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All Journal Ulul Albab: Jurnal Studi Islam Alchemy : Journal of Chemistry El-HARAKAH : Jurnal Budaya Islam Journal of Islamic Pharmacy Science and Technology Indonesia Walisongo Journal of Chemistry Molekul: Jurnal Ilmiah Kimia Jurnal Tumbuhan Obat Indonesia al Kimiya : Jurnal Ilmu Kimia dan Terapan
Elok Kamilah Hayati
Universitas Islam Negeri Maulana Malik Ibrahim Malang
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Environmental Science Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health

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PHYTOCHEMICAL TEST and BRINE SHRIMP LETHALITY TEST AGAINST Artemia salina LEACH OF ANTING-ANTING (Acalypha indica Linn.) PLANT EXTRACT Hayati, Elok Kamilah
ALCHEMY ALCHEMY (Vol 1 No 2
Publisher : Jurusan Kimia, Fakultas Sains dan Teknologi UIN Maulana Malik Ibrahim Malang

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Abstract

Phytochemical test and brine shrimp lethality test against Artemia salina Leach of anting-anting (Acalypha indica Linn.) plant extract had been conducted. Al Quran surah Asy Syu’ara verse 7 shows advantages of plant, such as to medicine. The aim of this research is to measure the toxicity level of each anting-anting extract with three different solvents using Artemia salina Leach and to find out the compound in extracts which has a bioactivity potency. Three solvents which used in maceration process to produce anting-anting extracts are ethanol, chloroform and n-hexane. Anting-anting plant was macerated for 24 hours and shacked for 5 hours. Each of solvent extract were examined with Brine Shrimp Lethality Test and its compound with reagent and supported by thin layer chromatography. The mortality of Artemia salina analyzed by probit analyst. The Lethal Concentration 50 (LC50) values of n-hexane, ethanol and chloroform extracts, respectively are 57,0933 ppm, 73,4575 ppm and 149,374 ppm. All three LC50 values  are less than 1000 ppm, from those numbers can be concluded that anting-anting extract has a bioactivity potency. The phytochemical compounds in each solvent extract are flavonoid (ethanol extract), steroid (chloroform extract) and triterpenoid (ethanol and n-hexane extract). Key Words: Anting-anting (Acalypha indica Linn.), Artemia salina Leach, phytochemical test, toxicity test
Combination of Calotropis gigantea Radix Extract and Artemisin as an Antimalarial Agent Against Plasmodium berghei Muti’ah, Roihatul; Hayati, Elok Kamilah; Fatati, Asnal
Journal of Islamic Pharmacy Vol 1, No 1 (2016): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v1i1.3456

Abstract

Calotropis gigantea radix is one of plant which has bioactive component as antimalarial.The purpose of this research are to know antimalarial activity from combination of Calotropis gigantea radix extract and artemisin. The research consist of extraction of Calotropis gigantea radix was done with extraction maseration method. Extraction was performed by maseration with  80% ethanol solvent. Concentrated extract was in vivo antimalarial tested to animal model. Mice were peritoneal infected with 106Plasmodium berghei ANKA and divided into 5 treatment groups: negative control; positive control (artemisin of dose 4 mg/kgBW); combination of artemisin(1/4 dose of artemisin standar) and Calotropis giganteain 3 doses: 0,1 mg/KgBW; 1 mg/KgBWand 10 mg/KgBW. Data of inhibition was analyzed using SPSS program with Two Way ANOVA Test dan continued with Tukey Test.The result shows that combination of Calotropis gigantea radix extract and artemisin with dose 10 mg/KgBB has higher antimalarial activity than control positive (artemisin). The value of parasite inhibition is 55,2% for dose 0.1 mg/KgBW ; 72,8% for dose 1 mg/KgBW ; 87,3% for dose 10 mg/KgBW and 56,06 mg/KgBW for control positive (artemisin). The phytochemical compounds in 80%  ethanol solvent extract are tannins and steroids. Keywords: Calotropis gigantea,antimalaria, combination, artemisin, Plasmodium berghei
Identification of Active Compounds Calotropis gigantea Stem Extracts as Antimalarials Agents on Animal Infected Plasmodium berghei Shofiyullah, Muhammad; Muti'ah, Ro’ihatul; Hayati, Elok Kamilah; Indradmojo, Chrystiaji
Journal of Islamic Pharmacy Vol 1, No 1 (2016): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v1i1.3454

