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Jurnal Kimia (Journal of Chemistry)

jchem
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Published by Universitas Udayana

ISSN : 19079850 EISSN : 25992740 DOI : 10.24843/JCHEM

Core Subject : Science,

Chemistry

Jurnal Kimia (Journal of Chemistry) publishes papers on all aspects of fundamental and applied chemistry. The journal is naturally broad in scope, welcomes submissions from across a range of disciplines, and reports both theoretical and experimental studies.

Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)

Articles 17 Documents

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Search results for , issue "Vol.13 No.2 Juli 2019" : 17 Documents clear

ISOLASI DAN IDENTIFIKASI GOLONGAN FLAVONOID PADA EKSTRAK ETIL ASETAT DAUN GEDI (Abelmoschus manihot L.) C. T. Theodora; I W. G. Gunawan; I M. D. Swantara
Jurnal Kimia (Journal of Chemistry) Vol.13 No.2 Juli 2019
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

The purpose of this experiment was to determine the flavonoid compounds in ethyl acetat extract of gedi leaves (Abelmoschus manihot L.). In this study, the method of extraction was maceration with semipolar solvent (ethyl acetat), flavonoid phytochemical screening, separation and purity test with chromatography and then identification of the compound using FTIR and UV-Vis spectrophotometer with shear reagent method. Analysis of FTIR spectra showed some functional groups such as OH, CH aliphatic, C = O, CO alcohol, C = C aromatic, and CO ether, whereas the analysis with UV-Vis spectra indicated the presence of band I at a wavelength of 409.4 nm and 238.40 nm for band II which is the auron specific wavelength. After the addition of shift reaget, there was a substitutions of OH groups in C-4, C-6 and C-3' and OR at C-4'. The flavonoid compounds contained in ethyl acetate extract of gedi leaf is suggested to be auron, 3',4,6-trihydroxy,4-alkoxy-auron. Keywords: auron, ethyl acetat extract, flavonoids, gedi leaf, isolation

MOLECULAR DOCKING TERPINEN-4-OL SEBAGAI ANTIINFLAMASI PADA ATEROSKLEROSIS SECARA IN SILICO N. M. P. Susanti; N. P. L. Laksmiani; N. K. M. Noviyanti; K. M. Arianti; I K. Duantara
Jurnal Kimia (Journal of Chemistry) Vol.13 No.2 Juli 2019
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Atherosclerosis is a chronic inflammatory disease that begins with endothelial dysfunction, it caused fat accumulation and plaque growth in the inner arteries walls. Endothelial dysfunction will activate the Mitogen Activated Protein Kinase (MAPK) pathway involving ERK1, ERK2, JNK1, JNK2, and p38MAPK proteins, as well as the Nuclear Factor Kappa B (NF-kB) pathway involving IKK proteins. Terpinen-4-ol is constituent found in the bangle rhizome. The purpose of this study were to determine the affinity and mechanisms of terpinen-4-ol against ERK1, ERK2, JNK1, JNK2, and p38MAPK proteins as anti-inflammatory in atherosclerosis performed using molecular docking method. The study was conducted exploratively with several steps such as preparation and optimization of terpinen-4-ol structure, preparation of 3D ERK1, ERK2, JNK1, JNK2, and p38MAPK proteins, validation method of molecular docking, and docking terpinen-4-ol in these proteins. The docking result are assessed from the binding energy and hydrogen bonds formed between terpinen-4-ol and proteins. The smaller value of binding energy terpinen-4-ol with target proteins showed the complex that form more stable. The result showed that terpinen-4-ol and has activity in inhibiting the inflammatory process because it is able to disturb ERK1, ERK2, JNK1, JNK2, and p38MAPK proteins with respective bond energy values -5,12; -5,24; -5,08; -5,88; and -4,99 Kcal/mol. The molecular mechanism in inhibiting the activity of ERK1, ERK2, JNK1, JNK2, and p38MAPK proteins is through the formation of hydrogen bonds in these proteins. These results show that terpinen-4-ol have the potential to inhibit inflammatory process and the formation of atherosclerotic plaque can be obstructed. Keywords : atherosclerosis, terpinen-4-ol, molecular docking, in silico

