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Contact Name
Rizky Abdulah
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r.abdulah@unpad.ac.id
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editorial@ijcp.or.id
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Kota bandung,
Jawa barat
INDONESIA
Jurnal Farmasi Klinik Indonesia
ISSN : 23375701     EISSN : 2337 5701     DOI : -
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Indonesian Journal of Clinical Pharmacy (IJCP) is a scientific publication on all aspect of clinical pharmacy. It published 4 times a year by Clinical Pharmacy Master Program Universitas Padjadjaran to provide a forum for clinicians, pharmacists, and other healthcare professionals to share best practice, encouraging networking and a more collaborative approach in patient care. Indonesian Journal of Clinical Pharmacy is intended to feature quality research articles in clinical pharmacy to become scientific guide in fields related to clinical pharmacy. It is a peer-reviewed journal and publishes original research articles, review articles, case reports, commentaries, and brief research communications on all aspects of Clinical Pharmacy. It is also a media for publicizing meetings and news relating to advances in Clinical Pharmacy in the regions.
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Articles 16 Documents
Search results for , issue "Vol 6, No 1 (2017)" : 16 Documents clear
Efek Astaxanthin dan Latihan Teratur terhadap Pola Stres Oksidatif Pria Setelah Aktivitas Berat Nova Sylviana; Hanna Gunawan; Ronny Lesmana; Ambrosius Purba; Ieva B. Akbar
Indonesian Journal of Clinical Pharmacy Vol 6, No 1 (2017)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (340.861 KB) | DOI: 10.15416/ijcp.2017.6.1.46

Abstract

Aktivitas fisik berat meningkatkan senyawa oksigen reaktif dalam tubuh yang diketahui dengan mengukur kadar malondialdehid (MDA) dari hasil proses lipid peroksidase yaitu kerusakan oksidatif pada biomolekul lipid akibat reaktivitas senyawa oksigen reaktif (SOR), namun pola perubahan kadar MDA plasma seseorang setelah beraktivitas fisik berat masih belum dipahami. Antioksidan potensial seperti astaxanthin dan latihan teratur diduga dapat memengaruhi pola perubahan kadar MDA tersebut. Untuk itu dilakukan penelitian eksperimental dengan subjek 15 orang pria terlatih dan 15 orang pria tidak terlatih anggota sebuah pusat kebugaran di Bandung, usia 18­–25 tahun yang terbagi menjadi kelompok yang mendapatkan suplemen astaxhantin atau plasebo selama satu minggu secara buta ganda. Setelah pemberian suplemen atau plasebo, setiap kelompok melakukan tes aktivitas anaerobik berat. Dilakukan pengukuran MDA rerata (mmol/mL) sebelum dilakukan tes, langsung setelah tes, 6 jam setelah tes, dan 24 jam setelah tes. Data yang dianalisis menggunakan uji ANOVA diikuti uji Duncan menunjukkan bahwa sebelum tes keempat kelompok mempunyai rerata yang hampir