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INDONESIA
Indonesian Journal of Cancer
Published by Rumah Sakit Kanker Dharmais (Pusat Kanker Nasional)
ISSN : 19783744     EISSN : 23556811     DOI : -
Core Subject : Health,
Health Professions
The Indonesian Journal of Cancer (official journal of the Dharmais Cancer Center Hospital) is a peer-reviewed, quarterly, open access journal. Submissions are reviewed under a broad scope of topics relevant to experimental and clinical cancer research. The journal publishes original research articles, case reports, systematic literature reviews, and letters to the editor under the following categories: Cancer prevention, diagnosis, surgery, systemic therapy, radiotherapy, paliative therapy, and molecular biology.
Arjuna Subject : -
Articles 7 Documents
 1 
Search results for , issue " Vol 4, No 2 (2010): Apr - Jun 2010" : 7 Documents clear
Uterine Malignant Mixed Mullerian Tumor (MMMT) RASJIDI, IMAM; ANDRIANA, KUSUMA; MULIARTHA, IKG
Indonesian Journal of Cancer Vol 4, No 2 (2010): Apr - Jun 2010
Publisher : "Dharmais" Cancer Center Hospital

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Abstract

It was reported, a case of Uterine Malignant Mixed Mullerian Tumor (MMMT) in 54 years old woman who has not reached menopause with nulliparity. The patient was wrongfully diagnosed with cervical cancer earlier and on the second visit, diagnosed with geburt myoma and perform extirpation. Anatomic pathological result from extirpation was MMMT. The patient was then performed TAH-BSO, pelvic and periaortic limphadenectomy, and peritoneal washing cytology. After performing surgical pathological staging, this patient was diagnosed with uterine MMMT IC grade 3. Adjuvant chemotherapy of choice given was Doxorubicin-Etoposide-Platamin (DEP) for six series. However, drug eruption happened before the completion of the first series. It was decided, to replace DEP with paclitaxel for 5 series weekly.
Nyeri Sebelum Kemoterapi sebagai Prediktor Rendahnya Kualitas Hidup Penderita Leukemia Limfoblastik Akut (LLA) Anak-Anak DANUAJI, RIVAN; MULATSIH, SRI; SUTARNI, SRI
Indonesian Journal of Cancer Vol 4, No 2 (2010): Apr - Jun 2010
Publisher : "Dharmais" Cancer Center Hospital

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Abstract

Chemotherapy and stem cell transplantation are the main therapy in childhood leukemia. Pain is one of symptom that may occur in acute lymphoblastic leukemia (ALL) and may influence quality of life (QOL). The aim of this study is to determine correlation between pain before chemotherapy and the QOL of children with ALL. A cohort retrospective study was conducted. Quality of life was measured by PedsQLTM 3,0 version. Univariate analysis showed 7 factors as predictor of QOL. There were age, father’s and mother’s education, family income, risk’s group, pain after and before chemotherapy. Multivariate analysis showed family income (RR: 1,61; 95% CI: 1.50 – 17.29) and pain after chemotherapy (RR: 3.24, 95% CI: 1.36 – 7.68) were significantly influenced ALL childhood’s QOL. Pain before chemotherapy could be used as a predictor of ALL childhood’s QOL. Family income and pain after chemotherapy was independent predictor.
Terapi Radikal pada Penderita Kanker Prostat: Tindak Lanjut Jangka Panjang dan Faktor Prediksi Survival UMBAS, RAINY; MOCHTAR, CHAIDIR A; HAMID, RIZAL A
Indonesian Journal of Cancer Vol 4, No 2 (2010): Apr - Jun 2010
Publisher : "Dharmais" Cancer Center Hospital

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Abstract

Radical treatment in the form of radical prostatectomy (PR) or external beam radiotherapy (EBRT) considered as gold standard in the management of localized and in some selected cases of locally advanced prostate cancer patients. Aim of this study is to know the treatment results of RP and EBRT in prostate cancer patients with T1-3 at “Cipto Mangunkusumo” Hospital and “Dharmais” Cancer Hospital, Jakarta. Analysis to the prediction factors in those two treatment modalities was also done. There were 110 patients among 610 prostate cancer patients in those two hospitals between January 1995 and December 2007 who received radical treatment. Radical prostatectomy was done to 43 patients with median age of 63 years (range: 50-74 years), and the other 67 patients with median age of 70 years (range: 50-82 years) were treated by EBRT. Median survival was 101 months and 85 months for patients treated with RP and EBRT respectively while 5-year survival rate was 68.4% and 69.2% for those respective groups. There was no clinical parameter in the group of patients who underwent PR which significantly correlated with survival. In the EBRT group, low grade tumor was significantly correlated with better survival. In conclussion, less than 20% of prostate cancer patients in those two hospitals underwent radical treatment in form of PR or EBRT. Median survival for patients treated with PR was better than those who received EBRT. Tumor grade was the only survival predictor factor in the EBRT group.
Skull Ganglioneuroblastoma: A Case Report ARIEF, M RADHIAN; ASHARI, SAMSUL; MAHYUDDIN, HILMAH
Indonesian Journal of Cancer Vol 4, No 2 (2010): Apr - Jun 2010
Publisher : "Dharmais" Cancer Center Hospital

