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Majalah Obat Tradisional
Published by Universitas Gadjah Mada
ISSN : 14105918     EISSN : 24069086     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
raditional Medicine Journal (Majalah Obat Tradisional), or Trad. Med. J. (ISSN 1410-5918 (print) and ISSN 2406-9086 (online)), is an international scientific journal published by Faculty of Pharmacy, Universitas Gadjah Mada, three times annually. Collaborating with Indonesian Pharmacist Association, Daerah Istimewa Yogyakarta, and we dedicate our journal to researches and development in traditional medicine. The journal receives papers on research laboratory, field research, and case studies of traditional medicine and its constituent, covering research topics including raw materials, cultivation, phytochemical, pharmacological effects and toxicology, formulation, and biotechnology.
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Articles 12 Documents
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Search results for , issue "Vol 30, No 3 (2025)" : 12 Documents clear
Phytochemical Analysis and Anti-Collagenase Activity of Celery (Apium graveolens L.) Extract Fahrizal Amanda Permana; Meitha Khansa Khairunnisa; Purwanto Purwanto; Sri Handayani; Riris Istighfari Jenie
Majalah Obat Tradisional Vol 30, No 3 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.91756

Abstract

Aging is a normal process experienced by humans. One of the causes of aging is the body's intrinsic activity, such as the activity of one of the extracellular matrix-breaking enzymes, collagenase. Demand for skin care to prevent aging is increasing, especially plant-based skin care. This study aims to explore the potency of celery extract as an anti-collagenase. In this study, we used celery extract as a sample obtained from the maceration process by seventy percent ethanol 70% as the solvent. Sample compounds are then detected by LC-HRMS to determine the major compounds contained in a sample and their concentrations. Anti-collagenase activity was observed by enzymatic assay. The LC-HRMS analysis confirmed that apigenin, hispidulin, and catechin were included in the celery extract, with apigenin as the major compound of celery with AUC 73479.21×103, the AUC of hispidulin is 17063.21×103, and catechin 61.14×103. The percentage of collagenase inhibition of celery extract up until 200 μg/mL was 59.22% with an IC50 value of 132.48 µg/mL. These data indicated that celery containing apigenin, hispidulin, and catechin has an anti-collagenase activity worth further exploring for a healthy skin supplement.
Moringa oleifera Linn: Extraction, Phytochemistry Constituent and Pharmacology Activity: A Review Yamin Yamin; Ruslin Ruslin; Ratna Asmah Susidarti; Abdul Rohman
Majalah Obat Tradisional Vol 30, No 3 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.94004

Abstract

Moringa oleifera, commonly known as the “miracle tree”, belongs to the Moringaceae family and is a plant that has functional food and nutraceutical properties. Various parts of this plant are rich sources of carbohydrates, proteins, amino acids, lipids, vitamins, polyphenols and minerals. This review is a comprehensive summary of the extraction method, phytoconstituents, traditional uses, and pharmacological activity of this plant, namely as an antioxidant, antimicrobial and antifungal, anti-inflammatory, anti-diabetic and anti-obesity, antiviral. This is because Moringa leaves contain flavonoids and phenolics. In addition, Moringa leaves contain a large number of phytochemicals which are excellent for the development of functional products applied in various industries including pharmaceutical, cosmetic, nutraceutical and food.
Simple Tool of Metabolomic Studies: TLC-Based Metabolite Profiling Peronema canescens Jack in Archipelago Indonesia Nurfijrin Ramadhani; Endang Lukitaningsih; Abdul Rohman; Arief Nurrochmad
Majalah Obat Tradisional Vol 30, No 3 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.95221