sama, sementara rerata MDA yang diperiksa pada setelah tes pada kelompok pria terlatih dengan suplementasi astaxanthin memiliki rerata MDA terendah, sementara yang tertinggi pada kelompok pria tak terlatih dengan plasebo (p<0,05). Perubahan rerata MDA pada setiap kelompok menunjukkan pola dinamis sama yaitu meningkat tajam langsung setelah tes latihan fisik, mulai mengalami penurunan pada jam ke–6 dan kembali ke rerata awal pada jam ke–24 (p<0,05), kecuali pada kelompok pria tak terlatih dengan plasebo meningkat 2 kali dari nilai awal. Hal ini menunjukkan astaxanthin dan latihan mempunyai efek positif terhadap peningkatan kadar MDA namun tidak memengaruhi pola perubahannya setelah aktivitas fisik berat.Kata kunci: Astaxanthin, latihan, malondialdehid The Effect of Astaxanthin and Regular Training on Dynamic Pattern of Oxidative Stress on Male under Strenuous ExerciseAbstractStrenuous physical activity will induce higher Reactive Oxygen Species (ROS) level in human body that can be measured by serum malondialdehyde (MDA) level. Malondialdehyde is product of lipid peroxidation process that defined as oxidative damage of lipid biomolecule by reactivity of reactive oxygen species. Still, the dynamic pattern of malondialdehyde (MDA) level under strenuous exercise is not fully understood. Potent antioxidant such as astaxanthin and training may altered the level of MDA. Thus, the purpose of this study is to understand the effect of astaxanthin to MDA dynamic pattern on training male after strenuous physical activity. It was a double blind, experimental study, conducted on thirty young male age, divided into untrained and trained groups. Supplement astaxanthin was given to 15 subject as well as plasebo for one week. After supplementation, subjects were tested with anaerobic strenuous physical activity. The values were analyzed with ANOVA test followed by Duncan test showed that in every group, mean of MDA before test was similar, started increasing significantly after test, began decreasing at 6th hour post test and back to baseline at 24th hour post test (p<0.05), except for group of untrained male with plasebo, the value still increase twice from baseline. The lowest mean of MDA was found on group of trained male with astaxanthin supplementation and the highest was found on group of untrained male with placebo (p<0.05). These findings support that astaxanthin and training might have positive effect to oxidative stress condition without altered its dynamic pattern in male after strenuous physical activity.Keywords: Astaxanthin, malondialdehyde, training
Pengaruh Pemberian Kombinasi Probiotik dan Seng terhadap Frekuensi dan Durasi Diare pada Pasien Anak di Rumah Sakit PKU Muhammadiyah Yogyakarta Nurul Huda; Dyah A. Perwitasari; Irma Risdiana
Indonesian Journal of Clinical Pharmacy Vol 6, No 1 (2017)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1056.811 KB) | DOI: 10.15416/ijcp.2017.6.1.11

