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All Journal Aesculapius Medical Journal Journal of Pharmaceutical and Sciences.
Adhindha Amalia
Universitas Lambung Mangkurat
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Literature Review: Efek Neuroprotektif Ekstrak Tanaman Kelor (Moringa oleifera) Model In vivo Cedera Otak Adhindha Amalia; Afifah Allisya; Muyassarah Salsabila
Aesculapius Medical Journal Vol 5 No 3 (2025): October
Publisher : Fakultas Ilmu Kedokteran dan Ilmu Kesehatan, Universitas Warmadewa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/amj.5.3.2025.245-260

Abstract

Traumatic Brain Injury (TBI) menjadi masalah kesehatan global dengan angka morbiditas dan mortalitas tinggi, terutama pada usia produktif. Pilihan terapi neuroprotektif yang efektif masih terbatas. Moringa oleifera mengandung senyawa bioaktif dengan potensi antioksidan, antiinflamasi, dan antiapoptotik. Literature review ini menganalisis efek neuroprotektif ekstrak Moringa oleifera pada model in vivo cedera otak dengan fokus pada ekspresi caspase-3 sebagai biomarker apoptosis. Pencarian literatur dilakukan melalui PubMed, ScienceDirect, Google Scholar, Wiley, dan Elsevier untuk artikel berbahasa Inggris periode 2015–2025 menggunakan kata kunci terkait. Seleksi dilakukan berdasarkan kriteria inklusi dan eksklusi, serta risiko bias dinilai menggunakan SYRCLE’s Risk of Bias. Enam studi memenuhi kriteria inklusi dan dianalisis. Ekstrak daun, biji, dan minyak Moringa oleifera menurunkan stres oksidatif, respon inflamasi, dan ekspresi caspase-3. Pemberian ekstrak memperbaiki fungsi kognitif dan perilaku pada hewan uji. Moringa oleifera berpotensi sebagai agen neuroprotektif pada TBI, namun penelitian lanjutan dan uji klinis pada manusia diperlukan untuk memastikan efektivitas dan keamanannya.  
Studi Perbandingan Antara Maserasi dan Accelerated Solvent Extraction (ASE) terhadap Hasil Ekstrak Daun Kalangkala (Litsea angulata) Nabila Hadiah Akbar; Putri Helena Junjung Buih; Khoirunnisa Muslimawati; Aditya Maulana Perdana Putra; Adhindha Amalia; Dhea Juliana Putri
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1305

Abstract

Kalangkala (Litsea angulata) is an endemic plant of Kalimantan that has long been used in local traditional medicine to manage various health conditions. Phytochemical reports indicate that Kalangkala contains diverse secondary metabolites, including phenolics, flavonoids, alkaloids, tannins, saponins, terpenoids, steroids, and carotenoids. Therefore, selecting an appropriate extraction method is essential to maximize metabolite recovery while minimizing degradation. This experimental study compared the extraction yield of Kalangkala leaf extract obtained using maceration and ASE (Accelerated Solvent Extraction) methods. Each method was performed in three replicates and the percentage yield was calculated. Maceration produced yields of 2.10-2.18%, whereas ASE produced higher yields of 13.25-14.01%. the mean yield of maceration was 2.14 ± 0.04% (95% Cl: 2.04-2.24), while ASE achieved 13.64 ± 0.38% (95%Cl: 12.69-14.58). A two-tailed Welch’s t-test confirmed a statistically significant difference between methods (p = 0.00032), with a mean difference of 11.49% (95% Cl: 10.56-12.42). In conclusion, ASE provided a higher extraction yield than maceration under the conditions evaluated in this study.
Co-Authors Afifah Allisya Akbar, Nabila Hadiah Buih, Putri Helena Junjung Dhea Juliana Putri Khoirunnisa Muslimawati Muyassarah Salsabila Putra, Aditya Maulana Perdana