Article Per Year (5 Year)
p-Index From 2021 - 2026
0.23
P-Index
This Author published in this journals
All Journal Dentino: Jurnal Kedokteran Gigi
Maharani Lailyza Apriasari
Unknown Affiliation
Dentistry

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
THE EFFECT OF GIANT SNAKEHEAD(Channa micropeltes)EXTRACT ON THE NUMBER OF MACROPHAGE IN DIABETES MELITUS WOUND HEALING (Research report) Khairunnida Khairunnida; Amy Nindia Carabelly; Maharani Lailyza Apriasari
Dentino : Jurnal Kedokteran Gigi Vol 4, No 1 (2019)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v4i1.6168

Abstract

Background:Giant snakehead contains albumin and omega-6 fatty acids which play an important role in diabetes mellitus wound healing. Wounds in people with diabetes mellitus have low level of albumin, thus inhibiting the macrophage function. Objective: To prove the effect of giant snakehead extract of 16mL/Kg dose of rats’ weight toward the number of macrophage on wistar rats’ back wounds with diabetes mellitus in day 4, 8 and 14. Method and Materials: This study applied pure experimental method with posttest-only control design. This study 36 wistar rats as sample which divided into 9 groups; group of giant snakehead extract with 16mL/Kg dose of rats’ weight, positive control group using haruan fish extract with 13.54mL/Kg dose of rats’ weight, and negative control group using BR2 feed. Results: The test result of One-way ANOVAon day 4 (p=0.022), day 8 (p=0.251) and day 14 (0.028). The test result of Post-hoc LSD showedthat there wereno significant differences on day 4 and 14 (p>00.5) between the groups of the giant snakehead extract and haruan fish extract. There wassignificant difference (p<00.5) between groups of the giant snakehead extract and BR2 feed. Conclusion: It can be concluded that giant snakehead extract at 16 mL / kg dose administered orally may increase the number of macrophage in wistar rat (Rattusnovergicus) induced diabetes mellitus back woundon day 4 and decreased macrophage cell count onday 8 and day 14.
EFFECT OF IRONWOOD BARK EXTRACT GEL ON LYMPHOCYTE COUNT IN BUCCAL MUCOSA WOUND HEALING RATS Mahmud Muhlisin; I Wayan Arya Krishnawan Firdaus; Maharani Lailyza Apriasari; Juliyatin Putri Utami; Erida Wydiamala
Dentino: Jurnal Kedokteran Gigi Vol 10, No 2 (2025)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v10i2.24161

Abstract

Background: Wounds are disruptions caused by chemical or physical trauma, resulting in tissue damage. During the healing process of oral mucosal wounds, the body initiates defensive and protective immune responses against injury. The acute inflammatory phase is the initial stage of wound healing, marked by the body’s response to injury within a few hours. Lymphocyte cells play a crucial role in the inflammatory phase as part of the adaptive immune system in wound healing. Secondary metabolites in the ironwood bark extract gel, such as proanthocyanidins, phenolics, and flavonoids, function as immunomodulators to enhance immune activity and act as anti-inflammatory and antioxidant agents to accelerate wound healing. Purpose: To prove the effect of ironwood bark extract gel at concentrations 5%, 12.5%, and 20% on lymphocyte cell number in the buccal mucosa incision wounds of male Wistar rats on days 3, 5, and 7. Methods: This study employed a pure experimental design with a post-test only with a control group design, using 36 male Wistar rats divided into treatment and negative control groups. Results: Two-way ANOVA tests revealed significant effects based on treatment and observation days (p < 0.05). Conclusion: Ironwood bark extract gel at concentrations of 5%, 12.5%, and 20% increased lymphocyte cell number on day 3, peaked on day 5 and decreased on day 7 compared to the control group (gel base). Keywords: eusideroxylon zwageri gel, lymphocyte cells, oral mucosal wound healing,
Co-Authors Amy Nindia Carabelly Erida Wydiamala I Wayan Arya Krishnawan Firdaus Khairunnida Khairunnida Mahmud Muhlisin Utami, Juliyatin Putri