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INDONESIA
INDONESIAN JOURNAL OF PHARMACY
Published by Universitas Gadjah Mada
ISSN : 23389427     EISSN : 23389486     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Indonesian Journal of Pharmacy (ISSN-e: 2338-9486, ISSN-p: 2338-9427), formerly Majalah Farmasi Indonesia (ISSN: 0126-1037). The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas Gadjah Mada (UGM) Yogyakarta Indonesia in collaboration with IAI (Ikatan Apoteker Indonesia or Indonesian Pharmacist Association) and only receives manuscripts in English. Indonesian Journal of Pharmacy is Accredited by Directorate General of Higher Education (DGHE) DIKTI No. 58/DIKTI/Kep/2013.
Arjuna Subject : -
Articles 9 Documents
 1 
Search results for , issue "Vol 23 No 4, 2012" : 9 Documents clear
SYNTHESIS AND ANALGESIC ACTIVITY OF 6-(MNITROPHENYL)-4-SUSTITUTED BENZYLIDENE-4,5-DIHYDROPYRIDAZIN-3(2H)-ONE DERIVATIVES Asif, Mohammad
Indonesian Journal of Pharmacy Vol 23 No 4, 2012
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (255.072 KB) | DOI: 10.14499/indonesianjpharm23iss4pp254-258

Abstract

Many  research  groups  have  been  interested  in  3(2H)-pyridazinones  for  the  development  of  potential  analgesic  and  antiinflammatory  agents.  Stimulated  by  these  findings,  three  6-(mNitrophenyl)-4-sustituted  benzylidene-4,5-dihydropyridazin-3(2H)-ones (IVa-IVc) have been synthesized and evaluated for analgesic activity  against  hot  plate  method.  Compounds IVa-IVc were prepared from 6-m-nitrophenyl-4,5-pyridazin-3(2H)-one by condensation  with  respective  aldehydes.  All  compounds  (IVa-IVc)  having nitro  phenyl  and  benzylidene  groups  at  position  6  and  4  of  the pyridazinone  ring  receptively.  All  compounds  (IVa-IVc)  showed significant  analgesic  activity  when  compare  to  control  group  and were found less potent than reference drug aspirin.Key words:Pyridazinones, analgesic, benzylidene, nitrophenyl.
CHOCOLATE FORMULATION AS DRUG DELIVERY SYSTEM FOR PEDIATRICS Mayank, Sharma; Kumar, Jain Dinesh
Indonesian Journal of Pharmacy Vol 23 No 4, 2012
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (525.272 KB) | DOI: 10.14499/indonesianjpharm23iss4pp216-224

Abstract

Chocolate  is  highly  sophisticated  and  infinitely  a  versatile food that can be combined to create completely different taste and texture  sensations.   The  objective  of  the  present  study  is  to develop  a  palatable  chocolate  formulation  of  Domperidone  and Cetirizine  for  pediatric  administration  and  to  increase  patient’s desire  to  consume  the  medication.  In  present  investigation chocolate  base  is  prepared  by  use  of  cocoa  powder,  coco  butter, lecithin,  and  pharmaceutical  grade  sugar.  Thereafter  drug  is incorporated  to prepared  chocolate base.  The medicated chocolate prepared  is  evaluated  for  appearance,  moisture  content determination using digital Karl Fischer titrator, blooming test, drug content  determination  &  drug  excipient  interaction  by  differential scanning calorimetry.Key words: Medicated Chocolate, Pediatrics, Chocolate formulation
ANTHELMINTIC ACTIVITY OF Cuminum cyminum, FOENICULUM VULGARE AND Eugenia caryophyllusAGAINST Pheritima posthuma Satish Kumar; Kamal Kumar Goyal; Syed Bilal
Indonesian Journal of Pharmacy Vol 23 No 4, 2012
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (527.726 KB) | DOI: 10.14499/indonesianjpharm23iss4pp225-230

