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Berkala Kedokteran
Published by Universitas Lambung Mangkurat
ISSN : 14120550     EISSN : 25485660     DOI : http://dx.doi.org/10.20527
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Berkala Kedokteran is a journal contains scientific articles from original research and literature review in medical and health scope. It is published twice in a year, on February and September.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 14 Documents
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Search results for , issue "Vol 17, No 2 (2021)" : 14 Documents clear
Hand Soap Activity Against the Number oOf Bacterial Colonies from the Housewife's Hand Swab Samples in a Temporary Landfill in Kelurahan Gadang Banjarmasin Farida Heriyani; Lia Yulia Budiarti; Widya Nursantari; Ayu Apriliani
Berkala Kedokteran Vol 17, No 2 (2021)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (321.06 KB) | DOI: 10.20527/jbk.v17i2.11665

Abstract

Abstract: Unhygienic waste handling in a temporary landfill, can make the surrounding environment a source of transmission of pathogenic bacteria and colonization of bacterial growth in the hands. The study aims to identify the type of bacteria on the hands and test the activity of hand wash soap in lowering the number of colonies of hand bacteria. The identification of bacteria against 30 hand swab samples derived from the hands of housewives in temporary landfill (TPS) in Kelurahan Gadang Banjarmasin, was carried out in conventional media. Test the activity of hand wash soap in lowering the number of colonies of hand bacteria using 2 different brands.  Bacterial identification is carried out by descriptive method and experimental testing of hand wash soa p activity use pretest-posttest design with control group design. The data was analyzed using shapiro wilk test and  wilcoxon test with 95% confidence level. Identification of hand swab bacterial isolates obtained Staphylococcus aureus (66.6%), Staphylococcus epidermidis (10%) and Escherichia coli (23.33%). Statistical analysis showed significant differences between the two brands of hand wash soap tested (sig. 0.000 >0.05). The conclusion of the type of gram-positive bacteria more widely found in the hands of housewives; Type B hand soap has a higher effectiveness in reducing the number of bacterial colonies on the hands than A-brand. Keywords: hand wash soap, housewife hand swab, number of colonies of hand bacteria.
Hesperidin Interaction with HMG-CoA-Reductase Enzyme in Hypercholesterolemia: A Study in Silico Annisa Rizqi Dwi Oktaviani; Veronica Shania Aprillia; Eko Suhartono; Noer Komari
Berkala Kedokteran Vol 17, No 2 (2021)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (402.773 KB) | DOI: 10.20527/jbk.v17i2.11692

Abstract

Abstract: Dyslipidemia is a degenerative disease occurred with increased levels of fat and cholesterol levels in blood. One of the proteins used as anti-cholesterol is an HMG-CoA-Reductase. Hesperidin in orange peel can reduce cholesterol levels by interacting with HMG-CoA-Reductase. To prove this, an in silico method was used by using swissdock.ch (http://swissdock.ch/docking#). The receptor protein in dyslipidemia was obtained from the RCSB Protein Data Bank (https://www.rcsb.org) namely HMG-CoA-reductase receptor with code PDB: 1HW9. The natural ligand, hesperidin, was obtained from PubChem with code: 10621 (https://pubchem.ncbi.nlm.nih.gov/). Protein was prepared by omitting the natural ligand residues present in the protein. Ligand and protein preparations were used by the chimera 1.15. The result of this study indicated that the interaction of hesperidin with several amino acid recidues was predicted to provide inhibitory activity on HMG-CoA reductase as the protein target. Inhibition of HMG-CoA reductase will reduce mevalonate synthesis so that cholesterol levels will decrease.  Keywords: hesperidin, HMG-CoA-Reductase, cholesterol, dyslhahipidemia
Correlation of Vitamin D with Ferritin in Pregnant Mothers Chronic Energy Deficiency of the Second Trimester Hendera Henderi; Salmon Charles P T Siahaan; Irwin Priyatna Kusumah; Heru Cahjono; Ferdinand A Tannus; Nimas Pristiwanto D S; Helen Octavia
Berkala Kedokteran Vol 17, No 2 (2021)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (231.646 KB) | DOI: 10.20527/jbk.v17i2.11675