Abstract

Berdasarkan Survei Kesehatan Rumah Tangga dan Riset Kesehatan Dasar dari tahun ke tahun, diare merupakan penyebab utama kematian balita di Indonesia. Penggunaan probiotik untuk diare akut pada anak sudah digunakan secara luas meskipun belum direkomendasikan oleh World Health Organization (WHO). Penelitian yang membandingkan penambahan probiotik pada terapi standar diare masih sangat terbatas, oleh karena itu penelitian ini dilakukan untuk mengetahui pengaruh pemberian probiotik yang diberikan secara bersamaan dengan terapi standar diare terhadap frekuensi dan durasi diare akut pada anak. Penelitian ini menggunakan desain kohort dengan pengambilan data dilakukan secara prospektif pada pasien diare akut pada anak di Unit Rawat Inap Anak RS PKU Muhammadiyah Yogyakarta periode September–Desember 2015. Subjek yang diamati adalah pasien yang mendapatkan terapi standar diare (cairan rehidrasi dan seng) sebagai kelompok I, dan yang mendapatkan terapi standar diare (cairan rehidrasi dan seng) yang dikombinasikan dengan probiotik sebagai kelompok II. Variabel pengamatan utama adalah frekuensi dan durasi diare. Perbedaan frekuensi diare dan durasi diare antar kelompok yang terdistribusi normal dianalisis dengan uji parametrik yaitu uji t-test tidak berpasangan, sedangkan yang tidak terdistribusi normal dianalisis dengan uji non-parametrik yaitu uji Mann-Whitney. Selama periode penelitian diperoleh 44 subjek yang memenuhi kriteria inklusi, yang terdiri dari 38 subjek yang mendapatkan terapi cairan rehidrasi, seng dan probiotik dan sebanyak 6 subjek yang mendapatkan terapi cairan rehidrasi dan seng. Frekuensi diare lebih sedikit pada kelompok I dengan nilai rata-rata 1 kali dibanding kelompok II yaitu 3 kali (p=0,024). Durasi diare lebih singkat pada kelompok I dengan nilai rata-rata 46 jam 30 menit dibanding kelompok II dengan nilai rata-rata 53 jam 10 menit (p=0,515). Dari penelitian ini disimpulkan bahwa pemberian probiotik pada terapi standar diare tidak menunjukkan penurunan pada frekuensi dan durasi diare dibandingkan dengan kelompok yang hanya diberikan terapi standar diare dalam tata laksana diare akut pada anak.Kata kunci: Diare, probiotik, prospektif, seng Effect of Probiotics and Zinc Combination to the Frequency and Duration of Diarrhea in Pediatrics Patients at PKU Muhammadiyah Hospital YogyakartaAbstractBased on the survey of household health and basic medical research over the years, diarrhea is a major cause of infant mortality in Indonesia. Probiotics have been used extensively in acute diarrhea in children, although are not recommended yet by Word Health Organization (WHO). Research on comparative of increasing probiotic research to standard therapy of diarrhea is still very limited. Therefore this study was conducted to determine the effect of probiotics given concomitantly with standard therapy of diarrhea to the frequency and duration of acute diarrhea in children. This study was conducted by cohort design with data collection was performed prospectively in children patients with acute diarrhea in the pediatric ward of PKU Muhammadiyah Hospital in Yogyakarta from September until December 2015. Subjects were receiving standard therapy of diarrhea (rehydration solution and zinc) as group I, and who received standard therapy diarrhea (rehydration solution and zinc) combined with probiotics as group II. The main observation variables were frequency and duration of diarrhea. Differences of diarrhea frequency and diarrhea duration between groups normally distributed were analyzed by parametric unpaired t-test, while not normally distributed were analyzed by non-parametric Mann-Whitney test. During the study period we recruited 44 subjects who met the inclusion criteria, which consisted of 38 subjects who received fluid rehydration therapy, zinc and probiotics and as much as 6 subjects who received therapy rehydration liquid and zinc. The results show the frequency of diarrhea in group I is less than group II, the average value of group I is 1 time and the average value of group II is 3 times (p=0.024). Duration of diarrhea was shorter in group I with the average value of 46 hours 30 minutes than in group II 53 hours 10 minutes (p=0.515). This study suggests that the administration of probiotics in the standard therapy of diarrhea did not significantly affect the reduction in the frequency of diarrhea and the duration of diarrhea, compared to the group given only the standard therapy of diarrhea in the management of acute diarrhea in children.Keywords: Diarrhea, probiotics, prospective, zinc
Heart-type Fatty Acid-Binding Protein (H-FABP) sebagai Penanda Biokimiawi untuk Membedakan Stroke Iskemik dan Hemoragik Eli Halimah; Evy Liswati; Erwin Sasmita
Indonesian Journal of Clinical Pharmacy Vol 6, No 1 (2017)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (6927.71 KB) | DOI: 10.15416/ijcp.2017.6.1.55

