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All Journal ODONTO Dental Journal Majalah Obat Tradisional Dentino: Jurnal Kedokteran Gigi Berkala Kedokteran Dental Journal (Majalah Kedokteran Gigi) Padjadjaran Journal of Dentistry Journal of Dentomaxillofacial Science Journal of Indonesian Dental Association E-Prodenta Journal of Dentistry Dentin Jurnal Pengabdian kepada Masyarakat Nusantara Jurnal Pengabdian Sumber Daya Manusia Odonto dental journal Jurnal Bioteknologi & Biosains Indonesia (JBBI)
Amy Nindia Carabelly
Department Of Oral And Maxillofacial Pathology, Faculty Of Dentistry, Lambung Mangkurat University, Banjarmasin, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences Other

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THE EFFECT OF TOMAN (Channa micropeltes) FISH EXTRACT ON EPITHELIAL THICKNESS IN DIABETES MELLITUS WOUND HEALING (In Vivo Study on the back of male Wistar rat (Rattus novergicus)) Audina, Nina; Nindia Carabelly, Amy; Aspriyanto, Didit
Dentino Vol 3, No 1 (2018)
Publisher : FKG Unlam

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Abstract

Background: Re-epithelialization is the process of formation of new epithelium which is important in wound healing process, the faster the process then the sooner the process of wound healing. Toman fish (Channa micropeltes) is trusted as an alternative medicine to accelerate wound healing. Toman fish contains albumin which acts an antioxidant. Antioxidant can reduce Reactive Oxygen Species (ROS) which increased at state of hyperglicemia in people with diabetes mellitus (DM), Thus accelerating the process of Re epithelialization on diabetes wound. Purpose: The Purpose of this research was to prove that fish extract Toman dose 16 ml/Kg body weight effect on thickness of the epithelium of Wistar Rat Injuries Induced DM are seen on the 2, 4 and 8 day. Material and methods: This research was true experimental design with posttest-only with control design with complete random design. This research used 27 Wistar rats are divided into 9 treatment groups, Toman fish extract dose 16 mL/Kg BW, Haruan fish extract 13,54 mL/Kg BW, and BR2 feed only. The calculation of epithelial thickness was calculates using the ImageJ software application by measuring histopathological results. Research result: The result of Two way Anova test and Post Hoc LSD test showed that there was a significant difference of effect on group Toman fish extract 16 mL/Kg BW with Haruan fish extract 13,54 mL/Kg BW and BR2 feed only to increase the thickness of the wound of epithelium of Wistar rat Induced DM. Toman fish extract showed the highest mean of epithelial thickness with 2nd day (76,69 µm), 4th day (99,21 µm) and 8th day (124,23 µm). Conclusion: There was effect of Toman fish extract dose 16 mL/Kg BW on increased epithelial thickness of Wistar rats wound on induced diabetes mellitus are seen on the days 2, 4 and 8.
THE TOXICITY OF METHANOL EXTRACT OF MAULI BANANA STEM (Musa acuminata) AGAINST BONE MARROW MESENCHYMAL STEM CELL IN VITRO Carabelly, Amy Nindia; Taat Putra, Suhartono; Suardita, Ketut
Dentino Vol 2, No 1 (2017)
Publisher : FKG Unlam

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Abstract

ABSTRACTThe latest regeneration therapy has developed towards the usage of Mesenchymal stem cells (MSC) including for aggressive periodontitis, but limited amounts of MSC need extra growth factor in cells culture process. Growth factor is quite expensive so an alternative source is needed. Mauli banana stem is a proven antioxidant and has the most bioactive tannin. Methanol extract of mauli banana stem is not toxic towards fibroblast cell BHK 21 with 25% concentrate, but there is no research about the toxicity of methanol extract of mauli banana stem against MSC. Purpose: To analyze the toxicity of methanol extract of mauli banana stem against MSC in vitro. Method and source: True experimental using the posttest only control group design. MSC culture with treatment methanol extract of mauli banana stem with dosage 2,5 mg/ml; 5 mg/ml; 7,5 mg/ml; 10 mg/ml. Treatment Con A5 μg/ml is used for positive control group and is not treated as negative control group. Each group is incubated for 24 hours and 48 hours, then it is given reagent MTT and is read with ELISA reader. Result: Kruskal-Wallis and independent-sample T-test result shows that there is a significant difference between treatment group and control group. Conclusion: Methanol extract of mauli banana stem with dosage 2.5 mg/ml; 5 mg/ml; 7.5 mg/ml; 10 mg/ml is toxic towards MSC in vitro under treatment for 24 hours and 48 hours.Key words : Mauli banana stem, Mesenchymal stem cells, Toxicity
THE EFFECT OF TOMAN FISH EXTRACT (Channa Micropeltes) ONNEUTROPHILIN DIABETES MELLITUSWOUND HEALING (In Vivo Study in the Back of Male Wistar Mice (Ratus Novergicus) Fajriani, Nuril; Nindia Carabelly, Amy; Laillyza Apriasari, Maharani
Dentino Vol 3, No 1 (2018)
Publisher : FKG Unlam