Abstract

Abstract: Based on the prevalence of the Kediri Health Office in 2013 and 2014, pregnancy in CED in Kediri was 6.6% and 6.7%, which was an increase of 0.1% from the previous year. According to the prevalence of CED pregnancy in Badas Puskesmas in 2013 and 2014, it was 7.8% and 6.1%. Aimed at knowing the differences in vitamin D levels in normal pregnancy with second trimester CED pregnancy; know the difference between ferritin in normal pregnancy and second trimester CED pregnancy; know the correlation between vitamin D and ferritin in normal pregnancy and second trimester CED pregnancy; know the correlation between vitamin D and UAC in normal pregnancy and second trimester CED pregnancy. This study used an analytical test (case-control) with randomization of pregnant and pregnant CED patients in the Sukomanunggal district. The results showed that the difference in Vitamin D (33.5380 ± 5.60498 vs 32.4300 ± 4.40708) p = 0.166, the comparison was not significant. The difference in ferritin (17.4080 ± 10.90625 vs 24.7420 ± 21.79586) p = 0.388 comparison was not significant. The correlation between vitamin D and ferritin (p = 0.030) had a significant relationship. There was no significant correlation between Vitamin D and UAC (p = 0.730). The correlation between ferritin and UAC (p = 0.304) was not significant.  Keywords: Vitamin D, Iron, Ferritin, UAC, CEDAbstract: Based on the prevalence of the Kediri Health Office in 2013 and 2014, pregnancy in CED in Kediri was 6.6% and 6.7%, which was an increase of 0.1% from the previous year. According to the prevalence of CED pregnancy in Badas Puskesmas in 2013 and 2014, it was 7.8% and 6.1%. Aimed at knowing the differences in vitamin D levels in normal pregnancy with second trimester CED pregnancy; know the difference between ferritin in normal pregnancy and second trimester CED pregnancy; know the correlation between vitamin D and ferritin in normal pregnancy and second trimester CED pregnancy; know the correlation between vitamin D and UAC in normal pregnancy and second trimester CED pregnancy. This study used an analytical test (case-control) with randomization of pregnant and pregnant CED patients in the Sukomanunggal district. The results showed that the difference in Vitamin D (33.5380 ± 5.60498 vs 32.4300 ± 4.40708) p = 0.166, the comparison was not significant. The difference in ferritin (17.4080 ± 10.90625 vs 24.7420 ± 21.79586) p = 0.388 comparison was not significant. The correlation between vitamin D and ferritin (p = 0.030) had a significant relationship. There was no significant correlation between Vitamin D and UAC (p = 0.730). The correlation between ferritin and UAC (p = 0.304) was not significant.  Keywords: Vitamin D, Iron, Ferritin, UAC, CED
Stabilization of the Interaction of the Compunds of Mallotus paniculatus Müll.Arg. on Gluthations S-Transferase (GSTs) Samsul Hadi
Berkala Kedokteran Vol 17, No 2 (2021)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (233.984 KB) | DOI: 10.20527/jbk.v17i2.11668

Abstract

Abstract: Gluthathione s-transferases (GSTs) play an important role against carcinogens, therapeutic drugs, and various types of cellular oxidative damage. Judging from its role in overcoming cellular oxidative damage, the activity of GSTs is one of the antioxidant enzymes. One of the plants that has been tested for its antioxidant ability is M. paniculatus. The content of M. paniculatus has been found so that it can be used to test the stability of the interaction between ligands and receptors. The aim of this research is to find compounds from M. paniculatus that have the potential to stabilize the interaction with the receptors. This docking method begins with ligand preparation and protein preparation followed by docking, visualization of interactions and analysis of the results. The research resulted in various docking scores with the various proteins involved. The stability of the interaction is obtained when the ligand binds to Glutathione S-transferase type A3 is hesperetin, sitosterol and sitosterol, to Glutathione S-transferase type theta-2 is β-daucostero, to Glutathione S-transferase type P is quercetin. Keywords: GSTs, M. paniculatus, docking

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