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All Journal Majalah Obstetri dan Ginekologi Biomedical Journal of Indonesia Majalah Kesehatan FKUB Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Jurnal Ilmu Kedokteran dan Kesehatan Journal of Issues in Midwifery Sciences of Pharmacy Journal of Food and Pharmaceutical Sciences Jurnal Info Kesehatan
Subandi Subandi
Fakultas Kedokteran Universitas Brawijaya
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health

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Pengaruh Pemberian Aromaterapi Lavender secara Inhalasi terhadap Penurunan Intensitas Nyeri Persalinan Fisiologis pada Primipara Inpartu Kala Satu Fase Aktif di BPM “Fetty Fathiyah” Kota Mataram Karlina, Sisca Dewi; Reksohusodo, Subandi; Widayati, Aris
Majalah Kesehatan FKUB Vol 2, No 2 (2015)
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (263.01 KB)

Abstract

Nyeri merupakan perasaan sensorik dan emosional yang tidak menyenangkan. Pada persalinan nyeri  disebabkan kontraksi miometrium, regangan segmen bawah rahim dan serviks, serta iskemia otot rahim sebagai proses fisiologis yang menimbulkan rasa takut dan khawatir yang dapat berdampak pada ibu dan janin. Aromaterapi adalah salah satu metode nonfarmakologis untuk menangani nyeri dengan memproduksi   enkefalin. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh pemberian aromaterapi lavender secara inhalasi terhadap penurunan intesitas nyeri persalinan fisiologis pada primipara inpartu kala I fase aktif. Desain penelitian ini adalah experimental dengan rancangan one group pretest-posttes without control. Jumlah sampel 20 orang yang ditentukan dengan metode purposive sampling. Variabel bebas adalah pemberian aromaterapi dan variabel terikatnya adalah nyeri persalinan. Uji statistik menggunakan paired t-test diperoleh nilaii p value = 0,000 (p value < 0,05) artinya pemberian aromaterapi lavender terbukti signifikan dapat menurunkan intensitas nyeri persalinan fisiologis kala satu fase aktif. Dapat disimpulkan bahwa terdapat pemberian aromaterapi lavender secara inhalasi mampu menurunkan intensitas nyeri persalinan fisiologis pada primipara inpartu kala satu fase aktif. Kata kunci: Aromaterapi Lavender, Nyeri persalinan, Primipara.
Factors Related to the Need of Sexuality Education in Primary School in Gondanglegi Sub-District, Malang Regency Wati, Linda Ratna; Putri, Rismaina; Ariani, Dewi; Hidayah, Nurul; Reksohusodo, Subandi; Silvani, Yulia
Journal of Issues in Midwifery Vol 1, No 1 (2017)
Publisher : Journal of Issues in Midwifery

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (269.831 KB) | DOI: 10.21776/ub.JOIM.2017.001.01.1

Abstract

Semakin tingginya kekerasan dan pelecehan seksual pada anak di wilayah Kabupaten Malang serta adanya proses tumbuh kembang anak, dimana pada usia 9-12 tahun anak mulai memasuki masa pubertas, maka anak sekolah dasar perlu mendapatkan pendidikan seksualitas. Dan pendidikan seksualitas akan lebih baik jika diberikan sesuai kebutuhan anak. Tujuan dari penelitian ini adalah menganalisis kebutuhan pendidikan seksualitas pada anak sekolah dasar di Kecamatan Gondanglegi Kabupaten Malang. Metode penelitian yang digunakan adalah metode kuantitatif dengan rancangan explanatory research dengan pendekatan cross sectional. Pengumpulan data menggunakan kuesioner pada 317 sampel pada 24 sekolah dasar. Analisa data secara univariat, bivariat dengan chi-square dan multivariate dengan regresi logistik. Hasil penelitian menunjukkan bahwa sebagian besar responden (70.03%) membutuhkan pendidikan seksualitas dengan variabel yang berpengaruh pada kebutuhan pendidikan seksualitas adalah informasi (OR= 4.870), pengetahuan (OR=3.028), dan sikap terhadap pendidikan seksualitas (OR= 4.271).
Laporan Kasus : Pubertas Dini Akibat Kanker Ovarium Tipe Embrional Reksohusodo, Subandi
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Publisher : Journal of Issues in Midwifery