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Abstract

Background: Toman fishcontains albumin and unsaturated fatty acids which can be an alternative of diabetes mellitus wounds healing process. People with diabetes mellitus have their neutrophil decreased. Albumin increases the number of neutrophil. Unsaturated fatty acid decreases the number of neutrophil. Purpose: To prove the effect of toman fish extract of 16 ml/Kg BW mice orally on thenumber of neutrophil in day 2, 4, and 8 of male wistarmice with diabetic wound. Materials and Method: This research applied pure experimental research method with posttest only control design. This research took 36 wistarmice which weredivided into negative control group which is given BR2 feed, treatment group which is giventoman fish extract in 16 mL/Kg BW mice and positive control group which is given haruan fish extract in 13.54 mL/Kg BW mice. The Result: One-way ANOVAshowedthat there wassignificant differenceof all groups in day 2 (p=0.000), day 4 (p=0.000) and day 8 (p=0.000). Post-Hoc LSD test for the average of neutrophil number showedthat there was significant difference (p<0.05) between the negative control group, treatment group and the positive control group. Conclusion: Toman fish extract has an effect which increasesthe number ofneutrophil in day 2 and decreasesthe number of neutrophil in day 4 and 8 on the healing of diabetic wound in mice.
OVERVIEW OF GLOMERULAR HYPERTROPHY AND HYDROPIC DEGENERATION OF DIABETIC RAT KIDNEY MODELS IN GIVING TOMAN FISH Carabelly, Amy Nindia; Sinaga, Udur; Dewi, Nurdiana
E-Prodenta Journal of Dentistry Vol 5, No 1 (2021)
Publisher : Fakultas Kedokteran Gigi UB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.eprodenta.2021.005.01.1

Abstract

Background: Traditional medicine is increasingly favored by the community as an effort to maintain and treat health because it has low side effects and is easy to obtain. Low side effects in administering traditional medicines if the dosage is right, so it is necessary to do an acute toxicity test. One of the consumers of traditional medicine is diabetes mellitus (DM) sufferer. DM can cause delay wound healing. Toman fish is proven to accelerate wound healing. DM sufferers need special attention to their kidneys because in addition to the toxic effects caused by improper doses of traditional medicine, the kidneys can also experience diabetic nephropathy. Objectives: To analyze changes in glomerular hypertrophy and hydropic degeneration in the administration of 16 mL / KgBW Toman fish extract orally for 14 days in diabetic wistar rat kidneys. Methods: This study was a true experimental design with a post test only with control group design. The study was divided into a treatment group of toman fish extract at a dose of 16 mL / Kg BW orally for 14 days in diabetic rat kidney models and a control group in the form of feeding only. Results: The administration of toman fish extract in DM rat showed changes in the glomerular hypertrophy picture of 25-50% and decreased glomerular hypertrophy score which was significantly different from the control group. There was no feature of hydropic degeneration in either group. Conclusions: Giving toman fish extract to DM rat can reduce glomerular hypertrophy and does not cause hydropic degeneration
ANTIBACTERIAL POTENTIAL OF KAPUL FRUIT SKIN (Baccaurea macrocarpa) ON Streptococcus sanguis Norhayati Norhayati; Siti Ujrumiah; Annisa Noviany; Amy Nindia Carabelly
ODONTO : Dental Journal Vol 6, No 2 (2019): December 2019
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.6.2.118-124