Abstract

Thistle (Calotropisgigantea) is a wild plant that contains secondary metabolites as a potential antimalarial drugs.This study aims to determine the content of active compound contained, the potential of ethanol extract of the stem thistle as an antimalarial, and knowing the best eluent used when TLC test.This study covers the extraction of stem thistle using maceration for 24 hours using ethanol 80%.Stirring assisted with shaker for 3 hours. Ekstrak concentrated phytochemical test, antimalarial activity was evaluated by experimental animals mice infected by Plasmodium berghei.Data degree of parasitaemia in mice were analyzed using Minitab 16 with Test TwoWay ANOVA followed by Tukey test.The results showed that ethanol extract stem thistle contains the active compound class of triterpenoids, and potentially as an antimalarial with ED50 values 152.878 mg / kg bw were included in both categories.TLC test results showed that the best eluent for the separation of triterpenoids of stem thistle extract is benzene: chloroform (3: 7) which produced 12 spots with Rf values of 0.04;0.06;0.14;0.21;0.29;0.35;0.41;0.48;0.80;0.84;0.88;0.91. Keywords: Antimalarial, Calotropisgigantea, Ethanol 80%, Plasmodium berghei, Thin Layer Chromatography
POTENSI TERAPI TUNGGAL ANTIMALARIA EKSTRAK ETANOL AKAR WIDURI (Calotropis gigantea) SECARA IN VIVO Fiisyatirodiyah, Fiisyatirodiyah; Hakim, Abdul; Muti’ah, Roihatul; Hayati, Elok Kamilah
Journal of Islamic Pharmacy Vol 1, No 1 (2015): Jurnal Farmasains
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v1i1.4173

Abstract

Tanaman Widuri mengandung beberapa golongan senyawa aktif, diantaranya flavonoid, alkaloid, terpenoid dan steroid.Senyawa-senyawa tersebut telah terbukti bermanfaat sebagai antimalaria.Selain itu, daun Calotropis proceraberpotensi antimalaria, sehingga diduga akar Calotropis gigantea juga berpotensi sebagai antimalaria karena mempunyai kekerabatan dalam satu genus.Penelitian ini bertujuan untuk mengetahui  efektivitas antimalaria ekstrak etanol 80 % akar Widuri (Calotropis gigantea) pada mencit terinfeksi Plasmodium berghei dan identifikasi golongan senyawa aktifnya.Tahapan penelitian ini meliputi analisis kadar air sampel basah, preparasi sampel, analisis kadar air sampel kering, kemudian ekstraksi senyawa aktif dengan maserasi. Setelah itu, dilakukan uji antimalaria dan dilanjutkan dengan uji fitokimia.Senyawa aktif yang positif terhadap uji fitokimia diidentifikasi dengan metode Kromatografi Lapis Tipis.Hasil kadar air sampel basah sebesar 51,17 %, sedangkan kadar air sampel keringnya sebesar 4,96 %. Isolasi senyawa aktif dilakukan dengan metode maserasi menggunakan pelarut etanol 80 %. Efektivitas antimalaria ekstrak etanol 80 % akar tanaman Widuri (Calotropis gigantea) dalam menghambat pertumbuhan Plasmodium berghei pada mencit adalah sangat baik dengan nilai ED50 sebesar 4,26 mg/Kg BB. Golongan senyawa aktif  yang terkandung dalam ekstrak etanol 80 % akar Widuri (Calotropis gigantea) berdasarkan uji reagen adalah golongan senyawa terpenoid dan saponin. Hasil identifikasi menggunakan Kromatografi Lapis Tipis menunjukkan bahwa eluen terbaik untuk golongan senyawa terpenoid adalah n-heksana : etil asetat (2 : 8) yang menghasilkan penampakan warna ungu pada panjang gelombang 366 nm dengan pereaksi Lieberman-Burchard, sedangkan eluen terbaik untuk saponin adalah kloroform : aseton (4 : 1) dengan penampakan warna ungu pada panjang gelombang 366 nm dengan pereaksi H2SO4 0,1 M. Kata kunci :Calotropis gigantea, antimalarial, Fitokimia, Kromatografi Lapis Tipis
PENGAWET MAKANAN: Sebuah Bahasan Untuk Penetapan Halalan Toyyiban Hayati, Elok Kamilah
ULUL ALBAB Jurnal Studi Islam Vol 10, No 2 (2009): Islamic Studies
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (547.78 KB) | DOI: 10.18860/ua.v10i2.6055