Abstract

Strok merupakan sindrom neurologis yang bersifat akut yang terjadi karena adanya penurunan aliran darah yang disebabkan oleh terhambat atau pecahnya pembuluh darah otak (cerebrovaskular) yang menyebabkan kerusakan jaringan otak. Berdasarkan patogenesisnya, terdapat dua jenis strok, yaitu strok iskemik dan hemoragik. Penanganan pengobatan pada kedua jenis strok tersebut sangat berbeda sehingga diperlukan diagnosis diferensial untuk membedakan kedua jenis strok tersebut. Tujuan penelitian ini yaitu untuk menentukan apakah Heart-type Fatty Acid-Binding Protein (H-FABP) dapat dijadikan sebagai parameter penanda biokimiawi untuk membedakan strok iskemik dan hemoragik. Penetapan kadar H-FABP dilakukan dengan menggunakan serum darah dan dianalisis dengan metode Enzyme Linked Immunosorbent Assay (ELISA) sandwich masing-masing menggunakan H-FABP test kit. Serum darah diambil dari 20 orang pasien strok iskemik dan 18 orang pasien strok hemoragik dari Instalasi Gawat Darurat (IGD), Unit Strok dan Instalasi Rawat Inap di salah satu Rumah Sakit Umum di Jakarta. Hasil penelitian menunjukkan bahwa kadar rata-rata H-FABP pada pasien strok iskemik sebesar 9,07 ng/mL sedangkan pasien strok hemoragik sebesar 18,54 ng/mL; secara statistik terdapat perbedaan kadar H-FABP yang signifikan antara pasien strok iskemik dan hemoragik (α=0,05). Dengan demikian, Heart-type Fatty Acid-Binding Protein (H-FABP) dapat dijadikan sebagai salah satu parameter penanda biokimiawi untuk membedakan strok iskemik dan hemoragik.Kata kunci: Heart-type Fatty Acid-Binding Protein (H-FABP), strok hemoragik, strok iskemik Heart-type Fatty Acid-Binding Protein (H-FABP) as a Biochemical Marker to Differentiate Ischemic and Hemorrhagic StrokeAbstractStroke is an acute neurological syndrome that occurs due to a decrease in blood flow caused by blocked or rupture of blood vessels of the brain (cerebrovascular) that causes damage to brain tissue. Based on the pathogenesis, there are two types of stroke, the ischemic and hemorrhagic stroke, in which the handling of treatment in both types of stroke are very different, so the differential diagnosis is required to distinguish the two types of stroke. The purpose of this study is to determine whether Heart-type Fatty Acid-Binding Protein (H-FABP) can be used as a parameter of biochemical marker to distinguish between ischemic and hemorrhagic stroke. H-FABP assay is performed using blood serum and analyzed by Enzyme Linked Immunosorbent Assay (ELISA) sandwich method, each using H-FABP test kit. Blood serum taken from 20 patients with ischemic strokes and 18 hemorrhagic stroke patients from one of a hospital in Jakarta. The results showed that the average H-FABP concentration in ischemic stroke‑patients is 9,07 ng/mL and hemorrhagic stroke‑patients is 18,54 ng/mL; statistically there are significant difference between H-FABP concentration in ischemic stroke‑patients and hemorrhagic stroke-patients (α=0.05). Thus Heart-type Fatty Acid-Binding Protein (H-FABP) can be used as one of the parameters of biochemical markers to distinguish between ischemic and hemorrhagic stroke.Keywords: Heart-type Fatty Acid-Binding Protein (H-FABP), hemorrhagic stroke, ischemic stroke
Efek Ekstrak Daun Singawalang (Petiveria alliacea) dalam Menurunkan Kadar Glukosa Darah melalui Peningkatan Ekspresi AMPK-α1 pada Tikus Model Diabetes Melitus Arifa Mustika; Roostantia Indrawati; Gadis M. Sari
Indonesian Journal of Clinical Pharmacy Vol 6, No 1 (2017)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (274.998 KB) | DOI: 10.15416/ijcp.2017.6.1.22