Abstract

Introduction: Recurrent aphthous stomatitis (SAR) is a recurrent ulceration lesion where many Streptococcus sanguis bacteria are found. Streptococcus sanguis bacteria can be killed by compounds that contain antibacterial. Kapul fruit (Baccaurea macrocarpa) is a typical Kalimantan fruit, has antioxidant and antibacterial activity which serves to kill Streptococcus sanguis. Method: Performed a quantitative phytochemical test on the kapul fruit peel and continued with the antibacterial activity test using the disc diffusion method of kapul fruit peel extract at the concentrations 20%, 40%, 60%, 80%, 100%,Chlorhexidine as a positive control and aquades as a negative (n=4/group). Result: From the phytochemical test, Kapul fruit peel extracts contain 35,851% of alkaloid, 23,225% of saponin, 2,395mg of tannin and 21,000mg of flavonoids. Kapul fruit peel extracts has the potential as an antibacterial against Streptococcus sanguis at concentration of 40%, 60%, 80% and 100%. The concentration at 100% has an equivalent to chlorhexidine as an antibacterial potential.Conclusion: The potential of Kapul peel Extract as antibacterial to Streptococcus sanguis bacteria on 40%, 60%, 80%, 100% concentration. The concentration at 100% has an equivalent to chlorhexidine as an antibacterial potential.
Clinical Analysis of Channa micropeltes for Treating Wound of Diabetes Mellitus Maharani Laillyza Apriasari; Marina Arum Syahadati; Amy Nindia Carabelly
Berkala Kedokteran Vol 16, No 1 (2020)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (439.385 KB) | DOI: 10.20527/jbk.v16i1.8096

Abstract

Abstract: Toman fish contains albumin and omega-6 fatty acid that are instrumental in the healing process of diabetes mellitus (DM) wound. People with DM usually have a prolonged wound healing process. Albumin controls the osmotic pressure, the development of granulation tissue, gives the energy to re-epithelialisation process and collagen base material. Omega-6 fatty acid interrupts phagocytosis induced by neutrophil cells. It increases the action of machropage cell, so that Toman fish can be used as an alternative in accelerating the DM wound healing process. The purpose of this research is to prove the effect of Toman fish extract at 16 mL/ KgBW rat dosage per oral on wound length and contraction on the back of wistar rat (Rattus novergiucs) with DM for 14 days. It was the experimental with a posttest only with control group design  used 12 wistar rat that were divided into 3 groups; the group of Toman fish extract with dose 16 mL/ Kg BW rat, positive control group using Haruan extract with dose 13,54 mL/ Kg BW rat and negative control group using Comfeed BR2 feed. One-way ANOVA test result for wound length and contraction (p= 0,000). The result Post-hoc Least Significant Difference test for wound length and contraction shows that there are significant differences between the group of Toman fish extract and Haruan fish extract (p= 0,000). There is also significant difference between the group of Toman fish extract and Comfeed BR2 feed (p= 0,000). There is no significant difference between the group of Haruan fish extract and Comfeed BR2 feed (p= 0,930). The research concluded that Toman fish extract at 16 mL/ Kg BW rat dosage affects the length and contraction of diabetic mellitus wound. Keywords: Channa micropeltes, clinical analysis, diabetes mellitus, wound
Anti Inflammatory Effect Of Toman Fish (Channa micropeltes) Extract In Wound Healing Process Maharani Laillyza Apriasari; Dewi Puspitasari; Amy Nindia Carabelly
Berkala Kedokteran Vol 14, No 2 (2018)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (320.431 KB) | DOI: 10.20527/jbk.v14i2.5335

