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INDONESIAN JOURNAL OF PHARMACY

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Published by Universitas Gadjah Mada

ISSN : 23389427 EISSN : 23389486 DOI : -

Core Subject : Health,

Medicine & Pharmacology

Indonesian Journal of Pharmacy (ISSN-e: 2338-9486, ISSN-p: 2338-9427), formerly Majalah Farmasi Indonesia (ISSN: 0126-1037). The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas Gadjah Mada (UGM) Yogyakarta Indonesia in collaboration with IAI (Ikatan Apoteker Indonesia or Indonesian Pharmacist Association) and only receives manuscripts in English. Indonesian Journal of Pharmacy is Accredited by Directorate General of Higher Education (DGHE) DIKTI No. 58/DIKTI/Kep/2013.

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Articles 16 Documents

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Search results for , issue "Vol 20 No 3, 2009" : 16 Documents clear

Evaluation of chromatographic dead times for retention indices determination in RP-HPLC using some homologous series Rinaldi Idroes
Indonesian Journal of Pharmacy Vol 20 No 3, 2009
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Dead time that defined as a retention time of unretained substance in the chromatographic coloumn, is needed to determine all retention parameters in coloumn chromatography such as corrected retention time, relative retention time and Kovats Retention Indices.This research reported a comparison between the iteration and linearization of corrected retention times of homologous series such as n-alkane, akylrylketone, alkylbenzene and 2-alkanone. Furthermore the iteration method provides better dead-time values and smaller standard deviations than the linearization method. Moreover, the dead-time calculation obtained according to homologous series is not depending on solvent composition for various homologous series.The n-alkane homologous series show better indication accuracy of fit (S/N) in comparison with other homologous series, thereafter 2-alkanone exhibit the second best adjustment.Keywords: Dead-time evaluation, homologous series, methanol/water solvent, RP-HPLC.

Ibuprofen salt production and its application in tablet dosage form Hadisoewignyo, Lannie; Fudholi, Achmad; Muchalal, M.
Indonesian Journal of Pharmacy Vol 20 No 3, 2009
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Ibuprofen is an anti-inflammatory drug and is practically insoluble in water. The low melting point and the poor flowability of ibuprofen can lead to process difficulty in tablets production. The purpose of this research was to make the sodium salt form of ibuprofen which has better solubility in water.Sodium ibuprofen salt was prepared by reacting the ibuprofen and sodium hydroxide, then characterized using TG/DTA, DSC, spectrophotometer UV-VIS, spectrophotometer IR, X-ray diffraction, and SEM. Tablets were prepared by wet granulation method.The characterization result showed that sodium ibuprofen result of the synthesis was dehydrate form with melting point of 199.9 °C. Granules of sodium ibuprofen result of the synthesis had better flowability and bigger density than ibuprofen granules. The physical characterization of the tablet showed that the formula of sodium ibuprofen resulted from the. Sodium ibuprofen showed the higher release rate than ibuprofen so can give quicker onset of action.Key words: sodium ibuprofen, ibuprofen, dissolution.

Potency of use ferrous sulphate from iron waste workshop bubut for raw material pharmacy Sunardi .
Indonesian Journal of Pharmacy Vol 20 No 3, 2009
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Iron Deficieny Anemia (IDA) representing one of especial micronutrient deficiency that happened in Indonesia. IDA suffered by Indonesia resident about 100 million soul. One of effort of handling IDA is supplementation by ferro sulphate. To serve the purpose of raw material pharmacy have to be up to standard quality of set in Pharmacopoeia of Indonesia Edition IV. This Research aimed to make, to purify and characterization ferro sulphate from iron waste. The produce with reacted iron waste and acid sulphate 25% during 2 day. Crystal dissociated and purified by recrystalization, and then characterization with SEM-EDS. Result of research showed that ferro sulphate from iron waste of workshop bubut fulfill the standard quality of in Indonesia Pharmacopoeia Edition IV.Key words : iron waste, ferrous sulfate, recrystalization, characterization.

Chemical investigation on Indonesian marine sponge Mycale phyllophila Hertiani, Triana; Edrada, Ru Angelie; Van Soest, Rob W.M.; ., Sudarsono; Muller, Werner E.G.; Proksch, Peter
Indonesian Journal of Pharmacy Vol 20 No 3, 2009
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Chemical investigation on marine sponge Mycale phyllophila collected from Bali, Indonesia has been performed. This study was aimed to isolate and to identify structures of the sponge secondary metabolites as well as to test their cytotoxic activity on mouse lymphoma cell line L5178Y.The sponge extract was fractionated by liquid-liquid partition followed with a vacuum liquid chromatography method. Structure elucidation was performed on the basis of extensive spectroscopic analysis involving one and two dimensional NMR spectroscopy as well as mass spectrometry. Cytotoxicity was tested on mouse lymphoma cell line L5178Y by using the microculture tetrazolium (MTT) assay. This study found a mixture of 5-pentadecyl-1H-pyrrole-2-carbaldehyde and (6’E)-5-(6’pentadecenyl)-1H-pyrrole-2-carbaldehyde as major constituents of the sponge extract. Those compounds were expected to be the active constituent to show growth inhibition of mouse lymphoma cell line (L5178Y) in vitro.Key words : Mycale phyllophila, cytotoxic agent, NMR spectroscopy.