Abstract

Peronema canescens Jack is a species of tropical plant utilized for its empirical applications, such as an antipyretic, antimalarial, immune stimulant, cold medicine, and mouthwash for its antiseptic properties. The objective of this study was to identify differences in the metabolite composition of P. canescens Jack leaves at different geographical locations. The metabolite profile was examined by thin-layer chromatography densitometry. The samples were collected from 10 distinct locations at varying elevations, with each location being sourced from three separate plants. Fingerprint metabolomics employs chemometric techniques such as Principal Component Analysis (PCA) and Hierarchical Cluster Analysis (HCA). The PCA analysis resulted in PC1 value of 41% and PC2 value of 32.6%, and these findings indicate the importance of considering the geographical locations where leaves are collected, as they reveal regional differences in the metabolism of P. canescens Jack secondary metabolites. Hierarchical cluster analysis (HCA) classified P. canescens Jack into four distinct clusters based on the closeness of their metabolite profiles. TLC is useful for the quality control of P. canescens Jack leaves based on variation geographical and authentication.
Cytotoxicity Study of Plantago major L. Extracts on RAW 264.7 Macrophages Ahmad Marzuki; Triana Hertiani; Retno Murwanti; Kurnia Rahayu Purnomo Sari; Almira Rahmayani
Majalah Obat Tradisional Vol 30, No 3 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.95828

Abstract

The use of medicinal plants in modern medicine is on the rise, particularly in addressing diabetes and its associated complications, such as persistent inflammatory wounds. Plantago major L. (P. major) is known for its rich distribution of bioactive compounds and its efficacy in treating diabetes, wound healing, inflammation, and oxidative stress. Before in vitro drug efficacy testing, it is essential to assess the toxicity of P. major extract. This study aims to evaluate the toxicity of P. major extracts on RAW 264.7 cells cultured in high-glucose DMEM media. This preliminary assessment is crucial for determining safe extract concentrations for subsequent anti-inflammatory activity testing using macrophage cells cultured in a hyperglycemic condition. Extracts were obtained from both leaf and non-leaf parts using maceration and UAE methods, resulting in four extract types: macerated leaf (DM), UAE leaf (DU), macerated non-leaf (NM), and UAE non-leaf (NU). Each extract was prepared in seven concentration series ranging from 7.81 to 500 μg/mL. Toxicity was assessed using the MTT method to determine cell viability after a 4-hour incubation. Significance against the control was analyzed using one-way ANOVA, and the effects of different plant parts, extraction methods, and their interaction were evaluated using two-way ANOVA. Results indicated that concentrations of 7.81-500 μg/mL for all four extracts did not significantly reduce cell viability (p > 0.05) compared to the control, with leaf extracts exhibiting higher viability percentages than non-leaf extracts, especially with the UAE extraction method at a concentration of 250 μg/mL (106.73 ± 4.20%). Variations in plant parts significantly affected (p < 0.05) cell viability percentages, whereas differences in extraction methods and their interaction did not have a significant effect. In conclusion, this study demonstrates that the four extracts at concentrations of 7.81-500 μg/mL are non-toxic to RAW 264.7 cells. Therefore, they are safe to use in anti-inflammatory activity testing.
Scoping Review: Metabolite and Pharmacological Activities in Lontar Fruit (Borassus flabellifer Linn.) Tince Bety Amarduan; Yulia Sari; Brian Wasita
Majalah Obat Tradisional Vol 30, No 3 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.97792

Abstract

The development of medicine depends heavily on medicinal plants. They include variousphytochemicals that can have physiological effects on people. Among them is the Borassus flabellifer Linn., also known as the lontar plant, which is a tropical plant in the Araceae family and is recognized for its medicinal qualities in traditional medicine. It is also referred to as the Palmyra palm. This study aims to gather information on the phytochemical compounds and pharmacological activities of palm fruit using a literature review. The literature search was conducted online using appropriate keywords and included both international and national indexed databases, covering the last 10 years (2014 - 2024). Tannins, saponins, glycosides, alkaloids, terpenoids, albuminoids, anthracene, betulinic acid, carotenoids, flavonoids, free anthraquinones, glucomannan, gums, lupeol, phlobatannin, phenols, quercetin, phytosterols, triterpenoids, quinones, cardiac glycosides, steroids, coumarins, and betacyanin have been identified as chemical components in palm fruit based on the 19 studies that were gathered. The pharmacological activities of palm fruit include antibacterial, antidiabetic, antihyperlipidemic, antihyperglycemic, antioxidant, and anticancer.
Immunostimulant Activities of Dioscorea esculenta L. Tubers Based on Phagocytic Activity and Lymphocyte Proliferation In Vitro Ika Puspitaningrum; Muthi&#039; Ikawati; Nanang Fakhrudin; Arief Nurrochmad
Majalah Obat Tradisional Vol 30, No 3 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.98776

