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All Journal Majalah Kedokteran Gigi Indonesia Padjadjaran Journal of Dentistry Journal of Indonesian Dental Association Jurnal Ilmiah Medicamento Jurnal AKAL: Abdimas dan Kearifan Lokal Jurnal Abdimas Kesehatan Terpadu
Roeslan, Moehamad Orliando
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Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences Transportation

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Effect of hexane extract of Clinacanthus nutans leaves on HSC-3 cells migration in vitro Roeslan, Moehamad Orliando; Qurrotuain, Noni Anis; Rahmawati, Dicha Yuliadewi; Monthanpisut, Paopanga Orliando
Majalah Kedokteran Gigi Indonesia Vol 9, No 3 (2023): December
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/majkedgiind.89452

Abstract

Cancer is a major health issue and considered the most life-threatening disease worldwide. The oral cavity is one of the top ten locations in the body most frequently affected by cancer. The most common type of oral cancer (90%) is squamous cell carcinoma. Leaves of C. nutans have many uses and benefits, one of which is its potential as an anticancer agent. This study aims to determine the effect of C. nutans leaves hexane extract on HSC-3 cell strain migration. The leaves of C. nutans were extracted using a hexane solvent with the maceration method. Various concentrations (500, 250, 100, 50 and 25 mg/mL) were assessed to identify the effect of C. nutans leaves hexane extract on HSC-3 cells migration at 0, 6, 12, 24 and 48 time point. The concentration of 500 μg/mL was found to possess the ability to inhibit migration and induce apoptosis by the 6th hour. The concentration of 250 μg/mL induced apoptosis by the 24th hour. Concentrations of 100 μg/mL and 50 μg/mL were capable of inhibiting cell migration, and the concentration of 25 μg/mL could only delay cell migration up to the 12th hour. In conclusion, hexane extract of C. nutans leaves can inhibit HSC-3 cells migration.
PELATIHAN PENCEGAHAN OSTEOPOROSIS DAN PENYULUHAN KESEHATAN GIGI DAN MULUT KEPADA LANSIA PANTI JOMPO 41 AL MADINIYAH Palupi, Anggraeny Putri Sekar; Roeslan, Moehamad Orliando; Hendriaty , Melanie; Mayun, I Gusti Ayu Ratih Utari; Goalbertus, Goalbertus; Rasad, Irvan Septrian Syah Putra; Claresta, Bianda
Jurnal AKAL: Abdimas dan Kearifan Lokal Vol. 5 No. 1 (2024): Jurnal AKAL : Abdimas dan Kearifan Lokal
Publisher : Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25105/akal.v5i1.17929

Abstract

Osteoporosis adalah penyakit dengan prevalensi yang setiap tahunnya terus meningkat di dunia. Penyakit ini menyerang jutaan orang di seluruh dunia. Osteoporosis ditandai dengan penurunan massa tulang dan perubahan mikro jaringan tulang, yang kemudian dapat menyebabkan kerapuhan tulang dan resiko patah tulang. Masalah kesehatan gigi dan mulut banyak terjadi di Indonesia. Kebersihan mulut yang buruk menyebabkan kesehatan mulut yang buruk, yang pada gilirannya berdampak negatif pada kesehatan dan kualitas hidup secara keseluruhan. Kurangnya pengetahuan dan pemahaman tentang kesehatan membuat masyarakat mengesampingkan perhatian terhadap kesehatan gigi dan mulut. Oleh karena itu perlu dilakukan pelatihan pencegahan osteoporosis dan penyuluhan Kesehatan gigi dan mulut. Kegiatan ini dilaksanakan di lansia Panti Jompo 41 Al Madiniyah, yang dihadiri oleh 20 peserta. Pengetahuan peserta dinilai dengan pre-test dan post-test. Hasil yang didapat menunjukkan pre dan post-test terdapat perbedaan yang bermakna (p<0,005). Kesimpulannya masyarakat lansia yang menjadi peserta PkM ini pengetahuannya meningkat setalah diberikan penyuluhan dan pelatihan.
Penyuluhan Penanganan Luka dengan Aloe vera dan Kedaruratan Trauma Gigi kepada Ibu-Ibu PKK Kelurahan Cideng Jakarta Pusat Roeslan, Moehamad Orliando; Poedjiastoeti, Wiwiek; Suwandi, Trijani; Zen, Yuniar; Wulansari, Selviana; Rizal, Muhammad Ihsan
JURNAL ABDIMAS KESEHATAN TERPADU Vol. 3 No. 2 (2024): Jurnal Abdimas Kesehatan Terpadu
Publisher : Fakultas Kedokteran Gigi, Universitas Trisakti bekerjasama dengan Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25105/jakt.v3i2.21192