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.JOIM.2021.005.01.5

Abstract

Embryonic carcinoma (EC) cells were the first pluripotent cells identified. These cells were derived from malignant germ cell tumors called teratocarcinomas. Embryonal carcinoma also affects young patients but is far less common than yolk sac tumor in the ovary and, when encountered, is always a component of a mixed germ cell tumor.1 Malignant germ cell tumors are subdivided into dysgerminoma and nondygerminomatous tumors. The most common types of nondysgerminomatous tumors are yolk sac and immature teratoma. Mixed germ cell tumors with embryonal carcinoma, nongestational choriocarcinoma, and polyembryoma are less common. Embryonal carcinomas, though rare, are one of the most malignant cancers arising in the ovary.2In this case report, a 4,5-year-old girl was diagnosed with suspected embryonal ovarian carcinoma after complaints having menstruation for three months, develop pubic hair and breast. This patients later had laparotomy surgical staging and undergoing chemotherapy. 
PENGARUH PEMBERIAN SARI TOMAT (Solanum lycopersicum L) DAN INSULIN TERHADAP KADAR GLUKOSA, KADAR LDL, KADAR KOLESTEROL DAN BERAT BADAN LAHIR TIKUS PUTIH STRAIN WISTAR (Rattus Norvegicus) BUNTING DENGAN MODEL DIABETES MELLITUS TIPE 2 Savitri, Faradea Ubaidurrohmah; Safitri, Risma Andani Ayu; Maharani, Wening Pangesthi; Andriani, Lela Dwi; Kalsum, Umi; Proborini, Astri; Reksohusodo, Subandi; Dian Hanifarizani, Rahma
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Publisher : Journal of Issues in Midwifery

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.JOIM.2021.005.01.2

Abstract

Diabetes Mellitus is a chronic disease caused by abnormal working insulin, insulin secretion or both so that the body tends to have high glucose levels. Type 2 diabetes mellitus can cause elevated levels of LDL and cholesterol. Risks obtained by fetuses with type 2 diabetes can be in the form of macrosomia due to hyperglycemia and hyperinsulin in the body of the fetus. Insulin is the first choice pharmacological therapy for type 2 DM that can be given during pregnancy. Non-pharmacological therapy as recommended by the World Health Organization (WHO) on a healthy diet by increasing consumption of fruits and vegetables. Good fruit consumed for pregnant women with diabetes mellitus (DM) type 2 is tomatoes (Solanum lycopersicum L). The purpose of this study was to determine the administration of tomato extract (Solanum lycopersicum L) and insulin can affect glucose levels, LDL levels, cholesterol levels and birth weight of white wistar strain (Rattus norvegicus) pregnant women with type 2 diabetes mellitus models. experimental design using the pre post test only control group design and post test only control group design. Termination was done on the 17th day of pregnancy and then followed by measurements of LDL levels, cholesterol and birth weight. Data analysis using the One Way Anova test and Kruskal Wallis then continued with the Post Hoc test using. The results showed that there were significant differences between glucose levels, LDL levels, cholesterol levels and BW born in the insulin treatment group and the tomato juice treatment (p value = 0.00 <α = 0.05). The conclusion of giving insulin and tomato juice affects a decrease in glucose levels, LDL levels, cholesterol levels and birth weight.
PRODUKSI TOTAL REACTIVE OXYGEN SPECIES PADA KULTUR JARINGAN MOLA HYDATIDOSA KOMPLIT DENGAN PEMAPARAN 17-BETA ESTRADIOL Reksohusodo, Subandi; Nurseta, Tatit
Majalah Kesehatan FKUB Vol 8, No 2 (2021): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.majalahkesehatan.2021.008.02.1

