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INDONESIAN JOURNAL OF PHARMACY

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Published by Universitas Gadjah Mada

ISSN : 23389427 EISSN : 23389486 DOI : -

Core Subject : Health,

Medicine & Pharmacology

Indonesian Journal of Pharmacy (ISSN-e: 2338-9486, ISSN-p: 2338-9427), formerly Majalah Farmasi Indonesia (ISSN: 0126-1037). The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas Gadjah Mada (UGM) Yogyakarta Indonesia in collaboration with IAI (Ikatan Apoteker Indonesia or Indonesian Pharmacist Association) and only receives manuscripts in English. Indonesian Journal of Pharmacy is Accredited by Directorate General of Higher Education (DGHE) DIKTI No. 58/DIKTI/Kep/2013.

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Articles 9 Documents

Search results for , issue "Vol 17 No 2, 2006" : 9 Documents clear

Activity of propyl p-benzoyloxybenzoate as mu-class glutathione s-transferase inhibitor Agnes Nora Iska Harnita; Enade Perdana Istyastono; Sudibyo Martono
Indonesian Journal of Pharmacy Vol 17 No 2, 2006
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Non-steroidal anti-inflammatory drugs (NSAIDs) are the most prescribed medicines. Anti-inflammatory activity was reported to have relationship with the inhibition of prostaglandin synthesis, one of the inflammation mediators. The inhibition mechanism might be through the cyclooxygenase (COX) inhibition, oxygen radical scavenging, and mu-class glutathione S-transferase (GST) inhibition. Aspirin has been used as a NSAID since a hundred years ago and was reported as cyclooxigenase-1 (COX-1) selective inhibitor. The selectivity leds to gastrointestinal ulceration. Propyl p-benzoyloxybenzoate was a new compound which was predicted to have anti-inflammatory activity and would be developed to be an NSAID with minimum side effect.mu-class GST inhibition was examined using formation reaction model of GS-CNB conjugate through conjugation of 1,2-dichloro-4-nitrobenzene (DCNB) and glutathione (GSH) with GST (prepared from rat’s liver) as a catalyst. GSTs were isolated from the rat liver cytosolic fraction by centrifugation according to Lundgren. Protein concentration of the cytosol was determined spectrophotometrically by using bovine serum albumin as a standard. The GST activity was determined using conjugation reaction rate between DCNB and GSH, followed by determination of IC50 of propyl p-benzoyloxybenzoate. The result showed that propyl p-benzoyloxybenzoate has activity as mu-class GST inhibitor with IC50 = 111.77 μM as the result from extrapolation.Key words: Anti-inflammatory, propyl p-benzoyloxybenzoate, inhibitor, mu-class glutathione S-transferase (GST).

Increasing of the bacteriostatic effects of HCl tetracycline–polyethylene glycol 6000 – tween 80 (PT) Riswaka Sudjaswadi
Indonesian Journal of Pharmacy Vol 17 No 2, 2006
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

The antibacterial effect of HCl tetracycline – polyethylene glycol-tween 80 (PT) solid dispersion in the mole fraction of 0,1; 0,5; 0,7; 0,9; and 1,0 on Saphylo coccus aureus and on Escherichia coli had been studied by using the diffusion methods, in order to obtain the roles of PT on the drug penetration through the membrane and on the bacteriostatic effects.The results shown that the effects on Staphylococcus aureus in the mole fraction of 0,1; 0,5; 0,9 seemed to be the same when using the diffusion method (hole systems), whilst using the diffusion method (paper disc), all agents performed the increased effects in the mole fraction of 0,5; 0,7; and 0,9; in comparison with the mol fraction of 1,0, respectively.It had been concluded that PT expressed the increased effects of HCL tetracycline from 100,00 % up to 124,54 % on Staphylococcus aureus, and 108,90 % to 127,27 % on Escherichia coli.Key words : solid dispersion, bacteriostatic, HCl tetracycline, PEG-tween 80.