Abstract

Ethanol  extract  of  fruit  of Cuminum  cyminum (EECC), aqueous  extract  of  fruit  of Cuminum  cyminum (AECC),  Ethanol extract  of  fruit  of  Foeniculum  vulgare (EEFV), aqueous  extract  of fruit of Foeniculum vulgare (AEFV) and Ethanol extract of flowering bud  of  Eugenia  caryophyllus(  EEEC),  aqueous  extract  of  flowering bud  of Eugenia  caryophyllus(  AEEC) were  taken  up  for  in  vitro studies  on  the  Anthelmintic  activity  against Pheritima  posthuma. Different  concentrations  (25,  50,  100,  200mg/mL)  were  used  for the activity is compared with the reference standard Albendazole at concentration 20mg/mL and normal saline( 0.9% NaCl) was used in control  treatment.  The  results  were  expressed  in  terms  of  time  in minutes  to  report  the  time  of  paralysis  and  time  of  death  of  the earth  worms.  The  results  obtained  from  study  indicate  towards anthelmintic  activity,  supporting  folk  used  of  all  three  plants compared with reference standard. The result established that EEEC and AEEC is more potent as compared with EECC, AECC and EEFV, AEFV.Key  words:  Anthelmintic  activity,  Cuminum  cyminum,  Eugenia caryophyllus, Foeniculum vulgare, Pheritima posthuma. 
REVIEW OF BIOLOGICAL ACTIVITIES OF HYDRAZONES Ali, Md. Rahmat; Marella, Akranth; Alam, Md. Tauquir; Naz, Ruksar; Akhter, Mymoona; Shaquiquzzaman, Md.; Saha, Rikta; Tanwar, Omprakash; Alam, Md. Mumtaz; Hooda, Jyoti
Indonesian Journal of Pharmacy Vol 23 No 4, 2012
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (994 KB) | DOI: 10.14499/indonesianjpharm23iss4pp193-202

Abstract

Hydrazones possess an azomethine  –NHN=CH   group  and are  considered  as derivatives  of aldehydes and  ketones  in which the  oxygen  atom  has  been  replaced  by  the  NNH2 functional group. These are widely studied molecules owing to their ease of preparation  and  diverse  pharmacological  potential.  This  has  led researchers  to  synthesize  different  heterocyclic  compounds bearing  hydrazones.  Medicinal  chemists  across  the  world  have done  immense  work  on  hydrazones  and  developed  agents  with better  activity  and  low  toxicity  profiles.  Following  different synthetic  protocols  and  through  proper  SAR  studies  differently substituted  hydrazones  have  been  developed  and  found  to  be active  against  different  pharmcological  targets.  They  are  known to  possess  different  biological  activities  viz.  antimicrobial,  antiinflammatory,  anticancer,  antimalarial  etc.  These  observations have  been  guiding  for  the  development  of  new  hydrazones  that possess  varied  biological  activities.  The  review  aims  at highlighting the diverse biological activities of hydrazones.Key words: Azomethine, Hydrazones, Pharmacological Potential
DEVELOPMENT THE VALIDATION OF INDONESIAN VERSION OF SF-36 QUESTIONNAIRE IN CANCER DISEASE Dyah Ariani Perwitasari
Indonesian Journal of Pharmacy Vol 23 No 4, 2012
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (219.137 KB) | DOI: 10.14499/indonesianjpharm23iss4pp248-253

