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All Journal Contagion: Scientific Periodical Journal of Public Health and Coastal Health Jurnal Info Kesehatan
Husnul Khotimah
Department of Pharmacology, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Public Health

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The Effect of Curcumin on Reactive Oxygen Species (ROS) Levels in the Hearts of Wistar Rats (Rattus norvegicus) as a Preeclampsia Model Lina Zafirah Sukaji; Berliana Noviasih Pertiwi; Bambang Rahardjo; Husnul Khotimah
Contagion: Scientific Periodical Journal of Public Health and Coastal Health Vol 7, No 3 (2025): CONTAGION
Publisher : Universitas Islam Negeri Sumatera Utara, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30829/contagion.v7i3.25816

Abstract

Abstract Background: Reactive Oxygen Species (ROS) are reactive oxygen molecules that play a central role in the pathogenesis of preeclampsia through oxidative stress mechanisms. Elevated ROS levels trigger damage to membrane lipids, proteins, and DNA, as well as activate inflammatory pathways, leading to injury of target organs, including the heart. Curcumin, a polyphenolic compound derived from Curcuma longa, possesses antioxidant and anti-inflammatory properties with the potential to suppress ROS production and improve cellular function. Objective: To examine the relationship between ROS and curcumin by integrating experimental findings in a Wistar rat preeclampsia model with supporting literature. Methods: A literature review was conducted through searches in PubMed, Scopus, and Google Scholar using the keywords “Reactive Oxygen Species,” “Curcumin,” and “Preeclampsia.” Primary data were obtained from thesis research with a post-test only control group design, using L-NAME induction to generate a preeclampsia model and administering curcumin at a specific dose. ROS levels were measured using the spectrophotometry method. Results: The study showed that ROS levels in the preeclampsia group increased significantly compared to the control group (p < 0.05). Curcumin administration reduced ROS levels by 39.21% compared to the preeclampsia group, approaching control values. These findings are consistent with literature reports indicating that curcumin suppresses ROS through NADPH oxidase inhibition, increased antioxidant enzyme activity, and modulation of the NF-κB pathway. Conclusion: Curcumin significantly reduces ROS levels in the preeclampsia model and has the potential to serve as an adjunctive therapy in preventing complications mediated by oxidative stress. Keywords: Curcumin, Reactive Oxygen Species, Preeclampsia, Oxidative Stress, Antioxidant.
Nanoemulsion of Curcuma longa Extract Improves the Developmental Process in High Glucose-Induced Zebrafish (Danio rerio) Embryos Devi Maya Arista; Rizki Amelia; Husnul Khotimah; Subandi Subandi; Fatnuraini Priyahita; Nabila Fathir; Nastyazka Subakti; Hafizhah Dini Syarafina
JURNAL INFO KESEHATAN Vol 23 No 3 (2025): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol23.Iss3.1889

Abstract

Gestational diabetes mellitus (GDM) is hyperglycemia during pregnancy, which can increase oxidative stress and reactive oxygen species (ROS). This oxidative stress can adversely affect fetal developmental processes, including body length, ocular development, blood flow, and heart rate. Curcuma longa extract, containing curcumin, has been shown to possess antidiabetic and antioxidant properties. Nanoemulsions have demonstrated efficacy in enhancing the pharmacokinetics and pharmacodynamics of herbal compounds. This study aimed to evaluate the effect of a nanoemulsion of Curcuma longa extract on body length, ocular apoptosis, blood flow, and heart rate in zebrafish (Danio rerio) embryos exposed to high glucose concentrations. Zebrafish has many benefits as it has 70% orthologous genes with humans, high fecundity, and rapid embryogenesis. Nanoemulsions were prepared using the self-nanoemulsifying drug delivery system (SNEDDS) technique. Embryos were allocated to five groups: control, 3% glucose, and 3% glucose with 1.25, 2.5, or 5 µg/mL nanoemulsion of Curcuma longa extract. The results showed that a 1.25 µg/mL nanoemulsion of Curcuma longa extract reduced phosphoenolpyruvate carboxykinase (PEPCK) expression, increased body length, and mitigated developmental process disorders by decreasing ocular apoptosis and maintaining blood flow and heart rate in high glucose-induced zebrafish embryos. These findings suggest that a nanoemulsion of Curcuma longa extract may have potential therapeutic applications in managing the adverse effects of hyperglycemia on fetal development in GDM.
Co-Authors Bambang Rahardjo Berliana Noviasih Pertiwi Devi Maya Arista Fatnuraini Priyahita Hafizhah Dini Syarafina Lina Zafirah Sukaji Nabila Fathir Nastyazka Subakti Rizki Amelia Subandi Subandi