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All Journal Jurnal Biodiversitas dan Bioteknologi
Nurhaifa Azzahra
Universitas Muhammadiyah Bandung

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Review: Teknologi Biosensor dalam Mendeteksi Senyawa Antidiabetes pada Tanaman Muhammad Farid Maksum; Nurhaifa Azzahra; Nelis Hernahadini
Jurnal Biodiversitas dan Bioteknologi Vol 2 No 2 (2025): Biodiverse: Jurnal Biodiversitas dan Bioteknologi
Publisher : Jurnal Biodiversitas dan Bioteknologi

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Abstract

Type 2 diabetes is a serious, widespread health problem worldwide that causes reduced quality of life, mortality, mortality and significant economic burden. The high number of diabetes sufferers in Indonesia has encouraged the development of anti-diabetic drugs, including those derived from plants used as traditional medicine. The role of biosensors in detecting antidiabetic compounds in plants is very important because they can provide fast, accurate and sensitive methods for biochemical analysis. The purpose of this review is to provide an overview of biosensor technology used for detecting antidiabetic compounds in plant leaves by discussing the general principles of biosensors, their mechanisms using electrochemical biosensor devices, paper-based biosensors, and microzone plastic-based biosensors. The literature study was carried out by searching articles from various leading journal databases, such as PubMed, Google Scholar, and ResearchGate. A review was carried out regarding biosensor devices as anti-diabetic compound detectors with three technical types, namely electrochemical, paperbased and microzone plastic-based. Based on sensitivity and other advantages, microzone plastic-based biosensors are the best biosensors compared to the other two biosensors. The use of microzone plastic-based biosensors is also very simple, requiring only the placement of the sample on the detection area, after which the compound can be detected through the scanner/sensor features embedded in the device
Review: Peran Protein Virus dalam Host Immune System Evasion Nurhaifa Azzahra; Nazif Muhammad; Wulan Pertiwi
Jurnal Biodiversitas dan Bioteknologi Vol 2 No 2 (2025): Biodiverse: Jurnal Biodiversitas dan Bioteknologi
Publisher : Jurnal Biodiversitas dan Bioteknologi

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The human body has an immune system that functions to protect the body from pathogens such as bacteria and viruses. This system consists of two types of immunity: non-specific immunity (innate immunity) and specific immunity (adaptive immunity). Non-specific immunity acts quickly using various cells and molecules to combat pathogens, while specific immunity takes longer but is more effective and has the ability to remember pathogens for a faster response in the future. Despite this, many viruses have developed mechanisms to evade detection and elimination by the immune system, known as immune evasion. This evasion is carried out in various ways, including modifications of viral proteins that disrupt immune pathways, such as antigen presentation, interferon signaling, and immune cell functions. This literature review aims to identify the various strategies used by viruses to evade the immune system. The method used is a literature search from various scientific journals such as PubMed, Wiley, and Elsevier. The analysis results show that viruses can avoid PRR detection, inhibit JAK-STAT signaling, and regulate autophagy to survive and replicate within the host body. This study provides an in-depth understanding of the immune evasion mechanisms by viruses, which are a major challenge in the treatment and prevention of infectious diseases. A deep understanding of these immune evasion mechanisms in crucial for developing more effective strategies to fight viral immune evasion, thereby enhancing the effectiveness of therapies and vaccines in the treatment and prevention of infectious diseases
Co-Authors Hernahadini, Nelis Muhammad Farid Maksum Nazif Muhammad Wulan Pertiwi