cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
-
Contact Email
-
Phone
-
Journal Mail Official
jip@uin-malang.ac.id
Editorial Address
Department of Pharmacy Building 2nd Floor, Faculty of Medicine and Health Sciences, 3rd Campus Universitas Islam Negeri (UIN) Maulana Malik Ibrahim Malang.
Location
Kota malang,
Jawa timur
INDONESIA
Journal of Islamic Pharmacy
Published by Universitas Islam Negeri Maulana Malik Ibrahim Malang
ISSN : 24605182     EISSN : 25276123     DOI : http://dx.doi.org/10.18860/jip
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Public Health
Welcome to Journal of Islamic Pharmacy (e-ISSN : 2527-6123) formerly Jurnal Farmasains (p-ISSN : 2460-5182) Department of Pharmacy, Universitas Islam Negeri Maulana Malik Ibrahim Malang, Indonesia. The journal was established in 2015 and online publication was begun in 2016. Since 2016, the journal has been published in English and only receives manuscripts in English.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 5 Documents
 1 
Search results for , issue "Vol 1, No 1 (2016): J. Islamic Pharm." : 5 Documents clear
Combination of Calotropis gigantea Radix Extract and Artemisin as an Antimalarial Agent Against Plasmodium berghei Muti’ah, Roihatul; Hayati, Elok Kamilah; Fatati, Asnal
Journal of Islamic Pharmacy Vol 1, No 1 (2016): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v1i1.3456

Abstract

Calotropis gigantea radix is one of plant which has bioactive component as antimalarial.The purpose of this research are to know antimalarial activity from combination of Calotropis gigantea radix extract and artemisin. The research consist of extraction of Calotropis gigantea radix was done with extraction maseration method. Extraction was performed by maseration with  80% ethanol solvent. Concentrated extract was in vivo antimalarial tested to animal model. Mice were peritoneal infected with 106Plasmodium berghei ANKA and divided into 5 treatment groups: negative control; positive control (artemisin of dose 4 mg/kgBW); combination of artemisin(1/4 dose of artemisin standar) and Calotropis giganteain 3 doses: 0,1 mg/KgBW; 1 mg/KgBWand 10 mg/KgBW. Data of inhibition was analyzed using SPSS program with Two Way ANOVA Test dan continued with Tukey Test.The result shows that combination of Calotropis gigantea radix extract and artemisin with dose 10 mg/KgBB has higher antimalarial activity than control positive (artemisin). The value of parasite inhibition is 55,2% for dose 0.1 mg/KgBW ; 72,8% for dose 1 mg/KgBW ; 87,3% for dose 10 mg/KgBW and 56,06 mg/KgBW for control positive (artemisin). The phytochemical compounds in 80%  ethanol solvent extract are tannins and steroids. Keywords: Calotropis gigantea,antimalaria, combination, artemisin, Plasmodium berghei
Profile Number of Mice Takizoit after Treatment With Alkaloid Fraction of Alstonia scholaris Leaves Hakim, Abdul
Journal of Islamic Pharmacy Vol 1, No 1 (2016): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v1i1.3455

Abstract

The prevalence of toxoplasmosis in Indonesia at 2006 was 43-88%. Drugs that have been the most widely used for the treatment of patients with toxoplasmosis include pyrimethamine and spiramicin. However, these drugs have been reported to cause side effects such as bone marrow suppression, penetrate the blood brain barrier, crossed the placenta and fetal blood. Therefore necessary to find alternative drugs for toxoplasmosis effective and safe. This research studied the effect of alkaloid fraction of leaves of plants Alstonia scholaris to the number takizoit profiles in intraperitoneal fluid of mice infected with Toxoplasma gondii. This research used the experimental animals were grouped as the control group and the treatment group. In the treatment group, each group was given treatment with fraction extract alkaloids from leaves of plants Pulai. The results showed the number takizoit mice infected with Toxoplasma gondii parasites without therapy is 957.5 x 103 whereas the alkaloid fraction of the ethanol extract of leaves is 737.5 x 103. Keywords: Leaves of Pulai (Alstonia scholaris), Toxoplasma gondii, toxoplasmosis.
Identification of Active Compounds Calotropis gigantea Stem Extracts as Antimalarials Agents on Animal Infected Plasmodium berghei Shofiyullah, Muhammad; Muti'ah, Ro’ihatul; Hayati, Elok Kamilah; Indradmojo, Chrystiaji
Journal of Islamic Pharmacy Vol 1, No 1 (2016): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v1i1.3454