Abstract

Frekuensi kejadian mola hydatidosa yang berpotensi menjadi penyakit trofoblast ganas terus meningkat. Mekanisme patologis yang mendasari penyakit tersebut belum dapat dieksplorasi secara mendalam, terdapat pemikiran bahwa mekanismenya terkait dengan kerusakan oksidatif yang berhubungan dengan produksi reactive oxygen species (ROS). Diketahui bahwa hormon estrogen dan metabolitnya dapat memproduksi ROS, untuk itu perlu dianalisis seberapa jauh keterlibatan estrogen (17β-estradiol) dalam patomekanisme penyakit ini melalui pengukuran total ROS. Penelitian ini dilaksanakan secara eksperimental dengan menggunakan randomized group control design. Rancangan percobaan yang digunakan adalah rancangan acak lengkap dengan 1 kelompok perlakuan, yaitu kelompok kultur jaringan mola hydatidosa yang mendapat suplementasi estrogen (17β-estradiol) dalam 4 dosis (5 mg/ml, 10 mg/ml, 20 mg/ml, 40 mg/ml) dan tanpa suplementasi. Dari hasil penelitian didapatkan perbedaan sangat bermakna kadar ROS antara kelompok kontrol dengan kelompok 17β-estradiol 5 mg/ml dan 17β-estradiol 40 mg/ml (p = 0,000 < 0,05), antara kelompok perlakuan 17β-estradiol 10 mg/ml dan 17β-estradiol 40 mg/ml (p = 0,000 < 0,05) dan antara kelompok perlakuan 17β-estradiol 20 mg/ml dan kelompok perlakuan 17β-estradiol 40 mg/ml (p = 0,000 < 0,05). Disimpulkan bahwa pemberian 17β-estradiol 20 mg/ml dan 40 mg/ml mempengaruhi produksi total ROS pada kultur jaringan mola hydatidosa. 
Effect of Nanocurcumin in Combination with Methotrexate on Telomerase Activity, NF-kb Expression, and Proliferation Index of Bewo Choriocarcinoma Cells: Pengaruh Kombinasi Nanokurkumin dengan Methotrexate terhadap Aktivitas Telomerase, Ekspresi NF-kb, dan Indeks Proliferasi Sel Koriokarsinoma Bewo Subandi Subandi; Sigit Purbadi
Indonesian Journal of Obstetrics and Gynecology Volume 11 No. 2 April 2023
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v11i2.1733

Abstract

Laporan Kasus Kanker Endometrium Tipe Sekretori: Kasus Jarang Subandi Subandi
Journal of Issues in Midwifery Vol. 7 No. 1 (2023): Volume 7 No 1
Publisher : Journal of Issues in Midwifery

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.JOIM.2023.007.01.5

Abstract

Endometrial cancer is the most common gynecological cancer in developed countries, second most in poor countries and developing countries after cervical cancer. Most endometrial cancer patients come with complaints of bleeding and come at an early stage. It’s important to make the right diagnosis to determine the appropriate treatment. Treatment depends on the stage determined by surgery. After surgery, the patient’s risk was classified as low, moderate, or high risk. This risk is determined by stage, cell type, differentiation, involvement of blood vessels and lymph vessels. From these risk factors, it is determined whether or not additional postoperative therapy is needed in the form of radiation or chemotherapy. Secretory type of endometrial cancer is a rare endometrial malignancy. This case’s population is 1-2% of all endometrial cancer. Histologically, this type of cancer belongs to type one. We report a secretory type of endometrial cancer case in a 41-year-old woman with a complaint of irregular menstruation, and a total hysterectomy, bilateral salpingo oophorectomy, bilateral pelvic lymphadenectomy and para-aortic lymphadenectomy was done. Histologically, secretory carcinoma must be separated from carcinoma clear cell to determine the prognosis.
Nano-curcumin in the decrease of proteinuria in white rats (Rattus norvegicus) with preeclampsia Subandi; Sahara, Aulia Ilma; Nurdiana
Majalah Obstetri & Ginekologi Vol. 32 No. 1 (2024): April
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V32I12024.8-13

