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INDONESIA
Majalah Kedokteran Gigi Indonesia
Published by Universitas Gadjah Mada
ISSN : 24600164     EISSN : 24422576     DOI : https://doi.org/10.22146/majkedgiind.36959
Core Subject : Health,
Dentistry
Arjuna Subject : -
Articles 12 Documents
 1   2 
Search results for , issue "Vol 9, No 3 (2023): December" : 12 Documents clear
Effect of hexane extract of Clinacanthus nutans leaves on HSC-3 cells migration in vitro Roeslan, Moehamad Orliando; Qurrotuain, Noni Anis; Rahmawati, Dicha Yuliadewi; Monthanpisut, Paopanga Orliando
Majalah Kedokteran Gigi Indonesia Vol 9, No 3 (2023): December
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/majkedgiind.89452

Abstract

Cancer is a major health issue and considered the most life-threatening disease worldwide. The oral cavity is one of the top ten locations in the body most frequently affected by cancer. The most common type of oral cancer (90%) is squamous cell carcinoma. Leaves of C. nutans have many uses and benefits, one of which is its potential as an anticancer agent. This study aims to determine the effect of C. nutans leaves hexane extract on HSC-3 cell strain migration. The leaves of C. nutans were extracted using a hexane solvent with the maceration method. Various concentrations (500, 250, 100, 50 and 25 mg/mL) were assessed to identify the effect of C. nutans leaves hexane extract on HSC-3 cells migration at 0, 6, 12, 24 and 48 time point. The concentration of 500 μg/mL was found to possess the ability to inhibit migration and induce apoptosis by the 6th hour. The concentration of 250 μg/mL induced apoptosis by the 24th hour. Concentrations of 100 μg/mL and 50 μg/mL were capable of inhibiting cell migration, and the concentration of 25 μg/mL could only delay cell migration up to the 12th hour. In conclusion, hexane extract of C. nutans leaves can inhibit HSC-3 cells migration.
Characterization of β-tricalcium phosphate derived from green mussel shells (Molarity variation) Santoso, Hillary Aurenne; Eddy, Eddy; Kesnatri, Manuel Romario; Putri, Tansza Setiana; Dipankara, Jackson; Nugroho, Astri Rinanti; Thi, Bang Le
Majalah Kedokteran Gigi Indonesia Vol 9, No 3 (2023): December
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/majkedgiind.89690

Abstract

β-Tricalcium phosphate (β-TCP) is a widely used bioceramic material. In dentistry, it is commonly used as bone graft material. β-TCP is osteoconductive, bioresorbable, bioactive, and has biocompatibility properties. This study aims to evaluate the optimum molarity of CaO and H3PO4 to synthesize β-TCP from a natural source (Perna viridis linn). This is laboratory experimental research conducted by reacting calcium compounds from green mussel shells and phosphoric acid using the dissolution precipitation method with variations in molarity ratio. X-ray diffraction (XRD), scanning electron microscope (SEM), and fourier transform infrared (FTIR) were used to identify the characteristics of β-TCP synthesized from green mussel shells. The XRD chart pattern showed the formation of peaks identical to the β-TCP (Sigma-Aldrich). However, formation of whitlockite phase was also seen in the results. FTIR results showed that phosphate, hydroxyl, and carbonyl groups were shown on the graph and could be identified as β-TCP. SEM characterization showed that the sample consisted of small particles irregularly shaped to form like aggregates. β-TCP synthesized using molarity ratio of 0.6M CaO: 0.4M H3PO4 had characteristics resembling β-TCP (Sigma-Aldrich).

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