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INDONESIA
IDJP (Indonesian Journal of Pharmaceutics)
Published by Universitas Padjadjaran
ISSN : -     EISSN : 25978748     DOI : -
Core Subject :
The Indonesian Journal of Pharmaceutics (IdJP) is an established international journal for pharmaceutical scientists concerned in all fields of pharmaceutical sciences, including pharmaceutical preformulation, formulation, manufacturing technologies, drug delivery systems, biopharmaceutics, and pharmacokinetics for drugs, vaccines and biologicals. IdJP also includes pharmaceutical engineering and industrial pharmacy topics.
Arjuna Subject : -
Articles 5 Documents
 1 
Search results for , issue "Vol 4, Issue 2, May - August, 2022" : 5 Documents clear
Optimization of Propolis and Vegetable Oils-based Soap Formulation to Enhance Product Quality and Antioxidant Properties Rahadatul 'Aisy; Efri Mardawati; Desy Nurliasari; Hana Nur Fitriana; Awaly Ilham Dewantoro; Desy Nurliasari
Indonesian Journal of Pharmaceutics Vol 4, Issue 2, May - August, 2022
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v4i2.41229

Abstract

Consumers demanded the quality of solid soap for the bath were having a solid texture, high foam stability, and fulfillment of the national quality standard in SNI 3522:2021. Soap characteristics and quality are affected by soap bases and the existence of natural additive matter with antioxidant properties such as propolis extracts. The study aims to determine an optimum formula for soap production using Response Surface Methodology (RSM) with Box-Behnken experimental design. The research conducted in several stages, its consist to propolis extraction, soap formulation and production, RSM analysis towards predetermined responses, model validation, and products characterization (in optimum formulation). Optimized factors consist of the content of propolis extracts, coconut oils, palm oils, and olive oils, while the response was moisture content, foam stability, and antioxidant inhibition. The results showed each response has a significant model to get an optimum formula for propolis extracts soap production. The optimum formula for soap production requires 1.545 g propolis extracts, 13.097 g coconut oils, 29.629 g palm oils, and 29.809 g olive oils with the model validation for each response were 95.5% moisture content, 96.5% foam stability, and 97.5% antioxidant inhibition. Soap characterization in the optimum formula fulfilled the quality standard requirement in SNI 3522:2021 its consists of 20.24% moisture content, 2.22% insoluble ingredients in ethanol, and 0.07% free alkali content. Keywords: Box-Behnken Design, Formula Optimization, Propolis Extracts, RSM, Solid Soap.
Evaluation of Shampoo by Quality Control: Review Arnita Annisanur; Ida Musfiroh
Indonesian Journal of Pharmaceutics Vol 4, Issue 2, May - August, 2022
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v4i2.40492

Abstract

Shampoo is a product that is used to clean hair from dirts and also for specific therapeutic objectives such as conquering dandruff and hair loss. Product evaluation is a step that cannot be avoided to ensure product quality, including shampoo. As stated in the Good Manufacturing Practice guidelines, in the process of releasing product, the quality control in pharmaceutical industry must guarantee that the appropriate tests have been performed. The purpose of this review is to determine what attributes need to be evaluated in shampoo preparations. Datas for this review were obtained from national and international scientific publications published in the last 10 years using websites such as PubMed, Science Direct, and Springer. The keywords used in the search process are shampoo, evaluation of shampoo, types of shampoo. Final number of articles that used are 50 articles. Based on the search results, it is concluded that the evaluation of shampoo preparations consisted of testing physical appearance, homogeneity test, pH, solid content, viscosity, cleansing ability, and others. Keywords: Shampoo, quality control, products evaluation.
Approaches for Drug Design and Discovery Karyn Elizabeth; Eri Amalia
Indonesian Journal of Pharmaceutics Vol 4, Issue 2, May - August, 2022
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v4i2.41005

