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Majalah Obat Tradisional
Published by Universitas Gadjah Mada
ISSN : 14105918     EISSN : 24069086     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
raditional Medicine Journal (Majalah Obat Tradisional), or Trad. Med. J. (ISSN 1410-5918 (print) and ISSN 2406-9086 (online)), is an international scientific journal published by Faculty of Pharmacy, Universitas Gadjah Mada, three times annually. Collaborating with Indonesian Pharmacist Association, Daerah Istimewa Yogyakarta, and we dedicate our journal to researches and development in traditional medicine. The journal receives papers on research laboratory, field research, and case studies of traditional medicine and its constituent, covering research topics including raw materials, cultivation, phytochemical, pharmacological effects and toxicology, formulation, and biotechnology.
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Articles 12 Documents
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Search results for , issue "Vol 29, No 2 (2024)" : 12 Documents clear
Molecular Networking Analysis and Antibacterial Potential of Ethyl Acetate Extracts of Sinomicrobium sp. PAP.21 using OSMAC Method Harwoko, Harwoko; Rahmawati, Anggun Tri; Riyanti, Riyanti
Majalah Obat Tradisional Vol 29, No 2 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.92311

Abstract

Challenges in drug discovery include biosynthetic gene clusters which remain silent under standard laboratory culture conditions. On the other hand, the rediscovery of the known compounds is inevitable. Accordingly, One Strain-MAny Compounds (OSMAC) approach and molecular networking analysis are currently applicable to discovering new bioactive compounds. Sinomicrobium sp. PAP.21 isolated from marine sediment collected in Cenderawasih Bay, West Papua, was added to the culture. Then, the bacterium was cultured in five different liquid media (RL1, A1BFe+C, NB, LB, and seawater) and incubated for 4, 5, and 7 days. The bacterial cultures were extracted using ethyl acetate (EtOAc) separately for each medium and incubation period, followed by LC-HRMS measurement. A total of 45 ethyl acetate extracts were assayed for in vitro antibacterial activity against Micrococcus luteus and Escherichia coli. Molecular networking analysis through GNPS indicated that three putative compounds possess antibacterial properties. EtOAc extracts from the A1BFe+C medium demonstrated antibacterial activity against M. luteus. However, none of them were active against E. coli. Collectively, Sinomicrobium sp. PAP.21 produced bioactive compounds exhibiting antibacterial potential, particularly against Gram-positive bacteria.
Essential Oil Profiling and Antibacterial Activity of Curcuma xanthorrhiza Roxb. Originated from Yogyakarta by GC-MS Rahman, Catur Aryanto; Rahmawati, Laily Mega; Santosa, Djoko; Indrasetiawan, Puguh; Purwanto, Purwanto
Majalah Obat Tradisional Vol 29, No 2 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.93649

Abstract

As a tropical country, Indonesia has a large diversity of flora and fauna, including numerous medicinal plants. Although herbs are widely used for medicinal purposes, their pharmacological effect often varies. This variability is frequently attributed to differences in the geographical locations where these plants are grown, leading to variations in the content of active metabolites. In this study, the profile of metabolite content in the essential oil of C. xanthorriza rhizomes was cultivated in three different regions in Yogyakarta, Indonesia, namely Mangunan, Ngawen, and Menoreh. Gas Chromatography-Mass Spectrometry (GC-MS) analysis was employed to assess the metabolite content of essential oil. At the same time, antibacterial activity against Escherichia coli and Staphylococcus aureus was evaluated using the microdilution method. Results indicated that the rhizome from Mangunan has the highest xanthorrhizol content with a percentage area of 21.07%. The Biplot on Principal Component Analysis (PCA) showed that the relationship of compound levels of the three essential oils has no similarity with one another. The Minimum Inhibitory Concentration at 50% (MIC-50) values of C. xanthorriza essential oils from Mangunan, Menoreh, and Ngawen regions were lower in inhibiting the growth of E. coli bacteria (1620.78 ppm; 1777.69 ppm; and 1688.39 ppm, respectively) compared to S. aureus bacteria (3080.80 ppm; 3340.14 ppm; and 2869.54 ppm, respectively).

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