Abstract

As the primary needs of human being, food we consume must be halal and good as prescribed by Muslim law which is explicitly stated in Quran and Hadith. Deciding the food is halal or not can be detected from its benefit and disadvantage, and also from its processing. The development of food industry has brought better change both qualitatively and quantitatively on the food. This caused a significant improvement on food ingredients such as preservative and texture of the food. The consumer needs fresh, cheap, and easy-serving as the consequence of practical life. The high demand on economic interest and the complexity of food causes the increase of chemical substance as the preservative, such as formalin. The use of preservative that is to preserve foodstuffs against decay is very dangerous as it brings negative effect to our health. Therefore, the idea of back to nature which promotes the optimal use of natural food must be highly recommended. This can, physiologically, be received easily into our body.
Antioxidant Activity of Flavonoid from Rhizome Kaemferia galanga L. Extract Hayati, Elok Kamilah; Ningsih, Rachmawati; Latifah, Latifah
ALCHEMY ALCHEMY (Vol. 4, No.2
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (320.957 KB) | DOI: 10.18860/al.v4i2.3203

Abstract

Kaemferia galanga L. rhizome is a traditional crop which is widely used for herbal medicine.  This research is started from the extraction of maceration using ethanol 80% and partition with chloroform:water. 80 % ethanol extract and chloroform fraction tested antioxidant activity with DPPH (1,1-diphenyl-2-picrylhydrazyl), phytochemicals with reagents, separation of the active compound by TLC (thin layer chromatography) analytical and preparative TLC, the identification of compounds with sliding reagent using UV-Vis. The test results on the antioxidant activity of 80% ethanol extract of 64,93% (100 ppm) and chloroform fraction of 54,9 % (100 ppm) with indigo IC50 of 13,07 mg/mL and 81,9 mg mL. 80 % ethanol extract and chloroform fraction has potential as a source of natural antioxidants. Phytochemical test showed 80% ethanol extract contains flavonoids, alkaloids and tannins. At the chloroform fraction extract containing flavonoids. The separation of the active compounds with analytical TLC using eluent PE: ethyl acetate (5: 1) resulted in 7 stain (Rf 0,06 to 0,96) and preparative TLC produce 8 spots (Rf from 0,19 to 0,83). Results from UV-Vis spectrum can be presumed that such a class of flavonoid compounds flavanones or dihidroflavonol. It can be seen from the wavelength range 210-285 nm in the bands I and 300-550 nm in band II. The addition of the reagent slide showed the presence of hydroxyl groups in ring A, B and C and O-hydroxy on ring A. Keywords: antioxidant activity, Kaemferia galanga rizhome, sliding reagent, Thin Layer Chromatography, 1,1-diphenyl-2-picrylhydrazyl 
UJI FITOKIMIA DAN UJI TOKSISITAS EKSTRAK ETANOL TANAMAN KESEMBUKAN (Paederia foetida Linn.) DENGAN METODE BRINE SHRIMP LETHALITY TEST Sukmawati, Datin An Nisa; Hayati, Elok Kamilah; Muti'ah, Roihatul
ALCHEMY ALCHEMY (Vol.3, No.2
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (222.563 KB) | DOI: 10.18860/al.v0i1.2918

