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Mutiara Medika: Jurnal Kedokteran dan Kesehatan
Published by Universitas Muhammadiyah Yogyakarta
ISSN : 14118033     EISSN : 26140101     DOI : 10.18196/mm
Core Subject : Health,
Health Professions Medicine & Pharmacology
Jurnal Mutiara Medika Fakultas Kedokteran dan Ilmu Kesehatan (MMJKK) Universitas Muhammadiyah Yogyakarta is a peer-reviewed and open access journal that focuses on promoting medical sciences generated from basic sciences, clinical, and community or public health research to integrate researches in all aspects of human health.
Arjuna Subject : -
Articles 3 Documents
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Search results for , issue " Vol 15, No 2 (2015)" : 3 Documents clear
Pengaruh Pemberian Jus Belimbing Wuluh (Averrhoa bilimbi L) terhadap Kadar HDL dan LDL-Kolesterol pada Tikus Putih Hiperkolesterolemia Anggoro, Dedy Sukmo; Astuti, Yoni
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 15, No 2 (2015)
Publisher : Universitas Muhammadiyah Yogyakarta

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Abstract

Hiperkolesterolemia terjadi jika kadar kolesterol melebihi batas normal. Belimbing wuluh mempunyai banyak kandungan senyawa yang dibutuhkan manusia diantaranya pektin. Pektin mempunyai peranan dalam menurunkan kadar kolesterol. Penelitian ini bertujuan untuk membuktikan  pengaruh  jus belimbing wuluh terhadap kadar HDL dan LDL-kolesterol pada tikus putih yang mengalami Hiperkolesterolemia. Penelitian ini merupakan penelitian eksperimental dengan rancangan penelitian pre and post test design. Penelitian ini menggunakan tikus putih (Strain Wistar) jantan berusia 2 bulan dengan berat badan rata-rata antara 180 - 260  gram. Jumlah subyek penelitian 16 ekor, dibagi menjadi 4 kelompok masing-masing terdiri dari 4 ekor tikus, yaitu kelompok I adalah kontrol, kelompok II perlakuan dengan dosis 2 ml/200grBB/ hari,Kelompok III dengan perlakuan 3 ml/200grBB/hari dan   kelompok IV dengan perlakuan 4ml/200grBB/ hari). Sebelum diberi perlakuan semua kelompok diberi kuning telur untuk proses hiperkolestrolemia selama 15 hari.Data di uji dengan paired t-test dan one-way anova. Hasil menunjukkan bahwa dosis jus Wuluh yang paling baik dan signifikan (p< 0,05) untuk menurunkan LDL-kolesterol dan menaikkan HDL-kolesterol serum darah tikus putih jantan yang mengalami hiperkolesterolemi adalah 4 ml/200grBB/hari. Dapat disimpulkan bahwa jus belimbing wuluh terbukti dapat menurunkan kadar LDL kolesterol dan menaikkan kadar HDL kolesterol pada tikus hiperkolesterolemia.Hypercholesterolemia occurs when cholesterol level exceeds from the normal value. Wuluh star fruit has some beneficial substances for human such as   pectin. Pectin was able to decrease cholesterol levels. This research aims to prove the influence of wuluh starfruit juice on serum HDL and LDL-cholesterol on hipercholesterolemia rats. This research is an experimental research, with the pre- pro test research design. This study used (Wistar strain) 2-month-old male rats which were an average weight between 180 to 260 grams. The Rats, were divided into 4 groups, each was 4 male rats. The group 1  as  placebo and group II used dose 2 ml/200gr weight/day, Group III used  dose 3 ml/200gr weight/day and  group IV used 4ml/ 200gr weight/day. Before treatment, all groups were given egg yolk for 15 days to make hipercholestrolemia. The data analyzed by one-way anova. The results showed that the best dose of wuluh star  Juice and most significant (p <0.05) to lower LDL-cholesterol and raise HDL-cholesterol blood serum  were 4 ml/200gr weight/day).The conclution of the research was Wuluh star fruit juice was  proved decrease LDL Cholesterol and increase HDL cholesterol on Hipercholesterolemia rats.
Hubungan Kadar Ekskresi Yodium Urin Ibu Menyusui dengan Perkembangan Bayi Usia Bawah 2 Tahun di Daerah Endemik GAKY Saputra, Rizky Hermawan; Noor, Zulkhah
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 15, No 2 (2015)
Publisher : Universitas Muhammadiyah Yogyakarta