Abstract

Maintaining the dental and oral health of their children is greatly aided by mothers' awareness of dental emergencies. Dental emergencies might involve issues that need to be treated right once, like infections, chipped teeth, or damaged teeth. Aloe vera is a natural substance with remarkable healing qualities, which is why it is used in first aid for wounds. Aloe vera gel, which is readily extracted contains anti-inflammatory, antibacterial, and antioxidant substances that can help relieve pain, minimize swelling, and prevent infection. In Cideng Village, Gambir District, Central Jakarta, PKK women received counseling on handling wounds with aloe vera plants and dental trauma emergencies to increase their knowledge and abilities in dealing with dental trauma problems and wound healing with aloe vera. Faculty of Dentistry Universitas Trisakti Team from the dentistry education study program, the dentistry profession study program, and the master of dentistry study program completed this Community Service activity. Counseling and instructional media, including power point, videos, and posters, are used as part of community service projects. Through exams administered prior to counseling and compared with those administered following counseling, an increase in knowledge of tooth trauma crises and wound treatment using Aloe vera was gained in this activity. This counseling exercise is a crucial step in learning more about using Aloe vera to heal wounds from oral and dental injuries. It is necessary to keep taking a structural approach to the community. It is anticipated that social media counseling would expand its influence inside the community.
Perkembangan Tren Terapi Pulpa Vital melalui Aplikasi berbagai Biomaterial: Penelitian Bibliometrik Widyastuti, Wiena; Anggraini, Wita; Fibryanto, Eko; Roeslan, Moehamad Orliando; Gunardi, Indrayadi; Rizal, Muhammad Ihsan; Khazin, Sobrina Mohamed; Wedagama, Dewa Made
Jurnal Ilmiah Medicamento Vol 11 No 2 (2025): Jurnal Ilmiah Medicamento (In progress)
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v11i2.11749

Abstract

Vital pulp therapy (VPT) is a crucial dental intervention designed to maintain the vitality of the dental pulp, particularly in carious lesions or trauma. The evolution of biomaterials in VPT has significantly affected dental practices by providing less invasive alternatives that safeguard tooth vitality and functionality. Continued exploration of the properties and effects of these materials is crucial for enhancing treatment strategies and optimizing dental care outcomes. Bibliometric analysis allowed the assessment of trends in the biomaterials used for VPT. Data mining was performed using the Scopus database and Boolean expressions. Data extraction and analysis were conducted using VOSviewer version 1.6.20., VOSviewer thesaurus, and Microsoft Excel. A total of 856 documents were identified, and the United States had the largest number of documents and citations (110 documents, 6,938 citations). The top three sources were the Journal of Endodontics, International Journal of Endodontics, and Dental Materials Journal. Mineral trioxide aggregate (MTA) is still the dominant biomaterial used in VPT to this day. MTA can accelerate dentinogenesis in VPT. The prominence of “MTA” and “VPT” as keywords highlights research on prevalence, causes, prevention, and evaluation, emphasizing the need to investigate biomaterial-driven healing, regeneration, stem cell activity, and gene expression.
Effect of Ethanol Extracts from Persea americana Leaves on HSC-3 Proliferation Tessalonica, Svetlana; Roeslan, Moehamad Orliando
Journal of Indonesian Dental Association Vol 3 No 2 (2020): October
Publisher : Indonesian Dental Association