Optimization of piroxicam tablet formula using flowlac, avicel and compritol by Simplex Lattice Design Method Tuti Sri Suhesti; Achmad Fudholi
Indonesian Journal of Pharmacy Vol 20 No 3, 2009
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Piroksikam is non steroid anti inflammation drug (NSAID) with small dose (10-20 mg daily) with a long time (t1/2) elimination. Piroxicam formulation was expected able to yield a good (quality) tablet to physical characteristic standard. Tablet r component was consisted of Flowlac 100 (filler), Avicel PH-101 (binder) and Compritol 888 ATO (lubricant).The research was done with simplex lattice design (SLD) by using 3 component, i.e. Flowlac (A), Avicel (B), and Compritol (C). Seven formula were needed, I,e, F1 (100 % A), F2 (100 % B), F3 (100 % C), F4 (50 % A and 50 % B), F5 (50 % B and 50 % C), F6 (50 % A and 50 % C),dan F7 (33.33% A, 33.33 % B, 33.33 % C). The optimization parameters of piroxicam tablets were flow rate of the tablet mass, tablet hardness, disintegration time, piroxicam content and the dissolution (C45), on SLD model; equations, contour plots, and superimposed of contour plots were obtained, by which the optimum formula was determined.Based on superimposed contour plot optimum formula was obtained with proportion of Flowlac (89.6 %), Avicel (7.4 %) and Compritol (3 %). The result of flowability was 21.46 g/second; hardness (6.46 kg); disintegration time (6.98 minutes); drug content (10.13 mg) and dissolution C45 (7.35 mg) Interaction of Flowlac-Avicel-Compritol could influence the physical properties and the release profile of tablet. Flowlac was the most dominant factor in increasing flowability, hardness and dissolution of tablet. Compritol was the most dominant factor in increating time of disintegration tablet.Key words: optimization; piroxicam; simplex lattice design.

Capability of boiling water of bay leaf (Eugenia polyantha W) for reducing Streptococcus sp. colony Agustin Wulan; Agus Sumono
Indonesian Journal of Pharmacy Vol 20 No 3, 2009
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Mouth is one of our body parts that have a lot of micro-organisms. The population of micro organism in mouth is higher than the other part of our body. Streptococcus mutant is a cariogenic bacterium that has the capability to produce polysaccharide and initiate the process of carries. There are many ways for preventing dental carries, one of them is using of antiseptic mouth washes. chlorhexidine is one of the most effective mouth washes used to prevent the dental carries and the plaque formation. Unfortunately, only some people who has easy access to the drugs store to get this medicine. So they use herbal that has capability for mouth washes, one of that herbal is bay leaf (Eugenia polyantha W). Aim of this study was to know capability of bay leaf (Eugenia polyantha W) as mouth washes for reducing Streptococcus sp colony.Saliva samples are taken from 50 patients that come in Dental Hospital Faculty of Dentistry Jember University. 50 patients are divided in 5 groups. Patients were instructed to rinse by 50 %, 75 %, 100 % boiling water of bay leaf, 0.2 % chlorhexidine and aquadest. Then, saliva was inoculates in TSA medium and incubated for 24 hours, before bacteria colony counting.Result of anova test showed there was significant different of amount of Sterptococcus colony in saliva patient that are rinsed by 50 %, 75 %, 100 % boiling water of bay leaf, 0.2 % chlorhexidine and aquadest (p < 0.05). Result of LSD test show there where significant different in each groups (p < 0.05). The conclusion of this study was boiling water of bay leaf can reduce Streptococcus sp colony.Key words : bay leaf, mouth washes, bacterial colony.

