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Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences
Published by Universitas Brawijaya
ISSN : 20875517     EISSN : 25274376     DOI : -
Core Subject : Agriculture, Social,
Agriculture, Biological Sciences & Forestry Environmental Science
The Journal of Tropical Life Science (JTLS) provides publication of full-length papers, short communication and review articles describing of new finding or theory in living system, cells and molecular level in tropical life science and related areas. The journal publishes articles that report novel findings of wide Tropical Life system phenomenon in the areas of biodiversity, agriculture, fisheries, health, husbandry, forestry and environmental technology. JTLS has 1 volume with 3 issues per year.
Arjuna Subject : -
Articles 4 Documents
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Search results for , issue "vol. 16 no. 2 (2026)" : 4 Documents clear
In Silico Drug Discovery Identifies Stigmasterol from Red Betel (Piper crocatum Ruiz & Pav) Stem as a Potential Antidiabetic Agent Sari, Putri Kharisma Novita; Febyaningrum, Vitasigi Dwi
Journal of Tropical Life Science Vol. 16 No. 2 (2026)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.16.02.02

Abstract

Type 2 diabetes (T2DM) is a metabolic disorder caused by insufficient insulin secretion and the inability of tissues to respond to insulin. Therapy can include the use of insulin in conjunction with other glucose-lowering agents, but these drugs have several limitations related to efficacy, tolerability, and potential side effects. The use of herbal medicines has begun to develop as a therapeutic option, including stigmasterol. Stigmasterol, which has been successfully isolated from several plants, has demonstrated antidiabetic activity in both in vivo and in vitro studies. This study aimed to conduct a comprehensive exploration of the potential, mechanism of action, protein targets, and profile of stigmasterol found in red betel stem as a candidate natural antidiabetic agent in silico. The results of this study indicate that stigmasterol has potential as a drug candidate for the therapy of T2DM with a predicted limited level of toxicity. Computational analyses suggest that stigmasterol may possess therapeutic potential against T2DM by regulating biological processes associated with insulin resistance and the AMPK signaling pathway, potentially through interactions with the key targets STAT3, AKT1, NFKB1, HMGCR, MTOR, and ACACA. Both ligand-based (Support Vector Machine regression) and structure-based (molecular docking) approaches show promising results regarding the activity of this compound. Therefore, stigmasterol is predicted as a potential candidate for further development as a natural antidiabetic agent through the multitarget mechanism of action generated from this modeling. However, the pharmacokinetic profile of stigmasterol indicates potential challenges in meeting drug-likeness criteria, which require further experimental validation.
Ferula assafoetida as a Multi-Target Therapeutic Candidate for Parkinson's Disease: A Narrative Review Selvaraju, Anusia; Mahat, Naji Arafat; Jemon, Khairunadwa; Mohd Nasir, Mohd Hamzah; Abdul Hamid, Azzmer Azzar; Mohamed Huri, Mohamad Afiq
Journal of Tropical Life Science Vol. 16 No. 2 (2026)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.16.02.01

Abstract

Parkinson’s disease (PD) presents a complex challenge in neurodegenerative research due to the persistent lack of disease-modifying therapies, prompting exploration of natural compounds with multi-target capabilities to modulate multiple pathways. Hence, this review evaluates the therapeutic potential of the ayurvedic plant, Ferula assafoetida, as a candidate for PD treatment. The phytochemical profile of F. assafoetida, rich in bioactive sulfur volatiles, phenolic acids, coumarins, and terpenes, aligns with mechanisms implicated in PD pathogenesis, including oxidative stress, inflammation, and mitochondrial dysfunction. Critically, recent activity-guided isolation studies have successfully identified specific sesquiterpene coumarins, such as karatavicinol and farnesiferol C, as potent monoamine oxidase-B (MAO-B) inhibitors, demonstrating efficacy in ameliorating motor deficits and protecting dopaminergic neurons in a murine 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of PD. This breakthrough provides the first direct experimental evidence for F. assafoetida in a PD model, transitioning its status from a traditional remedy to a source of validated, bioactive lead compounds. While mammalian models offer crucial translational validation, zebrafish, with their conserved dopaminergic pathways, genetic tractability, and suitability for high-throughput screening, emerge as an ideal complementary platform for accelerating future research. Advanced phytochemical profiling, integrating chromatographic methods and in silico molecular docking, could prioritize lead compounds for further investigation. The integration of gene expression analysis in zebrafish models, alongside behavioral assays, enables a comprehensive understanding of the impact of this plant on PD-related pathways. This pertinent evidence now positions F. assafoetida as a viable preclinical candidate. Future research should prioritize chemical standardization across different plant sources and in vivo mechanistic studies in zebrafish. By illustrating the synergy between phytochemistry and innovative model systems, this review lays the groundwork for exploring F. assafoetida as a promising candidate for novel PD therapies and related neurodegenerative disorders.
Structure of Mangrove and Associated Macrobenthos Communities Linked to Bioturbation Activities (Case Study: Northern Coast of East Java, Indonesia) Firdausi, Muhammad Azka Dzikri; Andristi, Adinda Martha Putri; Danendra, Hafiz Arya; Sari, Syarifah Hikmah Julinda; Saputra, Dhira Khurniawan; Yona, Defri
Journal of Tropical Life Science Vol. 16 No. 2 (2026)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.16.02.03