Abstract

Singawalang (Petiveria alliaceae) adalah tumbuhan yang banyak ditemukan di Indonesia dan secara empiris digunakan oleh penduduk untuk mengobati diabetes melitus. Hingga saat ini, penelitian tentang pengaruh dan mekanisme ekstrak daun Singawalang dalam menurunkan kadar glukosa darah belum banyak dilakukan. Tujuan penelitian ini adalah untuk mengetahui pengaruh ekstrak daun Singawalang terhadap penurunan kadar glukosa darah dan ekspresi AMPK-α1 pada hati. Jenis penelitian ini adalah penelitian eksperimental dengan rncangan acak lengkap. Penelitian dilakukan di Laboratorium Farmakologi dan Terapi dan Laboratorium Patologi Anatomi Fakultas Kedokteran Universitas Airlangga pada bulan April–Agustus 2015. Hewan coba tikus strain Rattus norvegicus dibuat model diabetes melitus, diinduksi dengan Streptozotocin. Sebanyak 25 tikus model diabetes melitus dibagi secara acak menjadi 5 kelompok. Kelompok perlakuan 1, 2 dan 3 adalah kelompok yang memperoleh ekstrak daun Singawalang dengan dosis 90 mg/kgbb, 180 mg/kgbb dan 360 mg/kgbb. Kelompok kontrol positif adalah kelompok yang memperoleh metformin dengan dosis 150 mg/kgbb dan kontrol negatif adalah kelompok tikus yang memperoleh vehikulum. Ekstrak dan metformin diberikan sehari sekali, personde selama 14 hari. Pada hari ke-15 setelah terapi, tikus diperiksa kadar glukosa darah dan dieuthanasia untuk diambil organnya. Ekspresi AMPK-α1 dinilai menggunakan imunohistokima. Data yang terkumpul dianalisis dengan ANAVA dan Wilcoxon (α=0,05). Hasil penelitian menunjukkan adanya perbedaan kadar glukosa darah yang bermakna antara kontrol negatif dengan dosis 90 mg/kgbb, dosis 360 mg/kgbb, dan kontrol positif, antara dosis 180 mg/kgbb dengan dosis 360 mg/kgbb dan kontrol positif. Analisis terhadap ekspresi AMPK-α1 pada hati tikus menunjukkan perbedaan yang bermakna antara dosis 180 mg/kgbb dengan dosis 360 mg/kgbb dan kontrol positif. Simpulan dari penelitian ini adalah ekstrak Singawalang dapat menurunkan kadar glukosa darah pada tikus model diabetes melitus melalui aktivasi AMPK-α1.Kata kunci: AMPK-α1, diabetes melitus, kadar glukosa darah, Singawalang Effect of Petiveria alliacea Leaves Extract in Decreasing Serum Level of Blood Glucose Level Through Activation of AMPK-α1 in Diabetes Mellitus Rat ModelsAbstractSingawalang (Petiveria alliaceae) is a medicinal herb that is used traditionally as folk medicine for various diseases. The plant has been used as an antidiabetic agent in Indonesian society. Until now, the effect and mechanism of action of Petiveria alliaceae as antidiabetic agent is not clear. The aim of the study was to determine the effect of Petiveria alliaceae to blood glucose level and to identify expression of AMPK-α1 in rat liver. The research was experimental study with randomized and was conducted at Laboratory Pharmacology and Therapy, and Laboratory Patology Anatomy, Faculty of Medicine, Universitas Airlangga, on April until August 2015. Twenty five male rats were injected by Streptozotocin to create diabetic rat models and randomly divided into 5 groups. The group 1, 2 and 3 are treatment groups that were given the ethanol extract of Petiveria alliaceae at dose 90 mg/kgbw, 180 mg/kgbw, and 360 mg/kgbw, orally, once daily for fourteen days. The fourth group is a negative control who were given distilled water and the fifth group is a positive control who were given metformin at dose 150 mg/kgbw. On the 15th day, blood glucose level were measured by glucometer and the rats were sacrificed to collect the liver. Expression of AMPK-α1 were assessed by immunohistochemistry. Data were analyzed by ANAVA and Wilcoxon (α=0,05). The results have been showed that there were significant differences in glucose blood level between negative control with the group were given the extract at dose 90 mg/kgbw, 360 mg/kgbw and positive control, between dose 180 mg/kgbw with dose 360 mg/kgbw and positive control. A significant differences of expression of AMPK-α1 showed between dose 180 mg/kgbw with dose 360 mg/kgbw and positive control. The conclusion of this study was the extract ethanol of Singawalang leaves reduce blood glucose level in diabetes mellitus rat models through increase in the expression of AMPK-α1.Keywords: AMPK-α1, blood glucose level, diabetes mellitus, Singawalang
Analisis Efektivitas Biaya Penggunaan Kombinasi Antipsikotik pada Pasien Rawat Inap Skizofrenia Rizky Abdulah; Riska F Siregar; Sofa D. Alfian
Indonesian Journal of Clinical Pharmacy Vol 6, No 1 (2017)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (7091.136 KB) | DOI: 10.15416/ijcp.2017.6.1.61