Abstract

The immune system plays an important role for the body, especially in protecting it from exposure to bacteria, viruses, and other foreign bodies. Improving the immune system can be done by daily consumption of certain foods. Foods that can be developed into an immunostimulant are tubers, one of which comes from the genus Dioscorea. Dioscorea esculenta L., known as gembili tuber, is widely found in Indonesia, but has not been widely tested for its activity as an immunostimulant both against the innate and adaptive immune systems. This study aims to determine the immunostimulant activity of aqueous extract (AE), polysaccharide fraction (PF), and non-polysaccharide fraction (NPF) of gembili tubers against macrophage phagocytosis activity and lymphocyte proliferation. Test of phagocytosis activity and lymphocyte proliferation was performed in vitro by adding AE, PF, NPF gembili tubers 12.5, 50, and 100 mg/mL, inulin 100 µg/mL, and positive control 10 mg/mL as a comparison in macrophage cells and mouse lymphocyte cells. Phagocytosis activity was expressed in phagocytosis capacity and phagocytosis index, while lymphocyte proliferative activity was expressed in proliferative stimulating index. The results showed that AE, PF, and NPF could increase macrophage phagocytosis activity, with the highest activity observed at AE 100 μg/ml, PF 100 μg/ml, and NPF 12.5 μg/ml. AE, PF, and NPF were also shown to increase lymphocyte proliferation activity, with the most significant enhancement observed at AE 12.5 μg/mL, PF 12.5, and NPF 50 μg/mL.
Effect of Diabetes on Cortisol Levels After the Administration of Stenochlaena palustris (Burm.) Bedd Helmi Susanti Simamora; Adi Prayitno; Muthmainah Muthmainah
Majalah Obat Tradisional Vol 30, No 3 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.98823

Abstract

Cortisol, is a steroid hormone, that plays a role as a stress hormone and is known to elevate blood sugar levels, leading to hyperglycemia. Hyperglycemia is characterized by high cortisol levels and insulin resistance in type 2 diabetes mellitus (T2DM). Kelakai (Stenochlaena palustris (Burm.) Bedd) has many health benefits, including its antioxidant content that can reduce blood sugar levels (hypoglycemia). This study aims to evaluate the cortisol level reduction in model rats with T2DM after being treated with Stenochlaena palustris (Burm.) Bedd extract by employing a laboratory experimental approach. The blood glucose analysis was performed using pre- and posttest control group designs, while the cortisol measurement followed a posttest control group design. The rats were divided into five groups: KN (normal group), K− (T2DM model rats) which became the control group in this research, K+ (T2DM model rats treated with metformin), and two experimental groups, namely, P1 and P2 (T2DM model rats treated with both metformin and kelakai extract at 400 and 800 mg/kgBW/day doses, respectively, administered through a nasogastric tube for 21 days). Statistics used parametric tests, namely, analysis of variance (ANOVA) with least significant difference post-hoc test. The results of the cortisol levels showed a significant difference (p ≤ 0.05).
Formulation of Instant Drink from (Moringa oleifera Lam.) and (Heterotrigona itama) using Foam Mat Drying Method Desy Siska Anastasia; Sri Luliana; Nabila Mayang Ningrum
Majalah Obat Tradisional Vol 30, No 3 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.99462

