensation with a total effect of 51.68%.Keywords: Compensation, performance, performance appraisal, pharmacy technical personnel

Gambaran Kepatuhan Pengobatan Pasien Diabetes Melitus Tipe 2 di Puskesmas Daerah Istimewa Yogyakarta Nur Rasdianah; Suwaldi Martodiharjo; Tri M. Andayani; Lukman Hakim
Indonesian Journal of Clinical Pharmacy Vol 5, No 4 (2016)
Publisher : Universitas Padjadjaran

Prevalensi diabetes melitus berdasarkan hasil riset kesehatan dasar (Riskesdas, 2013) tertinggi di Indonesia terdapat di provinsi DI Yogyakarta.terdapat di provinsi DI Yogyakarta. Diabetes melitus merupakan penyakit kronis yang membutuhkan pengobatan jangka panjang dan kompleks dimana salah satu penentu keberhasilan terapi bergantung pada kepatuhan penggunaan obat. Tujuan penelitian ini untuk mengetahui gambaran karakteristik pasien meliputi jenis kelamin, usia, tingkat pendidikan, durasi penyakit, komorbid, dan penggunaan ADO terhadap kepatuhan pasien diabetes melitus tipe 2. Penelitian ini menggunakan metode observasional dengan rancangan analisis potong lintang yang dilakukan secara retrospektif terhadap 123 pasien diabetes melitus tipe 2 rawat jalan di puskesmas daerah Yogyakarta pada bulan Agustus–September tahun 2015. Metode pengambilan sampel menggunakan teknik accidental sampling. Instrumen penelitian berupa lembar pengambilan data dan kuesioner Morisky Medication Adherence MMAS-8. Data dianalisis menggunakan Chi-Square. Hasil penelitian menunjukkan bahwa secara keseluruhan tingkat kepatuhan pasien diabetes melitus tipe 2 berada pada tingkat kepatuhan rendah. Hubungan antara pengaruh karakteristik pasien: jenis kelamin (p=0,275), usia (p=0,473), tingkat pendidikan (p=0,157), durasi penyakit (p=0,097), jumlah komorbid (p=0,79), dan ADO (p=0,401) terhadap tingkat kepatuhan tidak signifikan (p>0,05).Kata kunci: Diabetes melitus tipe 2, karakteristik pasien, kepatuhan The Description of Medication Adherence for Patients of Diabetes Mellitus Type 2 in Public Health Center Yogyakarta According to the Basic Health Research (Riskesdas 2013), the highest prevalence of diabetes mellitus in Indonesia is in Yogyakarta. Diabetes mellitus is chronic disease that needs the complex and a long term medical treatment, one of the success factor in the therapy depends on the patient adherence. The purpose of this research was to know and describe patient’s characteristics including gender, age, education, duration of the disease, comorbid, AOD usage through the adherence of type 2 diabetes mellitus. This research used an observational method with cross-sectional analysis that conducted retrospectively to 123 outpatients with diabetes mellitus type 2 in Yogyakarta Primary Health Care during August–September 2015. The sampling method the accidental sampling technique. Morisky Medication Adherence (MMAS) questionnaire was used and analyzed with Chi Square. The result of this research showed that the entirety of medication’s adherence level is low. The correlation between patients characteristic, gender (p=0.275), ages (p=0.473), educational level (p=0.157), disease’s duration (p=0.097), number of cormobid (p=0.79), and ADO (p=0.401) against the medication’s adherence level were not significant (p>0.05).Keywords: Adherence, diabetes mellitus type 2, patient characteristics

Potensi Interaksi Obat-Obat pada Resep Polifarmasi: Studi Retrospektif pada Salah Satu Apotek di Kota Bandung Sulastri Herdaningsih; Ahmad Muhtadi; Nurul Annisa
Indonesian Journal of Clinical Pharmacy Vol 5, No 4 (2016)
Publisher : Universitas Padjadjaran

Resep polifarmasi sangat umum terjadi dalam peresepan pasien rawat jalan maupun rawat inap di setiap fasilitas kesehatan. Polifarmasi dapat meningkatkan risiko terjadinya interaksi obat-obat atau Drug-drug Interactions (DDI’s) yang sebagian besar akan menimbulkan dampak merugikan dalam terapi pasien. Tujuan dari studi ini yaitu untuk menilai potensi DDI’s pada resep rawat jalan di salah satu apotek di kota Bandung. Data diproses melalui www.drugs.com database atau Drug Interactions Checker. Studi ini memaparkan prevalensi dan mengklasifikasikan jenis interaksi potensial berdasarkan level interaksi yaitu mayor, moderat dan minor. Total resep rawat jalan periode Januari–Maret 2014 adalah sebanyak 352 lembar resep yang didalamnya terdapat sebanyak 1.111 R/. Dari total keseluruhan jumlah lembar resep, terdapat 197 (55,97%) lembar resep yang masuk dalam kriteria inklusi. Sebanyak 121 lembar resep terdapat DDI’s potensial sebesar 34,38%. Keseluruhan DDI’s potensial yang terjadi adalah sebanyak 194 interaksi. DDI’s potensial mayor sebanyak 25 (12,89%), moderat sebanyak 134 (69,07%) dan minor 35 (8,04%). DDI’s terbanyak terdapat dalam kategori mayor dan moderat yang membutuhkan perhatian lebih dan tindakan pencegahan terhadap DDI’s potensial yang mungkin terjadi oleh dokter dan apoteker untuk memaksimalkan efektivitas terapi pasien.Kata kunci: Interaksi obat-obat, pasien rawat jalan, resep polifarmasiPotential of Drug-Drug Interaction in Polypharmacy Prescription: Retrospective Study on a Drugstore in Bandung Abstract Polypharmacy prescription very commonly occurs on prescribing the outpatient and inpatient in every health facility. Polypharmacy may increase the risk of Drug-drug Interactions (DDI’s) which mostly causes harm impact in the patient’s therapy. The aim of this study was to measure the potential of DDI’s on the outpatient prescription in one of the drugstore in Bandung. The data was processed through www. drugs.com database or Drug Interactions Checker. This study described the prevalence and classification of potential interactions based on interaction level of major, moderate, and minor. The number of outpatient prescription on January–March 2014 was 352 sheets of prescriptions with 1.111 R/. From overall numbers of prescriptions, there were 197 (55.97%) sheets of prescriptions on inclusion criteria. In 121 prescriptions, there were 34.38% of DDI’s potential. All of DDI’s potential occurs was 194 interactions. The major DDI’s potential of 25 (12.89%), moderate of 134 (69.07%) and minor of 35 (8.04%). The most of DDI’s found in major and moderate level need more attention and prevention aid against DDI’s potential that may occur by doctors and pharmacists to maximize the effectiveness of patient’s therapy.Keywords: Drug-drug Interactions (DDI’s), outpatient, polypharmacy prescription