Abstract

Tanaman Kesembukan (Paederia foetida L.) merupakan salah satu tanaman dari suku Rubiaceae (kopi-kopian) yang telah digunakan oleh masyarakat sebagai obat sariawan, obat demam, sesak nafas, obat tekanan darah tinggi, rematik dan herpes. Tujuan dari penelitian ini adalah untuk mengetahui tingkat toksisitas masing-masing ekstrak tanaman Kesembukan terhadap larva udang Artemia salina L. dan untuk mengetahui kandungan senyawa yang terkandung dalam masing-masing ekstrak tanaman kesembukan.Penelitian ini dilakukan dengan mengekstraksi sampel menggunakan pelarut etanol, kloroform dan n-heksana. Ekstrak pekat yang diperoleh digunakan untuk uji toksisitas terhadap larva udang Artemia salina L. dengan metode Brine Shrimp Lethality Test (Meyer, et al., 1982) dan untuk uji fitokimia dengan reagen. Senyawa dari hasil uji fitokimia diidentifikasi menggunakan kromatografi lapis tipis dengan beberapa eluen untuk mengetahui eluen yang terbaik. Data kematian larva udang Artemia salina L. dianalisis dengan analisis probit untuk mengetahui nilai LC50 pada masing-masing ekstrak.Hasil dari penelitian ini menunjukkan bahwa masing-masing ekstrak tanaman Kesembukan (Paederia foetida L.) memiliki tingkat toksisitas terhadap larva udang Artemia salina L.yang ditunjukkan dengan nilai LC50 kurang dari 1000 ppm. Nilai LC50 masing-masing ekstrak etanol, kloroform dan n-heksana adalah 226,787; 482,014; dan 146,181 ppm. Kandungan senyawa hasil uji fitokimia menggunakan reagen untuk masing-masing ekstrak tanaman Kesembukan adalah golongan senyawa steroid. Eluen terbaik untuk pemisahan senyawa pada ekstrak etanol adalah n-heksana : etil asetat (8:2) dengan nilai Rf= 0,22 dan 0,48. Pada ekstrak kloroform adalah n-heksana : etil asetat (7:3) dengan nilai Rf= 0,32; 0,45; 0,59; 0,63; 0,82; 0,85; 0,87 dan 0,94. Pada ekstrak n-heksana adalah n-heksana : etil asetat (8:2) dengan nilai Rf= 0,12; 0,38 dan 0,41.
IDENTIFIKASI DAN UJI AKTIVITAS GOLONGAN SENYAWA ANTIOKSIDAN EKSTRAK KASAR BUAH PEPINO (Solanum muricatum Aiton) BERDASARKAN VARIASI PELARUT Husnah, Muhibbatul; Barroroh, Himmatul; Hayati, Elok Kamilah
ALCHEMY ALCHEMY (Vol.1 No.1
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (214.317 KB) | DOI: 10.18860/al.v0i0.1664

Abstract

Telah dilakukan penelitian dengan mengidentifikasi dan menguji aktivitas golongan senyawa antioksidan ekstrak kasar buah pepino (Solanum muricatum Aiton) berdasarkan variasi pelarut. Buah tersebut diekstrak menggunakan pelarut aquades, etanol 70 %, etil asetat p.a., kloroform p.a., petroleum eter p.a. dan heksana p.a. Analisis kimia pada ekstrak  menunjukkan bahwa dalam ekstrak terdapat golongan senyawa asam askorbat, alkaloid dan karotenoid. Kekuatan Aktivitas antioksidan pada ekstrak diukur  menggunakan metode DPPH dengan parameter nilai EC50. Nilai EC50 Aktivitas antioksidan tertinggi dari berbagai ekstrak berturut-turut (etanol 70 %, 22,11 g/ml), (etil asetat, 23,81g/ml), (aquades, 28,31g/ml), (kloroform, 30,06g/ml), (petroleum eter, 32,80g/ml) dan (heksana, 38,92g/ml).Aktivitas antioksidan; buah pepino; alkaloid; asam askorbat; karotenoid; DPPH
THE STUDY OF ANTIOXIDANT ACTIVITY OF ETHANOL FRACTION FROM BLACK CUMIN (Nigella sativa, L.) Yuliani, Dewi; Hayati, Elok Kamilah; Adi, Tri Kustono
ALCHEMY ALCHEMY (Vol.3, No.1
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (413.982 KB) | DOI: 10.18860/al.v0i0.2897