Abstract

Moringa contains nutrients that benefit the food and health sectors. The part that has many benefits is the leaves. Moringa leaves contain the compound quercetin (flavonoid), which has antioxidant properties. Kelulut honey contains protocatechuic acid (PCA), which has potent antioxidant activity and OH groups to attract free radicals. The development of a functional drink from Moringa leaves and kelulut honey can be packaged more practically as an instant drink. This research aims to determine the physical characteristics, antioxidant activity, and panelists' preference level (hedonics) for instant drinks with variations of drying temperatures (50, 60, 70°C) and maltodextrin concentrations (15, 20, 30%). Instant drink uses the foam mat drying method with tween 80 as the foaming agent. The results showed that variations in temperature and concentration of maltodextrin influenced the physical characteristics of instant drinks with the best values for each test, which are water content (0.60%), flow time (1.68 g/sec), angle of repose (32°), tapping (6.08%), dissolution time in warm water (3.21 seconds). The best antioxidant activity value produced is 94.73% at 15% formula at 50°C temperature. The panelist's preference levels showed significant differences in smell, color, and taste, with the most preferred being the 15% formula.
Chemical Composition of Active Compounds in Standardized Cinnamon Simplicia (Cinnamomum verum) Sentot Joko Raharjo; Dewi Ratih Tirto Sari; Yanty Maryanty; Ita Tresnowati; Ernanin Dyah Wijayanti
Majalah Obat Tradisional Vol 30, No 3 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.100943

Abstract

Cinnamon (Cinnamomum verum) is widely recognized as a spice with a distinctive aroma that has a variety of applications in the culinary and health industries, due to its diverse active compounds. Standardization is essential to ensure the quality and uniformity of cinnamon raw materials. Previous studies primarily focused on identifying the most abundant compounds and bioactivity testing. However, a comprehensive analysis of the chemical composition of active compounds in different solvent extracts and essential oils has not been fully reported. This study aims to explore the chemical composition of active compounds in standardized cinnamon simplicia. Standardization parameters include water-soluble extractive, ethanol-soluble extractive, moisture content, ash content, microbial contamination levels, and qualitative and quantitative phytochemical analysis. Cinnamon was extracted using water, n-hexane, and steam distillation to obtain water extract, n-hexane extract, and essential oil, respectively, which were then analyzed by LC-MS and GC-MS. In general, all parameters set for the standardization of cinnamon simplisia met the applicable quality standards. The total phenolic content obtained was 3.99 ± 0.14 mgGAE/g, flavonoid content was 1.54 ± 0.10 mgQE/g, and total terpenoid content was 1.35 ± 0.13 mg/g. Furthermore, this study identified that the dominant active compounds in water extracts were polyphenols; n-hexane extracts contained major active compounds in terpenoids. At the same time, cinnamon essential oil showed the largest content of cinnamaldehyde. These findings provide important information regarding the chemical composition of cinnamon and its contribution to potential applications in the pharmaceutical and natural products industries.
In Vivo Antihyperlipidemic Activity of TD.HLM01 – A Vietnamese Traditional Remedy in Experimental Models Tung Thanh Tran; Ha Thi Thu Nguyen; Thuy Thanh Nguyen; Lien Huong Thi Nguyen; Van Hong Thi Nguyen; Hang Thi Thuy Nguyen; Quang Vinh Trinh; Hang Thi Thu Dinh; Duong Thuy Dau; Phong Xuan Pham; Nghia Trong Duong; Van Anh Thi Pham
Majalah Obat Tradisional Vol 30, No 3 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.101779

Abstract

One of the primary risk factors for cardiovascular disease nowadays is dyslipidemia. For many years, multi-herbal preparations have been the standard treatment approach for treating dyslipidemia. The purpose of this study was to assess the effects of TD.HLM01 hard capsule on experimental rodent models of endogenous and exogenous dyslipidemia. To create hyperlipidemia in the endogenous hyperlipidemia paradigm, mice were first given TD.HLM01 hard capsule therapy and intraperitoneal injections of poloxamer-407. In the exogenous model, rats were given a diet of oil-cholesterol mixture orally and treated with TD.HLM01 hard capsules for four consecutive weeks. Serum lipid parameters were evaluated in both experiments. The results indicated that TD.HLM01 significantly reduced TC, TG, and non-HDL-C levels in the experimental models of exogenous hyperlipidemia and endogenous hyperlipidemia. TD.HLM01 improved the serum LDH levels and ameliorated the elevated AST and ALT levels in cholesterol-induced hyperlipidemia rats. This study has demonstrated the potential efficacy of TD.HLM01 in hyperlipidemia experimental models in vivo.

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