Abstract

Drug discovery in general requires high costs and especially a very long time, which is around 11-16 years. This is because drug development must go through a complete series of research processes to obtain comprehensive data. However, in line with the community's need for the availability of quality drugs, having good efficacy and safety, the development of drug development technology using a computing system is carried out. This is in line with the development of science and collaboration between various disciplines. Approaches that can be used for computational drug discovery include Structure-Based Drug Design and Ligand Based Drug Design which are proven to accelerate and increase the possibility of finding new drugs. This article aims to provide an overview of several approaches to drug discovery development, especially the benefits of computational. The data were collected from 28 primary published journals and 28 supporting literatures. This article discusses the two computational methods, especially from the application aspect which is expected to be useful in the field of drug discovery and development to be more efficient in terms of time and cost. The traditional approach to new drug development takes about 11-16 years but using computational methods can shorten the drug discovery stage to 9-13 years. Keywords: Drug Discovery, Ligand Based CADD, Structure-Based CADD
Hospitalized patients on orexin receptor antagonists have a lower risk of falls Yukina Ohshima; Takuya Araki; Hideaki Yashima; Noriyuki Nakayama; Koujirou Yamamoto
Indonesian Journal of Pharmaceutics Vol 4, Issue 2, May - August, 2022
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v4i2.44186

Abstract

Falls and fall-related injuries remain a major safety concern in many hospitals and nursing homes. Although many studies have examined the relationship between accidents and sedating medications, further analysis is needed of the association between falls and individual hypnotics. The aim of this study was to clarify the association between hypnotics and the risk of falls in hospital. The impact of hypnotics on fall events was retrospectively evaluated in patients aged 20 years or older who were admitted to Gunma University Hospital between January 2013 and March 2022. Logistic regression analysis was performed with age, sex, and drug prescription status as the independent variables and fall events as the dependent variable. Of the 54,019 patients included in the study, 1,460 experienced a fall during hospitalization (incidence, 2.7%). The hypnotics prescribed included orexin receptor antagonists, melatonin receptor agonists, and benzodiazepine receptor agonists. Logistic regression analysis showed that age (odds ratio [OR] 1.04), male sex (OR 1.14), estazolam (OR 2.99), flunitrazepam (OR 2.34), brotizolam (OR 1.65), diazepam (OR 3.34), lorazepam (OR 2.93), alprazolam (OR 1.91), ethyl loflazepate (OR 2.81), zolpidem (OR 1.40), eszopiclone (OR 1.87), clonazepam (OR 1.94), and ramelteon (OR 2.15) independently contributed to falls. Short-acting benzodiazepine receptor agonists tended to have smaller ORs for fall risk. Orexin receptor antagonists were not associated with falls. Therefore, orexin receptor antagonists and short-acting benzodiazepine receptor agonists are likely safer than intermediate-acting and long-acting benzodiazepines. Keywords: fall risk, hypnotics, acute care hospitals
Review: Solubility And Bioavailability Enhancement Of Carvedilol Using Multicomponent Crystal Method Nadiyah Salma Athaya; Iyan Sopyan
Indonesian Journal of Pharmaceutics Vol 4, Issue 2, May - August, 2022
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v4i2.44137

Abstract

Carvedilol is included in the BCS class 2 classification, drugs that have low solubility and high permeability. Drugs with low solubility pose a major challenge for oral drugs in achieving the desired systemic circulation. Moreover, carvedilol is indicated for the treatment of cardiovascular disease and hypertension which requires a rapid pharmacological response. A way to increase drug solubility is by forming multicomponent crystals, including solvates, cocrystals, and salts. Cocrystal and salt formation methods are the most frequently used methods in the pharmaceutical field. The multicomponent crystal approach is a process of combining active drug ingredients with other compounds known as coformers which then interact through molecular bonds. Multicomponent crystals provide benefits to improve the physicochemical properties of drugs without affecting their pharmacological properties. In this review, we discuss the multicomponent crystal approach as an effort to increase the solubility and bioavailability of carvedilol. The main reference data used in this review are research journals published in the last 10 years (2012-2022) using the keywords carvedilol, multicomponent crystal, solubility, bioavailability, and using Google Scholar as a database. There is also a discussion on regulation of cocrystals, methods for forming multicomponent crystals, and characterization of multicomponent crystals. The multicomponent crystal approach has promising benefits in increasing the solubility and bioavailability of carvedilol in the body. Keywords: Carvedilol, multicomponent crystal, solubility, bioavailability

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