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Abstract

Introduction: Oral cancer has one of the highest death rates of all cancer types due to lack of treatment. Persea americana leaves consist of phenolic compounds that are known to have anticancer effects to inhibit the proliferation of human squamous carcinoma (HSC-3) cell lines. Ethanol extracts from P. americana leaves can inhibit the cell cycle in the G1/S and G2/M phases to give the cells time to repair damaged DNA. Objective: The aim of this study was to investigate the effect of ethanol extracts from P. americana leaves on HSC-3 proliferation. Methods: This study was conducted using experimental research and in vitro laboratory testing. Groups of extract consisted of four concentrations (100%, 50%, 25%, and 10%). Cytotoxic activity of the extracts was measured using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide tetrazolium (MTT) assay. Result: P. americana leave ethanol extracts with concentrations of 100% had a significant difference (p <0.05) compared to negative control. Conclusion: Ethanol extracts from P. americana leaves could inhibit HSC-3 proliferation.
Effects of Clinacanthus nutans and Aloe vera Extracts on bFGF Synthesis in Fibroblasts Anggraeni, Rezky; Roeslan, Moehamad Orliando
Journal of Indonesian Dental Association Vol 5 No 1 (2022): April
Publisher : Indonesian Dental Association

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Abstract

Introduction: Wound healing is an important but complicated process, containing a multifaceted process. The growth factor involved in the wound healing process is basic fibroblast growth factor (bFGF). Clinacanthus nutans (C. nutans) and A. vera are traditional plants that have the ability to induce fibroblast migration. However, no study has yet compared the effects of C. nutans and A. vera on bFGF protein synthesis associated with wound healing. Objective: The aim of this study was to evaluate the effect of extracts of C. nutans and A. vera on the fibroblast synthesis of bFGF in fibroblasts. Method: Clinacanthus nutans leaf powder was extracted using a solution of hexane and chloroform sequentially. While the A. vera gel is taken. Fibroblasts were treated with several concentrations (10, 50, and 100 µg/mL) within 24 hours. Synthesis of bFGF protein was tested using enzyme linked immunoabsorbent assay (ELISA). Result: The chloroform extract of C. nutans and A. vera up regulated the synthesis of bFGF. Concentration of 10 µg/mL C. nutans showed the highest bFGF protein synthesis compared to other treatment groups. Conclusion: Chloroform extract of C. nutans and A. vera can up regulated the synthesis of bFGF in fibroblasts. ABSTRAK Pendahuluan: Penyembuhan luka adalah proses penting namun rumit, yang terdiri dari beberapa fase penyembuhan. Faktor pertumbuhan yang berhubungan dengan proses penyembuhan luka adalah, basic fibroblast growth factor (bFGF). Clinacanthus nutans (C. nutans) dan Aloe vera (A. vera) adalah tumbuhan tradisional yang memiliki kemampuan untuk menginduksi migrasi fibroblas. Namun, belum ada penelitian yang telah membandingkan efek C. nutans dan A. vera terhadap sintesis protein bFGF yang berhubungan dengan luka penyembuhan. Tujuan: Tujuan dari penelitian ini adalah untuk mengetahui efek ekstrak C. nutans dan A. vera terhadap sintesis bFGF pada fibroblas. Metode: Bubuk daun C. nutans di ektraksi menggunakan larutan heksana dan kloroform secara berurutan. Sedangkan A. vera diambil gel nya. Fibroblas diberi perlakuan dengan beberapa konsentrasi (10, 50, dan 100 µg/mL) dalam waktu 24 jam. Sintesis protein bFGF diuji menggunakan enzym linked immunoabsorbent assay (ELISA). Hasil: Ekstrak kloroform C. nutans dan A. vera dapat meningkatkan sintesis protein bFGF lebih tinggi dibandingkan dengan kontrol negatif pada uji ELISA. C. nutans konsentrasi 10 µg/mL menunjukkan sintesis protein bFGF tertinggi dibandingkan dengan kelompok perlakuan lain. Kesimpulan: Ekstrak kloroform C. nutans dan A. vera dapat meningkatkan sintesis protein bFGF pada fibroblas.
Efficacy of World Health Organization-Recommended Homemade Hand Sanitizer Against Bacteria and Fungus Roeslan, Moehamad Orliando; Richi, Mario; Drestia, Aradhea Monica; Widyarman, Armelia Sari
Journal of Indonesian Dental Association Vol 4 No 2 (2021): October
Publisher : Indonesian Dental Association