SENYAWA KUERSETIN SEBAGAI AGEN ANTIKANKER KOLOREKTAL SECARA IN SILICO P. V. P. Putri; N. M. P. Susanti; N. P. L. Laksmiani
Jurnal Kimia (Journal of Chemistry) Vol.13 No.2 Juli 2019
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Colorectal cancer is a third rank malignant cancer in Indonesia, generally caused by the diet of the Indonesian people who have change with the consumption of food with high fat and low in fiber, also due to the production of carcinogenic substances from the breakdown of fat. In the condition of colorectal cancer there is overexpression of COX-2 and inhibition of Caspase-3 which causes the increase of cancer cells survival and causes inhibition of apoptosis mechanism. Quercetin is one of flavonoid which known have activity as an antitumor and tested in vitro can induce apoptosis on WiDr colorectal cancer cells . The purpose of this study was to determine the affinity and mechanism of quercetin compounds on COX-2 and Caspase-3 target proteins as colorectal anticancer by in silico with molecular docking. The study was conducted exploratively with the stages of preparing a database of 3D quercetin structures, as well as COX-2 and Caspase-3 proteins, optimization of 3D quercetin structure, protein preparation, molecular docking method validation, and quercetin docking on these proteins. Docking results were assessed from the binding energy and hydrogen bonds that formed between quercetin with proteins. The smaller binding energy value, the stronger the bond between quercetin and proteins is. The results showed that quercetin had an activity as a colorectal anticancer because it was able to inhibit COX-2 and induce Caspase-3 with binding energy values of -9.54 and -4.59. These results showed that quercetin has the potential to induce apoptosis in colorectal cancer. Keywords: colorectal cancer, quercetin, caspase-3, in silico

AKTIVITAS AGEN PENCERAH KULIT DARI KATEKIN SECARA IN SILICO N. K. M. Giantari; I W. I. Prayoga; N. P. L. Laksmiani
Jurnal Kimia (Journal of Chemistry) Vol.13 No.2 Juli 2019
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Darkening of the skin results from excessive production of melanin in the skin caused by an increase in tyrosinase related protein 1 enzyme activity. Catechins are flavonoid compounds which contain antioxidants. This study aims to determine the affinity and mechanism of catechins as skin lightening agents by inhibiting tyrosinase related protein 1 target proteins in silico using molecular docking methods. The study was carried out exploratively with the stages of preparing a database of 3D structures of catechins and tyrosinase related protein 1, optimization of 3D structure of catechins, protein preparation, validation of molecular docking methods, and docking of catechins in tyrosinase related protein 1. Docking results are assessed from the bonding energy and hydrogen bonds formed between catechins and proteins. The smaller the bond energy value, the stronger the bond between the catechins and proteins. The results showed that catechins had activity as skin lightening agents because they were able to inhibit the tyrosinase related protein 1 with a bond energy value of -6,35 Kcal/mol. The energy value of the catechin bond with the tyrosinase related protein 1 is smaller than the tyrosinase related protein 1 with its native ligand. This shows that catechins have greater potential and affinity in inhibiting the tyrosinase related protein 1 enzyme with hydrogen bonds on amino acid residues, namely ARG374. Based on the results obtained, catechins have activity as skin lightening agents with the mechanism of inhibiting the tyrosinase related protein 1 enzyme so that the amount of eumelanin formed is less and the skin becomes brighter. Key words: catechins, skin lightening, tyrosinase related protein 1, in silico, molecular docking

FORMULASI SEDIAAN SIRUP PENINGKAT IMUNITAS DARI HERBA MENIRAN (Phyllanthus niruri L.) W. O. Sugarda; K.D.C. Dewi; K.W.A. Putra; M.B. Yogiswara; C.B.A.C. Sukawati; P.A.R. Sutresna; N.L.G.J. Dewi; C.I.S. Arisanti; P.S. Yustiantara
Jurnal Kimia (Journal of Chemistry) Vol.13 No.2 Juli 2019
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Meniran herb (Phyllanthus niruri L.) is a plant that has been scientifically proven to have activity as a natural immunomodulator. The effectiveness of natural immunomodulators from meniran herbs can be improved by formulating the ethanolic extract of meniran herbs into syrup preparations. This research was conducted to find out that the herbal extracts obtained had fulfilled the parameters of extract quality standards so that they could be formulated into pharmaceutical products. Standardization of herbal extracts includes testing of moisture content, testing of total ash content, testing of acid-soluble ash content, and testing of total flavonoid levels. Ethanol extract of Meniran herbs was obtained by maceration using 95% ethanol. Testing the extract moisture content produced extracts with a moisture content of 7.295%. Total ash content was 3%, acid insoluble ash content was 1.2% and total flavonoid content was 3.15%. Keywords: formulation, immunity, syrup, Phyllanthus niruri L.

