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Dentino: Jurnal Kedokteran Gigi
Published by Universitas Lambung Mangkurat
ISSN : 23375310     EISSN : 25274937     DOI : 10.20527
Core Subject : Health,
Dentistry
Dentino [P-ISSN 2337-5310 | E-ISSN 2527-4937] is the journal contains research articles and review of the literature on dentistry which is managed by the Faculty of Dentistry, Lambung Mangkurat University. Dentino published twice a year, every March and September.
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Articles 21 Documents
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Search results for , issue "Vol 4, No 1 (2019)" : 21 Documents clear
THE EFFECT OF GIANT SNAKEHEAD(Channa micropeltes)EXTRACT ON THE NUMBER OF MACROPHAGE IN DIABETES MELITUS WOUND HEALING (Research report) Khairunnida Khairunnida; Amy Nindia Carabelly; Maharani Lailyza Apriasari
Dentino : Jurnal Kedokteran Gigi Vol 4, No 1 (2019)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v4i1.6168

Abstract

Background:Giant snakehead contains albumin and omega-6 fatty acids which play an important role in diabetes mellitus wound healing. Wounds in people with diabetes mellitus have low level of albumin, thus inhibiting the macrophage function. Objective: To prove the effect of giant snakehead extract of 16mL/Kg dose of rats’ weight toward the number of macrophage on wistar rats’ back wounds with diabetes mellitus in day 4, 8 and 14. Method and Materials: This study applied pure experimental method with posttest-only control design. This study 36 wistar rats as sample which divided into 9 groups; group of giant snakehead extract with 16mL/Kg dose of rats’ weight, positive control group using haruan fish extract with 13.54mL/Kg dose of rats’ weight, and negative control group using BR2 feed. Results: The test result of One-way ANOVAon day 4 (p=0.022), day 8 (p=0.251) and day 14 (0.028). The test result of Post-hoc LSD showedthat there wereno significant differences on day 4 and 14 (p>00.5) between the groups of the giant snakehead extract and haruan fish extract. There wassignificant difference (p<00.5) between groups of the giant snakehead extract and BR2 feed. Conclusion: It can be concluded that giant snakehead extract at 16 mL / kg dose administered orally may increase the number of macrophage in wistar rat (Rattusnovergicus) induced diabetes mellitus back woundon day 4 and decreased macrophage cell count onday 8 and day 14.

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