The temperature effect and humidity on dissolution rate of effervescent tablet ., Ansar; Rahardjo, Budi; Noor, Zuheid; ., Rochmadi
Indonesian Journal of Pharmacy Vol 17 No 2, 2006
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

The aim of this study was to measure the dissolution rate constant of passion fruit effervescent tablet during storage at temperature and relative humidity variations. Sample of passion fruit effervescent tablet prepared from passion fruit granular, aspartame, polyethylene glycol, citric acid, and sodium bicarbonate.The result showed and the dissolution rate constant increased with the increasing of temperature. At elevated RH as well. The amount of dissolution rate constant was is 0.0138 with coefficient of determination (R2) was 0.7337. This calculation suggested that the proposed mathematics models might be applicable to shelf life prediction of effervescent tablet.Key words: temperature, humidity, effervescent tablet

Influence of PEG 4000 concentration dissolution rate of ketoprofen in solid dispersion system of ketoprofen-PEG 4000 Fikri Alatas; Sundani Nurono S.; Sukmadjaja Asyarie
Indonesian Journal of Pharmacy Vol 17 No 2, 2006
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Influence of PEG 4000 concentration dissolution rate of ketoprofen was studied in solid dispersion system of ketoprofen-PEG 4000. Solid dispersion system was prepared by melting method with various weight ratio of ketoprofen-PEG 4000, i.e. 2:1, 1:1, 1:3, and 1:4. The dissolution test was carried out using the paddle method at temperature of 37±0,5°C and 50 rotations per minute (rpm) in 900 mL of hydrochloric acid buffer solution at pH 1.2. The dissolution rate of ketoprofen improved by increasing PEG 4000 concentration. Incorporation of sodium lauryl sulfate into solid dispersion system of ketoprofen-PEG 4000 enhanced the dissolution rate of ketoprofen.Key words : solid dispersion, ketoprofen, PEG 4000, sodium lauryl sulfate

Simulation of propranolol as antihypertensive agent on hyperglicaemic rabbit Kus Haryono; Sukati K.; Elly Wahyuddin
Indonesian Journal of Pharmacy Vol 17 No 2, 2006
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Diabetic and hypertention are two common deseases on older people one of fat soluble antihypertensive drugs is propanolol. There for is a study this undertakento observe how propanolol can reduce the blood sugar. This study used 12 male rabbits, divided into 4 grroups. Each group consisted 3 rabbits. The first group was used as negative control (given EDTA sodium liquid 1 % w/v). The second group was the treated group (given EDTA sodium suspension 1.% w/v and propranolol tablet suspension 0,006.% w/v). The third group also the treated group (given EDTA sodium suspension 1% and propranolol tablet suspension 0,02 % w/v). The fourth group was the positive control (given EDTA sodium liquid 1 % w/v only). Blood glucose level was measured before and after treatment by using spektrophotometer (578 nm). The result showed that colloidal CMC sodium liquid 1 % w/v lowered blood glucose level (not significant as 0,7 mg/dL). EDTA sodium liquid 1 % w/v + propranolol suspension 0,006 % w/v significantly lowered blood glucose level as 5,3 mg/dL, EDTA sodium liquid 1 % w/v + propranolol suspension 0,02% w/v also lowered the blood glucose level as 21,7 mg/dL, EDTA sodium liquid 1 % w/v significantly giving the effect on the increasing blood glucose level as 17,4 mg/dL.Key words : Propranolol, glucose, rabbit

Sequencing analysis of the hole DNA of a mutant gene of Klebsiela pneumoniae resistant against BRL 41897A (KSL 19 Mutant) M. Kuswandi
Indonesian Journal of Pharmacy Vol 17 No 2, 2006
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Previous article reported that three positive transformants of different K.pneumonie resistant mutants against BRL 41897A (KSL 19, KSL38 and KSL62) carrying TnphoA was sequenced. The results showed that the three different transformants of the mutants had different genes inserted TnphoA. Subsequently, we then cloned the wild typeM10 chromosome fragments into pUC18 and recombinants analysed by gel electrophoresis and Southern blotting using HindIII fragment from KIH 19 as aprobe. The clones were designated M19 carrying the hole gene which had an important role in the antibiotic resistantion. The plasmid DNA of positive clone was isolated, analysed by Southern blotting, and sequenced using primers based on sequencing data from KIH19. Sequencing data of KIH19 confirmed the sequence of M19 and the point of insertion of transposon. The amino acid sequence at the N terminus of disrupted gene ksl19 showed the characteristics of features of signal peptide structure. In order to characterise the M19 clone, further complementation analysis was carried out, by transformation of M19 plasmid into KSL19 mutant cell, designated T19, and then checked by gel electrophoresis and sensitivity test. The complementation studies showed that sensitivity to BRL 41897A was restored on transformation of a large (7 kb) fragment of DNA carrying ksl19 geneKey words: Resistant K.pneumoniae KSL19 mutants -BRL41897A, sequencing.