Abstract

A  Cancer  patients  need  long  term  therapy  in  the  treatment of their disease. One of the outcome of cancer treatment in patients of  quality  of  life.  Because  of  the  limited  instrument  for  measuring cancer patients’ quality of life in Indonesian version, thus this study is  aimed  to  develop  the  validation  of  Indonesian  version  of  Short Form-36  questionnaire  in  cancer  patients.  The  observational  study was  carried  out  in  this  study.  Data  were  collected  from  cancer patients  in  the  Oncology  Department  of   Sardjito  Hospital, Yogyakarta,  Indonesia,  who  were  treated  with  cisplatin  at  the dosage  of  ≥  50mg/m2 as  monotherapy  or  in  combinations.  The validation  process  involved  known-group  validity,  discriminant validity, convergent validity and factor analysis. About 203 subjects who  were  diagnosed  with  cancer  were  recruited  in  this  study.  Theknown-group  validity  test  showed  that  there  were  no  significant differences  of  SF-36  domains  among  different  diagnosa.  All  of  the questions  met  the  criteria  of  convergent  validity  except  for  the questions  number  26,  28,  30  and  32.  Furthermore,  the  questions number 2  and  28  did  not meet  the  criteria  of discriminant  validity. This  study  presents  that  many  questions  are  needed  to  be reconstructed,  due  to  the  result  of  factor  analysis  which  showed that  those  questions  are  loaded  significantly  with  other  domain’s questions.  The  development  of  Indonesian  version  of  SF-36  scales in cancer disease is still less unstatisfactory. According to the result of this study, future study with new construction of questions in this version is still necessary.Key words: validation, SF-36, Indonesia, cancer 
PHYSICAL PROPERTIES OF WOUND HEALING GEL OF ETHANOLIC EXTRACT OF BINAHONG (Anredera cordifolia (Ten) Steenis) DURING STORAGE. Sri Hartati Yuliani; Achmad Fudholi; Suwijiyo Pramono; Marchaban .
Indonesian Journal of Pharmacy Vol 23 No 4, 2012
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (251.975 KB) | DOI: 10.14499/indonesianjpharm23iss4pp203-208

Abstract

Binahong  (Anredera  cordifolia (Ten)  Steenis)  has  been used  as  wound  healing  in  traditional  Indonesian  medicine.  The developing of the dosage forms using the formulation technology approach  has  been  done.  The  aim  of  this  study  was  to  examine the  physical  properties  of  the  wound  healing  gel  of  ethanolic extract of binahong during storage. The factorial design method 3 factors  and  2  levels  was  employed  to  achieve  this  study.  The three  factors  used  in this  study  were Carbopol, CMC-Na  and Caalginate  with  low  and  high  level  for  each  factor.  The  physical properties  of  the  wound  healing  gel  of  ethanolic  extract  of binahong was evaluated on day 1, 30, 60 and 90 for viscosity and bioadhesion  study.   The  result  showed  that  CMC-Na  and  Caalginate  increased  the  alteration  of  physical  properties  of  wound healing  gel  of  ethanolic  extract  of  binahong  during  storage.  The carbopol  maintained  the  physical  properties  of  the  gel  during storage.Key words: bioadhesion, binahong, viscosity, wound healing gel.
ENHANCEMENT OF DISSOLUTION RATE OF MODAFINIL USING SOLID DISPERSIONS WITH POLYETHYLENEGLYCOLS Vyas Jigar; Patel Jayvadan; Jain D. A.
Indonesian Journal of Pharmacy Vol 23 No 4, 2012
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (401.463 KB) | DOI: 10.14499/indonesianjpharm23iss4pp209-215