Abstract

 Abstract: One phase of wound healing is the inflammatory phase. Haruan fish extract has shown to accelerate the healing process up because it has anti-inflammatory effects. Toman fish originates from the same genus as the Haruan fish, but its anti-inflammatory effect remains unknown. It was done to analyzed anti-inflammatory effects of Toman fish extract. This study was true experimental design with posttest-only control design. Twenty-seven male mice of Balb-C strain were divided into 3 groups. Incision wound of 1 cm was made along the back of the mice. Nine mice in each group were sacrificed on 3rd days, then histopathology examination was conducted with Haematoxylin eosin. There were significant differences between treatment group given Toman fish extract and positive control group given Haruan fish extract, and also compared to the negative control group in PMN cell examination. There were significant differences between treatment group given Toman fish extract and positive control group given Haruan fish extract compared to negative controls on the number of macrophage cells. Toman fish extract could lower the number of PMN cells and was able to increase the number of macrophages on the 3rd days. Toman fish has anti-inflammatory effects on the wound healing process. Keywords: Anti-inflammatory effects, haruan fish extract, macrophages, PMN cells, toman fish extract
THE EFFECT OF GIANT SNAKEHEAD(Channa micropeltes)EXTRACT ON THE NUMBER OF MACROPHAGE IN DIABETES MELITUS WOUND HEALING (Research report) Khairunnida Khairunnida; Amy Nindia Carabelly; Maharani Lailyza Apriasari
Dentino : Jurnal Kedokteran Gigi Vol 4, No 1 (2019)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v4i1.6168

Abstract

Background:Giant snakehead contains albumin and omega-6 fatty acids which play an important role in diabetes mellitus wound healing. Wounds in people with diabetes mellitus have low level of albumin, thus inhibiting the macrophage function. Objective: To prove the effect of giant snakehead extract of 16mL/Kg dose of rats’ weight toward the number of macrophage on wistar rats’ back wounds with diabetes mellitus in day 4, 8 and 14. Method and Materials: This study applied pure experimental method with posttest-only control design. This study 36 wistar rats as sample which divided into 9 groups; group of giant snakehead extract with 16mL/Kg dose of rats’ weight, positive control group using haruan fish extract with 13.54mL/Kg dose of rats’ weight, and negative control group using BR2 feed. Results: The test result of One-way ANOVAon day 4 (p=0.022), day 8 (p=0.251) and day 14 (0.028). The test result of Post-hoc LSD showedthat there wereno significant differences on day 4 and 14 (p>00.5) between the groups of the giant snakehead extract and haruan fish extract. There wassignificant difference (p<00.5) between groups of the giant snakehead extract and BR2 feed. Conclusion: It can be concluded that giant snakehead extract at 16 mL / kg dose administered orally may increase the number of macrophage in wistar rat (Rattusnovergicus) induced diabetes mellitus back woundon day 4 and decreased macrophage cell count onday 8 and day 14.
VIABILITY OF DUAL-SPECIES BIOFILM OF STREPTOCOCCUS MUTANS AND LACTOBACILLUS ACIDOPHILUS AFTER APPLICATION OF MAULI BANANA STEM GEL Amy Nindia Carabelly; Dhya Aurellia Salsabila Karno; Isyana Erlita; Aninditya Pimas Trianuanty
Dentino : Jurnal Kedokteran Gigi Vol 7, No 1 (2022)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v7i1.13104

Abstract

Introduction: Dual-species biofilm of Streptococcus mutans and Lactobacillus acidophilus in dental caries has a higher viability or ability to survive in comparison to mono-species biofilm, consequently it is more resistant to antibiofilm. Mauli banana stem gel (MBSG) contains isoleucine, cinnamic acid, and another bioactive constituents that may work as antibiofilm, hence it is able to decrease the viability of dual-species biofilm of S. mutans and L. acidophilus. This research aims to analyze the effect of MBSG on viability of dual-species biofilm of S. mutans and L. acidophilus. Material and methods: This research is a true experimental research with post test only with control group design which divides dual-species biofilm of S. mutans and L. acidophilus into 12 groups with 4 replications. Group 1 are given 0.2% chlorhexidine gel (positive control), group 2 are not given any treatment (negative control), group 3 are the media control, and group 4-12 are given MBSG concentration of 6.25%, 12.5%, 25%, 37.5%, 50%, 62.5%, 75%, 87.5%, and 98%. Each group is incubated for 72 hours, afterward is given MTT reagent and read using a microplate reader. Results: The result of Kruskal-Wallis (p=0,00) and Mann-Whitney test showed significant difference between all treatment groups and control groups. Conclusion: MBSG concentration of 6.25%, 12.5%, 25%, 37.5%, 50%, 62.5%, 75%, 87.5%, and 98% are able to decrease the viability of dual-spesies biofilm of S. mutans and L. acidophilus.
THE TOXICITY OF METHANOL EXTRACT OF MAULI BANANA STEM (Musa acuminata) AGAINST BONE MARROW MESENCHYMAL STEM CELL IN VITRO Amy Nindia Carabelly; Suhartono Taat Putra; Ketut Suardita
Dentino : Jurnal Kedokteran Gigi Vol 2, No 1 (2017)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v2i1.2595