STEROIDS FROM THE SUPER RED DRAGON FRUIT (Hylocereus costaricensis) H. Supriadi; S. Salam; F. F. Abdullah; A. Subarnas; R. Sidik; U. Supratman; Y. Shiono
Jurnal Kimia (Journal of Chemistry) Vol.13 No.2 Juli 2019
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Two steroids compounds, 7?-Hydoxy ?-sitosterol (1) and ?-sitosterol (2), have been isolated from ethyl acetate extract of the fresh Super Red Dragon Fruit (Hylocereus costaricensis).The chemical structure of compounds 1 and 2 were identified by spectroscopic data including UV, IR, NMR-1D, NMR-2D and mass as well as by comparing with previously reported spectral data. Compounds 1 and 2 were reported for the first time from dragon fruit (Hylocereus costaricensis). Keywords: 7?-Hydoxy ?-sitosterol, ?-sitosterol, Hylocereus costaricensis, steroids.

KADAR Fe DAN Zn DALAM KRIM KENTAL MANIS KEMASAN KALENG EXPIRE DAN NON EXPIRE MENGGUNAKAN HIDROGEN PEROKSIDA (H2O2) UNTUK DESTRUKSI BASAH SECARA SPEKTROFOTOMETRI SERAPAN ATOM (SSA) Putri Go; I W. Sudiarta; P. Suarya
Jurnal Kimia (Journal of Chemistry) Vol.13 No.2 Juli 2019
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Sweetened condensed milk is generally packaged in a can which is made from iron and zinc. Iron and zinc can have corrosion with the increasing of contact time and changing condition so that they will contaminate the milk. The purpose of this research are to determine the best wet destruction method, find out the effect of adding 30% H2O2 at varied volume in the process of wet destruction, to find out Fe and Zn content in expire and non-expired sweetened condensed milk and to compare the results with the national quality standard. Sample was wet destructed by using variation of 70% HNO3: 30% H2O2 which is 3:0 (method A); 3:0.5 (method B) 3:1 (method C); 3:2 (method D) then the results were measured by using Atomic Absorption Spectrophotometer. Analysis of Fe used standard addition curve method whereas the analysis of Zn used calibration curve method. The results of the analysis showed that the best variation of HNO3:H2O2 in wet destruction method was 3:0.5 for Fe analysis and 3:2 for Zn analysis. The addition of 30% H2O2 at varied volume in wet destruction for Fe analysis gave significantly different results for non-expired sweetened condensed milk but were not significantly different for expired sweetened condensed milk. Whereas, the analysis of Zn gave significantly different results for both non-expired and expired sweetened condensed milk. The metal content in the expired and non-expired sweetened condensed milk which were wet destructed by using the best solvent compotition obtained 0,2759 and 0,7126 mg/kg for Fe and 4,1645 and 2,4367 mg/kg for Zn metal. The Fe and Zn content in the sweetened condensed milk are still below the maximum limit that set by SNI. Keywords: Fe, H2O2, Atomic Absorption Spectrophotometer, sweetened condensed milk, Zn

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Ni Putu Diantariani

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+628123640424

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jurnalkimia@unud.ac.id

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Program Studi Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Udayana Kampus Bukit Jimbaran, Jimbaran, Bali, Indonesia

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Kota denpasar,

Bali

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Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Ni Putu Diantariani

Contact Email jurnalkimia@unud.ac.id

Phone +628123640424

Journal Mail Official jurnalkimia@unud.ac.id

Editorial Address Program Studi Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Udayana Kampus Bukit Jimbaran, Jimbaran, Bali, Indonesia

Location Kota denpasar, Bali INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Ni Putu Diantariani

Contact Email
jurnalkimia@unud.ac.id

Phone
+628123640424

Journal Mail Official
jurnalkimia@unud.ac.id

Editorial Address
Program Studi Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Udayana Kampus Bukit Jimbaran, Jimbaran, Bali, Indonesia

Location
Kota denpasar,

Bali

INDONESIA