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Abstract

Introduction: Handwashing is among the best practices to prevent the transmission of various diseases especially during the pandemic. Handwashing with soap can reduce respiratory tract infections. The World Health Organization (WHO) released guidelines for making homemade hand sanitizer. Objective: This study aimed to analyze the effectiveness of antibacterial hand- rub, as recommended by WHO, containing ethanol, hydrogen peroxide, and glycerol in varying concentrations against bacteria and fungus. Methods: This experimental laboratory study was designed to assay the efficacy of hand sanitizer ingredients—96% ethanol, 3% hydrogen peroxide, and 98% glycerol, as recommended by WHO—against Escherichia coli, Staphylococcus aureus, and Candida albicans. Commercial hand rubs were used in this study for comparison. Result: Minimum inhibitory concentration (MIC) testing showed that the WHO hand rub at 25% concentration inhibited E. coli and S. aureus growth, while 12,5% concentration inhibited C. albicans. Conclusion: The WHO-recommended homemade hand sanitizer containing ethanol, hydrogen peroxide, and glycerol at a concentration of 50% is effective in eliminating Escherichia coli, Staphylococcus aureus, and concentration of 25% is effective on Candida albicans. Further study is needed to analyse these materials against other bacteria and viruses.
Phytochemical composition and cytotoxic assessment of Carica papaya leaf extracts on human squamous carcinoma-3 Cells (in vitro): a laboratory experimental Roeslan, Moehamad Orliando; Rahma, Syafira Fayza; Kokilakanit, Paopanga
Padjadjaran Journal of Dentistry Vol 37, No 3 (2025): November 2025
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol37no3.61396

Abstract

Introduction: Oral cancer is one of the major diseases that can cause death worldwide. With the advancement of research on new drugs, medicinal plants have been explored as an alternative approach to cancer treatment. Papaya (Carica papaya) is a plant that has long been used in traditional medicine to treat various diseases. Ethanolic and aqueous extracts of C. papaya leaf have been reported to exhibit anticancer properties through mechanisms such as inhibiting cell proliferation and inducing apoptosis. This study aimed to analyze the cytotoxic effect of C. papaya leaf extract obtained with different extraction solvents on HSC-3 cell lines. Methods: This laboratory-based experimental study employed a post-test only control group design. The sample size was determined using the Federer formula, yielding four replicates per group. HSC-3 cell lines were treated with ethanolic and aqueous extracts of C. papaya leaf at concentrations of 125, 250, and 500 μg/mL for 24 hours, followed by a cytotoxicity test using the CCK-8 assay. Data were analyzed using one-way ANOVA followed by Tukey’s post hoc test. Results: Phytochemical analysis revealed the presence of alkaloids, flavonoids, and tannins in both ethanolic and aqueous extracts, whereas triterpenoids were detected only in the ethanolic extract, and saponins were detected only in aqueous extract. HSC-3 cells did not show any significant cytotoxic response to either extract at any tested concentration. Conclusion: Ethanolic and aqueous extracts of C. papaya leaf at concentrations of 125, 250, and 500 μg/mL did not exhibit any cytotoxic effects on HSC-3 cell lines.
Co-Authors Anggraeni, Rezky Anggraeny Putri Sekar Palupi Claresta, Bianda Dewa Made Wedagama Drestia, Aradhea Monica Fibryanto, Eko Goalbertus, Goalbertus Hendriaty , Melanie I Gusti Ayu Ratih Utari Mayun Indrayadi Gunardi, Indrayadi Khazin, Sobrina Mohamed Kokilakanit, Paopanga Monthanpisut, Paopanga Orliando Muhammad Ihsan Rizal, Muhammad Ihsan Qurrotuain, Noni Anis Rahma, Syafira Fayza Rahmawati, Dicha Yuliadewi Rasad, Irvan Septrian Syah Putra Richi, Mario Tessalonica, Svetlana Trijani Suwandi Widyarman, Armelia Sari Widyastuti, Wiena Wita Anggraini Wiwiek Poedjiastoeti, Wiwiek Wulansari, Selviana Yuniar Zen