Effect of ethanol extract of Erythrina fusca Lour (cangkring) leaves on suppression of cyclooxygenase-2 expression in raji cell line Zullies Ikawati; Agung Endro Nugroho; Winda Werdhinindah
Indonesian Journal of Pharmacy Vol 17 No 2, 2006
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

COX-2. COX-2 is expressed highly in inflammation and cancer cells. The effect of ethanol extract of Erythrina fusca Lour (cangkring) toward suppression of COX-2 expression in Raji cells was studied using immunocytochemistry method. This research showed that ethanol extract of E. fusca Lour leaves on concentration of 250,0; 125,0; dan 62,50 μg/mL was able to suppress the COX-2 expression significantly in comparison to control, with the inhibition of 70,19 ± 2,14 %; 44,69 ± 1,62 %; and 23,25 ± 2,21 %.Key words: COX-2 expression, anti-inflammation, anti cancer, Raji cells, ethanol extract of E. fusca leaves, immunocytochemistry

Study of antiemetic pattern on cancer patients with cancer by cytostatic therapy hospitals in Yogyakarta Perwitasari, Dyah Aryani
Indonesian Journal of Pharmacy Vol 17 No 2, 2006
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

The aim of the research was to know the description of antiemetic usage on the patients with cancer based on the medical records that were available in the hospital. Hereby, the use of antiemetic would be compared to literature for seeing the pattern.The study was a descriptive, analytic and retrospective study. The data taken from the medical records were written by doctor and nurses for cancer in patients hospital during Januari to June 2003. Data were grouped based on cytotoxic treatment with strong, medium and weak emetogenic effects, the condition of cancer patients, and antiemetic usage before and after having cytotoxic treatment.The results showed antiemetic usage before and after strong emetogenic cytotoxic treatment were not suitable because there was no combination with dexametason. Antiemetic usage which was used before and after mild emetogenic cytotoxic treatment were not suitable with ondansetron, metochlorpramide, combination of ondansetron â€“ metochlorpramide. The use of antiemetic on cancer patients who got strong and medium emetogenic cytostatic was not been suitable with literatures because the patients were not given dexamethasone as combination therapy. For cancer patients given before and after medical treatment with weak emetogenic effect werenâ€™t suitable in both of hospitals. Antiemetic usage before cytotoxic treatment that was not suitable was ondansetron and metoclopramide, where as antiemetic usage after cytotoxic that was suitable was metoclopramide.Key words: Antiemetic, Emetogenic Effect, Cytotoxic, hospital

Antimalaria test of artemisia spp. on Plasmodium falciparum ., Aryanti; Ermayanti, Tri Muji; Priadi, Kartika Ika; Dewi, Rita Martaleta
INDONESIAN JOURNAL OF PHARMACY Vol 17 No 2, 2006
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

The testing of inhibiton of Plasmodium falciparum by Artemisia annua, A.cina and A.vulgaris isolate and artemisinin content each of plants was conducted. Artemisia leaves extracted from n-hexane and then separated by column chromatography with n-hexane/ethylacetate as eluent. The column result tested to P.falciparum protozoa. The concentrations of agent were 100, 10, 1 and 0,1 Î¼g/mL using sulphadoxin pyrimetamin as a control positive. Then 50 Î¼l of cell suspension added to agent and incubated at 37oC for 30 hours and the number of live skizon calculated from 200 parasite asexual. The result showed that the increasing of agent concentration was increasing of parasite death. Percent of death parasite by agent of 100 Î¼g/mL similar with positive control at the concentration of 300 Î¼g/mL and the death by A.annua was 83.77%, A.cina 78.57 and A.vulgaris was 84.90% meanwhile positive control was 88.09%. The highest of artemisinin content found in A.annua was 4.99.Key words : anti-malaria, Plasmodium falciparum, Artemisia spp.

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