Abstract

HIGHLIGHTS The size of curcumin was modified to nano scale in order to enhance its bioavailability and facilitate its absorption in the body. As a herbal medicine, nano-curcumin has the ability to reduce proteinuria and serve as a preventive measure against preeclampsia.   ABSTRACT Objective: Since preeclampsia is one of the most serious hypertensive disorders in pregnancy, as it occurs in 5-7% of all pregnancies, and causes around 70,000 maternal deaths and 500,000 fetal deaths worldwide each year, this study aimed to determine the effect of nano-curcumin on proteinuria in pregnant white rats (Rattus norvegicus) with preeclampsia. Materials and Methods: In this study, 24 white rats (Rattus norvegicus) were randomly selected and divided into six groups. Inclusion criteria included healthy rats aged 8 weeks or older, with normal blood pressure and weight, while exclusion criteria included sick, deceased, or prematurely birthing rats, and those with high blood pressure. Treatment, administered over six days from gestational days 13-18, involved L-NAME and nano-curcumin injections. Groups included K- (no treatment) and K+, P1, P2, P3, and P4 (treated with L-NAME and varying nano-curcumin doses). Blood pressure and proteinuria were evaluated on gestation days 12, 15, and 19 to confirm the preeclampsia model and assess nano-curcumin's effect on proteinuria. Urine collected over 24 hours in metabolic cages preceded the rats' termination. Data analysis utilized IBM SPSS version 23, including the Shapiro-Wilk test, parametric independent sample t-tests, One-Way ANOVA tests, and LSD post-hoc tests to identify group differences.   Results: The results of this study showed that nano-curcumin had the effect of reducing proteinuria in white rats with preeclampsia. The significant results of the One-Way Anova test was p=0.001 (p <0.05) and the LSD post-hoc test revealed that the effective dose was 25 mg/ml. It was found that higher nano-curcumin dose had a higher average of proteinuria. Conclusion: Nano-curcumin can affect proteinuria in preeclampsia. The most effective dose is 25 mg/ml.
Nano Liposomal Curcumin as an Adjuvant: Enhancing Cisplatin Anticancer Effects in HeLa Cells Subandi, Subandi; Balindra, Fredlina Rossa; Gizta, Aura Bella; Khotimah, Husnul; Handono, Kusworini
Sciences of Pharmacy Volume 4 Issue 2
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0402347

Abstract

Cervical cancer, mainly driven by oncogenic HPV infections, remains a global health burden. Cisplatin is standard chemotherapy for advanced cases but is limited by toxicity. Nano liposomal curcumin, with improved bioavailability, may enhance cisplatin’s efficacy. This study investigated the combination’s effect on HeLa cells by analyzing Cyclin E1 and Bcl-2 expression. Nano liposomal curcumin was synthesized using thin-film hydration, yielding stable 32 nm nanoparticles. HeLa cells were divided into control and treatment groups, and varying doses of nano liposomal curcumin with cisplatin were received. Flow cytometry revealed significant reductions in Cyclin E1 (from 18.62 ± 1.45 to 5.79 ± 0.47) and Bcl-2 (from 32.56 ± 0.82 to 28.19 ± 0.30) at the highest dose (p < 0.05). Cell viability decreased to 9% with cisplatin alone and 1% with the combination. These results indicate that nano liposomal curcumin enhances cisplatin’s antiproliferative and pro-apoptotic effects, supporting its potential as an adjuvant to lower cisplatin doses while maintaining efficacy. Further research involving additional molecular markers, in vivo models, and clinical trials is needed to optimize dosing, confirm safety, and evaluate therapeutic potential.
A Synergistic Approach: Enhanced Apoptotic and Proliferative Inhibition of Cisplatin by Nanocurcumin in HeLa Cells Subandi, Subandi; Gizta, Aura Bella; Balindra, Fredlina Rossa; Handono, Kusworini; Khotimah, Husnul
Journal of Food and Pharmaceutical Sciences Vol 13, No 2 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.21389