Abstract

Mangrove ecosystems and their associated macrobenthos interact closely through bioturbation, a key process that regulates sediment reworking, oxygen exchange, and nutrient cycling. This study examined how variations in mangrove and macrobenthos community structure relate to bioturbation among the studied mangrove ecosystems. Sampling was conducted across four mangrove ecosystems along the northern coast of East Java. A total of six mangrove species were recorded, dominated by Rhizophoraceae, along with 40 associated macrobenthos species dominated by Gastropoda and Malacostraca. Mangrove stand density ranged from 633.3 to 1300 ind/ha and did not differ significantly among sites, indicating relatively stable vegetation structure despite low diversity. Conversely, macrobenthos density varied significantly across sites, ranging from 7.44 to 26.56 ind/m². The macrobenthos community showed moderate diversity but generally reflected stable ecological conditions. Burrowing hole density differed significantly among sites, ranging from 34.11 to 70.44 holes/m², indicating spatial variation in potential bioturbation intensity. Correlation analysis revealed that Malacostraca abundance had the strongest relationship with burrow density, indicating a moderate positive association and highlighting the potential role of Malacostraca as the main contributors to bioturbation processes in mangrove ecosystems. Overall, this finding indicates that bioturbation potential does not depend on a single factor but rather arises from the interplay among vegetation structure, macrobenthos community composition, and environmental conditions. Maintaining habitat and ecosystem conditions is essential for supporting functionally important macrobenthos groups and sustaining sediment-related ecosystem processes. Conservation and restoration efforts should therefore consider both vegetation structure and associated faunal communities.
Isolation and Probiotic Characterization of Lactobacillus plantarum from Etawa Goat Milk in Padang, Indonesia Annisa Farma; Tjong, Djong Hon; Purwati, Endang; Agustien , Anthoni; Khaira , Annisa
Journal of Tropical Life Science Vol. 16 No. 2 (2026)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.16.02.04

Abstract

Peranakan Etawa (PE) goat milk is a nutrient-rich dairy product that contains beneficial microorganisms with potential probiotic applications. Probiotic bacteria are known to support gut health, inhibit pathogenic microorganisms, and enhance the functional value of food products. However, the characterization of probiotic bacteria isolated from Etawa goat milk in Padang, Indonesia, remains limited. Therefore, this study aimed to isolate, characterize, and evaluate the probiotic potential of lactic acid bacteria obtained from Etawa goat milk collected in Padang, Indonesia. Bacterial isolation was performed using de Man, Rogosa, and Sharpe agar medium, followed by purification and characterization based on colony morphology, Gram staining, microscopic observation, and biochemical analysis through catalase testing. The probiotic properties of the isolates were evaluated by assessing their survival under acidic conditions at pH 3.0, resistance to 0.3% bile salts, and antimicrobial activity against Escherichia coli O157 and Staphylococcus aureus using the agar diffusion method. Three bacterial isolates, designated KG, PD, and EL, were successfully obtained from the milk samples. Among them, isolate PD demonstrated characteristics consistent with lactic acid bacteria, including Gram-positive reaction, rod-shaped morphology, and catalase-negative activity. This isolate showed moderate tolerance to acidic conditions, with a survival rate of 32.50%, and high resistance to bile salts, with a survival rate of 80.60%. In addition, PD isolate exhibited strong antimicrobial activity, producing inhibition zones of 19.19 mm against E. coli O157 and 13.79 mm against S. aureus. Molecular identification based on 16S ribosomal ribonucleic acid gene sequencing revealed 100% similarity to Lactobacillus plantarum strain CAU10666. In conclusion, L. plantarum isolate PD from Peranakan Etawa (PE) goat milk demonstrates promising probiotic potential and may be considered a suitable candidate for future development as a functional food ingredient or probiotic culture.

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