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Andi Zsazsa Rafiatul Muklis
STIKes Darul Azhar Batulicin
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Formulation and Evaluation of the Physical Stability of Liquid Soap Preparations with Sonneratia caseolaris Leaf Extract Muhammad Syarif Hidayatullah; Andi Zsazsa Rafiatul Muklis; Raisha Hamiddani Syaiful; Nur Mahdi
Journal of Pharmacology Experiment and Pharmaceutical Technology Vol. 1 No. 2 (2025): JPEPT
Publisher : DSM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64015/jpept.v1i2.11

Abstract

Red pidada leaf (Sonneratia caseolaris L.) is a plant that has benefits as an antioxidant with active compounds such as alkaloids, flavonoids, tannins, terpenoids, and saponins. Usually the local community uses this plant as a wet pupur. The purpose of this study was to determine whether red pidada leaves can be formulated into a liquid soap preparation that meets the requirements of physical properties and stability evaluation. This type of research is true experimental laboratory. Extraction of red pidada leaves is carried out by maceration using ethanol as a solvent. The formulation used three extract concentrations, namely F1 (2%), F2 (4%), and F3 (8%). Parameters carried out in the form of physical properties testing, including organoleptic test, pH, specific gravity, viscosity, foam resistance and stability testing with the cycling test method. The results of organoleptic physical properties testing on the three formulations showed that the F1 preparation was light brown, F2 brown, and F3 dark brown, had a distinctive aroma and had a liquid consistency in F1 and slightly thick in F2 and F3. Testing of pH, specific gravity, viscosity and foam resistance in the three formulations has met the requirements, except for the specific gravity test in the F3 preparation. Testing with the cycling test method has affected the evaluation of physical properties in the three formulations which causes a very thick consistency in the preparation. So that the tests that meet the requirements are only the pH and foam resistance tests, while the specific gravity is only in the F1 preparation.
EXPLORING THE ANTIDIABETIC POTENTIAL OF LANGSAT (Lansium Domesticum L.): A COMBINED EXTRACT APPROACH IN VIVO Juliana Handyka Rosanty Hutasoit; Andi Zsazsa Rafiatul Muklis; Nur Mahdi
Journal of Pharmacology Experiment and Pharmaceutical Technology Vol. 1 No. 2 (2025): JPEPT
Publisher : DSM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64015/jpept.v1i2.12

Abstract

Diabetes Mellitus is a chronic condition caused by increased blood glucose levels due to the body no longer being able to produce enough insulin hormone or use insulin effectively. Traditional medicine has long used Langsat, a native plant of Indonesia. Langsat is widely used by the community in treating various diseases, including as a worm medicine, fever medicine, diarrhoea medicine, and cancer medicine. This study aims to find out how well a mix of antidiabetics works with EKDL (Lansium domesticum L) in lowering blood sugar levels in male white mice (Mus musculus) and to figure out the best dose of EKDL for reducing blood sugar in the mice. Experimental research method using 35 white male mice divided into 7 groups, each group containing 5 mice, namely negative control, positive control, EK, ED, EKKDL 1:1, EKKDL 2:1, and EKKDL 1:2. The results of the ANOVA test of the EKKDL dose 1:2 (200 mg / 240 mg / kgBW) were effective in reducing blood sugar levels in mice. Analysis of blood sugar level data of mice using paired T-tests and post hoc. The results of the paired t-test showed a significant difference in blood sugar levels after treatment (p <0.005) and the results of the post hoc test showed that there was a significant difference (p < 0.005) and there was no significant difference (p > 0.005) between all EKKDL in reducing blood sugar levels in mice. The combination of langsat skin and leaf extract (Lansium domesticum L.) has effectiveness in reducing blood sugar levels in experimental animals.
Effectiveness Test Antidiarrhea of the Combination of Ziziphus Mauritiana Leaves and Curcuma Domestica Rhizome on Male Mice (Mus musculus) Rita Muliyani; Andi Zsazsa Rafiatul Muklis; Nur Mahdi
Journal of Pharmacology Experiment and Pharmaceutical Technology Vol. 1 No. 2 (2025): JPEPT
Publisher : DSM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64015/jpept.v1i2.14

Abstract

Diarrhea is a disease that experiences an increase in fecal mass and the number of bowel movements is more than 4 times per day. Synthetic drugs are often used to treat diarrhea, but they often cause dangerous side effects. Bidara leaves (Ziziphus mauritiana) and turmeric rhizomes (Curcuma domestica) are often used as alternative treatments to treat diarrhea because they contain potential diarrheal drugs. The purpose of this study is to determine the antidiarrheal effect of a combination of bidara leaf ethanol extract (BLEE) and turmeric rhizome ethanol extract (TREE) on male mice that were given PO with oleum ricini. The research method used was experimental with the induction of oleum ricini diarrhea with a combination dose of EEDB and EERK 4mg:2mg/20grBB, 2mg:4mg/20grBB and 4mg:4mg/20grBB. The results of the study with One Way ANOVA with a confidence level of 95% in this study were < 0.05 which means that there was a significant difference and continued LSD tests in all combination groups obtained a meaningful difference with the positive control group (attapulgite). The results of the study concluded that the combination of bidara leaves (Ziziphus mauritiana) and turmeric rhizomes (Curcuma domestica) had a stronger antidiarrheal effect than positive control (attapulgite).
Co-Authors Juliana Handyka Rosanty Hutasoit Muhammad Syarif Hidayatullah Nur Mahdi Raisha Hamiddani Syaiful Rita Muliyani