Hubungan Kepatuhan Menggunakan Obat Inhaler β2-Agonis dan Kontrol Asma pada Pasien Asma Sri Haryanti; Zullies Ikawati; Tri M. Andayani; Mustofa Mustofa
Indonesian Journal of Clinical Pharmacy Vol 5, No 4 (2016)
Publisher : Universitas Padjadjaran

Asma tetap menjadi masalah kesehatan yang dialami banyak anak-anak dan orang dewasa di dunia. Sebagai penyakit kronis, tata laksana asma memerlukan pengobatan yang berkelanjutan. Salah satu masalah penting dalam tata laksana asma adalah kepatuhan dalam pengobatan. Kepatuhan yang rendah terhadap anti-asma yang diberikan menyebabkan meningkatnya morbiditas dan mortalitas. Penelitian ini dilakukan untuk mengkaji hubungan kepatuhan terhadap anti-asma yang diberikan dengan kontrol asma. Penelitian ini merupakan penelitian observasional menggunakan rancangan potong lintang yang dilakukan di empat rumah sakit di Daerah Istimewa Yogyakarta selama enam bulan, yaitu antara bulan Juni sampai Desember 2015. Subjek penelitian adalah pasien dengan gangguan fungsi pernafasan yang menjalani pengobatan di poliklinik penyakit dalam di rumah sakit tersebut dan memenuhi kriteria inklusi dan eksklusi serta bersedia ikut dalam penelitian dengan menandatangani surat pernyataan persetujuan. Kepatuhan diukur dengan Morisky Medication Adherence Scale (MMAS) dan kontrol asma diukur dengan Asthma Control Test (ACT). Uji korelasi Pearson digunakan untuk mengkaji hubungan antara kepatuhan dan kontrol asma. Total sebanyak 67 pasien diseleksi dan 57 diantara memenuhi kriteria inklusi dan eksklusi. Berdasarkan kepatuhannya, pasien dikelompokkan ke dalam kepatuhan sedang (31 pasien atau 54%) dan kepatuhan rendah (26 pasien atau 46%). Berdasarkan kontrol asma, pasien dikelompokkan ke dalam kontrol asma sebagian (11 pasien atau 19%) dan tidak terkontrol asma (47 pasien atau 81%). Terdapat hubungan signifikan antara kepatuhan dengan kontrol asma (r=0,303, p<0,05). Kesimpulan, kepatuhan terapi dapat meningkatkan kontrol asma.Kata kunci: Anti-asma, kepatuhan, kontrol asma, tata kelola asmaRelationship Between Compliance of Using β2-Agonist Inhaler Drugand Asthma Control on Asthma Patient Asthma remains a health problem affecting a large number of children and adult in the world. Being a chronic disease, asthma management requires continous medications. One of the most important issues in asthma management is adherence to treatment. Poor compliance with prescribed anti-asthma leads to increase in morbidity and mortality. This study was conducted to evaluate the relationship between ompliance prescribed anti-asthma and asthma control. This was an observasional study using cross-sectional design conducted in four hospitals around Province of DI Yogyakarta during six months om June until December 2015. Subjects were patients with respiratory disorders who underwent treatment in internal medicine polyclinic in the hospitals, met the inclusion and exclusion criteria and willing to participate in the study by signing the informed consent. Compliance was assesseed by Morisky Medication Adherence Scale (MMAS) and asthma control was assessed by Asthma Control Test (ACT). Pearson’s correlation test was used to evaluate the relationship between compliance and asthma control. A total of 67 patients were selected and 57 of them met the inclusion and exclusion criteria. Based on the patient’s compliance, the patients were grouped into moderate compliance (31 patients or 54%) and low compliance (26 patients or 46%). Whereas based on the asthma control, the patients were grouped into partly controlled asthma (11 patient or 19%) and uncontrolled asthma (47 patients or 81%). There is a significant relationship between compliance with asthma control (r=0303, p<0.05). Conclusion, compliance can increase asthma control.Keywords: Anti-asthma, asthma control, asthma management, compliance

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