Abstract

Cisplatin is a widely used chemotherapeutic agent for cervical cancer, but its effectiveness is often limited by cellular resistance and severe side effects. Curcumin has demonstrated potential to enhance cisplatin's anticancer effects by inducing apoptosis and inhibiting cell proliferation; however, its clinical use is constrained by poor solubility and low bioavailability. To overcome these limitations, liposomal nanocurcumin was developed. This study aimed to evaluate the synergistic effects of cisplatin and nanocurcumin on Bax and BrdU expression as markers of apoptosis and proliferation in HeLa cervical cancer cells. A true experimental post-test only design was employed with five groups: HeLa cell control (no treatment), positive control (cisplatin 5 µg/mL), and three treatment groups receiving cisplatin 2.5 µg/mL combined with nanocurcumin at 25, 50, and 100 µg/mL. Cells were incubated for 48 hours and analyzedusing flow cytometry. The combination treatment significantly increased Bax expression and reduced BrdU expression compared to cisplatin alone, with the strongest effect observed at 100 µg/mL nanocurcumin. These findings suggest that nanocurcumin may serve as a promising adjuvant to enhance the therapeutic efficacy of cisplatin by promoting apoptosis and suppressing proliferation in cervical cancer cells.
Co-Authors AA Sudharmawan, AA Abd. Rasyid Syamsuri Aina Angelica Akhmalia, Qorry' Afyu Anandasari , Noni Fidya Ayu Anandasari, Noni Fidya Ayu Andriani, Lela Dwi Angelica, Aina Anisa Setyowati Aris Widayati Arista, Devi Maya Asih, Aliyah Tresna Astri Proborini Azahra, Mutiara Syifa Balindra, Fredlina Rossa Bambang Rahardjo Chatarina Umbul Wahyuni Daniel Happy Putra Dewi Ariani Dewi Azar Nuria Wardani Dian Hanifarizani, Rahma Fathir, Nabila Gizta, Aura Bella Gusti, Kharisma Ciptaning Hendy Setyo Yudhanto Hikmawan Wahyu Sulistomo Husnul Khotimah Husnul Khotimah Ihda Dian Kusuma Ihda Dian Kusuma Ita Sulistiani Kaspirayanthi, Ni Ketut Devy Kenty Wantri Anita Kenty Wantri Anita, Kenty Wantri Kharisma Ciptaning Gusti Khoir, Safa’atul Kridayanti, Novalia Kusworini Handono Maharani, Wening Pangesthi Melani Chysti Situmorang Nasution, Annio Indah Lestari Ni Ketut Devy Kaspirayanthi Noni Fidya Ayu Anandasari Novalia Kridayanti Nurdiana Nurdiana Nurdiana Nurdiana Nurdiana Ovinery, Amarsya Paramita, Galuh Anggarda Priyahita, Fatnuraini Rismaina Putri Rizki Amelia Safitri, Risma Andani Ayu Sahara, Aulia Ilma Savitri, Faradea Ubaidurrohmah Setyowati, Anisa Sigit Purbadi Silvani, Yulia Sisca Dewi Karlina, Sisca Dewi Situmorang, Melani Chysti Subakti, Nastyazka Sulistiani, Ita Sulistomo, Hikmawan Wahyu Syarafina, Hafizhah Dini Tatit Nurseta Tatit Nurseta Tri Yudani Mardining Raras Tri Yudani MR Wardani, Dewi Azar Nuria Wati, Linda Ratna Wiyasa, I Wayan Arsana Yudhanto, Hendy Setyo