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Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences
Published by Universitas Brawijaya
ISSN : 20875517     EISSN : 25274376     DOI : -
Core Subject : Agriculture, Social,
Agriculture, Biological Sciences & Forestry Environmental Science
The Journal of Tropical Life Science (JTLS) provides publication of full-length papers, short communication and review articles describing of new finding or theory in living system, cells and molecular level in tropical life science and related areas. The journal publishes articles that report novel findings of wide Tropical Life system phenomenon in the areas of biodiversity, agriculture, fisheries, health, husbandry, forestry and environmental technology. JTLS has 1 volume with 3 issues per year.
Arjuna Subject : -
Articles 2 Documents
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Search results for , issue "vol. 16 no. 2 (2026)" : 2 Documents clear
In Silico Drug Discovery Identifies Stigmasterol from Red Betel (Piper crocatum Ruiz & Pav) Stem as a Potential Antidiabetic Agent Sari, Putri Kharisma Novita; Febyaningrum, Vitasigi Dwi
Journal of Tropical Life Science Vol. 16 No. 2 (2026)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.16.02.02

Abstract

Type 2 diabetes (T2DM) is a metabolic disorder caused by insufficient insulin secretion and the inability of tissues to respond to insulin. Therapy can include the use of insulin in conjunction with other glucose-lowering agents, but these drugs have several limitations related to efficacy, tolerability, and potential side effects. The use of herbal medicines has begun to develop as a therapeutic option, including stigmasterol. Stigmasterol, which has been successfully isolated from several plants, has demonstrated antidiabetic activity in both in vivo and in vitro studies. This study aimed to conduct a comprehensive exploration of the potential, mechanism of action, protein targets, and profile of stigmasterol found in red betel stem as a candidate natural antidiabetic agent in silico. The results of this study indicate that stigmasterol has potential as a drug candidate for the therapy of T2DM with a predicted limited level of toxicity. Computational analyses suggest that stigmasterol may possess therapeutic potential against T2DM by regulating biological processes associated with insulin resistance and the AMPK signaling pathway, potentially through interactions with the key targets STAT3, AKT1, NFKB1, HMGCR, MTOR, and ACACA. Both ligand-based (Support Vector Machine regression) and structure-based (molecular docking) approaches show promising results regarding the activity of this compound. Therefore, stigmasterol is predicted as a potential candidate for further development as a natural antidiabetic agent through the multitarget mechanism of action generated from this modeling. However, the pharmacokinetic profile of stigmasterol indicates potential challenges in meeting drug-likeness criteria, which require further experimental validation.
Ferula assafoetida as a Multi-Target Therapeutic Candidate for Parkinson's Disease: A Narrative Review Selvaraju, Anusia; Mahat, Naji Arafat; Jemon, Khairunadwa; Mohd Nasir, Mohd Hamzah; Abdul Hamid, Azzmer Azzar; Mohamed Huri, Mohamad Afiq
Journal of Tropical Life Science Vol. 16 No. 2 (2026)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.16.02.01

Abstract

Parkinson’s disease (PD) presents a complex challenge in neurodegenerative research due to the persistent lack of disease-modifying therapies, prompting exploration of natural compounds with multi-target capabilities to modulate multiple pathways. Hence, this review evaluates the therapeutic potential of the ayurvedic plant, Ferula assafoetida, as a candidate for PD treatment. The phytochemical profile of F. assafoetida, rich in bioactive sulfur volatiles, phenolic acids, coumarins, and terpenes, aligns with mechanisms implicated in PD pathogenesis, including oxidative stress, inflammation, and mitochondrial dysfunction. Critically, recent activity-guided isolation studies have successfully identified specific sesquiterpene coumarins, such as karatavicinol and farnesiferol C, as potent monoamine oxidase-B (MAO-B) inhibitors, demonstrating efficacy in ameliorating motor deficits and protecting dopaminergic neurons in a murine 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of PD. This breakthrough provides the first direct experimental evidence for F. assafoetida in a PD model, transitioning its status from a traditional remedy to a source of validated, bioactive lead compounds. While mammalian models offer crucial translational validation, zebrafish, with their conserved dopaminergic pathways, genetic tractability, and suitability for high-throughput screening, emerge as an ideal complementary platform for accelerating future research. Advanced phytochemical profiling, integrating chromatographic methods and in silico molecular docking, could prioritize lead compounds for further investigation. The integration of gene expression analysis in zebrafish models, alongside behavioral assays, enables a comprehensive understanding of the impact of this plant on PD-related pathways. This pertinent evidence now positions F. assafoetida as a viable preclinical candidate. Future research should prioritize chemical standardization across different plant sources and in vivo mechanistic studies in zebrafish. By illustrating the synergy between phytochemistry and innovative model systems, this review lays the groundwork for exploring F. assafoetida as a promising candidate for novel PD therapies and related neurodegenerative disorders.

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