Abstract

ABSTRACTThe latest regeneration therapy has developed towards the usage of Mesenchymal stem cells (MSC) including for aggressive periodontitis, but limited amounts of MSC need extra growth factor in cells culture process. Growth factor is quite expensive so an alternative source is needed. Mauli banana stem is a proven antioxidant and has the most bioactive tannin. Methanol extract of mauli banana stem is not toxic towards fibroblast cell BHK 21 with 25% concentrate, but there is no research about the toxicity of methanol extract of mauli banana stem against MSC. Purpose: To analyze the toxicity of methanol extract of mauli banana stem against MSC in vitro. Method and source: True experimental using the posttest only control group design. MSC culture with treatment methanol extract of mauli banana stem with dosage 2,5 mg/ml; 5 mg/ml; 7,5 mg/ml; 10 mg/ml. Treatment Con A5 μg/ml is used for positive control group and is not treated as negative control group. Each group is incubated for 24 hours and 48 hours, then it is given reagent MTT and is read with ELISA reader. Result: Kruskal-Wallis and independent-sample T-test result shows that there is a significant difference between treatment group and control group. Conclusion: Methanol extract of mauli banana stem with dosage 2.5 mg/ml; 5 mg/ml; 7.5 mg/ml; 10 mg/ml is toxic towards MSC in vitro under treatment for 24 hours and 48 hours.Key words : Mauli banana stem, Mesenchymal stem cells, Toxicity
Co-Authors Agung Satria Wardhana Alya Royyana Annisa Noviany Annisa Noviany Annisa Vara Nurdianty Apriasari, Maharani Lallyza Aprilyani, Nur Arifin, Rahmad Ariyati Retno Pratiwi, Ariyati Retno Aspriyanto, Didit Audina, Nina Baitullah, Muhammad Akbar Bambang Setiawan Beta Widya Oktiani Budipramana, Melissa Christian, Tom Dewi Nurdiana Dewi Puspitasari Dewi Puspitasari Dewi, Renie Kumala Dhya Aurellia Salsabila Karno Dian Masita Dewi Dwipura, Irnamanda Erika Norfitriyah Eriwati, Yosi Kusuma Erni Marlina Fajriani, Nuril Fitri Syahrina Ghea Tri Andini Gita Puspa Ningrum Gusti Febby Aprilia Hamdani, Riky Hutami, Wijayanti Diah Wasi I Wayan Arya K. Firdaus Ichrom Nahzi, Muhammad Yanuar Ikhwan Faisal, Ikhwan Indah Listiana Kriswandini Jatmiko, Habibi Naufal Kamila, Syifa Ketut Suardita, Ketut Khairunnida Khairunnida Kurniasari, Annisa Maharani Laillyza Apriasari Maharani Laillyza Apriasari Maharani Lailyza Apriasari Maman Diki Wahyudi MARIA BINTANG Maria Tanumihardja, Maria Marina Arum Syahadati Martha Vania Saputri Maulida, Novi Dwi Milka Widya Sari Mira Hadistiana Mohd-Said, Shahida Muhammad Hasanu Reksi Muhammad Luthfi Nafisah, Riznasyarielia Nikmatun Nahzi, Yanuar Ichrom Nina Audina Norfitriyah, Erika Norhayati Norhayati Nurashfia Nurashfia Nuril Fajriani Pramitha, Selviana Rizky Priyawan Rachmadi Puspitasati, Dewi Putra, Fedriko Gamaliel Rahman, Yajma Kamiila Ramadhaniyah, Nur Renie Kumala Dewi Salsabila Karno, Dhya Aurellia Sari, Galuh Dwinta Sari, Milka Widya Sherli Diana Sinaga, Udur Sitepu, Alexander Siti Ujrumiah Suhartono Taat Putra Sutanti, Viranda Syahrina, Fitri Tri Putri, Deby Kania Trianuanty, Aninditya Pimas Utami, Juliyatin Putri Wahyudi, Maman Diki Wydiamala, Erida Yusrinie Wasiaturrahmah