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Abstract

Gangguan akibat kekurangan yodium (GAKY) pada bayi berdampak menghambat proses tumbuh kembang. Penelitian ini bertujuan untuk mengetahui hubungan kadar ekskresi yodium urin (EYU) ibu menyusui dengan perkembangan bayi usia dibawah dua tahun di daerah endemik GAKY. Penelitian ini bersifat observational dengan desain cross sectional. Sampel penelitian adalah 30 ibu menyusui yang memiliki bayi berusia dibawah dua tahun. Kadar EYU diukur dengan menggunakan Ammonium Persulfat Dry Digestion dan Perkembangan bayi dinilai dengan menggunakan Kuesioner Pra Skrining Perkembangan (KPSP). Kadar median EYU ibu kemudian dikorelasikan dengan status perkembangan bayi, menggunakan uji Spearman. Hasil menunjukkan bahwa kadar EYU ibu optimal (173,5 ppm). Sebanyak sembilan ibu (30%) memiliki status EYU optimal, namun status perkembangan bayi dengan kategori meragukan sebanyak 12 bayi (40%). Hasil uji korelasi antara kadar EYU ibu dengan status perkembangan bayi menunjukkan p = 0,428; r = 0,150. Disimpulkan bahwa tidak terdapat hubungan yang bermakna antara kadar EYU ibu menyusui dengan status perkembangan bayi usia dibawah dua tahun.Disorders due to iodine deficiency (GAKY) in infants have an effect inhibit the growth and development processes. This study aims to determine the relationship of urinary iodine excretion (UIE) of breastfeeding mothers with the development of infants aged under two years in the endemic areas of GAKY. This research is observational with cross sectional design. The sample was 30 breastfeeding mothers with babies under two years old. Urinary iodine excretion levels were measured using Dry Digestion Ammonium Persulfate and Infant Development were assessed using a Pre-Screening Appraisal Questionnaire (KPSP). The maternal UIE median level was then correlated with the infant’s developmental status, using the Spearman test. The results showed that the mother’s UIE level was optimal (173,5 ppm). There were nine mothers (30%) had optimal UIE status, but infant development status in the dubious category of 12 (40%). Result of correlation test between mother UIE level with infant development status showed p = 0,428; r = 0.150. It was concluded that there was no significant association between UIE of breastfeeding mothers and developmental status of infants aged under two years.
Tingkat Pencemaran Escherichia coli pada Air Rumah Tangga di Wilayah Kerja Puskesmas Mijen, Semarang Ratnaningrum, Kanti; Anggraini, Merry Tiyas; Dahlan, Pujangga Puspito Yunus
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 15, No 2 (2015)
Publisher : Universitas Muhammadiyah Yogyakarta

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Abstract

urangnya ketersediaan air bersih menimbulkan penyakit gangguan saluran pencernaan seperti diare. Sebagian besar bakteri penyebab diare adalah Escherichia coli. Insidensi diare dinilai masih jauh dari capaian target Puskesmas Mijen, Semarang. sehingga diperlukan penelitian tentang kontaminasi E. coli pada air rumah tangga di wilayah kerja Puskesmas. Penelitian ini bersifat observasional dengan rancangan cross sectional. Sampel ditentukan dengan  metode systematic random sampling dengan estimasi proporsi. Sampel diambil dari 10 kelurahan yang masuk dalam wilayah kerja. Kadar bakteri E. coli dalam air rumah tangga dilakukan di dengan metode most probable number (MPN). Terkumpul 36 sampel yang berasal dari 3 jenis sumber air yaitu sumur gali, sumur artesis dan perusahaan air minum (PAM). Uji laboratorium menunjukkan bahwa 55,6 % sampel air minum  telah memenuhi nilai uji bakteriologis E. coli. Air berasal dari sumur gali memiliki tingkat kontaminasi paling tinggi (100%) diikuti sumur artesis (34,61%) dan PAM bebas dari E. coli (0%).Lack of clean water supply causes gastrointestinal disorders such as diarrhea. Most of the bacteria that cause diarrhea are Escherichia coli. The incidence of diarrhea is still far from the target of Mijen Puskesmas, Semarang, so research on E. coli contamination on household water in Puskesmas work areas is needed. This research was observational with cross sectional design. The sample is determined by systematic random sampling method with estimated proportion. Samples were taken from 10 urban villages included in the work area. E. coli bacteria levels in household water are carried out in the most probable number (MPN) method. Collected 36 samples derived from 3 types of water sources ie dug wells, artesian wells and drinking water companies (PAM). Laboratory tests showed that 55.6% of drinking water samples had met the bacteriological test value of E. coli. Water derived from dug wells has the highest contamination rate (100%) followed by artesian well (34.61%) and PAM free from E. coli (0%).

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