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Abstract

Ganglioneuromas and ganglioneuroblastomas are tumors of the sympathetic nervous system that originate from neural crest sympathogonia, which are completely undifferentiated cells of the sympathetic nervous system. Along with neuroblastomas, ganglioneuromas and ganglioneuroblastomas are collectively known as neuroblastic or neurogenic tumors. Ganglioneuroblastoma is an intermediate tumor, a tumor that is between benign (slow-growing and unlikely to spread) and malignant (fast-growing, aggressive, and likely to spread). We report a rare case of skull ganglioneuroblastoma in a 4 months old child who came with a progressive increasing mass volume in the forehead. No other neurologic deficit was found. Serial Brain CT Scan was performed and showed progressive increasing of the mass volume. Comprehensive management was carry out for this patient.
Gambaran Kualitas Hidup Anak Usia 6-18 Tahun yang Menjalani Kemoterapi di Rumah Sakit Kanker “Dharmais”, Jakarta Barat UMIATI, MURDINI; RAKHMAWATI, WINDY; SIMANGUNSONG, BANGUN
Indonesian Journal of Cancer Vol 4, No 2 (2010): Apr - Jun 2010
Publisher : "Dharmais" Cancer Center Hospital

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Abstract

Quality of life is defined as minimal presence of the adverse impact of treatment on the patient’s perceptions of his or her own functioning. This study is to describe the quality of life among children who received chemotherapy. Twenty two children of age 6 to 18 years of age participated in this study. Data was collected by using the Pediatric Cancer Quality of Life Inventory-32 (PCQL-32) total scale. The result was measured and analyzed by using T score, lower score indicated better quality of life. The most frequent children who received chemotherapy reported high quality of life, 53,3% for 6-12 years and 57,1% for 13-18 years. The result of this study provides information on social functioning which supports interventions for the children who received chemotherapy. The findings indicated the importance for the health worker to provide attention during treatment of the related symptoms, whether physical, psychological or cognitive functioning. Keywords: quality of life, children, chemotherapy
Karsinoma Pelvis Renis dan Ureter di Jakarta: Karakteristik dan Faktor Risiko ZULFIKAR, YEVRI; UMBAS, RAINY; MOCHTAR, CHAIDIR A
Indonesian Journal of Cancer Vol 4, No 2 (2010): Apr - Jun 2010
Publisher : "Dharmais" Cancer Center Hospital

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Abstract

To study the characteristics,diagnosis and role of upper urinary tract stone as risk factors of renal pelvis and ureter malignancy. Data were collected from medical record of Urology Clinic Ciptomangunkusumo Hospital and Dharmais Cancer Hospital, Jakarta during the period between January 1995 and December 2009. The clinical factors which were studied are age, gender, symptoms, history of stone disease, imaging, histopathology , primary lesions of the tumor, and stage. There were 42 renal pelvis and ureter carcinoma patients during 15 years period. With mean age of 53.5 years (range 33 – 74). There were 54.8% cases associated with stone disease. The most common histopatology was Transitional Cell Carcinoma (TCC) (47.6%). Ninety two point nine percent cases with Squamous Cell Carcinoma (SCC) are associated with stone or history of operation for stone removal. Symptom of flank tumor occurred in 61.0 % patients, flank pain 58.5 %, and hematuria 53.7 %. Only 71.4 % of cases were detected pre operatively. Pre operative imaging detection were 89.3%, 53.8%, 20.7% for CT Scan USG and IVU respectively . Fifty two point five percents of patients were found on Stage IV and 47.8 % of these patients were associated with stone disease. Most of patients with renal pelvis and ureter carcinoma were associated with stone disease, especially in patients with SCC tumors. There are still some problems in detecting these tumors especially in early stage.
Identifikasi Fraksi Toksik Ekstrak Rumput Laut Eucheuma cottonii Lin DIRA SWANTARA, I MADE
Indonesian Journal of Cancer Vol 4, No 2 (2010): Apr - Jun 2010
Publisher : "Dharmais" Cancer Center Hospital

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Abstract

Based on previous research, seaweed extract of Eucheuma sp was reported having antitumour activities. Eucheuma cottonii collected from Pari Island (Seribu archipelago) showed toxicity towards Artemia salina. Toxicity test using Artemia salina as bioindicator was a prescreening testing for anticancer agent. The aims of this research were to isolate and identify any potentially anticancer agent from the most toxic fraction of E. cottonii extract. Sample was extracted with 85 % ethanol using maceration method. The crude ethanol exract was then partitioned into n-hexane, chloroform, and ethyl acetate. The most active fraction towards artemia salina toxicity test was then purified using silica gel column chromatography with n-hexane:chloroform (2:3) as eluent. The pure active fraction having LC50 14.80 ppm was contitued of five compounds which identified using Gas Chromatography-Mass Spectrometry as Cyclododecana (3.23%), Tetradecanoic acid (7.10%), Hexadecanoic acid (54.74%), Cholesta-4,6-dien-3?-ol (6.67%), and Cholest-5-en-dien-3?-ol (Cholesterol) (28.26%).

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