Abstract

Black cumin (Nigella sativa, L.) is a plant with a lot of advantages. Many research have been conducted on this plant and most of them use nonpolar, such as petroleum ether and chloroform, as a solvent in extraction process. In this research, extraction of black cumin using ethanol was applied.Black cumin extraction started with maceration using ethanol p.a. and partition using chloroform (1:1). The antioxidant activity of ethanol fraction of black cumin was examined by DPPH method. To identify the composition, phytochemical screening, including test for terpenoid, flavonoid, saponin, tannin and alkaloid, was also conducted.The result showed that the scavenging ability on DPPH method was 22.483% with IC50 2743.59. Phytochemical screening on ethanol fraction showed the presence of flavonoid, tannin and alkaloid. The study concluded that polar fraction of black cumin has small antioxidant activity.
Synthesis and Characterization of Mesoporous NaX Zeolite from Kaolin Loading of Soursop Leaves Extract (Annona muricata Linn.) Nasifah, Ilmin; Khalifah, Susi Nurul; Hayati, Elok Kamilah
ALCHEMY Vol 5, No 3 (2017): ALCHEMY
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1086.436 KB) | DOI: 10.18860/al.v5i3.4621

Abstract

Mesoporous NaX zeolite has been synthesized from calcined kaolin with the addition of 5M NaOH and CTABr surfactant as mesoporous template by hydrothermal method. The result of synthesis was used as anticancer loading agent of ethanol extract soursop leaves. Characteristics of zeolite were studied by XRD, IR spestroscopy, Nitrogen Adsorption and SEManalysis. The mesoporous NaX zeolite has been formed with mixing of A, Y, kaolinite and quartz phases. The surface of zeolite particles has changed from amorphous to regular and uniform particles. The pores of NaX zeolite belongs to mesoporous type with size 6.13 nm. Loading process of soursop leaves extract on zeolite decreased intensity and crystallinity of zeolite peaks. The new absorption in soursop leaves extract loaded on zeolite spectra was detected at 2928.174 cm-1. The surface of zeolite seen to be compact and irregular.
Co-Authors Abdul Hakim Abrilia, Putri Riza Akhmad Sabarudin Akyunul Jannah Alfi Istiqomah, Alfi Andiartama, Amanda Milano Anggraini, Maulinda Putri Datin An Nisa Sukmawati Deva Krisna Kadarani Dewi Yuliani Dewi Yuliani, Dewi Ella Wulandari Fadhila, Salma Iza Fatati, Asnal Fiddaroini, Saidun Fiisyatirodiyah, Fiisyatirodiyah Hidayaty, Alfianita Nuril Himmatul Barroroh Ifaridatul Chusna, Ifaridatul Indradmojo, Chrystiaji Laksono, Muhammad Teguh Latifah Latifah M. Rafi Madaniyah, Luailik Moh. Farid Rahman Muhammad Teguh Laksono Muhibbatul Husnah Muti'ah, Ro’ihatul Muti'ah, Roihatul Nasifah, Ilmin Rachmawati Ningsih Rachmawati Ningsih Roihatul Muti'ah Roihatul Mutiah Roihatul Muti’ah Shofiyullah, Muhammad Susi Nurul Khalifah Tri Kustono Adi Yani Triastutik, Yani