Abstract

Thistle (Calotropisgigantea) is a wild plant that contains secondary metabolites as a potential antimalarial drugs.This study aims to determine the content of active compound contained, the potential of ethanol extract of the stem thistle as an antimalarial, and knowing the best eluent used when TLC test.This study covers the extraction of stem thistle using maceration for 24 hours using ethanol 80%.Stirring assisted with shaker for 3 hours. Ekstrak concentrated phytochemical test, antimalarial activity was evaluated by experimental animals mice infected by Plasmodium berghei.Data degree of parasitaemia in mice were analyzed using Minitab 16 with Test TwoWay ANOVA followed by Tukey test.The results showed that ethanol extract stem thistle contains the active compound class of triterpenoids, and potentially as an antimalarial with ED50 values 152.878 mg / kg bw were included in both categories.TLC test results showed that the best eluent for the separation of triterpenoids of stem thistle extract is benzene: chloroform (3: 7) which produced 12 spots with Rf values of 0.04;0.06;0.14;0.21;0.29;0.35;0.41;0.48;0.80;0.84;0.88;0.91. Keywords: Antimalarial, Calotropisgigantea, Ethanol 80%, Plasmodium berghei, Thin Layer Chromatography
The Effect of Carica Pubescens Lenne and K. Koch Fruit Extract from Dieng Plateau and Cangar to the Amount of Fibroblasts Cells on the Healing of Oral Mucosal Inflammation Kristanti, Risma Aprinda
Journal of Islamic Pharmacy Vol 1, No 1 (2016): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v1i1.3457

Abstract

The purposes of this research are to know the effect of C.pubescens fruit extract on the amount of gingival fibroblasts in wound healing of Rattus norvegicus mouth cavity’s mucosal and to know the effect of C.pubescens comes from two different areas (Dieng and Cangar) on the amount of gingival fibroblasts in wound healing of Rattus norvegicus oral mucosa. Twenty eight rats are divided to be four groups (K1, K2, K3, and K4), each rat is wounded 1 cm on the gingival mucosa of lower jaw (specifically on the apical region of incisive teeth). K1 is the control group with aquadest treatment on the wound. The wound in the K2 is treated with C.pubescens fruit extract from Dieng. The wound in the K3 is treated with C.pubescens fruit extract from Cangar. And the treatment for K4 is medicated by policresulen (common medicine for oral mucosal wound). On the fifth day of the treatment, all rats are sacrificed, and the gingival tissue is taken up for the next step. Gingival tissue is smeared by Haematoxylin Eosin (HE) to analyze the amount of gingival fibroblasts histologically. The result of this research shows that the highest average amount of gingival fibroblasts comes from K4 (policresulen treatment). And there is no significant difference on the number of Rattus norvegicus gingival fibroblasts from all of the groups (K1, K2, K3, and K4). Keywords: fibroblast, gingival, wound, mucosa, mouth, C.pubescens
Catechins Green Tea Clones GMB4 Inhibit Inflammation Process of Atherosclerosis Through Decreasing TNF-Α Levels Susanti, Erna; Suratno, Febiyanti
Journal of Islamic Pharmacy Vol 1, No 1 (2016): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v1i1.3458

Abstract

Catechins Green tea clones GMB4 are potential natural subtances to inhibit  inflammation process in atherosclerosis. The purpose of this research to determine activity of  Catechins Green tea clones GMB4 to decrease TNF-α levels, as well as to determine optimal dose of Catechins. This research was conducted at the Laboratory of Physiology of the University of Brawijaya. The method used in this research is completely randomized design with five treatments: (1) Mice with standard feed (2) mice with high-fat diet (3) mice with high-fat diet + catechins 3mg / day (4) mice with a diet high fat + catechin 6mg / day (5) mice with high-fat diet + catechin 24mg / day. The treatment was done for 60 days and measured levels of TNF-α at the end of the research. The results showed that Catechins green tea clones GMB4 can inhibit the inflammatory process in atherosclerosis through decreasing levels of TNF-α at doses of 3mg / day. The conclusion of this research is catechins at a dose of 3 mg / day can inhibit inflammation in atherosclerosis significantly. Keywords : GMB 4 green tea clones, Catechins, inflammation, TNF-α

Page 1 of 1 | Total Record : 5

 1 

Filter by Year

2016 2016


Reset
Filter By Issues
All Issue Vol 10, No 1 (2025): J. Islamic Pharm. Vol 9, No 2 (2024): J. Islamic Pharm. Vol 9, No 1 (2024): J. Islamic Pharm. Vol 8, No 2 (2023): J. Islamic Pharm. Vol 8, No 1 (2023): J. Islamic Pharm. Vol 7, No 2 (2022): J. Islamic. Pharm. Vol 7, No 1 (2022): J. Islamic Pharm. Vol 6, No 2 (2021): J. Islamic Pharm. Vol 6, No 1 (2021): J. Islamic Pharm. Vol 5, No 2 (2020): J. Islamic Pharm. Vol 5, No 1 (2020): J. Islamic Pharm. Vol 4, No 2 (2019): J. Islamic Pharm. Vol 4, No 1 (2019): J. Islamic Pharm. Vol 3, No 2 (2018): J. Islamic Pharm. Vol 3, No 1 (2018): J. Islamic Pharm. Vol 2, No 2 (2017): J. Islamic Pharm. Vol 2, No 1 (2017): J. Islamic Pharm. Vol 1, No 1 (2016): J. Islamic Pharm. Vol 1, No 1 (2015): Jurnal Farmasains More Issue