Abstract

Skizofrenia merupakan salah satu gangguan jiwa dengan biaya tinggi dan risiko morbiditas seusia hidup. Studi farmakoekonomi pada pasien skizofrenia perlu dilakukan untuk mengetahui efisiensi pemilihan kombinasi antipsikotik. Penelitian ini bertujuan untuk menganalisis efektivitas biaya (cost-effectiveness) penggunaan kombinasi antipsikotik klozapin-haloperidol dan klozapin-risperidon pada pasien skizofrenia rawat inap di Rumah Sakit Jiwa Provinsi Jawa Barat tahun 2012–2013. Pengumpulan data dilakukan secara retrospektif dari rekam medis pasien yang meliputi komponen biaya langsung, antara lain biaya terapi antipsikotik, biaya penunjang, biaya tindakan medis, biaya rawat inap, dan biaya administrasi. Rata-rata rasio efektivitas biaya pada kombinasi antipsikotik klozapin-haloperidol sebesar Rp126.898/hari sedangkan pada kombinasi klozapin-risperidon sebesar Rp132.781/hari. Dengan mempertimbangkan waktu rawat inap sebagai efektivitas terapi, kombinasi antipsikotik klozapin-haloperidol lebih cost-effective dibandingkan klozapin-risperdion.Kata kunci: Antipsikotik, cost-effectiveness analysis, farmakoekonomi, haloperidol, klozapin, risperidon, skizofrenia Cost-effectiveness Analysis of Antipsychotic Combination Therapy in Schizophrenia InpatientsAbstractSchizophrenia is one of mental disorders with high cost and lifetime morbidity risk. Hence, it is necessary to analyze the cost-effectiveness of various combinations of antipsychotics. The aim of this study was to analyze the most cost-effective group of antipsychotic combinations in schizophrenia inpatients in West Java Psychiatric Hospital during 2012–2013. Data were collected retrospectively from medical record of patients who used antipsychotics clozapine-haloperidol or clozapine-risperidone therapy. Direct medical costs were obtained from antipsychotics costs, costs of medical treatment, medical expenses, hospitalization costs, and administrative costs. The results showed that the average cost-effectiveness ratio of antipsychotic clozapine-haloperidol was Rp126.898/day and Rp132.781/day for the combination of clozapine-haloperidol and clozapine-risperidone, respectively. Considering length of stay as the therapy effectiveness, it can be concluded that the combination of clozapine-haloperidol is more cost-effective than clozapine-risperidone.Keywords: Antipsychotic, clozapine, cost-effectiveness analysis, haloperidol, pharmacoeconomics, risperidone, schizophrenia
Perbandingan Profil Farmakokinetika Bupivakain 0,5% pada Pasien Hamil Normotensi dan Preeklampsia yang Menjalani Sectio Caesarea di RSUP dr. Sardjito Yogyakarta Helmina Wati; Dita A. D. Sandi
Indonesian Journal of Clinical Pharmacy Vol 6, No 1 (2017)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1858.14 KB) | DOI: 10.15416/ijcp.2017.6.1.32