Isolation and identification of eurycomanone from akar pasak bumi (Eurycoma longifolia, Jack) and its antiangiogenic activity Sugiyanto .; Nina Salamah; Mae Sri Hartati; Farida Hayati; Pinus Jumariyatno
Indonesian Journal of Pharmacy Vol 20 No 3, 2009
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Pasak bumi is one of the Indonesian original plants having anti cancer activity. One compound of akar pasak bumi, i.e eurycomanone was proven to have cytotoxic effect on cancer cell culture by apoptosis induction on HeLa cells. Therefore, this study was aimed to isolate and identify euycomanone from akar pasak bumi and to look at the anti angiogenic activity of the compounds on corio alantois membrane (CAM) of chicken embryo induced by bFGF.The akar pasak bumi was ground and was macerated with methanol. The macerate was fractioned by mean of VLC. Six fractions was obtained. The second fraction exhibited two spots on a TLC system, one spot was cochromatographed with eurycomanone as the reference standart and another spot exhibited blue fluorecence at 254 nm. This second fraction, then, was chromatographed on a preparative scale TLC to separate isolate A. Anti angiogenic test was performed for Isolate A at concentration series of 5, 10, 15, 20, 40 μg/mL respectively. Egg embrio (8-9 days) were divided into 8 groups. The first group was implanted paper disc only, the second group were given bFGF on Tris HCl buffer and the third group were given bFGF (on Tris HCl buffer) + 0,8 % DMSO. The fourth to eighth group were induced by 10 ng bFGF and the test preparation at the respective concentration. After incubation at 39 °C for 3 days, each egg was opened, the content of each was aspired and discarded, the CAM sticked to its shell was examined macroscopically and microscopically for the formation of new blood vessels.Based on spectral data of UV, IR, 1H NMR, 13C NMR and MS of isolate A and comparison with the spectral data of the standart, the isolate A was eurycomanone. Eurycomanone inhibited angiogenesis at concentration of 10 μg/mL.Key words: antiangiogenic, angiogenesis, E.longifolia, eurycomanone,CAM.

Antibacterial activity and GC-MS analysis of the Citrus amblycarpa (Hassk) Ochse essential oil Mulyani, Sri; ., Susilowati; Hutabarat, Maniur
INDONESIAN JOURNAL OF PHARMACY Vol 20 No 3, 2009
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

A research about anti-bacterial activity and components of essential oil from leaves and peels of Citrus amblycarpa have been done.The components of essential oil had been identified by using GC-MS and anti-bacterial activity against S. aureus ATCC 25923 and E. coli ATCC 25922 had been determined with liquid dilution method. The component of essential oil from leaves that can be identified are Î²-pinene, linalool, citronellal, citronellol and geraniol, while from peels are Î²-pinena, cymene, limonene and citronellal.Oil from the leaves has stronger anti-bacterial activity against S. aureus than from peels. On the other hand oil from peels is stronger anti-bacterial activity against E coli.Key words : Citrus amblycarpa, essential oil, anti-bacterial activity.

Potency of use ferrous sulphate from iron waste workshop bubut for raw material pharmacy Sunardi Sunardi
Indonesian Journal of Pharmacy Vol 20 No 3, 2009
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Iron Deficieny Anemia (IDA) representing one of especial micronutrient deficiency that happened in Indonesia. IDA suffered by Indonesia resident about 100 million soul. One of effort of handling IDA is supplementation by ferro sulphate. To serve the purpose of raw material pharmacy have to be up to standard quality of set in Pharmacopoeia of Indonesia Edition IV.This Research aimed to make, to purify and characterization ferro sulphate from iron waste. The produce with reacted iron waste and acid sulphate 25% during 2 day. Crystal dissociated and purified by recrystalization, and then characterization with SEM-EDS.Result of research showed that ferro sulphate from iron waste of workshop bubut fulfill the standard quality of in Indonesia Pharmacopoeia Edition IV.Key words : iron waste, ferrous sulfate, recrystalization, characterization.

Capability of boiling water of bay leaf (Eugenia polyantha W) for reducing Streptococcus sp. colony Agus Sumono
Indonesian Journal of Pharmacy Vol 20 No 3, 2009
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjpharm0iss0pp112-117

Mouth is one of our body parts that have a lot of micro-organisms. The population of micro-organism in mouth is higher than the other part of our body. Streptococcus mutant is a cariogenic bacterium that has the capability toproduce polysaccharide and initiate the process of carries. There are many ways for preventing dental carries, one of them is using of antiseptic mouth washes. chlorhexidine is one of the most effective mouth washes used to prevent thedental carries and the plaque formation. Unfortunately, only some people who has easy access to the drugs store to get this medicine. So they use herbal that has capability for mouth washes, one of that herbal is bay leaf (Eugeniapolyantha W). Aim of this study was to know capability of bay leaf (Eugenia polyantha W) as mouth washes for reducing Streptococcus sp colony.Saliva samples are taken from 50 patients that come in Dental Hospital Faculty of Dentistry Jember University. 50 patients are divided in 5 groups. Patients were instructed to rinse by 50 %, 75 %, 100 % boiling water of bay leaf, 0.2 % chlorhexidine and aquadest. Then, saliva was inoculates in TSA medium and incubated for 24 hours, before bacteria colony counting.Result of anova test showed there was significant different of amount of Sterptococcus colony in saliva patient that are rinsed by 50 %, 75 %, 100 % boiling water of bay leaf, 0.2 % chlorhexidine and aquadest (p < 0.05). Result of LSD test show there where significant different in each groups (p < 0.05). The conclusion of this study was boiling water of bay leaf can reduce Streptococcus sp colony.Key words : bay leaf, mouth washes, bacterial colony.

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