Abstract

Solid  dispersions  (SDs)  of  modafinil  (MDF)  were  prepared using polyethyleneglycols (PEGs), in 1;1, 1;2 and 1;4 proportions by  fusion,  solvent  evaporation  and  physical  mixing  method. Differential  scanning  calorimetry  (DSC)  and  X-ray  powder diffractometry (XRD)  were  used to examine the physical state  of the  drug.  The  data  from  the  XRD  showed  that  the  drug  was converted  to  amorphous  form  as  the  number  and  intensity  of peaks  were  decreased  in  solid  dispersion  as  compared  to  pure drug and physical mixture of drug and carrier. DSC thermograms also  confirmed  the  change  in  physical  state  of  the  drug  as  the peaks were altered or disappeared. With the  highest  ratio of the carriers (1:4), the drug  solubility was enhanced by 38.68, 34.78 and 9.29 folds in solvent evaporation, fusion and physical mixing methods  respectively.  Solid  dispersion  batch  S6  containing drug:PEG6000  in  1:4,  was  selected  to  be  formulated  as  tablet (batch  TS6)  and  evaluated  for in  vitro drug  dissolution  &  six month  stability.  An  increased  dissolution  rate  of  modafinil  was observed  from  SDs  and  PMs,  as  compared  to  pure  crystalline drug.  The  dissolution  rate  of  modafinil  from  its  PMs  or  SDs increased with an increasing amount of polymer.Key  words:  Fusion,  solvent  evaporation,  physical  mixture,  in  vitro dissolution, characterization. 
PREPARATION AND CHARACTERIZATION OF STAVUDINE ENTRAPPED LIPOSPHERES Ranjita Shegokar; Kamalinder Singh
Indonesian Journal of Pharmacy Vol 23 No 4, 2012
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (568.785 KB) | DOI: 10.14499/indonesianjpharm23iss4pp231-237

Abstract

Lipospheres  of  stavudine  were  prepared  by  melt  dispersion technique  using  trimyristin,  tripalmitin and  triastearin,  stearic acid, Compritol®  888  ATO  and  Precirol®  ATO  5  as  lipid  matrix  in  the various  drug-lipid  ratios.  Drug  entrapped  free  flowing  solid lipospheres  of  triglycerides  and  glyceryl  behenate  were characterized  for  surface  morphology,  particle  size  distribution, encapsulation efficiency, and in vitrorelease behavior. The effect of drug lipid ratio, the surfactant used, concentration of stabilizer, and stirring  speed  were  identified  as  the  key  variables  affecting  the formation  of  discrete  spherical  lipospheres  and  sustained  drug release  rate.  The  lipospheres  production  conditions  were  optimized by using 2% w/w sodium cholate and 1% Plural oleic as a stabilizer. The  concentration  of  lipid  used  had  pronounced  effect  on  particle size of the lipospheres. The incorporation efficiency was found to be in range of 30  to  50%. Increase  in concentration of surfactant and stirring  speed  produced  fine  spherical,  smooth,  and  round lipospheres.  All  the  prepared  lipospheres  exhibited  slow  release profiles dictating the Higuchi mode of release.Key  words: Lipospheres,  stavudine,  lipid  matrix,  hydrophilic  surfactant, drug release
PHYTOCHEMICAL STUDIES OF Acacia catechu Baluja, Shipra; Chanda, Sumitra; Solanki, Asif; Kachhadia, Nikunj
Indonesian Journal of Pharmacy Vol 23 No 4, 2012
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (15.106 KB) | DOI: 10.14499/indonesianjpharm23iss4pp238-247

Abstract

Acacia  catechu Willd.  belongs  to  the  family  Mimosaceae.  It is well known for the powder of wood known as Kathha” in India, which  has  wide  applications.  In  the  present  work,  the  dry  wood powder  is  extracted  in  various  solvents  such  as  1,4-dioxane, methanol,  dimethyl  formamide  (DMF),  acetone,  ethanol  and distilled water. The phytochemical and physicochemical properties of  these  various  solvent  extracts  were  studied.  The  phyto constituents  present  in  the  different  extracts  were  saponins, tannins,  sugars,  terpenes,  catechu-tannic  acid.  Alkaloids  were present  in  organic  solvents  only.  The  antibacterial  activity  of  all the extracts in DMSO was studied against five bacterial strains but none of the extracts inhibit any of the studied bacterial strains.Key  words: Acacia  catechu,  1,4-dioxane,  methanol,  dimethyl  formamide (DMF),  acetone,  ethanol,  distilled  water,  phytochemical analysis, physicochemical analysis.

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