Abstract

Pada kehamilan preeklampsia terjadi penurunan filtrasi glomerulus dan penurunan protein plasma dibandingkan terhadap hamil normotensi. Penelitian ini bertujuan melihat perbedaan profil farmakokinetika dengan model nonkompartemen bupivakain 0,5% antara pasien hamil normotensi dengan pasien hamil preeklampsia yang menjalani Sectio Caesarea (SC). Penelitian dilakukan terhadap 5 pasien hamil normotensi vs hamil preeklampsia yang menjalani SC dengan teknik epidural menggunakan bupivakain 0,5% dosis 75 mg di Gedung Bedah Sentral Terpadu (GBST) RSUP Dr. Sardjito Yogyakarta. Darah diambil sebanyak 3 cc pada menit ke-0;15’;20’;25’;30’;45’;60’;90’ melalui vena dan ditetapkan kadar bupivakain dengan menggunakan metode High Performance Liquid Chromatography (HPLC). Harga profil farmakokinetika bupivakain (AUC (Area Under Curve), AUMC (Area Under Moment Concentration), MRT (Mean Resident Time)) dihitung berdasarkan data kadar bupivakain dalam darah versus waktu dengan model nonkompartemen. Profil farmakokinetika pasien hamil normotensi dan hamil preeklampsia kemudian dianalisis dengan uji statistik untuk melihat ada tidaknya perbedaan. Hasil penelitian menunjukkan AUC(0–~) rata-rata pada pasien hamil normotensi dan pasien hamil preeklampsia secara berturut-turut adalah 109,56± 9,22 μg.mL–1.menit dan 133,780±25,47 μg.mL–1.menit. Nilai AUMC(0–~) rata-rata pada pasien hamil normotensi dan pasien hamil preeklampsia secara berturut-turut sebesar 6.956,41±2.559,99 µg/mL.menit2 dan 11.085,74±5733,94 µg/mL.menit2. Rata‑rata nilai MRT pasien hamil normotensi dan pasien hamil preeklampsia secara berturut-turut sebesar 64,06±25,70 menit dan 110,45±78,30 menit. Hasil uji statistik menunjukkan bahwa nilai AUC(0–~), AUMC(0–~), dan MRT pada obat bupivakain 0,5% antara pasien hamil normal dengan pasien preeklampsia tidak memiliki perbedaan yang signifikan (p>0,05). Kesimpulannya, profil farmakokinetik bupivakain pada pasien hamil normotensi dan preeklampsia tidak memiliki perbedaan yang signifikan.Kata kunci: Bupivakain, hamil normotensi, preeklampsia, profil farmakokinetik Comparison of Pharmacokinetics Profiles 0.5% Bupivacaine of Normal Pregnant Patients and Preeclampsia Patients Undergoing Sectio Caesarea at dr. Sardjito Hospital YogyakartaAbstractIn preeclampsia pregnancy, there is a decrease in glomerular filtration and plasma protein. This study was conducted on 5 patients with normotensive pregnancy and sectio caesarea with preeclampsia pregnancy used of bupivakain 0,5% dose of 75 mg. Blood was collected as much as 3 cc at minute 0; 15’;20’;25’;30’;45’;60’;90’, through a vein and set the levels of bupivacaine by using High Performance Liquid Chromatography (HPLC). The value of bupivacaine pharmacokinetic profile (AUC (Area Under the Curve), AUMC (Area Under Concentration Moment), MRT (Mean Time Resident)) were calculated based on the levels of bupivacaine in the blood versus the time with noncompartement models, and then were analyzed with statistical test. The result showed that the value of AUC(0–~); value of AUMC(0–~); value of MRT on average for patients with normal pregnancy and preeclampsia pregnant patients respectively were 109.56±9.22 μg.mL-1.minute and 133.78 ± 25.47 μg.mL-1.minute; 6,956.41 ± 2,559.99 µg/mL.minute2 and 11,085.74±5733,94 µg/mL.minute2; 64.06±25.70 minutes and 110.45± 78.30 minutes. Statistical analysis results showed that the value of AUC(0–~), AUMC(0–~), and MRT at bupivacaine had no significant difference (p>0.05).Keywords: Bupivacaine, normotensive pregnant, pharmacokinetics profiles, preeclampsia

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